Clinical trials: Suicide Risk
Depressive Disorder, Major
54135419SUI3002: A Study to Evaluate the Efficacy and Safety of Intranasal Esketamine in Addition to Comprehensive Standard of Care for the Rapid Reduction of the Symptoms of Major Depressive Disorder, Including Suicidal Ideation, in Adult Participants Assessed to be at Imminent Risk for Suicide
The purpose of this study is to evaluate the efficacy of intranasal esketamine 84 milligram (mg) compared with intranasal placebo in addition to comprehensive standard of care in reducing the symptoms of Major Depressive Disorder…
- Trial name
- Aspire II (NCT03097133)
- Testing
- Esketamine, Standard of Care
- Where
- 61 sites in United States, Argentina and 10 more
- Volunteers
- 230 people
- Sponsor
- Janssen Research & Development, LLC
Suicide, Depressive Disorder, Major
Promote Access to Stop Suicide: Comparison of Follow up Services for Youth at Risk for Suicide
This research study is designed to answer specific questions about new ways to provide services for youth at-risk of suicide.
- Conditions
- Suicide, Depressive Disorder, Major, Anxiety Disorders, Suicidal Ideation
- Trial name
- PASS (NCT03016572)
- Testing
- Standard of Care, Crisis Intervention, Wraparound Services
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- The Cleveland Clinic
Prostate Cancer
Randomized Trial of Suicide Gene Therapy and Prostate Cancer
This is a randomized, controlled trial that will test the hypothesis that replication-competent adenovirus-mediated suicide gene therapy in combination with 80 Gy intensity modulated radiotherapy (IRMT)will improve freedom from…
- Trial name
- ReCAP (NCT00583492)
- Testing
- Ad5-yCD/mutTKSR39rep-ADP, IMRT
- Where
- 2 sites in United States
- Volunteers
- 44 people
- Sponsor
- Henry Ford Health System
Depression - Major Depressive Disorder, Irritability
Teen Vulnerability to Irritability: Brain and Estrogen Changes
Purpose: Risk of severe psychopathology increases dramatically during adolescence, especially for females. Changes in ovarian steroids across the menstrual cycle produce windows of vulnerability to mood disturbances, particularly…
- Trial name
- TeenVIBE (NCT07544966)
- Testing
- Kurvelo
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
TBI, Suicide Prevention
A Mixed Methods Pilot Trial of the STEP Home Workshop to Improve Reintegration and Reduce Suicide Risk for Recently Transitioned Veterans
Risk of Veteran suicide is elevated during the first year of transition from military service to civilian life. Most Veteran suicides occur among Veterans who are not connected to VA healthcare.
- Conditions
- TBI, Suicide Prevention, Veterans, PTSD
- Trial name
- SH-SP (NCT05995678)
- Testing
- STEP-Home-SP, Transition Assistance Program, VA Solid Start
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Suicide
Suicide Prevention Intervention for At-Risk Individuals in Transition
The four year SPIRIT Trial, or Suicide Prevention Intervention for at-Risk Individuals in Transition, will recruit 800 pretrial jail detainees at risk for suicide.
- Trial name
- SPIRIT (NCT02759172)
- Testing
- Safety Planning Intervention
- Where
- 2 sites in United States
- Volunteers
- 800 people
- Sponsor
- Michigan State University
SNIIRAM Database
Suicidal Risk Factors Associated With Opioid Analgesics Use
There is an increase in prescriptions for analgesics opioids and overdose mortality in France. In the United States, the consumption of opioid analgesics is associated with excess mortality, especially suicide.
- Trial name
- SANTE (NCT04211077)
- Testing
- Date collection
- Where
- France
- Volunteers
- 273,221 people
- Sponsor
- University Hospital, Montpellier
Suicidal Ideation
Peer Mentorship to Reduce Suicide Attempts Among High-Risk Adults
This is a single-blind, randomized controlled trial to test the effectiveness of a peer mentorship intervention (PREVAIL) for reducing suicide risk compared to enhanced usual care among participants (N=455) at high-risk for…
- Trial name
- PREVAIL (NCT03373916)
- Testing
- Peer mentorship, Enhanced Usual Care
- Where
- 3 sites in United States
- Volunteers
- 455 people
- Sponsor
- University of Michigan
Computer Vision Syndrome
Tendency to Suicide as a Sequel of Computer Vision Syndrome
CVS-F4 questionnaire will be used as an instrument to survey prevalence of tendency to suicide among medical students in the Egyptian Universities and analyse associated risk factors and any correlated determents
- Trial name
- NCT05699057
- Testing
- Suicide GROUP
- Where
- Egypt
- Volunteers
- 3,512 people
- Sponsor
- Sohag University
Suicidal Ideation, Suicide, Attempted
Aftercare Focus Study (AFS): A Clinical Trial to Reduce Short-Term Suicide Risk After Hospitalization
Increasingly, the period after hospital admission is acknowledged as one of extremely high risk for suicidal patients. While it might be hoped that hospitalization would address and resolve suicide risk, a review of international…
- Conditions
- Suicidal Ideation, Suicide, Attempted, Distress, Psychological, Quality of Life
- Trial name
- NCT04693845
- Testing
- Collaborative Assessment and Management of Suicidality, Treatment as Usual
- Volunteers
- 150 people
- Sponsor
- University of Washington
Depression, Suicidal Ideation
Text2Connect, Component 2 of iCHART (Integrated Care to Help At-Risk Teens)
This study proposes to develop and examine a personalized, text-based intervention designed to improve engagement with mental health (MH) treatment.
