Clinical trials: Substance-Related Disorder
Stress Disorders, Post-Traumatic, Alcohol-Related Disorders
Primary Care Treatment Integrating Motivation and Exposure
This project aims to develop and test an integrated brief intervention to reduce heavy alcohol use and PTSD severity in veterans receiving Veterans Affairs Primary Care.
- Trial name
- PC-TIME (NCT03812146)
- Testing
- PC-TIME, PC-TAU
- Where
- 2 sites in United States
- Volunteers
- 63 people
- Sponsor
- Syracuse VA Medical Center
Hepatitis, Alcoholic
Pentoxifylline for Acute Alcoholic Hepatitis (AAH)
The goal of this study is to demonstrate the effectiveness of pentoxifylline compared to placebo in AAH while studying putative mechanisms that are plausible and testable.
- Trial name
- NCT00205049
- Testing
- pentoxifylline
- Volunteers
- 4 people
- Sponsor
- University of Wisconsin, Madison
Cocaine Abuse, Opiate Dependence
Pharmacotherapy Dosing Regimen in Cocaine and Opiate Dependent Individuals - 8
The purpose of this study is to examine two medications, modafinil and citalopram, in the treatment of cocaine dependent individuals who are maintained on methadone.
- Trial name
- NCT00218036
- Testing
- Modafinil 200mg, Modafinil 400mg, Citalopram 20mg
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Antisocial Personality Disorder, Substance Use Disorder
Justice-Involved Veterans and Moral Reconation Therapy
The purpose of this study is to determine whether Moral Reconation Therapy (MRT) is effective for reducing risk of criminal recidivism and improving other health-related outcomes (substance use, mental health, housing, and…
- Trial name
- MRT (NCT02524171)
- Testing
- Moral Reconation Therapy (MRT)
- Where
- 3 sites in United States
- Volunteers
- 344 people
- Sponsor
- VA Office of Research and Development
Tobacco Use Disorder
Reduced Nicotine Cigarette Purchasing Decisions
The goal of this project is to experimentally evaluate how expectations about reduced-nicotine cigarettes as well as actual nicotine content interact to determine behavioral and subjective response for these novel products.
- Trial name
- NCT04999644
- Testing
- Full Nicotine Cigarettes, Reduced Nicotine Cigarettes, Average Nicotine Expectancy
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Suicide, Substance-Related Disorders
Preventing Addiction Related Suicide (PARS)
The goal of this study is to evaluate the effectiveness and utility of the investigator's National Institute on Drug Abuse (NIDA) R21 developed "Preventing Addiction Related Suicide" (PARS) program by utilizing a novel stepped…
- Trial name
- PARS (NCT03166709)
- Testing
- Preventing Addiction Related Suicide (PARS), Intensive Outpatient Program standard session
- Where
- 16 sites in United States
- Volunteers
- 906 people, healthy volunteers welcome
- Sponsor
- University of Washington
Suicidal Ideation, Depression
Trial of the Rapid Antisuicidal Effects of Intranasal Ketamine in Comorbid Depression and Alcohol Abuse
This project aims to evaluate the potential rapid and sustained antisuicidal and antidepressant effects of a single intranasal dose of ketamine in inpatients during a mood episode in Major Depressive Disorder (MDD) or Bipolar…
- Conditions
- Suicidal Ideation, Depression, Alcohol Abuse
- Trial name
- NCT03539887
- Testing
- Intranasal ketamine
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- The University of Texas Health Science Center, Houston
Tobacco Use Disorder
Pilot Study of Nicotine Replacement for Smoking Cessation During Pregnancy
We plan to examine the feasibility, acceptability, preliminary quit rates, overall nicotine exposure and adverse effects of the nicotine inhaler for smoking cessation in pregnancy.
- Trial name
- NCT00888979
- Testing
- Nicotrol Inhaler
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Hartford Hospital
Alcohol Abuse
Human Alcohol Seeking Despite Aversion
Prolonged alcohol use results in drinking despite resultant problems and adverse consequences. The investigators propose to test a laboratory model of human seeking despite aversion to use as an early marker of disease onset, and…
- Trial name
- NCT03648840
- Testing
- Aversive Cue, Neutral Cue
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Indiana University
Chronic Pain, Opioid Addiction
Testosterone Replacement for Male Opioid Agonist Maintained Patients
This study is designed to develop an effective treatment intervention for chronic pain, symptomatic hypogonadism, and opioid addiction
- Conditions
- Chronic Pain, Opioid Addiction, Symptomatic Hypogonadism
- Trial name
- NCT01873989
- Testing
- Testosterone replacement, Waitlist control
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Yale University
Pain, Drug Overdose
Primary Care Intervention to Reduce Prescription Opioid Overdoses
The high rate of adverse events, including overdose, resulting from opioid pain medication use threatens the quality and safety of pain care in the Veterans Health Administration (VHA) and elsewhere and is a critical public…
- Conditions
- Pain, Drug Overdose, Opioid Use Disorders
- Trial name
- POST (NCT02464410)
- Testing
- Motivational intervention, Psycho-educational control, Long-term opioid therapy informed consent
- Where
- United States
- Volunteers
- 299 people
- Sponsor
- VA Office of Research and Development
Nicotine Addiction
Neural Mechanisms Associated With Risk of Smoking Relapse
This study will examine how abstinence-induced brain changes contribute to smoking cessation outcomes in treatment-seeking smokers.
