Clinical trials: Substance-Related Disorders
Opioid Dependence, Low Back Pain
Return to Work - Will Brief Intervention Reduce Opioid-induced Back Pain?
Background Back pain is among the most common cause for sick leave in the working population and is the main cause of years lived with disability globally.
- Conditions
- Opioid Dependence, Low Back Pain, Opioid Use
- Trial name
- NCT05437861
- Testing
- Brief Intervention
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospital, Akershus
Physical Exercise
Can Exercise Rewire the Brain Addiction Circuitry?
The aim of the present study is to apply neuroimaging techniques to investigate how physical exercise may influence the addiction circuitry, ultimately reducing alcohol consumption and craving in youth binge drinkers.
- Trial name
- REWIRED (NCT06317753)
- Testing
- Aerobic Exercise, Agility-Cognitive Exercise, Stretching/relaxation
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Minho
Bipolar Disorder, Depression
Brain Tissue Collection for Neuropathological Studies
The purpose of this study is to collect and study the brain tissue of deceased individuals to learn more about the nervous system and mental disorders.
- Conditions
- Bipolar Disorder, Depression, Anxiety Disorders, Schizophrenia
- Trial name
- NCT00001260
- Where
- 3 sites in United States
- Volunteers
- 2,161 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Alcohol Use Disorder, Treatment
Development and Testing of a Just-in-Time Adaptive Smart Phone Intervention to Reduce Drinking Among Homeless Adults
Homeless adults are 8 times as likely to be alcohol dependent compared with adults in the general population, yet few studies have examined the precipitants of alcohol use in this vulnerable population.
- Conditions
- Alcohol Use Disorder, Treatment, Homelessness
- Trial name
- Smart-T (NCT03746808)
- Testing
- EMA + App/Treatment Messages
- Where
- United States
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- University of North Texas Health Science Center
Cocaine-Related Disorders
Effectiveness of N-acetylcysteine in Treating Cocaine Dependent Individuals - 1
Recent findings have suggested that N-acetylcysteine (NAC) substantially reduces cocaine drug-seeking behavior in formerly cocaine dependent rats.
- Trial name
- NCT00136825
- Testing
- N-Acetylcysteine
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Substance Use Disorders, Adolescent Behavior
Addiction in Adolescence - Pathomechanisms and Treatment Evaluation
This study aims to investigate the sociodemographic background as well as psychiatric comorbidities of adolescent substance users with substance use disorders.
- Trial name
- MATRIX-A (NCT03444974)
- Testing
- adapted treatment according to the MATRIX-A therapy
- Where
- Germany
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Technische Universität Dresden
Healthy, Substance-related Disorders
Influence of Bupropion on the Effects of MDMA
The purpose of this study is to determinate the effect of a pre-treatment with bupropion, a dopamine and norepinephrine transporter inhibitor, on the pharmacodynamics and pharmacokinetics of 3,4-methylenedioxymethamphetamine…
- Trial name
- NCT01771874
- Testing
- MDMA, Bupropion
- Where
- Switzerland
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Substance Use, Depression
Trial of Automated Risk Appraisal for Adolescents
This is a study to find out which type of computer screening and nursing support can improve screening for high risk behaviors in doctor's offices.
- Conditions
- Substance Use, Depression, Suicidal Ideation, Risk Behavior
- Trial name
- TARAA (NCT00505440)
- Testing
- Telephone case management and motivational interviewing, Usual care
- Where
- United States
- Volunteers
- 1,185 people, healthy volunteers welcome
- Sponsor
- Nationwide Children's Hospital
Delayed Sleep Phase Syndrome
Experimental Manipulation of Sleep and Circadian Rhythms and the Role Played on Reward Function in Teens
Adolescence is a time of heightened reward sensitivity and greater impulsivity. On top of this, many teenagers experience chronic sleep deprivation and misalignment of their circadian rhythms due to biological shifts in their…
- Trial name
- CARRS-P2 (NCT04792697)
- Testing
- Increase morning bright light, Decrease evening blue light, Sleep Scheduling
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Tobacco Dependence, Schizophrenia
Cigarette Smoking in Smokers With and Without Schizophrenia
Higher rates and severity of tobacco dependence in people with schizophrenia, as compared with the general population, contribute to the lower life expectancy seen in this population.
