Clinical trials: Substance-Related Disorder
Opioid Use Disorder
Psilocybin for Opioid Use Disorder (OUD)
This is a double-blind, adaptive, 2-stage, multi-site, phase 2 randomized controlled clinical trial designed to evaluate effects of moderate and high dose psilocybin, relative to low-dose psilocybin control, in OUD patients who…
- Trial name
- NCT06796062
- Testing
- Psilocybin
- Where
- 5 sites in United States
- Volunteers
- 480 people
- Sponsor
- NYU Langone Health
Human Immunodeficiency Virus, Acquired Immunodeficiency Syndrome
HIV, Buprenorphine, and the Criminal Justice System
The aims of STRIDE were changed as of July, 2014. The revised project, called STRIDE2, has a longitudinal, non-randomized, observational study design.
- Conditions
- Human Immunodeficiency Virus, Acquired Immunodeficiency Syndrome, Opiate Addiction, Drug Dependence
- Trial name
- STRIDE (NCT01550341)
- Testing
- Buprenorphine/naloxone
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Yale University
Housing Problems, Drug Use
ED-Home Pilot Study
This is a single-arm pilot study to test the feasibility of homelessness prevention and substance use interventions to be delivered to at-risk patients in the Bellevue Hospital emergency department (ED).
- Conditions
- Housing Problems, Drug Use, Alcohol; Use, Problem
- Trial name
- NCT03864341
- Testing
- Referral to homelessness prevention services, Substance use services, Follow-up
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- NYU Langone Health
Opioid-use Disorder, Harmful; Use, Alcohol
Patient Driven Recovery With Nalmefene and Coaching
In collaboration with the First Pavlov State Medical University in St. Petersburg, Russia, we are proposing a pilot, open label, non-randomized clinical trial to evaluate the safety, feasibility, acceptability, and preliminary…
- Trial name
- NCT03279562
- Testing
- Nalmefene
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Yale University
Major Depressive Disorder, Nicotine Dependence
Treatment of Nicotine Dependence and Acute Depression
The purpose of this study is to assess the safety and feasibility of concurrent treatment of nicotine dependence (cigarette smoking) and acute depression.
- Trial name
- NCT00186446
- Testing
- bupropion and smoking cessation behavioral intervention
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Stanford University
Psychosis, Alcohol Use Disorder
Effects of Action-Based Cognitive Remediation on Substance Misuse in Early Phase Psychosis
Psychotic disorders impact 4.6 people per 1000 globally, with approximately 1.5 million Canadians affected. The age of onset for psychotic disorders often begin during the critical years of youth and early adulthood, resulting in…
- Conditions
- Psychosis, Alcohol Use Disorder, Cannabis Use Disorder
- Trial name
- NCT07056894
- Testing
- Action-Based Cognitive Remediation
- Where
- 2 sites in Canada
- Volunteers
- 50 people
- Sponsor
- Nova Scotia Health Authority
Substance Use Disorders, Criminal Behavior
Feasibility, Acceptability and Preliminary Treatment Effects of A-CRA for Youth in Compulsory Institutional Care
Substance abuse and criminal behavior are increasing among adolescents in Sweden. The Swedish National Board of Institutional Care, SiS, provides institutional care on basis of the Swedish laws Care of Young Persons (Special…
- Trial name
- NCT05081934
- Testing
- A-CRA, TAU
- Where
- Sweden
- Volunteers
- 42 people
- Sponsor
- Karolinska Institutet
Psychotic Disorders, Forensic Psychology
Illness Management and Recovery- a Cluster Randomized Controlled Trial Within a Forensic Mental Inpatient Setting
The purpose of the study is to investigate the effects of a psychoeducational intervention program, Illness Management and Recovery (henceforth abbreviated as IMR), when administered to inpatient forensic mental health patients.
- Conditions
- Psychotic Disorders, Forensic Psychology, Forensic Nursing, Antisocial Personality Disorder
- Trial name
- NCT04695132
- Testing
- Illness Management and Recovery treatment programme
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Karolinska Institutet
Fetal Alcohol Spectrum Disorders
My Health Coach App RCT
The goal of this clinical trial is to learn if the My Health Coach app helps adults with fetal alcohol spectrum disorders (FASD).
