Clinical trials: Substance Dependency
Insomnia, Nicotine Dependence
Study of Lunesta Versus Placebo for Sleep Problems Related to Smoking Cessation and Zyban
Objectives: The primary objective of this study is to determine the efficacy of eszopiclone at treating sleep problems related to withdrawal from nicotine in healthy smokers attempting smoking cessation.
- Trial name
- NCT00511134
- Testing
- Eszopiclone, Bupropion
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Yale University
Tobacco Use Disorder
Effect of Galantamine on Short-term Abstinence
This is a randomized, double-blind, placebo-controlled study to test whether a medication called galantamine (Brand Name: Razadyne) will help smokers quit and whether it reduces cognitive problems that smokers experience during a…
- Trial name
- GAL-K (NCT01669538)
- Testing
- Galantamine
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- University of Pennsylvania
Major Depressive Disorder, Alcohol Abuse
Acamprosate Added to Escitalopram and Behavioral Treatment for Comorbid Depression and Alcoholism
This is a study about treatment for people who suffer from both major depression and alcohol abuse or dependence. The study will examine whether the addition of acamprosate to escitalopram and behavioral interventions will…
- Conditions
- Major Depressive Disorder, Alcohol Abuse, Alcohol Dependence
- Trial name
- NCT00452543
- Testing
- acamprosate, escitalopram, Medical management
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Massachusetts General Hospital
Alcohol Dependence
CRF1 Antagonist GSK561679 in Alcoholism
Objective: To evaluate GSK561679, an orally available, brain penetrant selective CRH1 antagonist for its ability to reduce alcohol craving in recently detoxified alcohol dependent women in response to stress or alcohol-associated…
- Trial name
- NCT01187511
- Testing
- GSK561679
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Alcohol Dependence
Mindfulness Meditation for Health
The purpose of this 52-week clinical trial is to see if the meditation-based intervention, adjunctive to standard of care therapy, can reduce relapse and improve psychological health among adults recovering from alcohol…
- Trial name
- NCT01056484
- Testing
- Mindfulness Based Relapse Prevention for Alcohol Dependence, "Wait-list" control
- Where
- United States
- Volunteers
- 123 people
- Sponsor
- University of Wisconsin, Madison
Alcoholism, Cocaine Dependence
Vigabatrin for Cocaine and Alcohol Dependence
The purpose of this study is to evaluate the effectiveness of vigabatrin at reducing drug and alcohol use in individuals addicted to cocaine and alcohol. Vigabatrin is approved for the treatment of seizures.
- Trial name
- VGB (NCT01335867)
- Testing
- Vigabatrin
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Pennsylvania
Alcohol Use Disorder, Substance Use
Emergency Department Initiated Extended-Release Naltrexone and Case Management for the Treatment of Alcohol Use Disorder
This is a phase 4, open-label, feasibility study of extended release naltrexone (Vivitrol, Alkermes Pharmaceutical) and case management for treatment of alcohol use disorders in the ED.
- Conditions
- Alcohol Use Disorder, Substance Use, Alcohol Abuse or Dependence
- Trial name
- NCT04094584
- Testing
- Vivitrol (Extended Release Naltrexone)
- Where
- United States
- Volunteers
- 179 people
- Sponsor
- University of California, San Francisco
Alcohol Dependency
Alcohol Screening, Brief Intervention, and Referral to Treatment in a Military Treatment Facility
An alcohol Screening, Brief Intervention and Referral to Treatment (SBIRT) approach will be adapted for use in a large military hospital setting, and then pilot tested in a military emergency department (ED) to assess its…
- Trial name
- NCT02228967
- Testing
- SBIRT
- Where
- United States
- Volunteers
- 791 people, healthy volunteers welcome
- Sponsor
- San Diego State University
Alcoholism
Rapid Determination Of The Clinical Utility Of Perampanel For The Treatment Of Alcohol Dependence
The purpose of this study is to determine whether perampanel alters the response to alcohol for heavy drinkers. It is hypothesized that perampanel will reduce the rewarding and reinforcing properties of alcohol in the laboratory…
- Trial name
- NCT02120365
- Testing
- Perampanel
- Where
- 4 sites in United States
- Volunteers
- 22 people
- Sponsor
- Virginia Commonwealth University
Nicotine Dependence
Effects of Flavors on Nicotine Reinforcement in Smokers
To examine the acute reinforcing effects of menthol, a fruit flavor (green apple) or a fruit flavor plus menthol, alone or in combination with nicotine in smokers.
