Clinical trials: Substrate Ablation
Ventricular Tachycardia
A Study of Early Robotic Ablation by Substrate Elimination of Ventricular Tachycardia
Ventricular tachycardia (VT) is an abnormal rapid heartbeat which occurs after a heart attack and can cause sudden death. Patients at risk of this rhythm disturbance usually receive an implantable cardioverter defibrillator (ICD)…
- Trial name
- ERASE-VT (NCT01182389)
- Testing
- Robotic VT Ablation, Conventional Therapy
- Where
- 3 sites in United Kingdom
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Ventricular Tachycardia, Ventricular Arrythmia
Preventive VT Substrate Ablation in Ischemic Heart Disease
The investigators hypothesize that preventive VT substrate ablation in patients with chronic ICM, previously selected based on imaging criteria (BZC mass) for their likely high arrhythmic risk, is safe and effective in preventing…
- Conditions
- Ventricular Tachycardia, Ventricular Arrythmia, Sudden Cardiac Death, Sudden Cardiac Death Due to Cardiac Arrhythmia
- Trial name
- PREVENT-VT (NCT04675073)
- Testing
- Ventricular tachycardia substrate-based radiofrequency ablation
- Where
- Spain
- Volunteers
- 58 people
- Sponsor
- Centro Medico Teknon
Atrial Fibrillation
STAR-AF:Substrate Versus Trigger Ablation for Reduction of Atrial Fibrillation Trial
Patient Population: Patients with AF that is symptomatic and refractory to at least one antiarrhythmic medication. Patients must have AF that is paroxysmal (>4 episodes within 6 months, two episodes >6 hours within 1 year) or…
- Trial name
- NCT00367757
- Testing
- Ablate AF triggers via PVI, Substrate via CFAEs, Combined approach for AF ablation
- Where
- 8 sites in Canada, Italy and 2 more
- Volunteers
- 107 people
- Sponsor
- Abbott Medical Devices
Atrial Fibrillation, Persistent
Waveform Periodicity Analysis of Complex Fractionated Electrograms in Patients With Persistent Atrial Fibrillation
Atrial fibrillation (AF) has been the most frequently occurring, sustained arrhythmia, which causes significant morbidity and mortality. AF may not always be a totally random process.
- Trial name
- NCT05426603
- Testing
- Pulmonary vein isolation, Substrate ablation(PRISM based)
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Buddhist Tzu Chi General Hospital
Persistent Atrial Fibrillation
Correlation of the Arrhythmia Mechanism and Substrate to Ablate Persistent Atrial Fibrillation Study
This is a pilot study to assess the usefulness of ECG mapping, and enhanced MRI and PET scan imaging in identifying atrial fibrosis and arrhythmia circuits involved in persistent atrial fibrillation and in guiding an innovative…
- Trial name
- COAST-AF (NCT02184013)
- Testing
- Catheter ablation
- Where
- Canada
- Volunteers
- 52 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Brugada Syndrome
Epicardial Ablation in Brugada Syndrome
This prospective study evaluates the methodology and results of epicardial mapping/ablation in a large series of consecutive selected BrS patients and to verify if RFA could normalize the consequences of a genetic disease.
- Trial name
- BRUGADA_I (NCT02641431)
- Testing
- mapping/ablation, Ajmaline, ablation
- Where
- Italy
- Volunteers
- 135 people
- Sponsor
- IRCCS Policlinico S. Donato
Atrial Fibrillation, Persistent
Waveform Periodicity Analysis of Complex Fractionated Electrograms in Patients With Persistent Atrial Fibrillation
Atrial fibrillation (AF) has been the most frequently occurring, sustained arrhythmia, which causes significant morbidity and mortality. AF may not always be a totally random process.
- Trial name
- NCT05333952
- Testing
- Pulmonary vein isolation, Substrate ablation(PRISM based)
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Monomorphic Ventricular Tachycardia
Substrate Targeted Ablation Using the FlexAbility™ Ablation Catheter System for the Reduction of Ventricular Tachycardia
To demonstrate that scar-based ventricular tachycardia (VT) ablation using the FlexAbility™ ablation catheter system results in a superior clinical outcome compared to routine drug therapy in subjects with documented Monomorphic…
- Trial name
- STAR-VT (NCT02130765)
- Testing
- Cardiac catheter ablation with ICD/CRT-D
- Where
- 38 sites in United States, Australia and 3 more
- Volunteers
- 64 people
- Sponsor
- Abbott Medical Devices
VT Ablation, Arrhythmic Burden
Treatment Based on High Precision Cardiac Mapping
APOLO-VT aims to evaluate the feasibility, safety, and clinical impact of an integrated multimodal mapping workflow combining non-invasive structural and functional substrate characterization using Volumetric Electrocardiographic…
- Conditions
- VT Ablation, Arrhythmic Burden, Implantable Cardioverter-Defibrillator (ICD) Therapies, Slow-conduction Substrate
- Trial name
- APOLO-VT (NCT07746336)
- Testing
- ACORYS Mapping System
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Hospital Clinic of Barcelona
Atrial Fibrillation, Persistent
Noninvasive 3D Mapping in Persistent Atrial Fibrillation, to Describe Modifications of the Arrhythmogenic Substrate After Pulmonary Vein Isolation and Identify Potential Predicting Factors of Ablation Success
Atrial fibrillation (AF) is the most common cardiac arrhythmia in adults. It is a major cause of ischemic stroke and heart failure.
