Clinical trials: Substrate Ablation
Atrial Fibrillation (AF)
Efficacy and Safety of Individualized Pulsed Field Ablation Guided by Pulmonary Vein Antral Substrate Mapping for Atrial Fibrillation
This study will adopt a prospective, single-center, single-arm research design, enrolling 120 patients with paroxysmal or persistent atrial fibrillation who are scheduled to undergo catheter ablation for the first time.
- Trial name
- NCT07880262
- Testing
- Individualized Pulsed Field Ablation Guided by Pulmonary Vein Antral Substrate Mapping
- Volunteers
- 120 people
- Sponsor
- Xi'an Jiaotong University
Atrial Fibrillation, Arrhythmias, Cardiac
Atrial Fibrillation and Diabetes Mellitus
Single center prospective study to analyze the impact of diabetes mellitus on patients' outcome following radiofrequency-guided catheter ablation for atrial fibrillation.
- Conditions
- Atrial Fibrillation, Arrhythmias, Cardiac, Heart Diseases, Cardiovascular Diseases
- Trial name
- NCT05873920
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Heart and Diabetes Center North-Rhine Westfalia
Atrial Fibrillation
Impact of Anxiety on Cardiac Substrate Modification in Women With Atrial Fibrillation Undergoing Catheter Ablation
This pilot study aims to assess the impact of anxiety on the cardiac substrate remodeling in female patients with paroxysmal and persistent atrial fibrillation (AF).
- Trial name
- AWARE (NCT02547584)
- Testing
- Catheter ablation
- Where
- United States
- Volunteers
- 152 people
- Sponsor
- Texas Cardiac Arrhythmia Research Foundation
Tachycardia, Ventricular, Catheter Ablation
R Wave Sensing After VT Ablation
Sustained, monomorphic ventricular tachycardia (VT) is most commonly encountered in patients with structural heart disease, usually with ischemic aetiology.
- Conditions
- Tachycardia, Ventricular, Catheter Ablation, Follow-Up Studies, Electrodes
- Trial name
- RASA-VT (NCT03779165)
- Where
- 4 sites in Croatia, Switzerland
- Volunteers
- 100 people
- Sponsor
- University Hospital Sestre Milosrdnice
Non-paroxysmal Atrial Fibrillation
Pulsed-Field Ablation With/Without Electrogram Mapping
Pulsed field ablation (PFA) has demonstrated favorable safety and efficacy in atrial fibrillation ablation, particularly for pulmonary vein isolation (PVI).
- Trial name
- PEAK-AF (NCT07541989)
- Testing
- PFA-based PVI+PWI plus adjunctive ablation guided by Electrogram Mapping of Key Substrates, PFA-based PVI+PWI alone
- Where
- 10 sites in United States, China
- Volunteers
- 300 people
- Sponsor
- Xu Liu
Persistent Atrial Fibrillation
A New Approach to Target the Substrates of Persistent Atrial Fibrillation: The Sequential Substrate Ablation Approach
This is a prospective randomized controlled trial that compares the conventional stepwise approach with a new sequential substrate ablation approach for persistent atrial fibrillation.
- Trial name
- NCT02654353
- Testing
- Ablation
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Johannes Gutenberg University Mainz
Atrial Fibrillation
Trigger- vs. Substrate-Ablation for Paroxysmal Atrial Fibrillation
The purpose of this study is to compare two strategies of catheter-based treatment of paroxysmal atrial fibrillation: Pulmonary vein isolation either alone or combined with electrogram-guided substrate-ablation.
- Trial name
- NCT00196183
- Testing
- trigger-guided catheter-ablation, trigger+substrate-guided catheter ablation
- Where
- Germany
- Volunteers
- 98 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Ventricular Tachycardia
Stereotactic Management of Arrhythmia - Radiosurgery in Treatment of Ventricular Tachycardia
Prospective single-arm study investigating the safety of non-invasive cardiac radiosurgery for the treatment of ventricular tachycardia (VT).
- Trial name
- SMART-VT (NCT04642963)
- Testing
- Cardiac Radiosurgery
- Where
- 2 sites in Poland
- Volunteers
- 11 people
- Sponsor
- Maria Sklodowska-Curie National Research Institute of Oncology
Brugada Syndrome
Brugada Ablation of VF Substrate Ongoing MultiCenter Registry
Current treatment of high-risk Brugada Syndrome (BrS) patients (pts) with recurrent VF is limited. Catheter ablation (CA) has been performed for BrS but a large study with long-term outcomes of CA in BrS ablation are lacking.
- Trial name
- BRAVO (NCT04420078)
- Testing
- Catheter Ablation
- Where
- Thailand
- Volunteers
- 159 people
- Sponsor
- Pacific Rim Electrophysiology Research Institute
Atrial Fibrillation (AF)
Sex-Based Disparities in the Electrophysiological Substrate for Atrial Fibrillation and Its Impact on Clinical Outcomes
DISPARITY-AF is a prospective, single-center, observational registry designed to characterize the sex-based disparities in the electrophysiological substrate driving Atrial Fibrillation (AF).
