Clinical trials: Suicidal Behaviour
Depression Disorders, Suicidality
Effectiveness of the Adapt for Life, Mental Wellness and Suicide Prevention Program
Adapt for Life is a mental health and wellbeing program designed to help young people develop healthy behaviors and important life skills to manage stress and mental health challenges.
- Trial name
- AFL (NCT06979479)
- Testing
- school-based intervention
- Where
- United States
- Volunteers
- 1,102 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Suicide
Developing Adaptive Interventions for Suicidal College Students Seeking Treatment - SMART
This pilot study tested the feasibility of utilizing an adaptive intervention strategy for college students who are suicidal when first seeking treatment at a campus clinic.
- Trial name
- SMART (NCT02442869)
- Testing
- Stage 1 Treatment as usual (TAU), Stage 1 CAMS, Stage 2 CAMS
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- University of Nevada, Reno
Suicidal and Self-injurious Behavior
An ED-based RCT of Lethal Means Counseling for Parents of At-Risk Youth
The National Action Alliance to Prevent Suicide recently released a research agenda aimed at significantly reducing suicide over the next decade.
- Trial name
- NCT03143283
- Testing
- Safety Study Lethal Means Counseling
- Where
- 8 sites in United States
- Volunteers
- 575 people
- Sponsor
- Northeastern University
Depression
Low Pulse Amplitude Focal ECT (LAP Study)
This protocol proposes a pilot randomized clinical trial to examine whether Low Pulse Amplitude Focal ECT (LAP) has a more favorable cognitive profile compared to conventional unilateral ECT and that it has similar effects as…
- Trial name
- NCT02583490
- Testing
- spectrum 5000Q ECT device (RUL ECT), spectrum 5000Q ECT device (RUL LAP ECT)
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Augusta University
Suicide, Depression
Engaging Suicidal Patients in Mental Health Treatment
The investigators will identify characteristics of suicidal patients who do or do not attend a first mental health visit following referral using administrative data.
- Conditions
- Suicide, Depression, Mental Health Impairment, Suicidal Ideation
- Trial name
- NCT05021224
- Testing
- Caring Contacts, Reminders, Informational Poster
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Substance Abuse, Suicide
Functional Connectivity Alterations in Suicidal Patients Among Opioid Users
Suicide is the 10th leading cause of death for Americans of all ages and more people in the United States now die from suicide than die from car accidents.
- Conditions
- Substance Abuse, Suicide, Depression
- Trial name
- NCT05489042
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Suicide Attempt, Suicide
ASSIP, Attempted Suicide Short Intervention Program. Two Year Follow-Up Study
Objective Attempted suicide is the main risk factor for repeated suicidal behavior. However, evidence of the effectiveness of follow-up treatments for these patients is limited.
- Conditions
- Suicide Attempt, Suicide, Suicidal Ideation
- Trial name
- ASSIP (NCT02505373)
- Testing
- Attempted Suicide Short Intervention Program (ASSIP), Control Group (CG)
- Where
- Switzerland
- Volunteers
- 120 people
- Sponsor
- University of Bern
Suicidal Ideation, Alcohol Drinking
Computerized DBT Skills Training for Suicidal and Heavy Episodic Drinkers
Alcohol use is considered to be a significant risk factor among those who die by suicide, especially among those who drink to regulate their emotions.
- Trial name
- NCT02932241
- Testing
- Computerized Dialectical Behavior Therapy Skills Training
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Washington
Suicidal Ideation, Suicide Prevention
User Evaluation Think Life
This study aims to evaluate user experiences with the online self-help course Think Life, a suicide prevention intervention for individuals experiencing suicidal thoughts.
- Conditions
- Suicidal Ideation, Suicide Prevention, mHealth Intervention
- Trial name
- NCT07654127
- Testing
- Self-help course Think Life
- Where
- Belgium
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University Ghent
Self-Injurious Behavior, Self Harm
Treating Self Injurious Behavior: A Novel Brain Stimulation Approach
The purpose of this study is to explore the tolerability and effectiveness of transcranial direct current stimulation (tDCS) as a potential treatment for non-suicidal self-injury (NSSI).
- Conditions
- Self-Injurious Behavior, Self Harm, Self-injury, Self-inflicted Injury
- Trial name
- NCT04244786
- Testing
- Transcranial direct current stimulation, No intervention
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- New York State Psychiatric Institute
Suicidal Ideation, Suicide, Attempted
Skills to Enhance Positive Affect in Suicidal Adolescents
The prevalence of suicidal behaviors in adolescents remains unacceptably high and is a significant public health concern. The investigators propose a new treatment approach in which skills to increase positive emotions are taught…
- Trial name
- STEP (NCT02130583)
- Testing
- Positive Affect Skills Training, Treatment as Usual
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Brown University
Suicidality
A Study of Nopan Treatment of Acute Suicidality
Anecdotal evidence and several clinical studies found the mixed opioid agonist-antagonist Nopan to be an effective antidepressant with a rapid onset of action.
