Clinical trials: Supplementation
Immune Tolerance
Vitamin D Supplementation and Regulatory FoxP3+ T Cells in the GUT
In this pilot study the investigators aim to investigate the effects of vitamin D supplementation on regulatory FoxP3+ T cells in the gastrointestinal mucosa in healthy women and men.
- Trial name
- NCT01538485
- Testing
- Cholecalciferol
- Where
- Austria
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Insulin Resistance, Obesity
Pilot Study of GLY-LOW Supplementation in Postmenopausal Women With Obesity
A combination of generally regarded as safe (GRAS) compounds named GLY-LOW, which included: alpha lipoic acid, pyridoxamine, nicotinamide, piperine and thiamine, were examined in pre-clinical experiments.
- Conditions
- Insulin Resistance, Obesity, Cardiovascular Diseases, Cognitive Impairment
- Trial name
- NCT06242535
- Testing
- GLY-LOW
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Hoskinson Health and Wellness Clinic
Rheumatoid Arthritis
Fibres Supplementation in Rheumatoid Arthritis
Design: Randomized, double-blind, placebo-controlled study with 4 weeks of treatment with either fiber supplements or placebo. Primary outcome: variation in SCFA between baseline and week 4.
- Trial name
- SUPER-FIBRES (NCT04421313)
- Testing
- Dietary Fiber Supplementation
- Where
- France
- Volunteers
- 87 people
- Sponsor
- University Hospital, Montpellier
Rheumatoid Arthritis
A Pilot Study of Potassium Supplementation for Adult Patients With Rheumatoid Arthritis
Rheumatoid arthritis is the paradigmatic immune-mediated inflammatory arthropathy. With respect to rheumatoid arthritis (RA), patients have been described as having inappropriately low spontaneous and stimulated cortisol…
- Trial name
- NCT00461448
- Testing
- Potassium supplement
- Where
- 2 sites in Iran
- Volunteers
- 36 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Gastric Cancer Stage II, Non-small Cell Lung Cancer Stage II
Oncoxin® and Quality of Life in Cancer Patients
It is expected that additional support with certain micronutrients may improve prognosis, decrease the frequency of side effects and complications and maintain high relative dose intensity of anticancer treatments.
- Conditions
- Gastric Cancer Stage II, Non-small Cell Lung Cancer Stage II, Non-small Cell Lung Cancer Stage III, Gastric Cancer Stage III
- Trial name
- NCT03550482
- Testing
- ONCOXIN®
- Where
- 9 sites in Kazakhstan, Russia
- Volunteers
- 133 people
- Sponsor
- Catalysis SL
Pregnancy Related
Non-inferiority of Lower Dose Calcium Supplementation During Pregnancy
The World Health Organization currently recommends that pregnant women in populations with low calcium intake receive daily calcium supplementation (1500 - 2000 mg) divided into three doses which are preferably taken at…
- Trial name
- NCT03350516
- Testing
- Daily 500 mg elemental calcium as calcium carbonate, Daily1500 mg elemental calcium as calcium carbonate
- Where
- 3 sites in India, Tanzania
- Volunteers
- 22,000 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Prebiotics
Integrative Personal Omics Profiling for Dynamic Molecular Phenotypes Monitoring During Fiber Supplementation
The investigators propose a comprehensive, multiomic study that will integrate longitudinal data associating changes in specific gut bacteria and host in response to prebiotic fiber supplementation.
- Trial name
- NCT04706858
- Testing
- Dietary fiber supplementation
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Stanford University
Eye Disease
Pharmacokinetics of Trans-resveratrol Based Nutritional Supplement and Its Three Metabolites in Human Eyes and Blood
There is blood-eye barrier in eyes,but some oral medicines can enter in the tissues of eyes. The primary objective of the study is to study the Pharmacokinetics of Trans-resveratrol and Its three Metabolites in Human Eyes and…
- Trial name
- NCT02321176
- Testing
- trans-resveratrol
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Huazhong University of Science and Technology
Parkinson Disease
Whey Protein Supplementation in Patients With Parkinson's Disease
Many dietary supplementations are available to help people in balancing the protein intake and overcoming muscle mass loss. However, most of the products contain protein and could potentially affect levodopa action in people with…
- Trial name
- NCT05523791
- Testing
- Fortiral, Mg++
- Where
- Italy
- Volunteers
- 51 people
- Sponsor
- Ospedale Generale Di Zona Moriggia-Pelascini
Brain Health
Effects of Acute Ketone Supplementation on the Brain
The purpose of this study is to determine how a ketone ester supplement affects brain function, brain blood flow, and brain metabolism in healthy middle-aged and older adults.
