Clinical trials: Substance-related Disorders
Risk Behavior, Alcohol Use Disorder
TRAC-ER Intervention to Reduce Risky Alcohol Use and HIV Risk
Ecological momentary interventions (EMI), which use phones to deliver messages to reduce alcohol use and related risk behaviors during or prior to drinking events, can help to address triggers in real-time.
- Conditions
- Risk Behavior, Alcohol Use Disorder, HIV Infections
- Trial name
- TRAC-ER (NCT05576350)
- Testing
- Smartphone Based Alcohol Monitoring (SAM), Tracking and Reducing Alcohol Consumption (TRAC), TRAC-ER
- Where
- 2 sites in United States
- Volunteers
- 405 people, healthy volunteers welcome
- Sponsor
- University of Kentucky
Opiate Dependence, Heroin Dependence
Behavioral Naltrexone Therapy for Promoting Adherence to Oral Naltrexone vs Extended Release Injectable Depot Naltrexone
In pilot study now proposed, we plan to randomly assign 60 opioid dependent patients to the new model, Depot-BNT, or to BNT plus oral naltrexone for a 6-month trial.
- Trial name
- Depot-BNT (NCT00577408)
- Testing
- depot naltrexone, Oral Naltrexone
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- New York State Psychiatric Institute
Smoking Cessation, Substance Use Disorder
Intensive Referral to Reduce Smoking in Probationers
The purpose of this study is to determine if Intensive Referral Intervention increases motivation to quit cigarette smoking and quitting-related behaviors in probationers and also to determine if Intensive Referral Intervention…
- Trial name
- NCT03042650
- Testing
- Intensive Referral Intervention Group, Standard Practice Facilitated Group
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Nebraska
Cocaine Use Disorder
A Study to Investigate the Interaction Between TMP-301 and Cocaine.
This will be a randomized, double-blind, placebo-controlled, parallel-group study to assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of oral TMP-301, given concurrently with cocaine.
- Trial name
- NCT06648668
- Testing
- TMP-301
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Tempero Bio, Inc.
Opioid-use Disorder
Buprenorphine vs Buprenorphine/Naloxone on the Effects of Maternal Symptomatology
This study will assesses the efficacy of buprenorphine/naloxone vs buprenorphine on maternal withdrawal symptoms and drug cravings.
- Trial name
- NCT03740243
- Testing
- Buprenorphine/naloxone, Buprenorphine
- Volunteers
- healthy volunteers welcome
- Sponsor
- Stony Brook University
Amphetamine-Related Disorders, Tobacco Use Disorder
Effects of Stimulant Dependence on Human Striatal Dopamine System - 15
The purpose of this study is to determine whether DAT availability, assessed by WIN binding, in the striatum is altered in cocaine or methamphetamine dependence.
- Trial name
- NCT00000350
- Testing
- radioactive substance
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Substance Use, Mental Health Issue
Community Driven Substance Use Recovery for High Opioid Overdose Areas
The main goal of this current study is to develop and optimize methods for increasing access to, uptake of, and engagement in MAT (Medication Assisted Treatment) among communities of color.
- Conditions
- Substance Use, Mental Health Issue, Opioid Use, Medication Assisted Treatment
- Trial name
- IMANI U (NCT05260047)
- Testing
- IMANI, Telehealth MAT, Traditional MAT plus Referral and Linkage
- Where
- 8 sites in United States
- Volunteers
- 525 people, healthy volunteers welcome
- Sponsor
- Yale University
Alcoholism, Substance-related Disorders
Group Motivational Interviewing (GMI) For Homeless Veterans In VA Services
Homeless Veterans with substance use disorders (SUDs) are a major group served by VA and are heavily represented in VA housing. VA recently adopted a 'Housing First' approach emphasizing rapid housing placement to initiate…
- Conditions
- Alcoholism, Substance-related Disorders, Dual Diagnosis
- Trial name
- NCT02233738
- Testing
- Group Motivational Interviewing (GMI), Control Treatment Condition (CT)
- Where
- United States
- Volunteers
- 185 people
- Sponsor
- VA Office of Research and Development
Chronic Pain, Addiction Opiate
Cross-cultural Validation of a Screening Scale for the Misuse of Opioid Analgesics in Primary Care
Objective: Analgesic Opioids misuse among patients with chronic pain ranges from 0% to 50%. The general practitioner is the first prescriber of opioid analgesics Our objective was to validate in primary care the POMI…
- Trial name
- VAMOS (NCT05431985)
- Where
- 5 sites in France
- Volunteers
- 160 people
- Sponsor
- University Hospital, Clermont-Ferrand
Substance Use Disorder
Neuromodulation in Substance Use Disorders
The primary objective of this study is to assess the safety and feasibility of FUS neuromodulation in participants with OUD and/or other SUDs.
