Clinical trials: Substance-Related Disorder
Constipation
Feasibility Study of Oral Naloxone for Treatment of Methadone-induced Constipation
At least 30% of patients receiving methadone maintenance therapy (MMT) are suffering from constipation that often affects effectiveness of MMT and increases its impact on health care system.
- Trial name
- NCT02137213
- Testing
- Naloxone
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Centre for Addiction and Mental Health
Male Reproductive Problem
The Effects of Cannabis on Male Reproductive Functions
The purpose of this study is to understand the direct effects of cannabis on male reproductive functions. The investigators plan to conduct a double-blind, placebo-controlled clinical trial to examine both the chronic and acute…
- Trial name
- NCT06755346
- Testing
- Cannabis plant (THC 20mg), Cannabis (0%/ THC / 0% CBD), Cannabis plant (THC 40mg)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Kanako Hayashi
Social Skills, Self-Criticism
Development and Pilot Trial of an Intervention to Reduce Disclosure Recipients Negative Social Reactions and Victims Psychological Distress and Problem Drinking
The purpose of this randomized controlled trial is to evaluate an intervention, Supporting Survivors and Self: An Intervention for Social Supports of Survivors of Partner Abuse and Sexual Aggression (SSS).
- Conditions
- Social Skills, Self-Criticism, Post-traumatic Stress Disorder, Depression
- Trial name
- NCT03488927
- Testing
- Supporting Survivors and Self: An Intervention for Social Supports of Survivors of Partner Abuse and Sexual Aggression (SSS)
- Where
- United States
- Volunteers
- 1,268 people, healthy volunteers welcome
- Sponsor
- University of New Hampshire
Substance Abuse
Web-delivery of Evidence-based, Psychosocial Treatment for Substance Use Disorders
The main objective of this study is to evaluate the effectiveness of including an interactive, web-based version of the Community Reinforcement Approach (CRA), called the Therapeutic Education System (TES), as part of…
- Trial name
- CTN-0044 (NCT01104805)
- Testing
- Therapeutic Education System (TES), Treatment-as-Usual (TAU)
- Where
- 10 sites in United States
- Volunteers
- 507 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Alcohol Withdrawal
Study of Exploratory Plasmatic Markers of Alcohol Withdrawal
This research focuses on alcohol withdrawal in hospitals and its potential neurological consequences. Alcohol withdrawal is an event that induces physical symptoms, such as tremors, sweating, anxiety and requires medical support.
- Trial name
- STEP-AW (NCT05216705)
- Where
- France
- Volunteers
- 28 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Child Abuse, Child Neglect
Fostering Healthy Futures for Teens: An RCT
This study will implement and evaluate a mentoring program designed to promote positive youth development and reduce adverse outcomes among maltreated adolescents with open child welfare cases.
- Conditions
- Child Abuse, Child Neglect, Risk Behavior, Delinquency
- Trial name
- FHF-T (NCT03707366)
- Testing
- FHF-T
- Where
- United States
- Volunteers
- 234 people
- Sponsor
- University of Denver
Substance-Related Disorders
Disrupting SRFOH to Improve Substance Use and Mental Health Outcomes for Parents in Rural Regions
The study will evaluate the effectiveness of the Just Care for Families program in preventing Oregon Department of Human Services (ODHS)-involved parents in rural communities from escalating opioid and/or methamphetamine use and…
- Trial name
- NCT06560866
- Testing
- Just Care for Families
- Where
- United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Chestnut Health Systems
Alcohol Abuse Alcoholism, General Practice
Identification and Treatment of Alcohol Problems in Primary Care
The Identification and Treatment of Alcohol Problems in Primary Care (iTAPP) Study is a pragmatic cluster randomized controlled intervention trial evaluating the effectiveness of the 15-Method as an identification and treatment…
- Conditions
- Alcohol Abuse Alcoholism, General Practice, Screening and Brief Intervention
- Trial name
- iTAPP (NCT05916027)
- Testing
- The 15-Method
- Where
- Denmark
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Southern Denmark
Alcohol Use Disorder Cognitive Decline
NEUROPSYCHOLOGICAL REHABILITATION FOR ALCOHOL USE DISORDERS
This investigation will take place between September 2024 and June 2025, with the objective of analyzing executive deficits and the impact of Neuropsychological Rehabilitation on Alcohol Use Disorder, comparing different…
- Trial name
- AUD (NCT06933186)
- Testing
- Neuropsychological rehabilitation, Weekly therapeutic groups
- Where
- Portugal
- Volunteers
- 48 people
- Sponsor
- University of Lisbon
HIV/AIDS, Hepatitis C
Project I Test: Implementing HIV Testing in Opioid Treatment Programs
This study will test two active evidence-based "practice coaching" (PC) interventions to improve opioid treatment programs' (OTPs') provision and sustained implementation of on-site 1) HIV testing and linkage to care and 2)…
- Conditions
- HIV/AIDS, Hepatitis C, Substance Use Disorders, Opioid-use Disorder
- Trial name
- NCT03135886
- Testing
- Information Control, HIV and HCV Testing Practice Coaching Intervention, HIV Testing Practice Coaching Intervention
- Where
- United States
- Volunteers
- 418 people, healthy volunteers welcome
- Sponsor
- Columbia University
Substance Use Disorders
Benzodiazepine Discontinuation in Opioid Agonist Therapy
The proposed study is a clinical trial, designed to pilot test a Distress Tolerance-Benzodiazepine Discontinuation (DT-BD) intervention for patients on opioid agonist therapy who currently use benzodiazepines.
