Clinical trials: Suicidal Behaviour
Mood Disorders, Suicidal Ideation
Esketamine vs ECT for Acute Suicidality
This study is a multicenter, randomized, non-inferiority, parallel-group clinical trial designed to evaluate the efficacy and safety of esketamine compared with electroconvulsive therapy (ECT) in the treatment of suicidal…
- Conditions
- Mood Disorders, Suicidal Ideation, Depressive Episode
- Trial name
- NCT06355180
- Testing
- Esketamine, Electroconvulsive therapy
- Where
- 6 sites in China
- Volunteers
- 340 people
- Sponsor
- Capital Medical University
Suicide
Just-in-time Interventions for Reducing Short-term Suicide Risk
The goal of this study is to test the effects of just-in-time intervention strategies aimed to promote implementation of the safety plan and its components at different levels of suicidal urges and intent.
- Trial name
- NCT05793541
- Testing
- Phone call, Text messaging, Automated interactive smartphone-based tool
- Where
- United States
- Volunteers
- 185 people
- Sponsor
- Massachusetts General Hospital
Suicidal Ideation, Depression
Exploring the Effectiveness of a Suicide Ideation Prevention Program: Reframe-IT+
Suicide is a leading cause of death among young people, with worldwide prevalence rates of suicidal ideation, suicidal ideation with a plan, and suicide attempts in youth aged 14-21 years.
- Conditions
- Suicidal Ideation, Depression, Anxiety, Hopelessness
- Trial name
- Reframe-It+ (NCT06759441)
- Testing
- Reframe-It+
- Where
- Chile
- Volunteers
- 75 people
- Sponsor
- Universidad de los Andes, Chile
Suicide
High Risk Suicidal Behavior in Veterans
Suicide is a pressing problem in the US military, with evidence of increased risk for suicide particularly among soldiers serving in Iraq and Afghanistan.
- Trial name
- NCT02462694
- Testing
- Dialectical Behavior Therapy, Treatment As Usual
- Volunteers
- 91 people
- Sponsor
- Bronx Veterans Medical Research Foundation, Inc
Suicidal Ideation
Observational Study to Compare Outcomes of Different Psychiatric Treatment of Suicidal Adolescents
To address the unmet need of optimizing the treatment and management for adolescent suicidality, the investigators propose to evaluate the effectiveness and safety of telehealth services compared to inpatient and OCIC for…
- Trial name
- Pre-START (NCT04625686)
- Testing
- Mental Health Treatment
- Where
- 4 sites in United States
- Volunteers
- 249 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Suicide, Attempted
Skills to Enhance Positivity in Suicidal Youth
This is a Hybrid Type I Effectiveness-Implementation design. Specifically, this study proposes to test the effectiveness of STEP in reducing suicidal events and ideation in 216 adolescents, admitted to inpatient psychiatric care…
- Trial name
- STEP (NCT04994873)
- Testing
- STEP, Enhanced TAU
- Where
- 3 sites in United States
- Volunteers
- 200 people
- Sponsor
- Brown University
Non Suicidal Self Injury, Cognitive Behavior Therapy
Evidence-based Digital CBT for Nonsuicidal Self-Injury
To evaluate if evidence-based digital cognitive behaviour therapy for adolescents is an efficacious treatment when delivered as an adjunctive treatment to treatment as usual, compared to a control group consisting of treatment as…
- Trial name
- NCT07337473
- Testing
- Evidence-based digital cognitive behaviour therapy, Health Education
- Volunteers
- 100 people
- Sponsor
- Peking University Sixth Hospital
Suicidal Thoughts and Behaviors, Social Connectedness
Social Threat, Adolescent Relationships, and Suicidality Study
In recent years, adolescents are having higher rates of emotional health problems, such as suicidal thoughts and behaviors (STBs).
- Conditions
- Suicidal Thoughts and Behaviors, Social Connectedness, Responses to Social Threat
- Trial name
- STARS (NCT07294079)
- Testing
- Social threat
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Pittsburgh
Domestic Violence, Psychological Distress
GBV, Primary Trauma & Trauma Resilience & Understanding Self-help Therapy Utilization in Uganda
The goal of this community-based interventional study was to determine the effectiveness of the 'Trauma Resilience \& Understanding Self-help Therapy' (TRUST) in managing domestic violence \& primary trauma among formerly…
- Conditions
- Domestic Violence, Psychological Distress, Post-Traumatic Stress Disorder, Suicidality
- Trial name
- GBV (NCT06073964)
- Testing
- Trauma Resilience & Understanding Self-help Therapy
- Where
- Uganda
- Volunteers
- 284 people
- Sponsor
- Kampala International University
Depression, Anxiety
Efficacy of a Multi-level School Intervention for LGBTQ Youth
Efficacy of a Multi-level School Intervention for LGBTQ Youth
- Conditions
- Depression, Anxiety, Post Traumatic Stress Disorder, Coping Behavior
- Trial name
- NCT05541406
- Testing
- Proud & Empowered, Control Group
- Where
- 23 sites in United States
- Volunteers
- 228 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Suicide
Linguistic Characteristics of Suicidal Patients in the Emergency Department
The purpose of this study is to determine whether patients who have a high risk for serious suicide behavior will demonstrate a speech pattern that has a relationship to language patterns found in suicide notes.
