Clinical trials: Suicide, Ideation
Suicide, Suicidal Ideation
Telehealth to Reduce Suicidality and Improve HIV Care Engagement in Tanzania
The overall objectives of the proposed research are to develop a brief telehealth counseling intervention to provide support for people living with HIV and experiencing suicidal ideation, and to support HIV care engagement.
- Conditions
- Suicide, Suicidal Ideation, HIV Infections, Adherence, Medication
- Trial name
- NCT04696861
- Testing
- IDEAS for Hope, Enhanced Standard of Care (Safety Planning)
- Where
- 2 sites in Tanzania
- Volunteers
- 60 people
- Sponsor
- Duke University
Major Depressive Disorder
Ketamine Infusion for Treatment-resistant Major Depressive Disorder
Ketamine infusion has been shown to have rapid antidepressant properties, however the possible use of ketamine in treatment-resistant depression as augmentation has not been investigated.
- Trial name
- NCT01582945
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Massachusetts General Hospital
Suicide, Depression
Engaging Suicidal Patients in Mental Health Treatment
The investigators will identify characteristics of suicidal patients who do or do not attend a first mental health visit following referral using administrative data.
- Conditions
- Suicide, Depression, Mental Health Impairment, Suicidal Ideation
- Trial name
- NCT05021224
- Testing
- Caring Contacts, Reminders, Informational Poster
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Post Traumatic Stress Disorder, Suicidal Ideation
Reducing Suicidal Ideation Through Treatment of Nightmares-Post Traumatic Stress Disorder (PTSD)
Patients with PTSD, and frequent nightmares, and mild-moderate suicidal ideation, who are already taking a Selective Serotonin Reuptake Inhibitor (SSRI) or Serotonin Norepinephrine Reuptake Inhibitor (SNRI) will be randomized to…
- Conditions
- Post Traumatic Stress Disorder, Suicidal Ideation, Nightmares
- Trial name
- REST-ON PTSD (NCT02199652)
- Testing
- Prazosin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Augusta University
Depression and Suicide
Cognitive Behavioral Therapy Following Esketamine for Major Depression and Suicidal Ideation for Relapse Prevention
This is a rater-blinded, randomized controlled trial. All patients will receive esketamine for treatment of Major Depression with Suicidal Ideation (MDSI).
- Trial name
- ENDURE (NCT04760652)
- Testing
- Cognitive Behavioral Therapy CBT, TAU
- Where
- 3 sites in United States
- Volunteers
- 93 people
- Sponsor
- Yale University
Suicidal Ideation, Treatment Engagement
Motivational Interviewing to Prevent Suicide in High Risk Veterans
The purpose of study is to test the efficacy of an adaptation of Motivational Interviewing to Address Suicidal Ideation (MI-SI) on the severity of suicidal ideation in psychiatrically hospitalized Veterans at high risk for…
- Trial name
- NCT01544127
- Testing
- MI-SI+TAU, MI-SI-R+TAU, TAU Alone
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- VA Office of Research and Development
Suicidal Ideation
Peer Mentorship to Reduce Suicide Attempts Among High-Risk Adults
This is a single-blind, randomized controlled trial to test the effectiveness of a peer mentorship intervention (PREVAIL) for reducing suicide risk compared to enhanced usual care among participants (N=455) at high-risk for…
- Trial name
- PREVAIL (NCT03373916)
- Testing
- Peer mentorship, Enhanced Usual Care
- Where
- 3 sites in United States
- Volunteers
- 455 people
- Sponsor
- University of Michigan
Depression, Suicidal Ideation
Treatment of Suicidal Ideation With Intravenous Ketamine Infusion
This study is dedicated to achieving better treatments for suicidal thoughts. Specifically, the investigators are studying the effect of a medication called ketamine to quickly treat suicidal thoughts and depression.
- Trial name
- NCT01887990
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Alabama at Birmingham
Suicidal Ideation
Evaluation of a Computerized Intervention for Learning to Re-Evaluate Suicidal Thoughts
As rates of suicide have increased over the last several decades, research has identified that roughly two-thirds of individuals who attempt suicide do so within one year from the time that they begin to think about suicide.
- Trial name
- REST (NCT04254809)
- Testing
- Re-Evaluating Suicidal Thoughts, Healthy Social Living
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- Florida State University
Suicidal Ideation
Effect of Perimenstrual Ovarian Steroid Supplementation on Perimenstrual Suicidality
This within-person, crossover, 2-condition, placebo-controlled study compares the impact of two perimenstrual conditions on severity of suicidal symptoms in females with past-month suicidality but minimal risk of imminent suicide…
- Trial name
- NCT03720847
- Testing
- Estradiol Transdermal Patch 0.1 mg/24 hrs, Oral Micronized Progesterone, Inactive Clear Patch
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of North Carolina, Chapel Hill
Depression, Suicidal Ideation
BRITEPath- Phase 2
BRITEPath (BP) aims to support co-located mental health clinicians in the development of a high quality, effective, and personalized safety plan for referred patients who screen positive for depression and/or suicidal ideation.