- Trial name
- NCT07580547
- Testing
- Identifying extra-PV SRG sites
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Anat Milman
Persistent Atrial Fibrillation
AF Substrate Mapping and Guided Ablation
In this study, the investigators aim to identify and characterize, by means of an EnSite Velocity Research Software, the electrophysiological characteristics of substrates that sustain AF in patients with persistent AF and to…
- Trial name
- NCT02571218
- Testing
- Substrate+mCPVA, mCPVA
- Where
- Italy
- Volunteers
- 81 people
- Sponsor
- Abbott Medical Devices
Tachycardia, Ventricular
Ablation Targets of Scar-related Ventricular Tachycardia Identified by Dynamic Functional Substrate Mapping
This study aims at comparing the recurrence rates of ventricular tachycardia ablated after being mapped by 2 different techniques.
- Trial name
- NCT05086510
- Testing
- Radiofrequency ablation
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Ventricular Tachycardia
Ablation of Clinical Ventricular Tachycardia Versus Addition of Substrate Ablation on the Long Term Success Rate of VT Ablation
This study aims to assess whether a combined technique of substrate ablation and ablation of the clinically presenting VT at the site of early activation is superior to ablation of the clinically presenting VT alone, in enhancing…
- Trial name
- VISTA (NCT01045668)
- Testing
- Radiofrequency Catheter Ablation (RFCA)
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Texas Cardiac Arrhythmia Research Foundation
Ventricular Tachycardia
FLExAbility Sensor Enabled Substrate Targeted Ablation for the Reduction of VT Study
This clinical investigation is intended to demonstrate the safety and effectiveness of ventricular ablation therapy using the FlexAbility Sensor Enabled Ablation Catheter in patients with drug-refractory monomorphic ventricular…
- Trial name
- LESS-VT (NCT03490201)
- Testing
- Market Approved RF Ablation System, FlexAbility SE Ablation Catheter
- Where
- 32 sites in United States, Australia and 6 more
- Volunteers
- 592 people
- Sponsor
- Abbott Medical Devices
Ventricular Tachycardia
INTERVENE: Indian Trial of Endocardial Ventricular Substrate Ablation to Prevent Recurrent VT Events
This study to is being conducted in India to determine the role of catheter-based ablation for ventricular tachycardia (VT) in post- heart attack patients who meet established guidelines for implantable cardiodefibrillator (ICD)…
- Trial name
- INTERVENE (NCT02301390)
- Testing
- Amiodarone, Catheter Ablation
- Where
- 3 sites in India
- Volunteers
- 53 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Ventricular Tachycardia
Late Potentials and Ablation Index in Ventricular Tachycardia Ablation
There is an increasing evidence regarding the efficacy of a substrate-based ablation approach to ventricular tachycardia (VT). This approach involves identifying regions of scar and also areas displaying late potentials and…
- Trial name
- NCT03437408
- Testing
- Mapping and ablation
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Persistent Atrial Fibrillation
Substrate Guided Ablation Therapy for Atrial Fibrillation
Atrial fibrillation (AF), often referred to as an 'irregular heartbeat', is the most common abnormal heart rhythm worldwide. AF may be intermittent (termed paroxysmal) or sustained (termed persistent).Catheter ablation is…
- Trial name
- HEAT-AF (NCT04657978)
- Testing
- Substrate guided left atrial ablation
- Volunteers
- 30 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Atrial Fibrillation
Characterization of Arrhythmia Substrate to Ablate Persistent Atrial Fibrillation
A multicentre, parallel group, two arm, single-blinded randomized clinical trial, assessing the efficacy of a patient-tailored catheter ablation (CA) strategy guided by atrial low voltage area mapping in addition to pulmonary…
- Trial name
- COAST-AF RCT (NCT03347227)
- Testing
- Catheter ablation
- Where
- 14 sites in Canada
- Volunteers
- 510 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Monomorphic Ventricular Tachycardia, Myocardial Infarction
Using Ripple Mapping to Guide Substrate Ablation of Scar Related Ventricular Tachycardia.
The heart beat is controlled by electrical signals. Following a heart attack, part of the heart muscle dies and is later replaced by scar tissue.
- Conditions
- Monomorphic Ventricular Tachycardia, Myocardial Infarction, Dilated Cardiomyopathy
- Trial name
- Ripple-VT (NCT02216760)
- Testing
- Ripple Mapping guided VT ablation, Conventional VT ablation
- Where
- United Kingdom
- Sponsor
- Imperial College London
Atrial Fibrillation
Substrate Ablation and Remodelling in Non-paroxysmal Atrial Fibrillation (AF)
The investigators hypothesise that modification of the Atrial Fibrillation (AF) substrate by radiofrequency ablation would improve single procedure success rates for Radio Frequency Ablation (RFA) for Non-paroxysmal AF when…
- Trial name
- SMAAN-PAF (NCT01445925)
- Testing
- Pulmonary vein isolation (PVI), Pulmonary vein isolation + linear lesions, Pharmacological Substrate modification
- Where
- 2 sites in United Kingdom
- Volunteers
- 130 people
- Sponsor
- Liverpool Heart and Chest Hospital NHS Foundation Trust