- Trial name
- NCT07010016
- Testing
- NaviFus Model101
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Manish Ranjan
Heroin Dependence
Variance of Oral Methadone Dosage: Description of Implicated Factors
The purpose of this study is to describe clinical, pharmacokinetic and genetic factors associated with the variance of oral methadone dosage for patients at the steady state of heroin dependence maintenance treatment.
- Trial name
- METHADOSE (NCT00894452)
- Where
- France
- Volunteers
- 210 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Major Depressive Disorder, Alcohol Use Disorder
Treatment of Young Adults With Comorbid AUD/MDD: A Pilot Medication Trial
Recent reports have shown that alcohol misuse is a particularly serious problem among the 18 to 25 year old age group. Previous medication trials with SSRI antidepressants among young adults with co-occurring depressive…
- Trial name
- YAAD-P (NCT02646449)
- Testing
- Mirtazapine
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Opioid Use Disorder, Depressive Disorder
Ketamine for OUD and Comorbid Depression (OUDCD)
Methadone is a first-line, evidence-based treatment for opioid use disorder (OUD). Unfortunately, retention and adherence in methadone treatment is a major challenge.
- Trial name
- NCT05051449
- Testing
- Ketamine Hydrochloride
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Alcohol Use Disorder
Behavioral Effects of Drugs: Inpatient (36) (Alcohol, Duloxetine, and Methylphenidate)
This study will evaluate the behavioral effects of alcohol during maintenance on placebo, duloxetine, methylphenidate and duloxetine combined with methylphenidate using sophisticated human laboratory methods.
- Trial name
- BED[IN]:36 (NCT03575403)
- Testing
- Alcohol, Duloxetine (60 MG), Methylphenidate
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Craig Rush
Alcohol-Related Disorders, Alcohol Drinking
Stepped Interventions for Problem Drinkers
In a randomized controlled trial, patients recruited in general practices and fulfilling criteria for alcohol dependence, alcohol abuse, at-risk drinking or binge drinking will be allocated to three conditions: (1) Stepped Care…
- Trial name
- NCT00391742
- Testing
- Brief intervention
- Volunteers
- 450 people
- Sponsor
- University of Luebeck
Alcohol Use Disorder (AUD), Substance Use Disorders
The Anchor Study: Digitally Delivered Intervention for Reducing Problematic Substance Use
This study aims to validate W-SUDs as a digitally-delivered substance use disorder program through a fully-powered randomized control trial that will test the comparative efficacy of the mobile-app based substance use disorder…
- Trial name
- NCT04925570
- Testing
- W-SUDs, Digitally-delivered Psychoeducation
- Where
- United States
- Volunteers
- 258 people
- Sponsor
- Woebot Health
Substance-related Disorder
A Comprehensive Disease Management Program for Medically-Complex Substance Users
Disease management (DM) programs are being increasingly utilized by health plans to coordinate care, improve quality of care, and control costs in chronically ill individuals.
- Trial name
- NCT00865956
- Testing
- Contingency Management, Case management
- Where
- United States
- Sponsor
- Johns Hopkins University
Chronic Pain
MIVetsCan: Can-Coach Trial (Phase 2)
The goal of the MIVetsCan Can-Coach Trial is to test four coaching sessions to help Veterans with chronic pain use their own cannabis products more effectively to manage pain and related symptoms.
- Trial name
- NCT06283862
- Testing
- Educational Session
- Where
- United States
- Volunteers
- 468 people
- Sponsor
- University of Michigan
Alcohol Abuse
Mentored Research on Improving Alcohol Brief Interventions in Medical Settings
The NIAAA estimates that 16% (40 million) of adults in the US are drinking at unsafe levels. More than 50% of alcohol health consequences occur in risky, non-dependent drinkers.
- Trial name
- NCT02978027
- Testing
- Brief Advice, NIAAA Clinician's Guide, Motivational Interviewing (MI)
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Substance Use Disorders
Automated Assessment Using Facial Coding
Transition-age youth (TAY) from ages 18-26 are vulnerable to substance substance use disorder (SUD). This developmental period, termed "emerging adulthood" includes leaving home, entering college or working for the first time…
- Trial name
- R44DA042640 (NCT03551886)
- Testing
- Advanced Emotion App, Basic Emotion App
- Where
- United States
- Volunteers
- 153 people
- Sponsor
- Treatment Innovations