Clinical trials: Substance Related Disorder
Substance Use Disorder (SUD)
Identifying Substance Use Consequences
The goal of this study is to develop a new tool for measuring substance use disorder treatment outcome. We will start by interviewing people and gathering advisory groups to develop the items for this new tool.
- Trial name
- NCT07503067
- Testing
- none, there is no intervention in this study
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Mclean Hospital
Substance-Related Disorders
DOX as a Potential Treatment for Methamphetamine Dependence
The purpose of the study is to asses the potential interactions between methamphetamine and doxazosin in methamphetamine-dependent volunteers who are not seeking treatment.
- Trial name
- DOX-Meth (NCT02785393)
- Testing
- Sugar Pill, Doxazosin
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Stimulant Use, Alcohol Use Disorder
Neuromodulation and Cognitive Training for Substance Use Disorders
The relapsing nature of substance use disorder is a major obstacle to successful treatment. About 70% of those entering treatment will relapse within one year.
- Trial name
- NCT04426214
- Testing
- tDCS, Cognitive Training
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of Minnesota
Sex Trafficking, HIV
Digital Intervention Delivered Via Street Medicine to Increase HIV and Substance Use Care Among Survivors of Sex Trafficking
The goal of this clinical trial is to learn if the CONNECT program helps women with a history of sex trafficking get connected to substance use, HIV/STI, and mental health services.
- Conditions
- Sex Trafficking, HIV, Substance Use (Drugs, Alcohol), Mental Health
- Trial name
- NCT07699484
- Testing
- CONNECT
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Lifespan
Substance Abuse, Criminal Behavior
An Evaluation of the NJSPB SCF Project for Opioid-Involved High-Risk Parolees
This study entails an evaluation of the New Jersey State Parole Board Swift, Certain, and Fair (SCF) Supervision Program. The purpose of the evaluation is to test whether subjects assigned to SCF Supervision perform better than…
- Trial name
- NCT03812484
- Testing
- SCF Supervision, Parole-as-Usual
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Botec Analysis, LLC
Drug Abuse, Intravenous, Internet
Telemedicine and Social Media for People Who Inject Drugs (PWID) in Greece
The current study seeks to address questions regarding internet and social media usage as well as telemedicine concept and knowledge, by conducting targeted focus group discussions (FGDs) and administering cross-sectional…
- Conditions
- Drug Abuse, Intravenous, Internet, Social Media, Telemedicine
- Trial name
- NCT05794984
- Testing
- Focus group discussions and survey questionnaire
- Where
- Greece
- Volunteers
- 219 people
- Sponsor
- State University of New York at Buffalo
Alcohol-related Disorders
Evaluation of Case Management to Improve the Outpatient Care of Alcohol-related Disorders
The purpose of this study is to disseminate and transfer the comprehensive quality management interventions (CQM) for alcohol-related disorders in primary care developed during the first funding phase into routine care.
- Trial name
- NCT00314067
- Testing
- Online Comprehensive Quality Management System (CQM) of alcohol-related disorders in primary care, Physician training, Practice team training
- Where
- 2 sites in Germany
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- University Hospital Freiburg
Alcoholic Liver Cirrhosis
Dose Finding Study to Assess Safety and Efficacy of Stem Cells in Liver Cirrhosis
This study will evaluate the safety and efficacy of mesenchymal stem cells in patients with cirrhosis of liver. Stem cells will be injected into the hepatic artery. Improvement in various parameters will be observed over 2 years.
- Trial name
- NCT01591200
- Testing
- Allogeneic Mesenchymal Stem Cells
- Where
- 10 sites in India
- Volunteers
- 40 people
- Sponsor
- Stempeutics Research Pvt Ltd
Opioid Abuse, Prescription Opioid Abuse
Community Pharmacy-Based Prescription Drug Monitoring Program Opioid Risk Assessment Tool
This goal of this observational study is to develop and test the Opioid Risk Reduction Clinical Decision Support (ORRCDS) tool. The tool will be an opioid medication risk screener and decision support platform that will be used…
- Trial name
- PharmTool (NCT05706311)
- Testing
- Clinical Decision Support Tool (Moderate Risk), Clinical Decision Support Tool (High Risk), Standard of Care
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Utah
Drug Overdose
A Pilot Study of the Bioavailability of Nasal Naloxone
The overall is aim of this pilot study is to give a preliminary estimation of key parameters of the pharmacokinetics of a proper formulation of intranasal naloxone.
- Trial name
- NCT01939444
- Testing
- naloxone intranasal, naloxone intravenous
- Where
- Norway
- Volunteers
- 5 people
- Sponsor
- Norwegian University of Science and Technology
Opioid-use Disorder
Mobile Medication Adherence Platform for Buprenorphine-Naloxone During Treatment of Opioid Use Disorder: Phase I Study
The investigators will conduct a phase I study involving 41 participants selected randomly among patients prescribed buprenorphine-naloxone for opioid misuse as a feasibility trial of the study of the Pillsy device.
