Clinical trials: Suicide and Self-harm
Depression and Suicide
Cognitive Behavioral Therapy Following Esketamine for Major Depression and Suicidal Ideation for Relapse Prevention
This is a rater-blinded, randomized controlled trial. All patients will receive esketamine for treatment of Major Depression with Suicidal Ideation (MDSI).
- Trial name
- ENDURE (NCT04760652)
- Testing
- Cognitive Behavioral Therapy CBT, TAU
- Where
- 3 sites in United States
- Volunteers
- 93 people
- Sponsor
- Yale University
Sleep Disorder, Mental Health Issue
Improving Sleep in a Psychiatric Hospital
The purpose of this study is to examine effects of sleep promotion versus treatment as usual (TAU) on subjective, self-reported sleep while in inpatient psychiatric treatment, to examine effects of sleep promotion vs.
- Trial name
- NCT07010718
- Testing
- Scented Oil, Ear Plugs, Eye Mask
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- The University of Texas Health Science Center, Houston
Obsessions, Suicide
Obsessions and Suicidality in Youth With Bipolar 1 Disorder
Obsessive-compulsive disorder (OCD) is a common co-morbidity with bipolar I disorder, a comorbidity that is known to increase suicide risk.
- Conditions
- Obsessions, Suicide, Bipolar I Disorder, Obsessive-Compulsive Disorder
- Trial name
- NCT05878808
- Testing
- Psychometric assessment
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Cairo University
Suicide
Suicide Ideation Intervention in Nigeria
The research will use the Social Ecologic Model of behavior and WHO mhGAP framework to design a comprehensive intervention across three levels (individual, interpersonal, and social) of influence.
- Trial name
- NCT05103540
- Testing
- Comprehensive SEM-Based Program
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Babcock University
Suicide, Attempted
Effectiveness of a Case Management Algorithm: ALGOS After a Suicide Attempt
The suicidal behaviors are phenomena eminently multifactorial. It is thus always difficult to define univocal strategies of prevention of suicide repetition, during the emergency stay, i.e. almost in general population.
- Trial name
- ALGOS (NCT01123174)
- Testing
- ALGOS algorithm of case management
- Where
- 23 sites in France
- Volunteers
- 1,040 people
- Sponsor
- University Hospital, Lille
Suicide
Suicide Prevention for Sexual and Gender Minority Youth (Randomized Controlled Trial)
The overarching goal of this study is to evaluate a newly-developed suicide prevention program for sexual and gender minority youth and emerging adults.
- Trial name
- NCT05669976
- Testing
- Safety Planning Intervention with Navigation Services, Safety Planning Intervention
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- San Diego State University
Self-harm, Suicidal Ideation
Dialectical Behavior Therapy for Adolescents With Self-harm and Suicidal Behavior- an Open Trial
The goal of this pre-post-follow-up study is to examine how well the treatment Dialectical behavior therapy for adolescents (DBT-A) with a duration of 20 weeks for adolescents with self-harm and suicidal behavior works in routine…
- Conditions
- Self-harm, Suicidal Ideation, Suicide and Self-harm
- Trial name
- NCT06315075
- Testing
- Dialectical behavior therapy for adolescents (DBT-A)
- Where
- Norway
- Volunteers
- 140 people
- Sponsor
- Haukeland University Hospital
Psychological Distress, Suicidal Ideation
Development and Testing of imHere4U: A Digital Suicide Prevention Intervention for Cyberbullied Adolescents
The objective of this study is to test the feasibility and preliminary efficacy of Flourish (formerly referred to as imHere4U), a digital suicide prevention intervention for cyberbullied adolescents.
- Trial name
- NCT06002191
- Testing
- Flourish, Questionnaires of Online Experiences
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Pittsburgh
Suicide, Attempted, Suicide and Self-harm
Real-time Intervention for Suicide Risk Reduction: Primary Open Pilot
The goal of this study is to provide an initial pilot test of an Ecological Momentary Intervention (EMI) designed the reduce the distress associated with negative emotion among individuals at risk for suicide that pairs content…
- Trial name
- NCT03950765
- Testing
- Ecological momentary intervention
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Rutgers, The State University of New Jersey
Psychosis, Suicide
Targeting Emotion Dysregulation to Reduce Suicide in People With Psychosis
People with psychotic disorders are excluded from most suicide-focused clinical trials despite incredibly high rates of completed suicide, and interventions that have been tested for this population have shown limited impact on…
- Trial name
- NCT05440214
- Testing
- Dialectical Behavior Therapy Skills Training
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- University of Maryland, Baltimore
Suicidal Ideation, Self Injurious Behavior Without Suicidal Intent
Experiences of Brief Admission From the Perspective of Family and Significant Others
As a result of a randomized controlled trial (NCT02985047) BA is continuously offered to persons with self-harm at risk for suicide in Skåne, Sweden.
