Clinical trials: Sugar; Blood, Low
Type 1 Diabetes Mellitus
Mechanisms of Glucose Counterregulation in Pancreatic Islet Transplantation
Pancreatic islet transplantation improves glucose counterregulation and stabilizes glycemic control in patients with type 1 diabetes mellitus prone to severe hypoglycemia even if insulin independence is not achieved.
- Trial name
- NCT01668485
- Testing
- Hypoglycemic and euglycemic glucose clamp
- Where
- Germany
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Giessen
Diabetes Complications
Dose Response of Epinephrine
Epinephrine is the principal physiologic defense against hypoglycemia in type 1 and longer duration type 2 DM. Despite this, it is unknown how epinephrine regulates in-vivo endothelial function and atherothrombotic balance in…
- Trial name
- Epineprhine (NCT02692313)
- Testing
- Epinephrine, Saline infusion
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus
In-hospital Diabetes Management With Flash Glucose Monitoring (isCGM) - the INDIGO Study, Part B
The aim of the study is to investigate the applicability of a Flash glucose monitoring sensor (Freestyle Libre, isCGM) for in-hospital glucose monitoring in patients with diabetes and hypoglycemia (<3,9 mmol/l) during the…
- Conditions
- Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus, Diabetes Mellitus
- Trial name
- INDIGO (NCT04630925)
- Testing
- isCGM
- Where
- Denmark
- Volunteers
- 1 people
- Sponsor
- University of Aarhus
Pregnancy in Diabetic
Incidence of Hypoglycemia in Pregnant Ladies With or Without Gestational Diabetes Fasting Ramadan
The physiological change in food and sleep pattern during Ramadan impacted hypoglycemia risks among pregnant women. Few studies investigated the incidence of hypoglycemia pregnant women with or without diabetes during fasting in…
- Trial name
- NCT04862390
- Testing
- Continuous glucose monitoring
- Where
- Saudi Arabia
- Volunteers
- 30 people
- Sponsor
- King Abdullah International Medical Research Center
Congenital Disorders of Glycosylation
Clinical and Basic Investigations Into Known and Suspected Congenital Disorders of Glycosylation
Background: Proteins, fats, and other molecules are the body s building blocks. Many of these molecules must have sugars, or chains of sugars, attached to work properly.
- Trial name
- NCT02089789
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Primary Adrenal Insufficiency, Intermittent Fasting
Risks of Intermittent Fasting in Patients With Primary Adrenal Insufficiency
In primary adrenal insufficiency, there is an increased risk of hypoglycaemia and dehydration. These risks have been little studied particularly during intermittent fasting.
- Trial name
- NCT06299020
- Testing
- intermittent fasting
- Where
- Tunisia
- Volunteers
- 30 people
- Sponsor
- Hopital La Rabta
Type 2 Diabetes
Study on Lixisenatide and Counterregulation to Hypoglycemia
In hypoglycemia, there is a counterregulation to restore glucose levels. An important part of this counterregulation is the release of the hormone glucagon.
- Trial name
- NCT02020629
- Testing
- Lixisenatide
- Where
- Sweden
- Volunteers
- 18 people
- Sponsor
- Lund University
Diabetes Mellitus, Type 1
Closed Loop and Education for Hypoglycemia Awareness Restoration
The purpose of the CLEAR study is to determine the effect on counterregulatory responses (CRR) of intervening (by attempting to strictly avoid hypoglycemia) to improve awareness of hypoglycemic symptoms among adults with type 1…
- Trial name
- CLEAR (NCT06325202)
- Testing
- Omnipod 5 or Medtronic 780G, My HypoCOMPaSS Education, HARPdoc Education
- Where
- 8 sites in United States, Australia and 1 more
- Volunteers
- 324 people
- Sponsor
- Milton S. Hershey Medical Center
Diabetes Mellitus
Effect of GLP-1 on Insulin-dose, Risk of Hypoglycemia and Gastric Emptying Rate in Patients With Type 1 Diabetes
The aim of the study is to investigate the effect of Victoza (a GLP-1 receptor agonist)on insulin-dose, risk of hypoglycemia and gastric emptying rate during hypoglycemia in patients with type 1 diabetes.
- Trial name
- NCT00993720
- Testing
- Liraglutide, continuous insulin therapy
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Hvidovre University Hospital
Type 1 Diabetes Mellitus With Hyperglycemia, Type 1 Diabetes Mellitus With Hypoglycaemia
The Expert System VoiceDiab in Children With Diabetes
The purpose of this study to conduct the preliminary investigation on the efficacy and safety in terms of postprandial glucose value and the rates of hypoglycaemia when expert VoiceDiab system supports patient's decision on…
- Trial name
- VoiceDiab (NCT02403427)
- Testing
- VoiceDiab expert system
- Where
- Poland
- Volunteers
- 42 people
- Sponsor
- Instytut Diabetologii Sp. z o.o.
