Clinical trials: Substance-Related Disorders
Cannabis, Driving Under the Influence
Cannabis Edibles and Simulated Driving
The goal of this human laboratory experiment is to determine the acute and residual effects of a range of doses of orally administered cannabis edibles on driving simulator performance in people who use cannabis recreationally.
- Trial name
- NCT06595576
- Testing
- Cannabis - Low Dose (2 mg), Cannabis - Medium Dose (10 mg), Cannabis - High Dose (20 mg)
- Where
- Canada
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Nicotine Addiction, E-Cig Use
Quit Smoking Study for People Who Use E-Cigarettes
The overarching aim of this proposed randomized controlled trial (RCT) is to test nicotine replacement therapy (NRT) with text message support for two smoking cessation approaches among young adult dual users of combustible…
- Conditions
- Nicotine Addiction, E-Cig Use, Quitting Smoking
- Trial name
- NCT04946825
- Testing
- Nicotine replacement therapy patch, Nicotine replacement therapy lozenge, Quit electronic cigarettes
- Where
- United States
- Volunteers
- 396 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Metabolic Side Effects of Drugs and Substances
Metabolic Imprints of Alcoholic Beverages
Metabolic imprints of five different types of alcohol will be investigated in two study groups. The study will be an assessor-blinded, parallel dietary trial (crossover design).
- Trial name
- MetAl (NCT03384147)
- Testing
- Drinking, Abstaining
- Where
- Denmark
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Addiction Opiate
Comparison Between Different Psychotherapy Interventions Regarding Their Effect on Substance Craving
the study aim is to compare betwenn the effect of mindfulness based relapse prevention and other evidence based psychotherapy interventions regaring substance craving.
- Trial name
- NCT05256485
- Testing
- cognitive behavioral therapy,mindfulness based relapse prevention,twelve-step therapy
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Sara Harby
Smoking Cessation, Nicotine Addiction
Nicotine Receptor Levels and Smoking Cessation
The investigators propose to use positron emission tomography (PET) imaging to determine whether nicotinic receptor availability at pretreatment predicts smoking cessation success.
- Trial name
- NCT01788943
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Alcohol Abuse, Risk Behavior
Computerized Screening and Brief Physician Advice to Reduce Teen Drinking
The goal of this project is to adapt a computerized Screening and Brief Advice (SBA) protocol that has demonstrated efficacy in reducing underage drinking among adolescent primary care patients and then to test it in a multi-site…
- Trial name
- NCT00849589
- Testing
- Computerized screening and brief physician advice, Computerized SBA with technological extenders
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Lung Carcinoma, Tobacco Use Disorder
Intermittent or Continuous Acetylsalicylic Acid and Gene Expression in the Nasal Tissue of Current Smokers
This randomized phase II trial studies the safety and effects of acetylsalicylic acid (aspirin) taken continuously or intermittently on gene expression in the nasal tissue of current smokers.
- Trial name
- NCT02123849
- Testing
- Aspirin, Laboratory Biomarker Analysis
- Where
- 2 sites in United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Stigma, Activity Space
Health Outcomes by Neighborhood - Baltimore
Background: Researchers have been studying patterns of mood and drug use in specific neighborhoods. This study will look at environmental factors that may affect drug use, addiction, and treatment seeking in Baltimore…
- Conditions
- Stigma, Activity Space, Social Networks, HIV Status
- Trial name
- NCT01571752
- Where
- United States
- Volunteers
- 1,651 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Opioid-use Disorder
Intervention Development and Pilot Study to Prevent Untreated Native Hawaiian and Pacific Islander Opioid Use Disorder
This study will design and pilot/feasibility test a culturally grounded intervention to increase the treatment seeking of Pacific Islanders with opioid use disorders in formal services.
- Trial name
- NCT04898478
- Testing
- Treatment Seeking Intervention for Pacific Islanders with Opioid Use Disorders
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, Riverside
Drug Overdose
Bioavailability of a New Formulation of Nasal Naloxone for Prehospital Use
Overdose with potential deadly outcome is a serious problem among opioid abusers, not least in Norway. The annual death toll from overdose is about 250, twice the annual death toll from traffic accidents.
