Clinical trials: Substance-Related Disorders
Nicotine Addiction
Acute and Chronic Nicotine Modulation of Reinforcement Learning
The purpose of this study is to use functional magnetic resonance imaging (fMRI) to investigate the acute and chronic effects of nicotine on motivational behavior and prediction error-related neural activation.
- Trial name
- NicLearning (NCT01830842)
- Testing
- Nicotine polacrilex, satiety, abstinence
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Duke University
HIV Infections
A Test of Behavioral Intervention for Women at High Risk for HIV Infection
The purpose of this study is to find out if it is possible to conduct a group counseling program for women at risk for HIV infection. Women have been the fastest-growing group with new AIDS diagnoses.
- Trial name
- NCT00006440
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Addiction
A Study to Assess 18-Methoxycoronaridine (18-MC HCl) in Healthy Volunteers
The primary objective of this study is to assess the safety and tolerability of a single day dosing and a separate multiple day dosing of 18-MC HCl administered orally, each part of the study having a different set of healthy…
- Trial name
- NCT04292197
- Testing
- 18-MC Compound
- Where
- Australia
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Definium Therapeutics US, Inc.
Addiction, Depression/Anxiety
Healing Lodge First Face Training Evaluation Study
The purpose of this study is to evaluate a culturally grounded training program, xaʔtus (meaning First Face) for Mental Health. This program will train community members in how to recognize and respond to youth and adults…
- Conditions
- Addiction, Depression/Anxiety, Trauma, Psychological, Self-harm
- Trial name
- NCT06290180
- Testing
- First Face for Mental Heatlh
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Cambridge Health Alliance
HIV Infections, Sexually Transmitted Diseases, Bacterial
Mobile Enhanced Prevention Support for People Leaving Jail
This study will provide HIV prevention and related support services to men who have sex with men and transgender women who have substance use disorders and are either leaving jail or recently released from jail.
- Conditions
- HIV Infections, Sexually Transmitted Diseases, Bacterial, Hepatitis C, Substance Use Disorders
- Trial name
- MEPS (NCT04036396)
- Testing
- Mobile Enhanced Prevention Support, Usual Care plus Customized Referrals
- Where
- 3 sites in United States
- Volunteers
- 233 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
HIV Infections, Substance Use Disorders
Couples ART Adherence Intervention for PWID in Kazakhstan
The fastest growing HIV epidemics globally are driven by injection drug use, but only a small percentage of HIV-positive people who inject drugs (PWID) have achieved viral suppression.
- Trial name
- NCT03555396
- Testing
- SMART Couples 2, Standard of Care
- Where
- Kazakhstan
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Columbia University
Male Reproductive Problem
The Effects of Cannabis on Male Reproductive Functions
The purpose of this study is to understand the direct effects of cannabis on male reproductive functions. The investigators plan to conduct a double-blind, placebo-controlled clinical trial to examine both the chronic and acute…
- Trial name
- NCT06755346
- Testing
- Cannabis plant (THC 20mg), Cannabis (0%/ THC / 0% CBD), Cannabis plant (THC 40mg)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Kanako Hayashi
Nicotine Use Disorder
Neural Basis of Eating Behavior in Abstinent Smokers
The purpose of this research study is to better understand why people gain weight when they quit smoking by examining food intake and changes in brain activity in smokers when they are smoking as usual compared to when they have…
- Trial name
- SIT (NCT03438188)
- Testing
- Practice Quit Attempt
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Healthy, Condom Use
Nen ŨnkUmbi/EdaHiYedo Plus (We Are Here Now Plus): a Multi-level Intervention to Reduce Health Disparities Among American Indian Youth
We Are Here Now - Plus (NE+) is a holistic, culturally centered, and multilevel intervention for American Indian youth to improve sexual health, mental health, and substance use outcomes.
- Conditions
- Healthy, Condom Use, Mental Health, Substance Use (Drugs, Alcohol)
- Trial name
- NE+ (NCT07460973)
- Testing
- NE+, Control
- Where
- United States
- Volunteers
- 843 people, healthy volunteers welcome
- Sponsor
- Montana State University
Healthy Volunteer
Challenging the Endocannabinoid System in Sleep Restricted Healthy Volunteers to Modulate Physiological Arousal (CANISLEEP) Study
The goal of this study is to learn about the body's response to cannabis based products in sleep deprived people who are currently experiencing anxiety but are otherwise healthy.