- Trial name
- CRYOVEST (NCT04229160)
- Testing
- Noninvasive mapping (Cardioinsight® system), long-term cardiac monitoring (LINQ system), Atrial Fibrillation ablation procedure
- Where
- 4 sites in France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Rouen
Atrial Fibrillation (AF)
Characterization of Left Atrial Substrate by Comparison of Bipolar Voltage Maps With Standard Focal 4.5 mm Tip Electrode, 1 mm Ring Electrode, and Microelectrode Catheters Using InTEllaMap Orion and IntellaNav MIFI O
This study is to investigate the correlation and to obtain the coefficient of correlation between the global and local bipolar signals (voltage maps) of the LA in sinus rhythm using a focal 4.5 mm irrigated-tip ablation catheter…
- Trial name
- CHAZESubstrate (NCT04095559)
- Testing
- multipolar mapping catheter, multielectrode circular catheter, irrigated ablation catheter
- Where
- Switzerland
- Volunteers
- 25 people
- Sponsor
- University Hospital, Basel, Switzerland
Ventricular Tachycardia
Non-invasive Ablation of Ventricular Tachycardia
Phase I/II study of 4-D Navigated Non-invasive radiosurgical ablation of ventricular tachycardia (NIRA-VT).
- Trial name
- NCT03601832
- Testing
- 4-D navigated stereotactic radiosurgical ablation
- Where
- 3 sites in Czechia
- Volunteers
- 10 people
- Sponsor
- University Hospital Ostrava
Atrium; Fibrillation
Personalised Ablation Strategies in AF
Atrial fibrillation (AF) is the most common arrhythmia with an expected rise in prevalence over the next decade. Catheter ablation is a safe treatment option in eliminating AF however, success rates still remains variable.
- Trial name
- PAS (NCT05633303)
- Testing
- Substrate guided ablation
- Where
- United Kingdom
- Volunteers
- 160 people
- Sponsor
- Barts & The London NHS Trust
Ventricular Tachycardia (VT), Ischemic Cardiomyopathy
Targeted Ablation to Isolate Scar Channels Causing Ventricular Tachycardia
The goal of this study is to map conducting channels within scar that cause ventricular tachycardia (VT) in patients with scar in their hearts in order to block these channels from causing VT with targeted radiofrequency ablation…
- Conditions
- Ventricular Tachycardia (VT), Ischemic Cardiomyopathy, Nonischemic Cardiomyopathy
- Trial name
- NCT07814079
- Testing
- Selective Substrate Isolation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- New York Medical College
Atrial Fibrillation
Substrate and Trigger Ablation for Reduction of Atrial Fibrillation Trial - Star AF II Study
This investigation is designed with the hypothesis that combined PV Antral Isolation and Ablation of Complex Fractionated Electrograms (PVI+CFE) approach will offer a higher success rate compared to the Wide Circumferential…
- Trial name
- Star AF II (NCT01203748)
- Testing
- PVI + Lines ablation, PVI, PVI + CFE ablation
- Where
- 2 sites in Australia, Canada
- Volunteers
- 589 people
- Sponsor
- Abbott Medical Devices
Atrial Fibrillation
a Novel Individualized Substrate Modification Approach for the Treatment of Long-standing Persistent Atrial Fibrillation
The purpose of this study is to compare effectiveness of two substrate modification approaches in long-standing persistent atrial fibrillation patients, and hypothesized that a substrate-based, individualized substrate…
- Trial name
- NCT02477592
- Testing
- individualized substrate modification, stepwise ablation
- Where
- China
- Volunteers
- 220 people
- Sponsor
- RenJi Hospital
Atrial Fibrillation
Line Versus Spot Ablation in Persistent Atrial Fibrillation
In this randomized study dealing with the ablative treatment of persistent atrial fibrillation, two ablation strategies are compared: a more anatomically guided linear ablation scheme versus an electrophysiological guided focal…
- Trial name
- NCT00196157
- Testing
- linear anatomically oriented ablations, focal electrophysiological oriented ablations
- Where
- Germany
- Volunteers
- 116 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Atrial Fibrillation Mechanisms, Persistent Atrial Fibrillation
'Understanding the Electrophysiological Substrate Underlying Persistent Atrial Fibrillation Study II (USURP AF- Study II)'
Atrial fibrillation (AF) is the most common type of chronic heart rhythm disease worldwide, with significant associated co-morbidities.
- Conditions
- Atrial Fibrillation Mechanisms, Persistent Atrial Fibrillation, Substrate Ablation, Pulmonary Vein Isolation
- Trial name
- USURPAF (NCT04041778)
- Testing
- Catheter ablation
- Where
- United Kingdom
- Volunteers
- 17 people
- Sponsor
- University of Leicester
Atrial Fibrillation
Hidden Slow Conduction Ablation for Recurrent Atrial Fibrillation: Unmasking the Arrhythmogenic Substrate (Unmask-AF)
Over recent years, pulmonary vein isolation (PVI) procedures have demonstrated progressively enhanced efficacy and safety, resulting in a substantial increase in the number of atrial fibrillation ablations, not only as a…
- Trial name
- NCT06657170
- Testing
- Pulmunary veins reconnection plus hidden slow conduction ablation, Pulmunary veins (PV) reconnection ablation only
- Volunteers
- 212 people
- Sponsor
- Centro Medico Teknon
Ventricular Tachycardia (VT), Ischemic Cardiomyopathy
MRI-guided Ventricular Tachycardia Ablation in Patients With Structural Heart Disease
Ventricular tachycardia (VT) is a life-threatening heart rhythm disorder that frequently occurs in patients with structural heart disease, such as ischemic or non-ischemic cardiomyopathy.
- Conditions
- Ventricular Tachycardia (VT), Ischemic Cardiomyopathy, Non-ischemic Cardiomyopathy
- Trial name
- MAGNET-VT (NCT07896980)
- Testing
- LGE-MRI-integrated EAM-guided catheter ablation, Conventional EAM-guided catheter ablation
- Where
- China
- Volunteers
- 526 people
- Sponsor
- China National Center for Cardiovascular Diseases