Clinical trials: Superficial Siderosis
Cerebral Amyloid Angiopathy, Siderosis
Cerebellar Superficial Siderosis in Cerebral Amyloid Angiopathy
Cerebellar superficial siderosis (SS) has been recently reported to be present in about 10% of both hereditary (n=50) and sporadic (n=46) cerebral amyloid angiopathy (CAA) patients on 3T MRI using susceptibility-weighted imaging…
- Trial name
- CSS (NCT05394636)
- Testing
- None, pure observational study
- Where
- France
- Volunteers
- 111 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Superficial Siderosis
Therapeutic Antioxidant Supplementation
A remotely administered study, non-randomized, non-blinded, controlled parallel assignment phase 2 trial to determine if oral inosine or inositol hexaphosphate will provide an effective long-term therapy to combat or slow neural…
- Trial name
- TAS-SS21 (NCT04890808)
- Testing
- Inosine, IP6
- Volunteers
- 50 people
- Sponsor
- Superficial Siderosis Research Alliance Inc.
Cerebral Amyloid Angiopathy
High Frequency Imaging in Cerebral Amyloid Angiopathy
Cerebral amyloid angiopathy (CAA), caused by amyloid beta depositions in the walls of small cerebral vessels, is remarkably common in the elderly.
- Trial name
- HIFI-CAA (NCT06128824)
- Testing
- MR Imaging
- Where
- 3 sites in Germany
- Volunteers
- 75 people
- Sponsor
- Martin Dichgans
Cerebral Amyloid Angiopathy
Cortical Superficial Siderosis and Risk of Recurrent Intracerebral Hemorrhage in Cerebral Amyloid Angiopathy.
Cerebral amyloid angiopathy (CAA) is a major cause of lobar intracerebral hemorrhage (ICH) in the elderly with high risk of recurrence.
- Trial name
- CORELIA (NCT03464344)
- Testing
- neurological, neuropsychological and MRI evaluation
- Where
- 4 sites in France
- Volunteers
- 170 people
- Sponsor
- University Hospital, Toulouse
Superficial Siderosis
Haemdall: Developing a Quantitative MRI Biomarker of Infratentorial Superficial Siderosis of the Central Nervous System
Haemdall: Using Medical Imaging to measure Brain Iron in Superficial Siderosis. This study is looking at a new way of using MRI scans to potentially measure the amount of iron on the surface of the brain.
- Trial name
- Haemdall (NCT07098650)
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Perspectum
Siderosis, Neurological Disorder
Audiovestibular Function in Infratentorial Superficial Siderosis
One in six people in the United Kingdom and over 400 million people worldwide have disabling hearing loss. This figure will double by 2050 as predicted by the World Health Organisation.
- Conditions
- Siderosis, Neurological Disorder, Rare Diseases, Age Related Hearing Loss
- Trial name
- AViSS (NCT04200664)
- Testing
- Hearing assessment, Vestibular/balance assessment, Quality of life assessment
- Where
- 2 sites in United Kingdom
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University College, London
Intracerebral Hemorrhage, Cerebral Amyloid Angiopathy
Superficial Siderosis in Patients With Suspected Cerebral Amyloid Angiopathy
Aim of the SuSPect-CAA study is to prospectively evaluate the prognostic significance of cortical superficial siderosis in patients with suspected cerebral amyloid angiopathy with a primary focus on future stroke and mortality.
- Conditions
- Intracerebral Hemorrhage, Cerebral Amyloid Angiopathy, Ischemic Stroke
- Trial name
- SuSPect-CAA (NCT01856699)
- Where
- Germany
- Volunteers
- 302 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Superficial Siderosis
Observational Study of Deferiprone (Ferriprox®) in the Treatment of Superficial Siderosis
Superficial siderosis is a progressive neurological disease caused by iron deposition in the central nervous system (CNS) from chronic subarachnoid bleeding.
- Trial name
- NCT01284127
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Johns Hopkins University