- Trial name
- NCT02837510
- Testing
- Standard smoking cessation counseling
- Where
- United States
- Volunteers
- 119 people
- Sponsor
- University of Pennsylvania
Alcohol Disorders
Open Label Pilot Study of Perampanel for the Treatment of Alcohol Use Disorder
The purpose of this research study is to test the safety, tolerability, and effectiveness of the drug Perampanel when used in persons who drink and wish to stop drinking. Perampanel has been approved by the U.S.
- Trial name
- NCT04502589
- Testing
- Perampanel Tablet, Disulfiram
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Virginia Commonwealth University
Alcoholism
Varenicline for Alcohol Dependence
The primary objective of this study is to assess the efficacy of varenicline in reducing the proportion of heavy drinking days during the last 8 weeks of treatment in subjects with alcohol dependence confirmed by Diagnostic and…
- Trial name
- NCIG 003 (NCT01146613)
- Testing
- Varenicline
- Where
- 7 sites in United States
- Volunteers
- 200 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Opioid Dependence
Completion of OST - a Prospective Study
Only limited information on the process of completing long-term opiate substitution treatment (OST) with substances like methadone exist.
- Trial name
- NCT01722435
- Testing
- Opiate Substitution Treatment
- Volunteers
- 78 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Risk Reduction Behavior, Health Behavior
Alcohol, Marijuana, and Risky Sex: Group Interventions With Detained Adolescents
This research is studying behaviors that young people engage in that may place them at risk for contracting a sexually transmitted disease like HIV/AIDS, and what kind of educational program works best to reduce these risky…
- Conditions
- Risk Reduction Behavior, Health Behavior, Sexual Behavior, Adolescent Behavior
- Trial name
- MARS (NCT01170260)
- Testing
- INFORMATION-ONLY SEXUAL RISK REDUCTION (INFO-ONLY), SEXUAL PLUS ALCOHOL RISK REDUCTION (SRRI+ETOH), SEXUAL + ALCOHOL + MARIJUANA RISK REDUCTION
- Where
- United States
- Volunteers
- 460 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Alcohol Dependence, Post-Traumatic Stress Disorder (PTSD)
Progesterone Effect on Individuals Diagnoses With AD and PTSD.
This is a randomized control trial with an anticipated 36 participants diagnosed with post-traumatic stress disorder (PTSD) and comorbid alcohol dependence. Participants will be randomized to receive either progesterone (200 mg.
- Trial name
- NCT02187224
- Testing
- Progesterone
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Yale University
Nicotine Dependence
Impact of Varenicline on Blood-Oxygen-Level Dependent (BOLD) Functional Magnetic Resonance Imaging (fMRI) Activation on Smokers
The purpose of this study is to evaluate the impact of varenicline treatment on cue induced craving to smoking using brain imaging.
- Trial name
- GRAND (NCT00934024)
- Testing
- varenicline
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Medical University of South Carolina
Substance Use Disorders
Mindfulness Based Relapse Prevention: Efficacy and Mechanisms
The broad, long-term objective of the proposed randomized clinical trial is to evaluate the efficacy, moderators and mechanisms of change of two cognitive-behavioral aftercare treatments for alcohol and other drug (AOD) use…
- Trial name
- MBRP (NCT01159535)
- Testing
- Mindfulness Based Relapse Prevention, Relapse Prevention, Treatment as Usual
- Where
- United States
- Volunteers
- 286 people
- Sponsor
- University of Washington
Insomnia
The Efficacy of CBT-I in Alcoholics & Its Effects on Remission & Relapse
Insomnia is a highly prevalent disorder in those recovering from alcoholism. It has been associated with anxiety and depressive symptoms, as well as an increased risk of relapse back to the drinking.
- Trial name
- NCT01987089
- Testing
- Cognitive Behavioral Therapy for Insomnia (CBT-I)
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- VA Office of Research and Development
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