- Trial name
- NCT03243630
- Testing
- IV nicotine, Menthol flavor, green apple
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Yale University
Smoking, Sleep Disturbance
Racial Differences in Circadian and Sleep Mechanisms for Nicotine Dependence, Craving, and Withdrawal
The number one preventable cause of death in the world is tobacco use. Cigarette smoking in particular, costs an estimated $300 billion due to expenses related to medical care and lost productivity.
- Conditions
- Smoking, Sleep Disturbance, Nicotine Dependence
- Trial name
- NCT03968900
- Testing
- Sleep restriction condition, Sleep extension condition
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University of Alabama at Birmingham
Smoking, Nicotine Dependence
A Trial of E-cigarettes in Current Cigarette Smokers
The purpose of this study is to examine cigarette smokers' use of electronic cigarettes (e-cigarettes), and how use of e-cigarettes affects short term smoking behavior.
- Conditions
- Smoking, Nicotine Dependence, Nicotine Dependence, Other Tobacco Product
- Trial name
- NCT02357173
- Testing
- electronic cigarette, cigarette group
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Medical University of South Carolina
Nicotine Dependence, Nicotine Withdrawal
Progesterone and Brain Imaging Study
Male and female smokers were recruited to undergo 2 phases of smoking cessation. Each phase was 4 days long and involved 3 brain-imaging scans, blood draws and an intervention involving progesterone or a matched placebo.
- Trial name
- NCT01954966
- Testing
- Progesterone
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Cocaine Dependence, Depressive Symptoms
Clinical Efficacy of Sertraline Augmented With Gabapentin in Depressed, Recently Abstinent Cocaine-dependent Humans
To examine the clinical efficacy of sertraline (200 mg/day) alone or sertraline in combination with gabapentin. The purpose of this study is to examine whether the antidepressant sertraline alone or combined with gabapentin…
- Trial name
- NCT00654953
- Testing
- sertraline, gabapentin
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- University of Arkansas
Opioid-Related Disorders, Heroin Dependence
Combining Neuro-Imaging and Non-Invasive Brain Stimulation for Clinical Intervention in Opioid Use Disorder
The overarching goal of this project is to expand the traditional expertise in non-invasive neuromodulation at the University of Minnesota towards developing novel paired-neuromodulation approaches using transcrancial direct…
- Conditions
- Opioid-Related Disorders, Heroin Dependence, Morphine Dependence
- Trial name
- NCT04495673
- Testing
- Transcranial Direct Current Stimulation (tDCS), Cognitive Training
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Minnesota
Smokeless Tobacco Use
Highdose Nicotine Patch Therapy for Smokeless Tobacco Use
Smokeless tobacco use ("chewing") is associated with negative health effects. To date, no medications have been shown to help chewers quit long-term.
- Trial name
- NCT00939029
- Testing
- nicotine replacement therapy (nicotine patches)
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Alcohol Drinking, Alcohol Use Disorder
Effect of Theta Burst Stimulation on Alcohol Cue Reactivity
Alcohol Use Disorder (AUD) is prevalent, devastating, and difficult to treat. The intransigence of AUD is readily apparent in the Trauma Unit of Wake Forest University Baptist Hospital, wherein 23% of trauma related admissions…
- Conditions
- Alcohol Drinking, Alcohol Use Disorder, Trauma Injury, Alcohol Dependence
- Trial name
- NCT04223154
- Testing
- Real iTBS to the dlPFC
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Wake Forest University Health Sciences
Schizophrenia, Bipolar Disorder
Individualizing Incentives for Alcohol in the Severely Mentally Ill
The investigators will evaluate the efficacy of a 2 various contingency management (CM) interventions (High-Magnitude CM, Shaping CM) for treating heavy drinking among individuals with serious mental illness and alcohol…
- Conditions
- Schizophrenia, Bipolar Disorder, Major Depressive Disorder, Alcohol Dependence
- Trial name
- NCT03481049
- Testing
- Usual CM, High-Magnitude CM, Shaping CM
- Where
- 2 sites in United States
- Volunteers
- 392 people, healthy volunteers welcome
- Sponsor
- Washington State University