- Trial name
- NCT06638463
- Testing
- My Health Coach app
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Rochester
Depression, Anxiety
Efficacy of a Multi-level School Intervention for LGBTQ Youth
Efficacy of a Multi-level School Intervention for LGBTQ Youth
- Conditions
- Depression, Anxiety, Post Traumatic Stress Disorder, Coping Behavior
- Trial name
- NCT05541406
- Testing
- Proud & Empowered, Control Group
- Where
- 23 sites in United States
- Volunteers
- 228 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Alcoholism
Naltrexone Treatment for Alcoholism
This study will evaluate the effectiveness of the medication naltrexone (Revia) for treating alcoholism. Individuals will be inpatients for a 2 week period and provide assessments of their alcohol withdrawal symptoms, craving…
- Trial name
- NCT00000438
- Testing
- naltrexone (Revia)
- Where
- United States
- Volunteers
- 192 people
- Sponsor
- Johns Hopkins University
Healthy Volunteers
Phase I Trial of High-Density Theta Burst Stimulation (hdTBS)
Background: Transcranial magnetic stimulation (TMS) uses magnetic pulses to affect brain activity. A type of TMS called theta burst stimulation (TBS) is approved to treat people with major depression.
- Trial name
- NCT06868914
- Testing
- TMS (MagVenture MagPro 100 with MagOption)
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Substance Use Disorder
Neuromodulation in Substance Use Disorders
The primary objective of this study is to assess the safety and feasibility of FUS neuromodulation in participants with OUD and/or other SUDs.
- Trial name
- NCT07010016
- Testing
- NaviFus Model101
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Manish Ranjan
Nicotine Dependence
Brain Activity and Smoking Cessation
In the current study, the investigators propose to test: (1) whether brain activation and connectivity in a resting state, assessed by ASL perfusion MRI, BOLD fMRI, and diffusion tensor imaging (DTI) predicts smoking relapse, and…
- Trial name
- NCT01186055
- Testing
- Smoking Cessation Counseling
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Alcohol Related Disorders
Hepatic Function in Alcoholics Following 5 Days of Acetaminophen Dosing
The study objective was to determine if liver injury develops in alcoholic patients during or following 5 days of therapeutic acetaminophen dosing.
- Trial name
- NCT00427206
- Testing
- acetaminophen (4g/day)
- Where
- 2 sites in United States, Canada
- Volunteers
- 181 people, healthy volunteers welcome
- Sponsor
- Denver Health and Hospital Authority
Post Traumatic Stress Disorder, Problem Drinking
Tools for Health and Resilience Implemented After Violence Exposure (Project THRIVE)
Sexual assault victimization is a common and particularly harmful form of trauma that is associated with increased risk for high-risk drinking and other conditions of public health concern, such as PTSD.
- Trial name
- NCT03703258
- Testing
- App-based intervention
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of Washington
Nicotine Addiction
Developing Evidence to Inform Regulatory Policy on Nicotine Content in E-Liquids
The goal of this observational study is to learn if electronic cigarette users who currently choose to use lower nicotine eliquids have reduced harm compared those who choose higher nicotine eliquids.
- Trial name
- NCT06619964
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Rochester Institute of Technology
Alcohol Abuse, Substance Use
Adaptation and Evaluation of Bright Horizons
This study will test if a program called 'Bright Horizons' is effective at reducing binge substance use among adolescents. Bright Horizons is a culturally adapted intervention developed and tested through a partnership between…
- Trial name
- NCT05743699
- Testing
- Bright Horizons, Case Management
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Alcohol Use Disorder
Exploration of Gemfibrozil as a Treatment for AUD
This study will examine the efficacy of the medication gemfibrozil in reducing alcohol consumption in individuals with an alcohol use disorder who are seeking treatment for alcohol-related problems.
- Trial name
- NCT03539432
- Testing
- Gemfibrozil 600 MG
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- The Mind Research Network
Tobacco Use Disorder, Smoking Cessation
Mechanisms of Lorcaserin for Smoking Cessation
Identifying new medication options is critical for curbing the health burdens of cigarette smoking. Currently approved smoking cessation medications act on nicotinic receptors, and additional work is needed to identify…
- Trial name
- NCT04396834
- Testing
- Lorcaserin Oral Tablet
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- The Mind Research Network
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