- Conditions
- Suicidal Ideation, Self Injurious Behavior Without Suicidal Intent, Self-Harm, Deliberate
- Trial name
- NCT04962217
- Testing
- Semi-structured interviews
- Where
- Sweden
- Volunteers
- 14 people
- Sponsor
- Region Skane
Bipolar Disorder
Observation of Clozapine Treatment Safety in Bipolar Disorder.
The purpose of the registry is to record incidence of adverse events during treatment with clozapine in patients suffering from bipolar disorder.
- Trial name
- CloGD (NCT06011460)
- Testing
- Clozapine
- Where
- Poland
- Volunteers
- 30 people
- Sponsor
- Medical University of Gdansk
Suicide and Self-harm
Preventing Suicide With Safe Alternatives for Teens and Youths (SAFETY)
Suicide is the leading cause of death in the age span 10-19 years in Sweden. The most robust predictor of future suicide attempt and suicide death is prior suicide attempt.
- Trial name
- SAFETYF2022 (NCT05537623)
- Testing
- Safe Alternatives for Teens and Youths (SAFETY), Supportive Therapy
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Region Stockholm
Suicidal Ideation
Dynamic Deconstructive Psychotherapy Versus Brief Intervention and Contact for Suicidal Adolescents and Young Adults
The purpose of this clinical trial is to assess whether 6 months of treatment with Dynamic Deconstructive Psychotherapy (DDP) is more effective for reducing thoughts of suicide in suicidal adolescents and young adults than usual…
- Trial name
- NCT05988489
- Testing
- Dynamic Deconstructive Psychotherapy (DDP), Brief Intervention and Contact (BIC)
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- State University of New York - Upstate Medical University
Opioid Use, Opioid-use Disorder
Suicide Prediction and Prevention for People at Risk for Opioid Use Disorder: Supplement to COMPUTE 2.0
This study integrates the Mental Health Research Network (MHRN) suicide risk models into Opioid Wizard, an electronic health record (EHR) clinical decision support (CDS) to identify and treat patients at high risk of opioid use…
- Conditions
- Opioid Use, Opioid-use Disorder, Suicide
- Trial name
- NCT04939727
- Testing
- OUD-CDS + Suicide Risk Model associated CDS
- Where
- United States
- Volunteers
- 115 people
- Sponsor
- HealthPartners Institute
Major Depressive Disorder
Effectiveness of Interpersonal Psychotherapy (IPT) for Men and Women Prisoners With Major Depression
This study will examine the effects of a first-line treatment for major depressive disorder (MDD), interpersonal psychotherapy (IPT), among men and women prisoners.
- Trial name
- NCT01685294
- Testing
- Group IPT for Depression + TAU
- Where
- 5 sites in United States
- Volunteers
- 181 people
- Sponsor
- Brown University
Psoriasis
Post-Marketing Surveillance Study of OTEZLA
To evaluate the safety and efficacy of OTEZLA in actual clinical settings of use in patients with Psoriasis vulgaris that is with an inadequate response to topical therapies and Psoriasis arthropathica 1.
- Trial name
- NCT03284879
- Where
- Japan
- Volunteers
- 1,086 people
- Sponsor
- Amgen
Depression, Suicide
Antidepressant Drug Exposure and Risk of Suicide Attempt Resulting in Medical Intervention in US Adults
The primary objective of the study is to estimate the incidence of suicide attempts resulting in a medical encounter or hospitalization in seven propensity matched cohorts of subjects: patients treated with duloxetine for…
- Trial name
- NCT00763724
- Volunteers
- 254,432 people
- Sponsor
- Eli Lilly and Company
Suicidal, Suicidal Ideation
Intramuscular Ketamine for Suicidal Patients in the Evanston Hospital Emergency Department for Suicidal Distress
This pilot study aims to evaluate the feasibility and acceptability of administering intramuscular ketamine for the acute reduction of suicidal distress during psychiatric boarding at the Evanston Hospital ED.
- Conditions
- Suicidal, Suicidal Ideation, Suicidal Ideation and Behavior, Depression / Major Depressive Disorder
- Trial name
- KEDS-C (NCT07810023)
- Testing
- Ketamine (0.5 mg/kg)
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Endeavor Health
Insomnia, Suicidal Ideation
Targeting Adolescent Insomnia to Lessen Overall Risk of Suicidal Behavior
This study will test the effectiveness of a sleep-related primary suicide prevention program entitled TAILOR (Targeting Adolescent Insomnia to Lessen Overall Risk of Suicidal Behavior), which includes specific behavior-change…
- Conditions
- Insomnia, Suicidal Ideation, Suicide, Attempted
- Trial name
- TAILOR (NCT05390918)
- Testing
- TAILOR, Enhanced Usual Care
- Where
- United States
- Volunteers
- 235 people
- Sponsor
- Jeff Bridge