- Trial name
- T2C (NCT03982043)
- Testing
- Text2Connect
- Where
- 4 sites in United States
- Volunteers
- 47 people
- Sponsor
- University of Pittsburgh
Eating Disorders, Suicide Risk
Cognitive-Behavioral and Digital Therapy for Suicide Risk in Eating Disorders
The purpose of this study is to determine if adding a digital intervention to standard cognitive-behavioral therapy (CBT) is more effective in preventing suicide risk and reducing eating disorder symptoms.
- Trial name
- NCT07417826
- Testing
- Cognitive Behavioural Therapy (CBT), Cognitive Behavioural Therapy (CBT) + Digital Therapy (DT)
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- Universitat Autonoma de Barcelona
Substance Use, Depression
Trial of Automated Risk Appraisal for Adolescents
This is a study to find out which type of computer screening and nursing support can improve screening for high risk behaviors in doctor's offices.
- Conditions
- Substance Use, Depression, Suicidal Ideation, Risk Behavior
- Trial name
- TARAA (NCT00505440)
- Testing
- Telephone case management and motivational interviewing, Usual care
- Where
- United States
- Volunteers
- 1,185 people, healthy volunteers welcome
- Sponsor
- Nationwide Children's Hospital
Suicide
Combined TMS and Brief Cognitive Behavioral Therapy to Reduce Suicide
High rates of Veteran suicide remain a tragedy. Rates of Veteran suicide have not decreased for 10 years, despite the best efforts of the field.
- Trial name
- NCT03952468
- Testing
- Transcranial Magnetic Stimulation, Brief Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- VA Office of Research and Development
Suicide, Help-Seeking Behavior
Reducing Help-Seeking Stigma in Young Adults at Elevated Suicide Risk
Although there exist interventions that therapeutically impact suicide risk, the connection of individuals at elevated suicide risk to mental health care services remains an ongoing challenge.
- Conditions
- Suicide, Help-Seeking Behavior, Health Behavior
- Trial name
- NCT03646903
- Testing
- Cognitive Bias Modification, Psychoeducation
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Florida State University
Emotion Regulation
Testing an Intergenerational Model of Suicide Risk in Mother-child Dyads
The investigators are interested in learning more about how the role of mothers' emotions has on the transmission of suicide risk to children.
- Trial name
- NCT06463054
- Testing
- Dialectical Behavior Therapy Skills Group Training, Safety Planning Intervention
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Pittsburgh
Suicidal, Suicide, Attempted
Improving Coping to Reduce Suicide Risk Following ED Discharge
The researchers hope to learn whether an electronic safety plan (ESP) and a supportive text messaging program are feasible and acceptable to adult patients with recent suicidal thoughts or behavior after emergency department (ED)…
- Conditions
- Suicidal, Suicide, Attempted, Suicidal Ideation
- Trial name
- NCT06614946
- Testing
- Electronic Safety Plan (ESP), Text support
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Michigan
Suicide Attempt, Suicidal Ideation
Bae: A Smartphone Application for a Better Following Adolescents at Risk of Suicidal Behavior: Study of Acceptability and Preliminary Results of Efficacy
Suicidal behavior among adolescents is a major public health problem. Exacerbation of suicidal risk most often occurs when the young person is in his or her natural environment, far from the health care system.
- Trial name
- BAE (NCT04686162)
- Testing
- bae application
- Volunteers
- 100 people
- Sponsor
- University Hospital, Montpellier
Suicidal Ideation, Suicidal Behavior
Multimodality Adaptive Intervention for Post-Inpatient Hospitalization Suicide Risk Reduction
The goal of this clinical trial is to learn whether a combination of brief digital and clinician-delivered interventions can help adults leaving a psychiatric hospitalization cope with suicidal thoughts and prevent…
- Trial name
- NCT06764108
- Testing
- Self-monitoring, JITAI, Self-guided SSI
- Volunteers
- 360 people
- Sponsor
- Massachusetts General Hospital
Suicidal Ideation and Behavior
Stepped-Care for Suicidal Youth and Children
The goal of this RCT study is to test the efficacy of a stratified stepped-care (SSC) model in reducing suicidal thoughts and behaviors (STB) in children and adolescents. The main questions it aims to answer are: 1.
- Trial name
- SURE-CARE (NCT07321171)
- Testing
- IPC-A-SCI (Interpersonal Counseling for Suicide Crisis Intervention), IPT-A-SCI (Interpersonal Psychotherapy for Adolescents with Suicidal Crisis Intervention)
- Where
- Israel
- Volunteers
- 350 people
- Sponsor
- Shira Barzilay