- Trial name
- NCT01046851
- Testing
- Nopan
- Where
- 3 sites in Israel
- Volunteers
- 60 people
- Sponsor
- Prof. Yoram Yovell
Suicidal Ideation
Effects of Ketamine in the Acute Phase of Suicidal Ideation
The primary objective of this study is to assess the efficacy of ketamine versus a placebo for the short-term (at 72h, i.e. 24h after the last perfusion) relief of suicidal ideation, measured using the BSS hetero questionnaire…
- Trial name
- KETIS (NCT02299440)
- Testing
- Baseline evaluation, 1st perfusion of ketamine, 1st perfusion of saline
- Where
- 9 sites in France
- Volunteers
- 156 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Major Depressive Disorder, Major Depressive Episode
SAINT for MDD in an Inpatient Setting Follow-on
Randomized, multi-site, sham-controlled, double-blinded study
- Conditions
- Major Depressive Disorder, Major Depressive Episode, Suicidal Ideation
- Trial name
- NCT06462820
- Testing
- Active SAINT Stimulation
- Where
- 4 sites in United States
- Volunteers
- 2 people
- Sponsor
- Magnus Medical
Suicide, Attempted, Suicide, Ideation
Relapse Prevention for Suicidal Dually Diagnosed Youths
The purpose of this study is to develop, refine, and pilot test an augmenting cognitive behavior relapse prevention intervention (CBT-RP) for suicidal, depressed, and alcohol/substance abusing adolescents.
- Conditions
- Suicide, Attempted, Suicide, Ideation, Depression, Substance Abuse
- Trial name
- CBT-RP (NCT00589641)
- Testing
- CBT-RP (relapse prevention) + Enhanced TAU, Enhanced TAU Alone
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Duke University
Suicide and Depression, Psychological Distress
Preventing Psychological Distress and Suicidal Behaviours: a Web-based and Mobile Suicide Prevention Intervention in the General Population
An interventional research study will be undertaken to assess the effectiveness of the promotion at the local level of an e-health tool for suicide and psychological distress prevention (the StopBlues application and website).
- Conditions
- Suicide and Depression, Psychological Distress, Anxiety Disorders, Local Authorities Promotion
- Trial name
- PRINTEMPS (NCT03565562)
- Testing
- Promotion of the e-health tool by local authorities, Promotion of the e-health tool by local authorities and GPs
- Where
- France
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Suicide, Suicide, Attempted
Pilot Study of Health System/Community Partnership for Enhanced Outreach to Prevent Suicide Attempts
The goal of this clinical trial is to test an enhanced outreach intervention (EOI) delivered by Samaritans of Boston (a community organization that provides support during mental health crises) for people after they leave an…
- Conditions
- Suicide, Suicide, Attempted, Suicidal Ideation
- Trial name
- NCT05825820
- Testing
- Enhanced Outreach Intervention (EOI) plus Care as Usual
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
Psychiatric Disorder
Evaluation of a Modularized Cognitive Behavioral Group Therapy Programme for Young Adults (CHANGE-Study)
This prospective, non-randomised, pre-post feasibility study evaluates CHANGE, a novel 8-session modularized cognitive behavioral group psychotherapy for young adults (18-25 years) with psychiatric disorders receiving inpatient…
- Trial name
- CHANGE (NCT07772180)
- Testing
- CHANGE - modularized group psychotherapy
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Max-Planck-Institute of Psychiatry
Suicidal Ideation Active, Suicidal and Self-injurious Behavior
Operation Worth Living Project With Suicidal Soldiers at Ft. Stewart
This is a randomized controlled trial comparing the use of new clinical intervention (the "Collaborative Assessment and Management of Suicidality--CAMS") versus enhanced care as usual for suicidal Soldiers who are seen at…
- Trial name
- OWL (NCT01300169)
- Testing
- The Collaborative Assessment and Management of Suicidality, Enhanced Care as Usual
- Volunteers
- 150 people
- Sponsor
- The Catholic University of America
HIV, Suicide
Suicide Assessment and Feasible Evidence-based Treatments for Youth Living With HIV in Lilongwe
The overall aim of this study is to determine the feasibility, fidelity, acceptability, and preliminary effectiveness of the Friendship Bench +Safety Planning intervention in reducing suicidal ideation and behaviors (SIBs) and…
- Trial name
- NCT06770101
- Testing
- Behavioral: Enhanced Friendship Bench + Safety Planning, Augmented usual care
- Where
- 4 sites in Malawi
- Volunteers
- 60 people
- Sponsor
- University of Pennsylvania