- Trial name
- MAP4BUP (NCT04656899)
- Testing
- Reminders messages to improve adherence.
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Washington State University
Alcohol Consumption
Network Support for Alcohol Treatment 2
The Network Support project is part of an ongoing effort to improve treatment for alcohol dependent patients. The Network Support Project is designed to help patients change their social network from one that reinforces drinking…
- Trial name
- NCT01129804
- Testing
- Coping Skills Training
- Where
- United States
- Volunteers
- 193 people
- Sponsor
- UConn Health
Hazardous Alcohol Use
PrEP and Alcohol - Enhancing HIV Pre-Exposure Prophylaxis (PrEP)
The present investigation entails a pilot randomized controlled trial to explore whether a stand-alone, alcohol-reduction, brief intervention (with a module on substance use and depression) would be feasible, acceptable, and…
- Trial name
- NCT05097430
- Testing
- Alcohol-focused brief intervention
- Where
- 3 sites in Canada
- Volunteers
- 122 people
- Sponsor
- Centre for Addiction and Mental Health
Opioid Use Disorder
Symptom-inhibited Fentanyl Induction
The goal of this clinical trial is to test a treatment strategy for individuals with opioid use disorder (OUD) who use fentanyl.
- Trial name
- SIFI (NCT05905367)
- Testing
- Fentanyl, Methadone, Slow-release oral morphine
- Where
- Canada
- Volunteers
- 48 people
- Sponsor
- Pouya Azar
Alcohol Dependence
Telephone-Based Continuing Care for Alcohol Dependence
Alcohol dependency is the second most common psychiatric disorder and a major public health concern. As addictive disorders and now thought to be chronic disorders for many patients there is a need for the development of expanded…
- Trial name
- NCT02030093
- Testing
- Telephone-based counseling
- Where
- Switzerland
- Volunteers
- 317 people
- Sponsor
- University of Bern
Opioid-Related Disorders, Hepatitis C (HCV)
Kentucky Outreach Service Kiosk (KyOSK): Reducing HIV, HCV, and Overdose Risk
This study will test the effectiveness, implementation outcomes, and cost effectiveness of a locally-tailored, health kiosk to reduce overdose, hepatitis C, and HIV risk behavior and improve linkage to care in rural Appalachia.
- Conditions
- Opioid-Related Disorders, Hepatitis C (HCV), Human Immunodeficiency Virus (HIV), Drug Overdose
- Trial name
- NCT05657106
- Testing
- Health kiosk
- Where
- United States
- Volunteers
- 752 people, healthy volunteers welcome
- Sponsor
- April M Young
Alcohol Use Disorder
Clinical and Mechanistic Effects of Psilocybin in Alcohol Addicted Patients
Effects of serotonin 2A/1A receptor stimulation by psilocybin on alcohol addicted patients: a randomized double-blind placebo-controlled study
- Trial name
- NCT04141501
- Testing
- Psilocybin
- Where
- Switzerland
- Volunteers
- 37 people
- Sponsor
- University of Zurich
Cannabis Dependence
A Mobile App to Reduce and/or Quit Cannabis Use
This study aims to develop an App-based intervention (CANQUIT) aimed at regular cannabis users. The efficacy of this intervention will be evaluated in the short-term (1-month follow-up) and long-term (3- and 6-months follow-ups)…
- Trial name
- CANQUIT (NCT06733792)
- Testing
- CBT-based intervention, Self-help guide
- Where
- 2 sites in Spain
- Volunteers
- 120 people
- Sponsor
- Alba González-Roz, PhD
Tobacco Use Cessation, Tobacco Use Disorder
Text Messaging for Supporting Quit Attempts
This study is a preliminary research aimed to compare the feasibility and effectiveness of motivational interview (MI), Personalized text messages (TM) and usual care for outpatients, with focus on smoking cessation as the main…
- Trial name
- NCT02571244
- Testing
- Motivational Interview plus text message
- Where
- Brazil
- Volunteers
- 66 people
- Sponsor
- Federal University of Juiz de Fora
Survivors of Childhood Cancer, Substance Use
Feasibility of Incorporating a Standardized Substance Use Measure With Linked-Brief Intervention Into Routine Psychosocial Care of Adult Childhood Cancer Survivors
The ASSIST Study is designed to explore whether a brief, evidence based substance use screening and counseling approach can be easily integrated into routine survivorship care at St. Jude Children's Research Hospital.
- Trial name
- NCT07516301
- Testing
- WHO ASSIST v3.1 Screening with Feedback, ASSIST Linked Brief Intervention (10 Step Motivational interviewing (MI)/FRAMES), WHO ASSIST v3.1 Screening (No Feedback)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- St. Jude Children's Research Hospital