- Trial name
- NCT01594138
- Testing
- Standardized questionnaires and a ubiquitous questionnaire
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Suicide, Suicide, Attempted
Implementability and Effectiveness of the Safety Planning Intervention for Suicidal Behavior
The Safety Plan Intervention (SPI) has demonstrated to reduce suicide reattempts and to increase the ambulatory follow-up in american war veterans.
- Conditions
- Suicide, Suicide, Attempted, Suicidal Ideation
- Trial name
- NCT04230434
- Testing
- Safety Plan Intervention
- Where
- Spain
- Volunteers
- 58 people
- Sponsor
- Instituto de Investigación Hospital Universitario La Paz
Suicide
Coping Long Term With Attempted Suicide - Adolescents
This study is to develop an adjunctive intervention for acutely suicidal adolescents who have been admitted to a psychiatric inpatient unit.
- Trial name
- CLASP-A (NCT01748760)
- Testing
- CLASP-A intervention, Treatment as Usual
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Brown University
Psychosis, Suicide Prevention
Cognitive AppRoaches to coMbatting Suicidality
This is a randomised controlled trial which investigates the effectiveness of CARMS (Cognitive AppRoaches to coMbatting Suicidality) therapy in reducing suicidal thoughts and how well CARMS works in practice within the NHS.
- Conditions
- Psychosis, Suicide Prevention, Suicidality
- Trial name
- CARMS (NCT03114917)
- Testing
- Cognitive AppRoaches to coMbatting Suicidality (CARMS)
- Where
- 4 sites in United Kingdom
- Volunteers
- 329 people
- Sponsor
- University of Manchester
Suicidal Ideation
Ask Suicide-Screening Questions (ASQ) for Youth With Autism Spectrum and Neurodevelopmental Disorders
Background: Suicide is the second leading cause of death for young people ages 10-24 years. There is no gold standard for evaluating suicidal thoughts and behaviors in young people with autism spectrum disorder (ASD) or other…
- Trial name
- NCT04317118
- Where
- 3 sites in United States
- Volunteers
- 278 people
- Sponsor
- National Institute of Mental Health (NIMH)
Depressive Episode, Posttraumatic Stress Disorder
Transcranial Magnetic Stimulation (TMS) for Suicidal Ideation
The purpose of this study is to determine whether transcranial magnetic stimulation (TMS) is effective in the treatment of suicidal thinking in individuals with a depressive episode and either posttraumatic stress disorder…
- Conditions
- Depressive Episode, Posttraumatic Stress Disorder, Traumatic Brain Injury
- Trial name
- NCT01212848
- Testing
- Transcranial Magnetic Stimulation
- Where
- 2 sites in United States
- Volunteers
- 42 people
- Sponsor
- INTRuST, Post-Traumatic Stress Disorder - Traumatic Brain Injury Clinical Consortium
Depressive Disorder, Major, Generalized Anxiety Disorder
Student Precarity and Psychiatry
Since the COVID-19 pandemic, mental health disorders have increased significantly, particularly among young people. In France, the proportion of young people aged 18 to 25 suffering from depression almost doubled between 2017 and…
- Conditions
- Depressive Disorder, Major, Generalized Anxiety Disorder, Suicidal Ideation, Loneliness
- Trial name
- PEPSY (NCT07618208)
- Testing
- Questionnaires
- Volunteers
- 45,000 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Suicidal Ideation, Social Behavior
Massive Mental Health Screening Using Smartphones in 24 Pre-graduate Education Centers in Mexico City: TEDUCA Survey Protocol
The objective of this study is to make a massive suicide risk and social behavior assessment in 24 pre-graduate education centers in Mexico City (approximately 30,000 students aged between 15 and 22 years), taking also into…
- Conditions
- Suicidal Ideation, Social Behavior, Depression, Depressive Disorder
- Trial name
- TEDUCA (NCT04067076)
- Testing
- Self-administered evaluation questionnaire
- Where
- Mexico
- Volunteers
- 30,000 people
- Sponsor
- Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
Depressive Disorder, Major, Suicidal
A Study of SLS-002 (Intranasal Racemic Ketamine) in Adults With Major Depressive Disorder at Imminent Risk of Suicide
The purpose of the study is to evaluate the efficacy, safety, and tolerability of SLS-002 (intranasal racemic ketamine) in addition to standard of care on symptoms of Major Depressive Disorder (MDD) and suicidality, in…
- Trial name
- NCT04669665
- Testing
- SLS-002, Standard of care, Intranasal device
- Where
- 21 sites in United States
- Volunteers
- 164 people
- Sponsor
- Seelos Therapeutics, Inc.
Suicide, Attempted
An Initial Feasibility Study of Brief Cognitive Behavioral Therapy for Suicidal Inpatients
Suicide is a major public health problem. Although inpatient treatment provides immediate stabilization and crisis management, the risk of suicide post-discharge is substantial.
- Trial name
- NCT03442699
- Testing
- Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Hartford Hospital