- Trial name
- KETO-BRAIN (NCT07711990)
- Testing
- Ketone Ester Drink
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Christopher Crabtree
Knee Osteoarthritis, Vitamin D Deficiency
Prospective, Assessment of Vitamin D and Calcium Supplementation, Improvement of Nutritional Status and Preoperative Rehabilitation in Patients Before Knee Arthroplasty.
Prospective randomized study of 150 patients qualified for knee arthroplasty between 2015 and 2017. Patients were randomized into 3 groups receiving vitamin D and calcium supplementation, increased protein supply and preoperative…
- Conditions
- Knee Osteoarthritis, Vitamin D Deficiency, Pain, Postoperative, Arthropathy of Knee
- Trial name
- NCT04291833
- Testing
- Intervention group 1, Intervention group 2, Control group 0
- Where
- Poland
- Volunteers
- 150 people
- Sponsor
- Jagiellonian University
ACL Reconstruction
Protein Supplementation After ACL Surgery
The purpose of the study is to assess the longitudinal post-operative care effects of protein supplementation on muscle atrophy in the post-operative period following ACL reconstruction.
- Trial name
- NCT06311058
- Testing
- Whey protein isolate, Protein + BAA
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- The Methodist Hospital Research Institute
Reflux Disease, Microbiome
Development of a Preparation for Supportive Supplementation of Probiotics in Patients With Reflux
A two-arm, double-blind, randomized, placebo-controlled study investigating the efficacy of a probiotic preparation developed as supportive supplementation of probiotics in patients with reflux.
- Conditions
- Reflux Disease, Microbiome, Probiotics Supplement
- Trial name
- NCT07600008
- Testing
- A probiotic dietary supplement
- Where
- Czechia
- Volunteers
- 50 people
- Sponsor
- University Hospital Olomouc
Hypertriglyceridemia
Docosahexenoic Acid (DHA) Supplementation and Cardiovascular Disease in Men With High Triglycerides
The purpose of this study is to determine the effects of supplementing diets of hyperlipidemic men with DHA (docosahexenoic acid) on risk factors for cardiovascular disease.
- Trial name
- NCT00728338
- Testing
- Docosahexenoic acid (DHA), Olive oil
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- USDA, Western Human Nutrition Research Center
Diabetes
Personalized Management of Type 2 Diabetes Using AI-Guided (GenAIS TM) Dietary Supplementation
This randomized controlled trial investigates the effectiveness of AI-guided dietary supplement prescriptions compared to standard physician-guided prescriptions in managing Type 2 diabetes (T2D).
- Trial name
- NCT06469658
- Testing
- The standard practice dietary supplements intervention, The AI-guided practice dietary supplements group
- Where
- Russia
- Volunteers
- 160 people
- Sponsor
- S.LAB (SOLOWAYS)
Postoperative Pain, Inflammation
Effect of Oral Choline Supplementation on Postoperative Pain
This research will test whether consuming additional choline before gynecological surgery decreases postoperative pain.
- Trial name
- NCT00720343
- Testing
- Choline
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Columbia University
Colorectal Cancer
Vitamin D Intervention and Associated Changes in the Gut Microbiome and Vitamin D Levels in Healthy Adults
Although dietary vitamin D supplementation has been used in the clinical setting for decades, the effect of supplementary vitamin D consumption on the structure of the microbiome has not been studied in humans in fine scale or…
- Trial name
- VDMT (NCT05387876)
- Testing
- Vitamin D intervention
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Baylor University
TMJ, Osteoarthritis
Efficacy of PRGF Supplementation After TMJ Arthrocentesis in Patients With TMJ Osteoarthritis
Temporomandibular joint (TMJ) osteoarthritis (OA) affects articulating tissues secondary to inflammation resulting in intracapsular pain.
- Trial name
- NCT04731233
- Testing
- Plasma Rich in Growth Factor (PRGF) Supplementation, Triamcinolone Acetonide
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Florida
Dietary Modification
Beef Protein Supplementation in Endurance Athletes
The aim of this project is to investigate the potential benefits of combining a new protein beef hydrolysates extract with a regular endurance training programme on (a) body composition (b) performance (c) muscle structure (d)…
- Trial name
- Beef (NCT02675348)
- Testing
- Dietary Supplement: Beef Protein, Dietary Supplement: whey Protein, Dietary Supplement: CHO
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Greenwich
Type 2 Diabetes, Insulin Resistance
Metabolic Control Before and After Supplementation With Lactobacillus Reuteri DSM 17938 in Type 2 Diabetes Patients
Recent data suggest that the trillions of bacteria in the investigators gastrointestinal tracts (gut microbiota) can function as an environmental factor that modulates the amount of body fat.
- Trial name
- NCT01620125
- Testing
- Lactobacillus reuteri DSM 17938
- Where
- Sweden
- Volunteers
- 12 people
- Sponsor
- Vastra Gotaland Region
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