Clinical trials: Substance Related Disorders
Marijuana Impairment
Neuroscience of Marijuana Impaired Driving
Marijuana is one of the most widely used substances. However, marijuana intoxication is not fully understood in relation to driving.
- Trial name
- MJDriving (NCT02757313)
- Testing
- Low dose THC marijuana, High dose THC marijuana
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Yale University
Evaluate PK Profile, Evaluate PD Profile
A Study Testing the Effects of Different THC Doses on Psychological and Biological Function
The goal of this clinical trial is to learn how a investigational medicinal product (THC) affects psychological and physical responses in healthy adults with prior cannabis use experience.
- Conditions
- Evaluate PK Profile, Evaluate PD Profile, Healthy Adults, Safety and Tolerability in Healthy Volunteers
- Trial name
- DRATT (NCT07346690)
- Testing
- AVCN319301b (6mg), AVCN319301b (9mg), AVCN319301b (15mg)
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Risk Behavior, Substance Abuse
Juvenile Offender HIV Prevention and Drug Abuse Services
This study will determine the clinical effectiveness, moderators and mechanisms of change, and economic impact of an integrative, family-based intervention that concurrently targets change in HIV/Sexually Transmitted Disease…
- Conditions
- Risk Behavior, Substance Abuse, Delinquency
- Trial name
- Day Treatment (NCT01922297)
- Testing
- Day Treatment MDFT-HIV, Day Treatment SAU
- Where
- United States
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- University of Miami
Alcohol Abuse
CARES: A Mobile Health Program for Alcohol Risk Reduction
In this fast-track STTR, Phase 1 will develop and test a mobile phone app among 40 adult community college students. The app is designed to reduce risky drinking behaviors and improve user safety.
- Trial name
- NCT03927482
- Testing
- CARES mobile smart phone app, Check Your Drinking
- Where
- United States
- Volunteers
- 239 people, healthy volunteers welcome
- Sponsor
- The Miriam Hospital
Smokeless Tobacco Use, Tobacco Dependence
Novel Determinants and Measures of Smokeless Tobacco Use: Study 1
The extent of toxicity varies considerably across different brands of smokeless tobacco (ST) products and data suggest that greater toxicity may result in greater health risks.
- Trial name
- NCT01067586
- Where
- 3 sites in United States
- Volunteers
- 359 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Cannabis Intoxication, Alcohol Intoxication
Vaporized Cannabis Administration and Co-Administration of Alcohol on Impairment
This human laboratory study will use cognitive, behavioral, and subjective measures to characterize impairment associated with co-use of alcohol and vaporized cannabis.
- Trial name
- NCT06293040
- Testing
- Cannabis, Alcohol
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Alcohol Drinking, Alcohol Intoxication
Efficacy of the Dietary Food Supplement ALCOFILTRUM in Alleviating Alcohol Hangover Symptoms
The aim of this open-label, randomized, crossover, comparative pilot study is to assess efficacy and safety of the dietary food supplement ALCOFILTRUM in healthy volunteers who consume alcohol.
- Trial name
- NCT05757089
- Testing
- ALCOFILTRUM
- Where
- Belarus
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- AVVA Pharmaceuticals Ltd.
HIV, Cannabis
Effects of Cannabidiol and Tetrahydrocannabinol on Microbiome and Neuroinflammation in HIV
This study has the potential to contribute to a more complete understanding of the independent and combined effects of cannabis use and HIV on the brain and on inflammation.
- Conditions
- HIV, Cannabis, THC, Neuroinflammatory Disease
- Trial name
- CAMI (NCT05514899)
- Testing
- THC, CBD
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Opioid Overdose
Pharmacokinetics (PK) and Safety of Multiple Doses of Intranasal Naloxone in Healthy Adults
This study will be a Phase 1, single-center, open-label, randomized cross-over study to evaluate the PK of a new AP003 device which delivers two sprays of 4 mg naloxone hydrochloride intranasally.
- Trial name
- NCT05377255
- Testing
- 16 mg naloxone AP003, 8 mg naloxone NARCAN Nasal Spray
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Emergent BioSolutions
Opioid-related Disorders
Abuse Liability of Suboxone Versus Subutex
The study is designed to compare the abuse liabilities of intravenous buprenorphine and buprenorphine/naloxone in individuals who are physically dependent on sublingual buprenorphine.
