Clinical trials: Substance-Related Disorders
Adverse Childhood Experiences, Nicotine Dependence, Cigarettes
Neurobehavioral Mechanisms Linking Childhood Adversity to Increased Risk for Smoking
The purpose of this study is to evaluate how certain childhood experiences influences brain function and responses to nicotine exposure in a group of nonsmoking young adults.
- Trial name
- NCT05665465
- Testing
- Nicotine nasal spray 0.5 mg
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Duke University
Cardiovascular Risk Factor, Nicotine Dependence
Vaping High vs. Low Nicotine E-Liquid
This study will examine the effects of electronic cigarette e-liquid nicotine content in a randomized, crossover clinical and behavioral pharmacology study of experienced adult e-cigarette users (N=36).
- Trial name
- NCT04047836
- Testing
- Low Nicotine E-Liquid, Medium or High Nicotine E-Liquid
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Nicotine Dependence
Coping Skills Treatment for Smoking Cessation
The primary purpose of this study is to evaluate the efficacy of a new type of exposure- and acceptance-based smoking cessation treatment vs.
- Trial name
- Project-WIN (NCT01061528)
- Testing
- Transdermal Nicotine
- Where
- United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Butler Hospital
Alcohol Abuse, Drug Abuse
Effects of Levetiracetam (Keppra) on Alcohol Consumption
The overall goals of this study are to (1) expand knowledge about interactions of levetiracetam with alcohol by assessing the effects of levetiracetam compared to placebo in moderate and heavy social alcohol users and (2) to test…
- Trial name
- NCT01168687
- Testing
- Levetiracetam (Keppra)
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Methamphetamine Abuse, Methamphetamine-dependence
Clinical Trial of High Dose Lisdexamfetamine and Contingency Management in MA Users
The goal of this clinical trial is to learn if administering a high dose stimulant with Contingency Management reduces days of use in adults who use methamphetamine better than the usual treatment provided by the clinic.
- Conditions
- Methamphetamine Abuse, Methamphetamine-dependence, Addiction, Substance, Addiction
- Trial name
- NCT05854667
- Testing
- Treatment as Usual plus lisdexamfetamine (LDX-01), Treatment as Usual plus lisdexamfetamine (LDX-01) plus Contingency Management
- Where
- 4 sites in Canada
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Nightmare
Treating Nightmares Among Domiciliary Patients
The purpose of the study is to assess the efficacy of a 2-session intervention to reduce nightmares among Veterans admitted VA mental health residential rehabilitation treatment programs.
- Trial name
- NCT04341987
- Testing
- brief Imagery Rehearsal Therapy, Treatment As Usual
- Volunteers
- healthy volunteers welcome
- Sponsor
- Canandaigua VA Medical Center
Substance Abuse Problem
Adaptation Processes in School-based Substance Abuse Prevention
The purpose of this study is to determine if a new substance use prevention curriculum for rural middle schools is effective in reducing substance use and to study how prevention curriculum get implemented by teachers.
- Trial name
- kiR (NCT02715206)
- Testing
- keepin' it REAL classic, keepin' it REAL rural, control
- Where
- 2 sites in United States
- Volunteers
- 2,827 people, healthy volunteers welcome
- Sponsor
- Penn State University
Risk Reduction Behavior, Interpersonal Relations
A Community-health Worker Delivered HIV/STI Prevention Intervention for Internally Displaced Women in Leogane, Haiti
The investigators will develop, deliver and evaluate a solar powered tablet-based individual and group focused HIV/STI prevention intervention with internally displaced women in Leogane, Haiti.
- Conditions
- Risk Reduction Behavior, Interpersonal Relations, Mental Disorders
- Trial name
- FASY (NCT01492829)
- Testing
- individual and group-based, community health worker delivered
- Where
- Haiti
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Women's College Hospital
Alcohol Intoxication
Accuracy of Self-estimation of Blood Alcohol Concentration Compared to Object Values
This will be a prospective survey study. The participants will all be volunteers of legal drinking age. Each participant will consume one alcoholic beverage (beer) at a time and then will be asked to verbally estimate their…
- Trial name
- NCT02722564
- Testing
- self estimation of breath alcohol content, breath alcohol content as measured by Alco Sensor IV device, drink a beer
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- St. Luke's Hospital and Health Network, Pennsylvania
Alcohol Problem, Harm Reduction
Game-Based Intervention to Reduce Alcohol-Related Harms Among Sexual and Gender Minority Youth
This is a randomized controlled trial to examine the efficacy of a game-based intervention to reduce alcohol-related harms among sexual and gender minority youth.
