Clinical trials: Substance-Related Disorder
Nicotine Dependence
YMCA Exercise Intervention for Smoking Cessation Study
Cigarette smoking is the leading cause of death and disability in the United States. Although smoking has declined since 1964, it is still very common among some groups of people.
- Trial name
- NCT03080090
- Testing
- Aerobic exercise, Smoking Cessation Intervention
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Jasper A. Smits
Chronic Pain, Opioid Dependence
Pilot Study of Varenicline to Treat Opioid Dependence
The objective of this proposal is to explore the potential of varenicline as a pharmacotherapeutic agent for opioid dependence and addiction.
- Trial name
- NCT01436474
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Mayo Clinic
Alcohol Use Disorder
ED Initiated Oral Naltrexone for AUD
This study will recruit Emergency Department (ED) patients with moderate to severe alcohol use disorder (AUD) who are interested in initiating medication assisted treatment (MAT). The study is split into two phases.
- Trial name
- NCT04817410
- Testing
- Emergency Department Initiated Oral Naltrexone
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Alcohol Abuse, Criminal Behavior
Mindfulness for Alcohol Abusing Offenders
Over half of state and federal prisoners meet clinical criteria for alcohol abuse or dependence, and after release from prison, over three-quarters of offenders are re-arrested within five years.
- Trial name
- MIT (NCT03883646)
- Testing
- Mindfulness, Relapse Prevention
- Where
- United States
- Volunteers
- 392 people
- Sponsor
- The Mind Research Network
Substance-Related Disorders, Stress Disorders, Post-Traumatic
Combined Treatment for Patients With Comorbid Substance Use Disorders and Post-traumatic Stress Disorder (PTSD): an Integration of Cognitive-behavioral Treatment (CBT) and Trauma-focused Structured Writing Therapy
This study is a randomized controlled trial comparing two treatments for patients with comorbid substance use disorder (SUD) and post-traumatic stress disorder (PTSD) conducted within two different routine clinical settings for…
- Trial name
- NCT00763542
- Testing
- CBT for SUD, Structured writing therapy for PTSD
- Where
- Netherlands
- Volunteers
- 130 people
- Sponsor
- VU University of Amsterdam
Alcohol Dependence, Alcohol Drinking
Characterization Imaging Instruments in Alcoholics and Non-Alcoholics
Background: People with alcoholism have differences in their brains compared with healthy people. People who are dependent on alcohol also perform differently on behavioral tasks.
- Conditions
- Alcohol Dependence, Alcohol Drinking, Alcohol-Related Disorders, Alcoholism
- Trial name
- NCT02108080
- Where
- United States
- Volunteers
- 389 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Tobacco Use Disorder
An fMRI Study of the Effects of Clavulanic Acid on Drug Addiction
This research study is looking into the effects of clavulanic on smoking behavior in adult cigarette smokers. The primary study hypothesis is that, compared to placebo, clavulanic acid will reduce smoking over the course of the…
- Trial name
- NCT03713424
- Testing
- Clavulanic Acid
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Alcoholic Cirrhosis
Alcohol Biomarker Study
Objective: To validate ethyl glucuronide in scalp hair, fingernail and urine as a biomarker for alcohol use in patients with alcoholic cirrhosis.
- Trial name
- NCT04363424
- Where
- Netherlands
- Volunteers
- 191 people
- Sponsor
- Maastricht University Medical Center
Opioid-Related Disorders
Alternate-Day Buprenorphine. Phase V - 6
The purpose of this study is to evaluate buprenorphine blockade challenge.
- Trial name
- NCT00000224
- Testing
- Buprenorphine
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Nicotine Dependence, Depression
Vigorous Exercise for Depressed Smokers
In this project the investigators will develop and pilot test a supervised, vigorous intensity exercise intervention for depressed female smokers.
