Clinical trials: Substrate Utilization
Drug Use
Neurobiological Substrate of Social Context on Cognitive Control in Drug Users
The aim of the present project is to reveal, using Functional Magnetic Resonance Imaging (fMRI) in drug users, a specific modulation of brain structures and circuits involved in cognitive control (and especially those of…
- Trial name
- STNdrugaddict (NCT03508362)
- Testing
- Functional Magnetic Resonance Imaging (fRMI)
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Postprandial Effect of Carbohydrate Beverage Consumption
Fat Burning After a Meal
The purpose of the study is to determine how adding a carbohydrate beverage to a meal with different protein levels affects the rate at which one's body burns fats, sugars, and proteins.
- Trial name
- NCT02211599
- Testing
- 15% protein, 30% protein, Sweetened beverage
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- USDA Grand Forks Human Nutrition Research Center
Overweight, Obesity
Energy Expenditure and Substrate Oxidation in a Whole Room Calorimeter
The investigators aim to establish a protocol for metabolic rate measurements obtained using continuous monitoring of oxygen consumption and carbon dioxide production in a whole room calorimeter setting.
- Conditions
- Overweight, Obesity, Body Weight
- Trial name
- NCT04061369
- Testing
- Low fat meal, Moderate fat meal, High fat meal
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- USDA, Western Human Nutrition Research Center
Obesity
Impact of Black Pepper on Energy Expenditure and Substrate Utilization
As obesity rates worldwide continue to increase, there is a focus on identifying active food ingredients which increase metabolic rate which can be used as a dietary supplement in the treatment of overweight and obesity.
- Trial name
- NCT01729143
- Testing
- 24-hour energy expenditure and substrate utilization
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Overweight and Obesity
Biking vs. Running: Comparison of EPOC, Substrate Oxidation, Appetite and Energy Intakes in Men With Overweight/Obesity.
The management of obesity involves hygienic and dietary measures that include appropriate nutrition and an increase in physical activity (PA).
- Trial name
- BIKERUN (NCT06082310)
- Testing
- Exercise
- Where
- France
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Laboratoire des Adaptations Métaboliques à l'Exercice en conditions Physiologiques et Pathologiques
Healthy
Pre-workout Supplement Versus Caffeine on Energy Expenditure.
The primary purpose of this study was to examine the acute effects of a multi-ingredient pre-workout supplement versus an ergogenic dose of caffeine (6 mg/kg) on energy expenditure during low-intensity exercise.
- Trial name
- NCT04539054
- Testing
- ENGN Shred, Nutricost caffeine powder, Crystal Light
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Northern Illinois University
Overweight and Obese Adults, High Intensity Interval Exercise (HIIE)
Acute Effects of Isoenergetic HIIE vs. MICE on Key Parameters of Fat Mass Loss in Young Females With Overweight or Obesity
Overweight and obesity, particularly increased total and/or abdominal fat mass (FM), are strongly linked to the development of cardiovascular diseases.
- Trial name
- COMEFIT (NCT06868862)
- Testing
- Exercise
- Where
- Brazil
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Laboratoire des Adaptations Métaboliques à l'Exercice en conditions Physiologiques et Pathologiques
Healthy
Timing of Meal and Caffeine Intake on Substrate Use and Exercise Efficiency
During the past decades, considerable emphasis has been directed to analyzing the potential role of caffeine on substrate use and exercise performance.
- Trial name
- NCT04106752
- Testing
- Caffeine
- Where
- Lebanon
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- American University of Beirut Medical Center
Weight Loss, Other Effects of High Altitude
Substrate Utilization, Exercise Performance, and Skeletal Muscle Response to Energy Deficit and Altitude Acclimatization
This research will evaluate nutrition requirements for missions at high altitude (i.e. >7800 feet above sea level) and the information obtained can be used to optimize nutrient content specifications for combat rations.
- Trial name
- NCT02731066
- Testing
- Standard pro, High pro, carbo bev
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Healthy, Lactate Blood Increase
The Lactate Project: Investigating the Impact of Lactate to Preserve Vital Organ Blood Supply and Function in Heart and Brain
The aim of the proposed study is to investigate the effect of increased plasma lactate concentrations on the heart and brain's metabolism of other energy sources, primarily glucose in the brain and glucose and FFA in the heart.