- Trial name
- NCT00710385
- Testing
- Heroin, Naloxone, Low Bup Dose
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Tobacco Dependence
Safety, Tolerability and Efficacy of the Nicotine Patch and Gum for the Treatment of Adolescent Tobacco Dependence
The purpose of this study is to test the safety, tolerability, compliance and efficacy of two different forms of nicotine replacement therapy (NRT) (the nicotine transdermal patch and the nicotine gum) in a nicotine-dependent…
- Trial name
- NCT01208935
- Testing
- Nicotine Patch, Nicotine Gum
- Where
- United States
- Volunteers
- 157 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Prevention, Family Function
Familias Unidas: Preventing Substance Abuse in Hispanic Youth
The focus of this study will be to test the Familias Unidas Intervention program among Hispanic 8th graders in the Miami-Dade County Public School System.
- Conditions
- Prevention, Family Function, Substance Use, Sexual Behavior
- Trial name
- NCT01038206
- Testing
- Familias Unidas
- Where
- United States
- Volunteers
- 746 people, healthy volunteers welcome
- Sponsor
- University of Miami
Nicotine Addiction
tDCS Effects on Resisting Smoking: Dose Ranging Study
Behaviors such as tobacco use, unhealthy diet, and sedentary behavior have far-reaching health implications. These modifiable behaviors account for a substantial proportion of deaths from cancer, cardiovascular disease and…
- Trial name
- RDR (NCT02624284)
- Testing
- transcranial direct current stimulation (tDCS)
- Where
- United States
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Opioid Use Disorder
Investigation of the Pharmacokinetic Profile of CBD
The goal of the current study is to evaluate the bioavailability of CBD in normal healthy Individuals. This is an open cross-overdesign study in healthy individuals to assess the safety and pharmacokinetic (PK) effects of…
- Trial name
- NCT05269706
- Testing
- Cannabidiol 200mg, Epidiolex, Cannabidiol 400mg
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yasmin Hurd
Substance Use Disorders, Insomnia
Feasibility of Brief Behavioral Therapy for Insomnia (BBTI) in SUD Recovery
The goal of this clinical study is to learn whether treating sleep problems is helpful in people with substance abuse problems who are living in a residential treatment program.
- Trial name
- BBTI_SUDs (NCT05935735)
- Testing
- Brief Behavioral Therapy for Insomnia (BBTI)
- Where
- United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Nicotine Dependence, Nicotine Withdrawal
Human Laboratory Study of Varenicline and Bupropion for Nicotine Dependence
The objective of this proposal is to elucidate effects of bupropion SR + varenicline on smoking-cessation related processes in early abstinence using a human laboratory model.
- Trial name
- ChanBan (NCT00749658)
- Testing
- Bupropion, Varenicline
- Where
- United States
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Marijuana Use, Cannabis Use
THC + CBD and Memory Study
Memory deficits are one of the most consistently observed cognitive effects of marijuana use. There is evidence that some decrements attributable to the primary psychoactive ingredient, delta-9-tetrahydrocannabinol (THC), may be…
- Conditions
- Marijuana Use, Cannabis Use, Cannabis Intoxication
- Trial name
- NCT04855526
- Testing
- High THC/No CBD Marihuana, High THC/High CBD Marihuana, No THC/No CBD Marihuana
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Hartford Hospital
Cardiovascular Disease, Alcohol Use Disorder
Mortality Reductions Based on AUD/Heavy Alcohol Use, HIV Risk, and Cardiovascular Risk
The purpose of this research study is to investigate if a personalized intervention including parts such as navigation (focus on patient outreach efforts, missed and completed encounters), personalization (individual health…
- Conditions
- Cardiovascular Disease, Alcohol Use Disorder, HIV Risk, Substance Use Disorders
- Trial name
- NCT05828849
- Testing
- Navigation, compensation, and personalization
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Smoking Cessation, Tobacco Use Disorder
Effectiveness of Reducing Smoking in Facilitating Smoking Cessation in Adolescents - 2
Currently one in five high school students smoke. Smoking can harm adolescents well before they reach adulthood by causing a number of immediate, sometimes irreversible, health risks and problems.
- Trial name
- NCT00158158
- Testing
- Usual Care, Smoking Reduction
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Nicotine Addiction, Cigarette Smoking
Abuse Liability of Reduced Nicotine Content Cigarettes in the Context of Concurrent E-Cigarette Use
Three hundred-twenty (320) adult smokers of menthol or non-menthol combustible cigarettes will be recruited and randomly assigned to one of five groups (n=64/group), who will be asked to switch for 12 weeks to ad libitum use of…
- Trial name
- DUAL (NCT02870218)
- Testing
- Smoking research cigarettes with e-cigarette, Nicotine discrimination thresholds
- Where
- 2 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Rose Research Center, LLC
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.