- Trial name
- NCT01860924
- Testing
- exercise, health education
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Tobacco Use Disorder
Safety of Combining Modafinil and Nicotine Replacement Therapy in Treating Nicotine Dependent Adolescents
Nicotine is one of the most widely abused substances in the United States. Nicotine replacement therapy (NRT) is currently an effective treatment for nicotine dependence; however, even with NRT most people fail at quitting…
- Trial name
- NCT00258479
- Testing
- ModafinilNicotine Replacement Therapy, Modafinil
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Catherine Martin, MD
Hepatitis C
DBS TaT in Peer-assisted Telemedicine for Hepatitis C
The purpose of this study is to compare the rate of treatment initiation achieved by peer-assisted telemedicine contingent on phlebotomy (usual care) versus that achieved with a new protocol, called Dried Blood Spot Test and…
- Trial name
- NCT06409169
- Testing
- DBS TaT, Usual Care
- Where
- United States
- Volunteers
- 141 people
- Sponsor
- Oregon Health and Science University
Opioid Abuse (Disorder), Clinical Decision Support
Adaptive Decision Support for Addiction Treatment (ADAPT) Serial Randomized Testing for Usability, Round 3
This study is stage 2, round 3 of a larger study which refines and optimizes the EMBED clinical decision support (CDS) to increase number of ED physicians following standard of care for the administration of buprenorphine to…
- Trial name
- NCT07793383
- Testing
- Refined EMBED CDS, Provider alert that nurse completed COWS
- Where
- 3 sites in United States
- Volunteers
- 100 people
- Sponsor
- Yale University
Cocaine-Related Disorders
Glutaminergic Agents for Cocaine Abuse - 5
The purpose of this study is to evaluate glutaminergic agents for cocaine abuse.
- Trial name
- NCT00000280
- Testing
- Nimodipine
- Where
- United States
- Sponsor
- Yale University
Alcohol Use Disorder
Multimodal Neuroimaging of Alcohol Cues, Cortisol Response, and Compulsive Motivation
This study proposes to examine both the peripheral and central nervous system responses when light social drinkers and binge/heavy social drinkers are exposed to visual ethanol cues, followed by oral ethanol.
- Trial name
- NCT04412824
- Testing
- Intravenous blood draw
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Auburn University
Substance Abuse, Executive Dysfunction
Working Memory Training in Adults With Substance Abuse and Executive Function Deficits.
The purpose of this study is to evaluate the effects of a computerized working memory training program on substance abuse, psychosocial functioning, cognitive performance and psychiatric problems in adults with substance abuse…
- Conditions
- Substance Abuse, Executive Dysfunction, Anxiety, Depression
- Trial name
- NCT02068261
- Testing
- Computerized Cogmed working memory training, Treatment as usual
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Örebro Läns Landsting
Alcohol Use Disorder, Mild, Alcohol Use Disorder, Moderate
Substituting SMSs for Provider-delivered Care to Improve Alcohol Use Outcomes
The goal of this clinical trial is to test whether a technology-substituted intervention (mhGAP-Remote) derived from the World Health Organization's (WHO) Mental Health Gap Action Programme-Intervention Guide (mhGAP-IG) is…
- Trial name
- NCT05925270
- Testing
- mhGAP-Remote, mhGAP-Standard
- Where
- 3 sites in Lesotho
- Volunteers
- 255 people
- Sponsor
- University Hospital, Basel, Switzerland
Major Depressive Disorder, Nicotine Dependence
Sequential Use of Fluoxetine for Smokers With Elevated Depressive Symptoms
The primary purpose of this study is to determine whether, among smokers with elevated depressive symptoms, sequential antidepressant pharmacotherapy with fluoxetine (20 mg) begun 8 weeks prior to and extended throughout standard…
- Conditions
- Major Depressive Disorder, Nicotine Dependence, Depression
- Trial name
- NCT00578669
- Testing
- Fluoxetine, Dextrose
- Where
- United States
- Volunteers
- 206 people, healthy volunteers welcome
- Sponsor
- Butler Hospital
Alcoholism
Naltrexone Maintenance Treatment of Alcoholism
The purpose of this study is to determine the long-term effectiveness of naltrexone treatment in alcohol-dependent patients who respond to short-term treatment.
- Trial name
- NCT00000450
- Testing
- Naltrexone Tablet
- Where
- United States
- Volunteers
- 159 people
- Sponsor
- The Scripps Research Institute
Alcohol Dependence, Cocaine Dependence
Human Behavioral Pharmacology Laboratory (HBPL) Study of Varenicline's Impact on Cocaine and Alcohol Craving
This is a Phase II within-subjects double-blind placebo-controlled human laboratory study. The purpose of the study is to determine the efficacy of varenicline (Chantix) for reducing cue-induced cocaine and alcohol craving.
- Trial name
- NCT01151813
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Pennsylvania
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