Hypoglycemia, Diabetes Mellitus, Type 1
Safety and Efficacy of G-Pen Compared to Lilly Glucagon for Hypoglycemia Rescue in Adult Type 1 Diabetics
This is a blinded, randomized crossover study to compare the safety and efficacy of G-Pen (glucagon injection) to Lilly Glucagon (glucagon for injection [rDNA origin]) for hypoglycemia rescue of adult patients with type 1…
- Trial name
- NCT02656069
- Testing
- G-Pen (glucagon injection), Lilly Glucagon (glucagon injection [rDNA origin])
- Where
- 7 sites in United States, Canada
- Volunteers
- 80 people
- Sponsor
- Xeris Pharmaceuticals
Hyperinsulinism-Hyperammonemia Syndrome
Vitamin E Supplementation in Hyperinsulinism/Hyperammonemia Syndrome
Investigators will assess the tolerability of oral Vitamin E supplementation in subjects with congenital hyperinsulinism (HI) and hyperammonemia (HA) syndrome.
- Trial name
- NCT03797222
- Testing
- Vitamin E
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Elizabeth A Rosenfeld
Type 1 Diabetes Mellitus With Hypoglycemia
Efficacy of Closed-loop Insulin Therapy in Adults Prone to Hypoglycemia
This study is a RCT of 3 month at home comparing closed-loop control (CLC) system vs sensor and pump therapy (S\&P), with a 3-month extension phase, in Type 1 diabetic patient prone to hypoglycemia.
- Trial name
- DCLP2 (NCT04266379)
- Testing
- Closed-loop insulin infusion driven by continuous glucose monitoring through an algorithm, in free-life conditions, Continuous Subcutaneous Insulin Infusion and Continuous Glucose Monitoring
- Where
- 2 sites in France
- Volunteers
- 72 people
- Sponsor
- University Hospital, Montpellier
Diabetes Mellitus, Type 1, Hypoglycemia
Telemedicine Monitoring of Nocturnal Incidents
Reducing hypoglycemia is an important aspect of management of type 1 diabetes (T1D) in older adults, many of whom have hypoglycemic unawareness, cognitive impairment, or both.
- Trial name
- TELE-MONITOR (NCT04328896)
- Testing
- CGM-Tele-monitoring
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Southern California
Type 1 Diabetes
Determining the Appropriate Intensity of Exercise to Prevent Post-exercise Hypoglycemia in Persons Living With T1D
Over 300, 000 youth and young adults across Canada are living with Type 1 Diabetes (T1D) which is considered the most common endocrine condition.
- Trial name
- NCT03583268
- Testing
- Exercise
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University of Manitoba
Hyperinsulinemic Hypoglycemia, Postprandial Hypoglycemia
Dasiglucagon in the Treatment of Postprandial Hypoglycaemia After Roux-en-Y Gastric Bypass
The aim of this study is investigating the effect of a novel glucagon analogue administration in gastric bypass operated individuals, who are reactive hypoglycemic.
- Trial name
- NCT03984370
- Testing
- ZP4207
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Type 1 Diabetes
Exercise Detection Study
The risk of hypoglycemia in individuals with type 1 diabetes increases considerably during exercise. As a result, many patients with type 1 diabetes experience fear of and reluctance to pursue physical activity, in order to avoid…
- Trial name
- NCT02688218
- Testing
- Aerobic Exercise, Resistance Exercise
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Potential Abnormality of Glucose Tolerance, Appetitive Behavior
Determining the Glycemic Effects of Three Types of Spaghetti
This study investigated the effects of thee types of spaghetti No7 on the glycemic response
- Trial name
- NCT05197283
- Testing
- Glucose as reference food, White bread, Regular spaghetti
- Where
- Greece
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Agricultural University of Athens
Diabetes, Diabetes Mellitus, Type 1
Comparison of Insulin Detemir and NPH With Respect to Lowering the Blood Sugar and Symptoms Experienced by Type 1 Diabetics During Hypoglycaemia
This trial is conducted in UK. The aim of this clinical trial is to investigate lowering the blood sugar and symptoms experienced during hypoglycaemia
- Trial name
- NCT00760448
- Testing
- insulin detemir, insulin NPH
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- Novo Nordisk A/S