- Trial name
- CANISLEEP (NCT07656350)
- Testing
- THC, CBD, THC + CBD
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- King's College London
Smoking Cessation, Nicotine Dependence
Study Assessing Efficacy and Safety of NFL-101 on Reduction of Reinforcing Properties of Cigarettes (PRECESTO)
PRECESTO is a randomized, double-blind, cross-over trial on 34 smokers who do not want to stop smoking and get high satisfaction from smoking.
- Trial name
- PRECESTO (NCT06091826)
- Testing
- NFL-101
- Where
- France
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- NFL Biosciences SAS
Tobacco Use Disorder
Maintaining Nonsmoking: Older Smokers - 1
The purpose of this study was to examine pharmacological and psychological interventions for smokers over 50.
- Trial name
- NCT00086385
- Testing
- Nicotine polacrilex, Bupropion
- Where
- United States
- Volunteers
- 403 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Mental Health
Educational Intervention for Optimizing Adolescent Mental Health Screening and Treatment in Pediatric Residency
The purpose of this study is: 1) to assess pediatric resident knowledge of adolescent mental health; 2) to assess pediatric resident comfort level for screening, assessing, and treating mental health disorders in adolescents…
- Trial name
- NCT00768352
- Testing
- Educational intervention
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Brooke Army Medical Center
Nicotine Dependence
IV Nicotine Induced Changes in Hormone Function, Mood States and Behavior
Clinical studies are proposed to analyze the interactions between nicotine, alterations in endocrine hormones, mood and cardiovascular measures.
- Trial name
- NCT01589055
- Testing
- Intravenous Nicotine
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mclean Hospital
Alcohol Drinking, Alcohol Intoxication
Smartphone-paired Breathalyzers and Loss- and Gain-framed Texts for Reducing Drinking and Driving
This project aims to demonstrate the feasibility of a scalable behavioral intervention using smartphone-paired breathalyzers and text message aimed at reducing drinking and driving among individuals who report heavy drinking.
- Conditions
- Alcohol Drinking, Alcohol Intoxication, Alcohol Impairment, Drive
- Trial name
- BESAFE (NCT03335735)
- Testing
- Loss-framed text message, Gain-Framed text message
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Hepatitis C, PrEP
HepC Micro-elimination on MSM and TGW Population.
This is an observational study, in which a single visit will be carried out, which includes a questionnaire on sexual habits and in which the possibility of carrying out a screening for Hepatitis C will be offered.
- Conditions
- Hepatitis C, PrEP, Drugs of Abuse
- Trial name
- NCT06847958
- Where
- Spain
- Volunteers
- 13,161 people, healthy volunteers welcome
- Sponsor
- Projecte dels NOMS Hispanosida
Opioid-Related Disorders, Benzodiazepine-Related Disorders
De-prescribing Program to Evaluate Falls in Older Adults
Purpose: The proposed study will implement and evaluate the effect of an opioid and benzodiazepine (BZD) de-prescribing intervention on falls risk in older adults.
- Conditions
- Opioid-Related Disorders, Benzodiazepine-Related Disorders, Falls Injury
- Trial name
- NCT04272671
- Testing
- Educational Intervention
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Anxiety Disorders, Depressive Disorder
Treating Adolescents With CBT and OBH
The purpose of this study is to examine various behavioral, social, and emotional changes that result from engaging in an OBH and CBT treatment program designed for adolescents.
- Conditions
- Anxiety Disorders, Depressive Disorder, Substance Use Disorders
- Trial name
- NCT04760938
- Testing
- Outdoor Behavioral Healthcare (OBH), Cognitive Behavioral Therapy (CBT)
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of New Hampshire
Parenting, Parent-Child Relations
Parenting Young Children Study
Opioid use is rising at unprecedented levels and has reached epidemic proportions in some areas of the country, particularly rural areas.
- Conditions
- Parenting, Parent-Child Relations, Opioid Misuse, Opioid Use Disorder
- Trial name
- NCT05180487
- Testing
- Family Check-Up
- Where
- United States
- Volunteers
- 356 people, healthy volunteers welcome
- Sponsor
- University of Oregon
Drug Abuse
The Effects of Expectation on Natural and Drug -Induced Rewards
Background: Environmental cues frequently induce expectancies in individuals that may strongly influence the actual experience associated with the cue.
- Trial name
- NCT01036230
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
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