Clinical trials: Substrate Ablation
Atrial Fibrillation, Persistent Atrial Fibrillation
Left Atrial Arrhythmia Substrate Identification After Confirmed durABLE Pulmonary Vein Isolation
Under current practice, patients with persistent atrial fibrillation, can be offered one of two types of ablation treatment. Both of these treatments are aimed at electrically isolating the 4 pulmonary veins (PVs) at the back of…
- Trial name
- LAUDABLE (NCT04111731)
- Testing
- Cryoballoon pulmonary vein isolation, Radiofrequency pulmonary vein isolation, Repeat electrophysiological study
- Where
- 3 sites in United Kingdom
- Volunteers
- 44 people
- Sponsor
- Liverpool Heart and Chest Hospital NHS Foundation Trust
Ventricular Tachycardia
STereotactic Ablative Radiosurgery of Recurrent Ventricular Tachycardia in Structural Heart Disease
A multicentre trial on clinical effects of radiosurgical ablation of ventricular tachycardia (VT).
- Trial name
- NCT04612140
- Testing
- Radiosurgery, Repeated catheter ablation
- Where
- 2 sites in Czechia
- Volunteers
- 22 people
- Sponsor
- University Hospital Ostrava
Ischemic Ventricular Tachycardia
Dynamic Substrate Mapping (DSM) for Ischemic VT
This is a prospective, non-randomized study to determine the feasibility of using a new technique called Dynamic Substrate Mapping (DSM) to help guide the treatment of ischemic ventricular tachycardia (IVT).
- Trial name
- DSM (NCT00558857)
- Testing
- Dynamic Substrate Mapping-guided ablation
- Where
- 3 sites in United States
- Volunteers
- 5 people
- Sponsor
- Abbott Medical Devices
Persistent and Long Lasting or Chronic Atrial Fibrillation, Atrial Fibrillation Ablation
SUbstrate Ablation in Persistent Atrial Fibrillation for Elimination of Recurrences (SUPAFER).
Antecedents: electrical isolation of pulmonary veins is the standard treatment for patients with atrial fibrillation. However, its efficacy is lower in persistent and chronic forms of this arrhythmia compared to paroxysmal atrial…
- Conditions
- Persistent and Long Lasting or Chronic Atrial Fibrillation, Atrial Fibrillation Ablation, Linear Left Atrial Ablation, Daily Transtelephonic Electrocardiogram
- Trial name
- SUPAFER (NCT06291506)
- Testing
- Radiofrequency ablation of heart atrial tissue.
- Where
- Spain
- Volunteers
- 176 people
- Sponsor
- Hospital Universitario La Paz
Ventricular Tachycardia
The Use of CT to Identify Damaged Heart Muscle in Patients Undergoing Ventricular Tachycardia Ablation.
Patients with ventricular tachycardia (VT) undergo catheter ablation. During the ablation procedure, the heart is mapped to determine areas of heart muscle damage. The heart scarring areas are often the source of the VT.
- Trial name
- NCT00583284
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- The Cleveland Clinic
Atrial Arrhythmias
Pulmonary Vein Isolation Plus Left Atrial Slow Zone Mapping and Ablation
Pulmonary Vein Isolation Plus Left Atrial Slow Zone Mapping and Ablation: An AcQMap Substrate Characterization Study (PLASZMA)
- Trial name
- PLASZMA (NCT04512794)
- Testing
- AcQMap High Resolution Imaging and Mapping System
- Sponsor
- Acutus Medical
Atrial Fibrillation (AF)
Empirical Anatomy-Based Ablation vs Emphasize Map-Guided Substrate Ablation in Persistent Atrial Fibrillation : (COMPASS-AF)
This study is aimed to compare the clinical efficacy of two different catheter ablation strategies in patients with persistent atrial fibrillation.
- Trial name
- COMPASS-AF (NCT07726901)
- Testing
- Anatomy-based ablation, Emphasize map-guided ablation
- Where
- 2 sites in South Korea
- Volunteers
- 360 people
- Sponsor
- Samsung Medical Center
Brugada Syndrome
Brugada Syndrome Substrate Characterization and Ablation
Independent, single center, prospective study, to evaluate the efficacy, in consecutive BrS patients undergoing catheter ablation, at medium-long term follow-up after epicardial substrate homogenization.
- Trial name
- UNCOVERBrS (NCT05643209)
- Testing
- ablation
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Maria Cecilia Hospital
Ventricular Tachycardia (VT)
Dynamic Voltage Mapping to Personalise the Ventricular Tachycardia Substrate
Ventricular tachycardia (VT) is a life-threatening heart rhythm disorder and one of the commonest causes of heart-related sudden death. It often affects people who have had a heart attack or other structural heart damage.