- Conditions
- Alcohol Problem, Harm Reduction, Alcohol-Related Harm
- Trial name
- NCT06215664
- Testing
- Singularities Game, Food4Thought
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Concussion, Mild
The Combined Effect of Chronic Cannabis Use and Subconcussive Head Impacts on Brain Health
The purpose of this pilot study is to better understand the effects of chronic cannabis (THC) use on the neural responses to subconcussive head impacts, as a form of repetitive soccer headings.
- Trial name
- NCT04641832
- Testing
- Soccer heading
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Indiana University
Alcohol Consumption, Alcohol Abuse
Web-Based Training for EAP Alcohol Screening, Brief Intervention, and Refer
The goal of the proposed research is to complete the development of a web-based program to train Employee Assistance Program (EAP) and EAP-affiliated managed behavioral health organization (MBHO) practitioners to conduct…
- Trial name
- BigAl2 (NCT02489032)
- Testing
- SBIRT Training & Support Tool, Waitlist Control
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Oregon Center for Applied Science, Inc.
Tobacco Use Disorder
The Effects of Sedatives on Tobacco Use Disorder
This proposal will obtain preliminary data on the effect of a single sub-anesthetic dose of a sedative on cigarette craving and smoking behavior as well as measuring tolerability and acceptability.
- Trial name
- SED-TUD (NCT03813121)
- Testing
- midazolam intravenous infusion, ketamine intravenous infusion
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Behavior, Health
Train Your Brain 2.0 - Improving Memory and Decision Making Among Youth
The goal of this clinical trial is to deliver a computer-based working memory training program to improve delay discounting (DD) and prevent substance misuse among at-risk adolescents in a traditionally underserved area.
- Trial name
- NCT06242704
- Testing
- Working Memory Training, Working Memory
- Where
- 2 sites in United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Wayne State University
Tobacco Use Disorder
Nicotine Regulation for Dual Users of E-cigarettes and Cigarettes
Cigarette smoking remains the leading cause of preventable morbidity and mortality in the US. Use of multiple tobacco products is becoming increasingly prevalent, with dual use of e-cigarettes and cigarettes representing the most…
- Trial name
- RDEC (NCT06614504)
- Testing
- Varying the nicotine content of cigarettes, Varying the nicotine content of e-cigarettes
- Where
- 2 sites in United States
- Volunteers
- 308 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Amphetamine-Related Disorders, Amphetamine Abuse
Investigation of Serotonin Neurotransmission in MDMA Users Using Combinated Dexfenfluramine Challenge and PET Imaging
Illicit use of the psychostimulant "Ecstasy" (3,4-methylenedioxymethamphetamine, MDMA) is considered a major public health issue.
- Trial name
- DEXFEN_PET (NCT01296802)
- Testing
- dexfenfluramine
- Where
- Switzerland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Alcohol Use Disorders
Randomized Trial of Intensive Motivational Interviewing (IMI) to Improve Drinking Outcomes Among Women
A Phase II Randomized Clinical Trial (RCT) is proposed to compare a 9-session model of intensive motivational interviewing (IMI) to standard motivational interviewing techniques (SMI) among alcohol dependent women.
- Trial name
- NCT02272023
- Testing
- Intensive Motivational Interviewing, Single session of Motivational Interviewing
- Where
- United States
- Volunteers
- 215 people, healthy volunteers welcome
- Sponsor
- Public Health Institute, California
Chronic Pain, Fatigue
Real-world Momentary Assessment of Kratom Use Accompanied by Product Assays: A Natural-history Study for Interdisciplinary Characterization of Kratom Use and Pharmacology
Background: Mitragyna speciosa, also called kratom, is a plant used in Southeast Asia for its psychoactive effects. Its use has increased in the US, and an estimated 10 million adults may take it at least semiregularly.
- Conditions
- Chronic Pain, Fatigue, Substance Use Disorders
- Trial name
- NCT05457803
- Where
- United States
- Volunteers
- 396 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Hepatitis C, Drug Users
The Impact on Linkage-to-care of an Alternative Hepatitis C Screening Method in PWID
Screening, diagnosis and treatment of HCV in PWID, should be part of a harm reduction strategy. Treatment of HCV infected PWID should be delivered in a multidisciplinary care setting with services to reduce the risk of…
- Conditions
- Hepatitis C, Drug Users, Harm Reduction, HIV
- Trial name
- NCT02971488
- Testing
- Screening for HCV in PWID and Linkage-To-Care
- Volunteers
- 529 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario Infanta Leonor
Nicotine Dependence, Nicotine Withdrawal
Progesterone and Brain Imaging Study
Male and female smokers were recruited to undergo 2 phases of smoking cessation. Each phase was 4 days long and involved 3 brain-imaging scans, blood draws and an intervention involving progesterone or a matched placebo.
- Trial name
- NCT01954966
- Testing
- Progesterone
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
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