- Trial name
- NCT06665763
- Testing
- Sodium Lactate Solution
- Where
- 2 sites in Denmark
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Amyotrophic Lateral Sclerosis, Neurodegenerative Diseases
Quantitative Measurement of Nutritional Substrate Utilization in Patients With Amyotrophic Lateral Sclerosis (ALS)
The work of Nau et. al (Nau KL, Bromberg MB, Forshew DA, Katcha Vl. Individuals with amyotrophic lateral sclerosis are in caloric balance despite losses in mass.
- Trial name
- NCT00714220
- Where
- United States
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- Drexel University College of Medicine
Energy Intake, Substrate Utilization
Breakfast Consumption and Energy Balance in Active Adult Males
Exercising in the fasted state results in greater fat oxidation during exercise and results in decreased caloric intake in the meals after exercise. However, the studies that examine fasted vs.
- Conditions
- Energy Intake, Substrate Utilization, Hormones, Satiety
- Trial name
- NCT04862208
- Testing
- Maltodextrin supplement, Whey supplement, Water
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Ohio University
Cycling Performance, Muscular Adaptations
The Effects of a Train High, Sleep Low Strategy
The investigators will examine the long-term effects of a combined training and diet intervention that, acutely, increases fat oxidation during exercise.
- Conditions
- Cycling Performance, Muscular Adaptations, Substrate Utilization
- Trial name
- NCT03045588
- Testing
- Combined exercise and diet intervention
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Type 1 Diabetes
Comparison of the Use of Energy Substrates and Hormonal Regulation of Blood Sugar During Exercise of Increasing Intensity Between Children With Type 1 Diabetes and Non-diabetic Control Children.
The type 1 diabetes is a common chronic disease characterised by the stop of production of insulin by the pancreas. A lot of factors modify blood glucose.
- Trial name
- DIABSPORT (NCT03139864)
- Testing
- controlled physical activity
- Where
- France
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Healthy
Effects of a Multi-Ingredient Pre-Workout Supplement on Energy Expenditure During Running
The primary purpose of this study was to examine the acute effects of one versus two doses of a multi-ingredient pre-workout supplement on energy expenditure during moderate-intensity treadmill running.
- Trial name
- NCT04352998
- Testing
- One dose pre-workout condition, Two dose pre-workout condition
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Northern Illinois University
Physical Fitness, Mitochondrial Function, Bioenergetics
Effects of Acute Exercise in Fasting and Fed States in Individuals With Different Aerobic Fitness Levels
The aim of this study is to investigate the effects of aerobic fitness level, feeding status, and acute exercise on whole-body metabolic fuel utilization and mitochondrial function in peripheral blood mononuclear cells (PBMCs) in…
- Conditions
- Physical Fitness, Mitochondrial Function, Bioenergetics, Mitochondria, Energy Metabolism
- Trial name
- NCT07813403
- Testing
- Acute Moderate-Intensity Cycling Exercise, Ad Libitum Mixed Meal
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Healthy Subjects or Volunteers
Hydrogen-Rich Water and Resting Metabolism in Young Adults
The H2REST trial is a randomized, double-blind, placebo-controlled crossover study investigating the acute effects of a single dose of hydrogen-rich water (HRW) on resting metabolism in healthy young adults.
- Trial name
- H2REST (NCT07098221)
- Testing
- Molecular Hydrogen
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Novi Sad
Healthy Aging
Effects of Astaxanthin Supplementation on Metabolism, Cognition, and Physical Function in Older Adults
This study evaluated whether astaxanthin supplementation affects the body's ability to use fat for energy, cognitive performance, and physical function in healthy older adults.
- Trial name
- NCT07876193
- Testing
- Astaxanthin Oral Capsule
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of North Alabama
Liver Cirrhoses
Indirect Calorimeter Based Study in Patients With Liver Cirrhosis
Part I- Observational study In the first part , investigator would investigate and compare the energy requirements and substrate utilization in healthy subjects and in patients with liver cirrhosis of various etiologies across…
- Trial name
- METALIC (NCT03871894)
- Testing
- Indirect calorimetry based nutritional intervention till patient in ICU(Intensive care unit), Standard and fixed nutritional intervention till patient in ICU
- Where
- India
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Institute of Liver and Biliary Sciences, India
Healthy Adults
FueL Use During eXercise in Males and Females
This study will investigate whether pre-exercise nutrition influences sex differences in fuel utilization during endurance exercise.
- Trial name
- FLUX (NCT07829237)
- Testing
- Pre-exercise carbohydrate beverage, Pre-exercise protein beverage, Fasted control beverage
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Toronto