- Trial name
- NCT04001114
- Testing
- Sampling Research Cigarettes
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Alcohol Withdrawal Syndrome
The "Prediction of Alcohol Withdrawal Severity Scale" (PAWSS)
Although there are several tools that can be used to evaluate the severity of ongoing alcohol withdrawal syndrome (AWS), there is no available tool that can predict which patients are at risk for developing AWS at the time…
- Trial name
- PAWSS (NCT01637415)
- Where
- United States
- Volunteers
- 409 people, healthy volunteers welcome
- Sponsor
- Stanford University
Nicotine Use Disorder
Study to Assess PK, PD, Nicotine Extraction, Palatability, Subjective Effects of Nicotine Pouches - Daily Nicotine Users
This is an explorative, open-label, randomised, 3-way cross-over study to assess pharmacokinetics (PK), pharmacodynamics (PD), safety and tolerability, nicotine extraction, palatability and subjective effects after single use of…
- Trial name
- NCT06170138
- Testing
- Test product 1 - Test product 2 - Comparator product
- Where
- Sweden
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Amplicon AB
Nicotine Dependence
Measuring Smoking Behaviors While Using Varenicline
This study will demonstrate the behavioral responses to varenicline, helping to better understand its mechanisms. Hypotheses for the study are to observe decreases in smoking topography and nicotine cigarette choice on…
- Trial name
- NCT00948155
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Opioid-Related Disorders
Pharmacokinetic Evaluation of Intranasal, Intramuscular, and Oral Naltrexone in Healthy Volunteers
To determine the pharmacokinetics of 2 intranasal doses and 1 oral dose of naltrexone compared to an intramuscular dose of naltrexone.
- Trial name
- NCT02750748
- Testing
- Naltrexone, Intravail
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Opioid-Related Disorders, Substance-Related Disorders
Effects of Subanesthetic Concentrations of Nitrous Oxide - 1
The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used…
- Trial name
- NCT00000249
- Testing
- 20% N2O, 30% N2O, 40% N2O
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Substance-Related Disorders
Abuse Liability of Controlled-Release Oxycodone Formulations
The objective of this study is to examine the abuse liability of a single 40mg dose of 2 controlled release oxycodone formulations (Apo-Oxycodone CR® and OxyNEO®) in non-dependent recreational opioid users by assessing the…
- Trial name
- NCT02101840
- Testing
- Apo-Oxycodone CR®, OxyNEO®
- Where
- Canada
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Tobacco Use Disorder
Effect of a Non-Invasive Brain Stimulation Technique on Smoking Cessation Behaviors
In this pilot study, the feasibility of using tDCS (a non-invasive brain stimulation technique) while performing a task requiring cognitive flexibility will be examined in smokers and initial data will be collected regarding the…
- Trial name
- NCT03386253
- Testing
- active tDCS
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Fetal Alcohol Spectrum Disorders, Fetal Alcohol Syndrome
RCT of Prenatal Choline Supplementation During Pregnancy to Mitigate Adverse Effects of Prenatal Alcohol Exposure
Although the adverse effects associated with prenatal alcohol exposure (PAE) are well known, many women continue to drink heavily during pregnancy, putting their infants at risk for fetal alcohol spectrum disorders.
- Trial name
- NCT04395196
- Testing
- Choline bitartrate
- Where
- South Africa
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- Wayne State University
Substance Use
Evaluation of EBT With Young, Substance Abusing Homeless Mothers
A dearth of information is available regarding how best to intervene with substance use disordered homeless mothers and their young children.
- Trial name
- NCT02577666
- Testing
- Ecologically Based Therapy, Housing Only, Treatment as Usual
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Substance Use Disorders
TAU vs m-SBIRT in Primary Care
The goal of this research is to leverage technology in primary care clinics to improve screening, brief intervention and referral to Substance Use Disorder (SUD) treatment, and treatment attendance by comparing 1.
- Trial name
- NCT06250153
- Testing
- m-SBIRT (mobile-Screening, Brief Intervention, and Referral to Treatment)
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
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