- Trial name
- BZD-OAT (NCT04109118)
- Testing
- Distress Tolerance - Benzodiazepine Discontinuation (DT-BD), BZD discontinuation protocol
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Boston Medical Center
Alcohol Use Disorder (AUD)
eTSF for Latinx Young Adults With Alcohol Use Disorder
The goal of this clinical trial is to learn if the eTSF intervention is feasible among Latinx young adults with alcohol use disorder.
- Trial name
- NCT06722690
- Testing
- eTSF, Educational materials
- Volunteers
- 40 people
- Sponsor
- Tulane University
Mood Disorder, Anxiety Disorder
Validation of an Automated Online Language Interpreting Tool - Phase Two.
There is a pressing national need to provide higher-quality, more effectively accessible language interpretation services to improve the health outcomes of Americans who have limited English proficiency (LEP).
- Conditions
- Mood Disorder, Anxiety Disorder, Substance Use Disorder, Chronic Medical Condition
- Trial name
- NCT03538860
- Testing
- Active comparator: Human interpreter, Intervention: Asynchronous Telepsychiatry
- Where
- United States
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Renal Insufficiency, Kidney Disease
A Study to Evaluate the Pharmacokinetics Of Sativex® in Subjects With Severe Renal Impairment or End Stage Renal Disease, Compared to Matched Subjects With Normal Renal Function.
The study aims to determine the pharmacokinetic (PK) profile of a single oromucosal dose of Sativex® (i.e. how the body absorbs, distributes, metabolises and excretes the drug) when subjects have severe renal impairment or end…
- Trial name
- NCT02325024
- Testing
- Sativex
- Volunteers
- healthy volunteers welcome
- Sponsor
- GW Pharmaceuticals Ltd
Prevalence, Depression
Effectiveness of Brahma Kumaris Raja Yoga Meditation on Quality of Life of Youth in the Deaddiction Center of Biratnagar
Drug addiction is a public health problem, mainly youths are involved in the addiction and the major reason were due to peer pressure.
- Conditions
- Prevalence, Depression, Happiness, Quality of Life
- Trial name
- NCT06367023
- Testing
- Rajyoga Meditation Practice
- Where
- Nepal
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Manipur International University
Alcohol Dependence
Defining the Clinical Role of Topiramate in the Treatment of Alcohol Dependence in Australia
To compare the clinical effectiveness, tolerability, and cost-effectiveness of topiramate to active control (naltrexone) on treatment outcomes for alcohol dependence in a double-blind randomised controlled trial.
- Trial name
- NCT03479086
- Testing
- Topiramate, Naltrexone
- Where
- Australia
- Volunteers
- 180 people
- Sponsor
- South West Sydney Local Health District
Addictive Behavior, Food Preferences
Food Choices in Healthy Weight Women
This study will examine differences in habituation to foods high in sugar and fat content versus those that are not, in normal weight women.
- Conditions
- Addictive Behavior, Food Preferences, Food Habits, Healthy
- Trial name
- NCT02481362
- Testing
- CAKE, APRICOTS
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- The University of Tennessee, Knoxville
Opioid Use Disorder
Positron Emission Tomography (PET) Trial to Evaluate Target Occupancy of CVL-354 at Kappa and Mu Opioid Receptors in Brain Following Oral Dosing
The primary purpose of this study is to assess the target occupancy at kappa and mu opioid receptors in the brain after single oral doses of CVL-354 in healthy adult participants.
- Trial name
- NCT05547542
- Testing
- CVL-354, [11C]-LY2795050, [11C]-carfentanil
- Where
- 2 sites in United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Cerevel Therapeutics, LLC
Chronic Pain, Opiate Dependence
Developing Brain Stimulation as a Treatment for Chronic Pain in Opiate Dependent
Effective control of chronic pain is a top priority in the United States, as approximately 10% of adults have severe chronic pain - most of which is chronic lower back pain (CLBP).
- Conditions
- Chronic Pain, Opiate Dependence, Lower Back Pain
- Trial name
- NCT03681769
- Testing
- iTBS to the left dlPFC, cTBS to the mPFC
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Medical University of South Carolina
Opioid-Induced Constipation
Phase 2 Randomized, Double-Blind, Placebo-Controlled, Parallel Group Trial of Linaclotide Administered to Patients With Opioid-Induced Constipation Receiving Chronic Opioid Treatment for Non-Cancer Pain
The purpose of this study was to evaluate the safety and efficacy of linaclotide for the treatment of opioid-induced constipation (OIC), in adults receiving stable opioid treatment for chronic non-cancer pain that has been…
- Trial name
- NCT02270983
- Testing
- Linaclotide 145 micrograms, Linaclotide 290 micrograms
- Where
- 77 sites in United States
- Volunteers
- 254 people
- Sponsor
- Forest Laboratories
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