Clinical trials: Suicidal Behavior
Suicidal Ideation
Peer Mentorship to Reduce Suicide Attempts Among High-Risk Adults
This is a single-blind, randomized controlled trial to test the effectiveness of a peer mentorship intervention (PREVAIL) for reducing suicide risk compared to enhanced usual care among participants (N=455) at high-risk for…
- Trial name
- PREVAIL (NCT03373916)
- Testing
- Peer mentorship, Enhanced Usual Care
- Where
- 3 sites in United States
- Volunteers
- 455 people
- Sponsor
- University of Michigan
Suicidal Ideation
Effect of Perimenstrual Ovarian Steroid Supplementation on Perimenstrual Suicidality
This within-person, crossover, 2-condition, placebo-controlled study compares the impact of two perimenstrual conditions on severity of suicidal symptoms in females with past-month suicidality but minimal risk of imminent suicide…
- Trial name
- NCT03720847
- Testing
- Estradiol Transdermal Patch 0.1 mg/24 hrs, Oral Micronized Progesterone, Inactive Clear Patch
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of North Carolina, Chapel Hill
Suicide, Attempted
An Initial Feasibility Study of Brief Cognitive Behavioral Therapy for Suicidal Inpatients
Suicide is a major public health problem. Although inpatient treatment provides immediate stabilization and crisis management, the risk of suicide post-discharge is substantial.
- Trial name
- NCT03442699
- Testing
- Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Hartford Hospital
Suicidal Ideation
The Elders' Resilience Curriculum
The overall goal of this research is to better understand if and how the Elders' Resilience Curriculum (ERC), a culturally grounded, school-based upstream suicide prevention program taught by White Mountain Apache Tribe (WMAT)…
- Trial name
- NCT06045273
- Testing
- Elders' Resilience Curriculum
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Suicidal Ideation, Suicide, Attempted
Reducing Suicide Ideation Among Young People
It is Cluster Randomized Control Trial research to examine feasibility and relevance of the modified tool Nae Disha for Life, which will incorporate suicide prevention and resilience to reduce suicide ideation among young people…
- Trial name
- NCT06474312
- Testing
- Nae Disha
- Where
- India
- Volunteers
- 363 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Suicidal Ideation
Unique Effects of Perimenstrual Estradiol or Progesterone Supplementation on Perimenstrual Suicidality
This within-person, crossover, 3-condition, placebo-controlled study compares the impact of three perimenstrual conditions on severity of suicidal symptoms in females with past-month suicidality but minimal risk of imminent…
- Trial name
- CLEAR-2 (NCT03498313)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Illinois at Chicago
Depression, Suicidal Ideation
BRITEPath- Phase 2
BRITEPath (BP) aims to support co-located mental health clinicians in the development of a high quality, effective, and personalized safety plan for referred patients who screen positive for depression and/or suicidal ideation.
- Trial name
- NCT04672798
- Testing
- BRITEPath, Treatment As Usual (TAU)
- Where
- 6 sites in United States
- Volunteers
- 101 people
- Sponsor
- University of Pittsburgh
Suicide, Attempted, Suicide and Depression
Ketamine Versus Midazolam for Recurrence of Suicidality in Adolescents
This project aims to examine the signal of efficacy of ketamine, a rapidly acting medication shown to decrease suicidality in adults in as short as hours or days, as opposed to weeks.
- Conditions
- Suicide, Attempted, Suicide and Depression, Suicide Threat
- Trial name
- TASK (NCT04592809)
- Testing
- Ketamine Hydrochloride, Midazolam Hydrochloride
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Texas Southwestern Medical Center
Traumatic Brain Injury, Suicidality
Executive Dysfunction and Suicide in Psychiatric Outpatients and Inpatients
Those with traumatic brain injury (TBI) are at increased risk for suicidal behavior, and suicidality is associated with executive dysfunction.
- Trial name
- NCT01043432
- Where
- United States
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Nonsuicidal Self Injury, Self Hatred
Single-Session Intervention Targeting Self-Injurious Behavior in Adolescents
Participants (aged 13-16) will be randomized to: (1) an online, active control group program encouraging feelings disclosure (i.e.
- Conditions
- Nonsuicidal Self Injury, Self Hatred, Suicidal Thoughts, Suicide Attempts
- Trial name
- Project SAVE (NCT04498143)
- Testing
- Project SAVE ("Stop Adolescent Violence Everywhere") SSI, Active Comparator: Supportive Therapy ("Share Your Feelings") SSI
- Where
- United States
- Volunteers
- 565 people, healthy volunteers welcome
- Sponsor
- University of Denver
Suicidal Ideation
Evaluation of a Computerized Intervention for Learning to Re-Evaluate Suicidal Thoughts
As rates of suicide have increased over the last several decades, research has identified that roughly two-thirds of individuals who attempt suicide do so within one year from the time that they begin to think about suicide.