- Trial name
- DYNAMITE-VT (NCT07573579)
- Testing
- Dynamic Voltage Mapping, Standard of Care Ablation
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Liverpool Heart and Chest Hospital NHS Foundation Trust
Atrial Fibrillation
CPVI Alone Versus. CPVI Plus Electrophysiological Substrate Ablation in the LA During SR for the Treatment of Non-PAF
The primary objective of this investigation is to compare the efficacy of two different AF ablation strategies in patients with non-paroxysmal AF: CPVI plus electrophysiologic substrate ablation in the left atrium during sinus…
- Trial name
- STABLE-SR_II (NCT03448562)
- Testing
- CPVI, STABLE-SR
- Where
- China
- Volunteers
- 300 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Paroxysmal Atrial Fibrillation
Additional Low Voltage Area Ablation in Older Patients With Paroxysmal Atrial Fibrillation
The primary objective of this investigation is to compare the efficacy of two different AF ablation strategies in older patients with paroxysmal AF: Pulmonary vein isolation alone versus additional low-voltage substrate…
- Trial name
- STABLE-SR-III (NCT03462628)
- Testing
- CPVI plus low-voltage substrate modification, CPVI alone
- Where
- China
- Volunteers
- 438 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Ventricular Tachycardia, Catheter Ablation
Stepwise Approach To sUbstrate Modification for Ventricular Tachycardia
The goal of this trial is to test the impact of a step-wise approach for catheter ablation of recurrent ventricular tachycardia, (irregular heart rhythms that originate in the bottom chambers of the heart), in patients with a…
- Conditions
- Ventricular Tachycardia, Catheter Ablation, Tachycardia, Ventricular
- Trial name
- STRATUM VT (NCT01546207)
- Testing
- catheter-based ablation
- Where
- 10 sites in United States, Brazil and 3 more
- Volunteers
- 4 people
- Sponsor
- Vivek Reddy
Persistent Atrial Fibrillation, Atrial Fibrillation (AF)
Atrial Remodeling After PFA Substrate Modification for Persistent AF (PeAF)
Atrial fibrillation (AF) is associated with both electrical and structural remodeling of the left atrium. While successful catheter ablation has been shown to reverse some aspects of atrial remodeling, the impact of pulsed-field…
- Conditions
- Persistent Atrial Fibrillation, Atrial Fibrillation (AF), Atrial Remodeling, Pulsed Field Ablation
- Trial name
- NCT07675395
- Testing
- Pulsed-Field Ablation with FARAWAVE Catheter System
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Ventricular Tachycardia, Ischemic Cardiomyopathy
Impact of PREVENTIVE Substrate Ablation of Coronary Chronic Total Occlusion on Implantable cardioVerTer-Defibrillator Interventions
The aim of this study is to assess whether preventive substrate ablation of chronic total occlusion infarct-related artery (CTO-IRA) area in heart failure (HF) patients correlates with lower appropriate implantable cardiac…
- Trial name
- PREVENTIVE VT (NCT03421834)
- Testing
- Catheter ablation of ventricular tachycardia, Optimal medical treatment
- Where
- 5 sites in Croatia, Slovenia
- Volunteers
- 60 people
- Sponsor
- University Medical Centre Ljubljana
Atrial Fibrillation
Substrate abLatIon as Concomitant trEatment for Left Atrial Macroreentrant Tachycardia
SLICE-LAMRT is a multicenter, prospective, randomized, double-blind trial that will be carried out in patients older than 18 years with atypical flutter suspected to be of left atrial origin.
- Trial name
- SLICE-LAMRT (NCT05842499)
- Testing
- Line Set Strategy, Conventional strategy
- Where
- Spain
- Volunteers
- 128 people
- Sponsor
- Hospital Universitario 12 de Octubre
Ventricular Tachycardia
Stereotactic Non-invasive Ablation of Ventricular Tachycardia
STereotactic Ablative Radiosurgery of recurrent Ventricular Tachycardia in structural heart disease (STAR-VT).
- Trial name
- NCT03819504
- Testing
- 4-D navigated stereotactic radio surgical ablation
- Where
- 3 sites in Czechia
- Sponsor
- University Hospital Ostrava
Atrial Fibrillation (AF), Atrial Fibrillation Mechanisms
Substrate Remodelling and Targeted Ablation in AF
Atrial fibrillation (AF) is the most common heart rhythm disorder, affecting millions worldwide and causing symptoms such as palpitations, fatigue and breathlessness.
- Conditions
- Atrial Fibrillation (AF), Atrial Fibrillation Mechanisms, Catheter Ablation, Low Voltage Areas
- Trial name
- STRATA-AF (NCT07047235)
- Testing
- Pulmonary vein reisolation, Ganglionic plexi ablation, Substrate ablation
- Where
- United Kingdom
- Volunteers
- 160 people
- Sponsor
- Barts & The London NHS Trust
Monomorphic Ventricular Tachycardia
Trial to Evaluate the Efficacy and Safety of Substrate Ablation of Monomorphic Ventricular Tachycardia
To compare the efficacy and safety of substrate-based radiofrequency catheter ablation vs. antiarrhythmic drug therapy in patients with ischemic cardiomyopathy and scar-related sustained monomorphic ventricular tachycardia.
- Trial name
- NCT03734562
- Testing
- Ablation, Antiarrhythmic drug
- Where
- Spain
- Volunteers
- 180 people
- Sponsor
- Hospital General Universitario Gregorio Marañon
Ventricular Tachycardia
Ultra-high Density Mapping With Multielectrode Catheter vs Conventional Point by Point Mapping for Ventricular Tachycardia Substrate Ablation
Ultra-high density mapping with multielectrode catheter may improve slow conduction channels identification in ventricular tachycardia substrate ablation procedures compared to conventional point by point mapping.
- Trial name
- NCT02083016
- Testing
- Ablation guided by conventional mapping., Ablation guided by ultra-high density mapping with multielectrode catheter.
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Hospital Clinic of Barcelona
Atrial Fibrillation
Reversal of Atrial Substrate to Prevent Atrial Fibrillation Pilot Study
This is a pilot study to assess feasibility to conduct a multi-center, randomized trial to examine the effect of aggressive risk factor control and arrhythmia trigger-based intervention on the atrial substrate, which is involved…
- Trial name
- RASTA-AF (NCT03186976)
- Testing
- Aggressive Risk Factor Control, Standard of Care
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- Nova Scotia Health Authority