- Trial name
- NCT04672798
- Testing
- BRITEPath, Treatment As Usual (TAU)
- Where
- 6 sites in United States
- Volunteers
- 101 people
- Sponsor
- University of Pittsburgh
Suicidal Ideation, Depression
Trial of the Rapid Antisuicidal Effects of Intranasal Ketamine in Comorbid Depression and Alcohol Abuse
This project aims to evaluate the potential rapid and sustained antisuicidal and antidepressant effects of a single intranasal dose of ketamine in inpatients during a mood episode in Major Depressive Disorder (MDD) or Bipolar…
- Conditions
- Suicidal Ideation, Depression, Alcohol Abuse
- Trial name
- NCT03539887
- Testing
- Intranasal ketamine
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- The University of Texas Health Science Center, Houston
Bipolar Disorder, Major Depressive Episode
Ketamine for Suicidality in Bipolar Depression
This study is designed to compare the effectiveness of two medications, Ketamine and Midazolam, for rapidly relieving suicidal thoughts in people suffering from bipolar depression.
- Conditions
- Bipolar Disorder, Major Depressive Episode, Suicidal Ideation
- Trial name
- NCT01944293
- Testing
- Ketamine, Midazolam
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- New York State Psychiatric Institute
Depression, Suicide
Concurrent Treatment for Depressed Parents and DepressedAdolescents
This study will develop an integrated treatment for adolescents who are depressed and suicidal and their parents who are depressed and have a history of suicidality.
- Trial name
- NCT00951821
- Testing
- Concurrent treatment, Adolescent treatment only
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Brown University
Suicidal Ideation
Career Enhancement Training Study (USAF)
A study evaluating a training program to decrease risk for suicidal thoughts and behaviors among early career trainees in the United States Air Force.
- Trial name
- CETS (NCT04067401)
- Testing
- Wingman Connect, Stress Management
- Where
- United States
- Volunteers
- 1,485 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Suicidal Ideation
Home-based tDCS for Prevention of Suicidal Ideation
Risk for suicide is elevated in the period after discharge from hospital among adults with major affective disorder. The primary objective of this study is to investigate the feasibility of delivering tDCS sessions for high-risk…
- Trial name
- NCT05280756
- Testing
- Home-based transcranial direct current stimulation (tDCS)
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of Rochester
Autism Spectrum Disorder, Depression
Group Depression Treatment for Autistic Youth
Higher rates of depression are reported by autistic adolescents as compared to their non-autistic peers, which is problematic given adverse outcomes (e.g., negative self-esteem, lower academic performance) that are associated…
- Conditions
- Autism Spectrum Disorder, Depression, Suicidal Ideation, Self Esteem
- Trial name
- NCT05430022
- Testing
- Autism-adapted Group Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Vanderbilt University Medical Center
Depression, Suicidal Ideation
Paroxetine/Bupropion in Depression With Suicide Attempt or Thoughts: fMRI Study
This study uses functional magnetic resonance imaging (fMRI) to investigate the effects of two different antidepressant medications (Paxil CR versus Wellbutrin XL) on reward processing in depressed patients who have attempted…
- Trial name
- NCT01748955
- Testing
- Paroxetine CR for Major Depressive Episode, Bupropion XL for Major Depressive Episode
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- New York State Psychiatric Institute
Depression, Anxiety, Suicidal Ideation
A Trauma-Informed Approach for Positive Youth Development for Montana Students
Given the prevalence of suicide and mental health issues in rural Montana, this project is intended to help mitigate stressors that may contribute to poor behavioral and mental health in high school-aged children.
- Conditions
- Depression, Anxiety, Suicidal Ideation, Stress, Trauma
- Trial name
- NCT04664855
- Testing
- Trauma-Informed Yoga
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Montana State University
Suicide and Self-harm, Emotion Regulation
Supplementing Brief Psychotherapy With a Mobile App
Suicide is among the leading causes of death worldwide, and the risk of suicide is highest in the period immediately following discharge from inpatient psychiatric care.1Importantly, despite the enormously elevated risk during…
- Trial name
- NCT05867316
- Testing
- Unified Protocol
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Rutgers, The State University of New Jersey