- Trial name
- REST (NCT04254809)
- Testing
- Re-Evaluating Suicidal Thoughts, Healthy Social Living
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- Florida State University
Bipolar Disorder, Major Depressive Disorder
Reducing Suicide Risk in Adolescents and Young Adults Via a Psychobehavioral Intervention to Regularize Daily Rhythms
The purpose of this study is to advance a non-pharmacologic suicide preventive intervention with wide dissemination potential as an innovative high-yield solution to reduce suicide rates.
- Conditions
- Bipolar Disorder, Major Depressive Disorder, Mood Disorders, Suicide
- Trial name
- NCT05317481
- Testing
- BE-SMART-DR, psychoeducational control comparator condition (CC)
- Where
- 2 sites in United States
- Volunteers
- 65 people
- Sponsor
- Yale University
Depression, Suicidal Ideation
Social Connections and Late Life Suicide
With the long-term goal of improving interventions for late-life suicide, the purpose of this study is to examine whether a mechanism by which behavioral interventions reduce risk for late-life suicide is by increasing social…
- Trial name
- NCT02188485
- Testing
- ENGAGE
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- University of Rochester
Suicide Prevention
Suicide Prevention Program for Veterans Discharged From Community Care Settings
The goal of this pilot randomized controlled trial is to test an adapted suicide prevention program (the Building VA Engagement, Self-efficacy, and Social Support To Prevent Suicide or BESST) in rural Veterans discharged from…
- Trial name
- NCT06139887
- Testing
- BESST, Standard Mental Health Care
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- White River Junction Veterans Affairs Medical Center
Suicidal Ideation, Suicide Attempt
Written vs Electronic Safety Planning Study
Safety planning is a brief, ED-feasible intervention which has been demonstrated to save lives and has been universally recommended by every recent expert consensus panel on suicide prevention strategies.
- Conditions
- Suicidal Ideation, Suicide Attempt, Mental Health
- Trial name
- NCT04026308
- Testing
- Safety Net App
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Arkansas
Suicide
Developing a Mobile Intervention to Reduce Suicidal Cognitions in Veterans
Suicide cognitions are conceptualized as enduring, chronic vulnerability factors that predispose individuals to suicidal crises. Therefore, modification of these beliefs may reduce suicidal thoughts and behaviors.
- Trial name
- NCT04881903
- Testing
- Mobile Intervention for Suicidal Thoughts (MIST), Mobile Intervention for Reducing Anger (MIRA)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- VA Office of Research and Development
Suicidal Ideation, Suicide, Attempted
Improving Treatment Outcomes for Suicidal Veterans With PTSD
The efficacy of cognitive processing therapy (CPT) for reducing the symptoms of posttraumatic stress disorder (PTSD) across populations including military personnel and veterans is well supported.
- Conditions
- Suicidal Ideation, Suicide, Attempted, Ptsd
- Trial name
- NCT04690582
- Testing
- Cognitive Processing Therapy (CPT), Crisis Response Plan (CRP), Safety Planning Intervention (SPI)
- Where
- United States
- Volunteers
- 157 people
- Sponsor
- Ohio State University
Suicide
Increasing Treatment Seeking Among Suicidal Veterans Calling the Crisis Line
The goal of this research plan is to test the effectiveness of a brief, cognitive behavioral (CB) intervention to promote behavioral health treatment engagement among at-risk Veterans who call the Crisis Line but are resistant to…
- Trial name
- NCT01771965
- Testing
- CB Intervention
- Where
- 2 sites in United States
- Volunteers
- 19 people
- Sponsor
- VA Office of Research and Development
Depression, Self-injurious Behavior
Interpersonal Psychotherapy for Depressed Adolescents Engaging in Non-suicidal Self-injury
The purpose of this study is to examine the feasibility of using Interpersonal Psychotherapy for Depressed Adolescents (IPT-A) to treat adolescents who are experiencing symptoms of depression and are engaging in non-suicidal…
- Trial name
- IPT-ASI (NCT00401102)
- Testing
- Interpersonal Psychotherapy for Depressed Adolescents
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- New York State Psychiatric Institute
Self-Injurious Behavior, Self Harm
Treating Self Injurious Behavior: A Novel Brain Stimulation Approach
The purpose of this study is to explore the tolerability and effectiveness of transcranial direct current stimulation (tDCS) as a potential treatment for non-suicidal self-injury (NSSI).
- Conditions
- Self-Injurious Behavior, Self Harm, Self-injury, Self-inflicted Injury
- Trial name
- NCT04244786
- Testing
- Transcranial direct current stimulation, No intervention
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- New York State Psychiatric Institute