- Trial name
- NCT02158117
- Testing
- nasal naloxone
- Where
- Norway
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Opioid Use Disorder, Healthy
Adversity, Brain and Opioid Use Study
The way people process and remember information may be related to adverse childhood experiences and Opioid Use Disorder symptoms.
- Trial name
- NCT06355778
- Testing
- Magnetic Resonance Imaging (MRI), Computer Tasks
- Where
- United States
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Substance Use Disorders
Community Wise: An Innovative Multi-level Intervention to Reduce Alcohol and Illegal Drug Use
The current project seeks to implement the Multiphase Optimization Strategy (MOST) and Community Based Participatory Research (CBPR) principles to identify the most efficient, scalable, and sustainable combination of Community…
- Trial name
- NCT02951455
- Testing
- Critical Dialogue, Capacity Building Project, Quality of Life Wheel
- Where
- United States
- Volunteers
- 602 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Drug Abuse Prevention
Stand By Me: Anti-Drug Elite Adventure-Based Training Program
This project is expected to establish a network of resilient young people with good anti-drug knowledge to mobilize them to assist in current or future anti-drug work, expanding the antidrug capacity of our community.
- Trial name
- NCT07064343
- Testing
- Aspirin
- Where
- Hong Kong
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Drug Overdose, Virtual Reality
Use of Virtual Reality for Overdose Management Educational Trainings
This cluster-randomized trial will compare changes in attitudes and knowledge on administering naloxone based on exposure to either a virtual reality educational training or the current standard educational trainings (e.g.
- Trial name
- NCT04091659
- Testing
- Virtual Reality Education, Standard Education
- Where
- United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Drug Safety
Safety and Tolerability of Namisol in the Elderly
The results of phase I Namisol® study (Klumpers et al. Br J Clin Pharmacol, 2012), implicate that Namisol® may have a favorable PK and PD characteristics and is safe to use in people.
- Trial name
- THC (NCT01740960)
- Testing
- delta-9-tetrahydrocannabinol
- Where
- Netherlands
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Heroin Dependence
Reinforcing Effects of Intranasal (IN) Buprenorphine Versus Buprenorphine/Naloxone
The study is designed to compare the abuse liabilities of intranasal buprenorphine and buprenorphine/naloxone in individuals who are physically dependent on sublingual buprenorphine.
- Trial name
- NCT01760473
- Testing
- Intranasal challenge drug
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Nasal Sinus; Inflammation, Opioid Abuse
Pain Management Following Sinus Surgery
This Study evaluates the effect of adding Non-steroidal anti-inflammatories (NSAIDs) to the post-operative pain management of sinus surgery patients and wether or not this addition reduces or eliminates the need for narcotic pain…
- Conditions
- Nasal Sinus; Inflammation, Opioid Abuse, Pain, Postoperative
- Trial name
- NCT03822962
- Testing
- Ibuprofen 600Mg Tablet, Standard Regimen | Tylenol
- Where
- 2 sites in United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Substance Abuse, Decision Making, Shared
Data2Action Oregon Project: Supporting Data-driven Decision-Making for Substance Use Services, Policy, and Overdose Prevention
Oregon's decision makers (e.g., community service providers, public health, justice, advocacy groups, payers) are calling for comprehensive, current, and trusted data to inform how they allocate resources to improve substance use…
- Conditions
- Substance Abuse, Decision Making, Shared, Implementation Science, Decision Making
- Trial name
- D2A Oregon (NCT06852170)
- Testing
- Co-Design Sessions (CDS), Data products
- Where
- United States
- Volunteers
- 341 people, healthy volunteers welcome
- Sponsor
- Chestnut Health Systems
Mild to Heavy Alcohol Consumption
Cognitive, Behavioral and Aging Effects of Pain Medication in Alcohol Users
The purpose of this study is to examine the relationship between heavy alcohol use, pain, and response to pain medication in older adults.
- Trial name
- CAAP (NCT02945293)
- Testing
- Oxycodone
- Where
- United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- University of Washington
Drug Abuse, Healthy
Abuse Potential of Single Doses of Lorcaserin in Healthy Recreational Polydrug Users
The purpose of this study is to evaluate the abuse potential of lorcaserin in healthy recreational polydrug users.
- Trial name
- NCT00828659
- Testing
- Active Comparator #1, Active Comparator #2, Active Comparator #3
- Where
- Canada
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Eisai Inc.
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