Clinical trials: Supportive Therapy
IgA Nephropathy
Supportive Versus Immunosuppressive Therapy for the Treatment Of Progressive IgA Nephropathy
Evaluation of the efficacy of an immunosuppressive therapy added to a comprehensive supportive therapy to induce a clinical remission in patients at risk for progressive IgAN Investigation of differences between the treatments…
- Trial name
- STOP-IgAN (NCT00554502)
- Testing
- supportive therapy with: ACE-inhibitor / ARB / Statin, supportive and immunosuppressive therapy
- Where
- 34 sites in Germany
- Volunteers
- 148 people
- Sponsor
- RWTH Aachen University
Decision Support System, Outcome
Assisted Fluid Management (AFM) System and Postoperative Outcome After High-risk Abdominal Surgery
Goal directed fluid therapy (GDFT) or "Personalized fluid therapy" may benefit high-risk surgical patients but these strategies are infrequently implemented.
- Trial name
- PEFLA (NCT06011187)
- Testing
- Routine care, AFM
- Where
- 17 sites in United States, Belgium and 3 more
- Volunteers
- 2,007 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Depression
Implementation of Problem-Solving Treatment in Community Health Centers (PST-Aid)
Although evidence-based clinical interventions (CI) are a preferred treatment option for patients with depression, CIs are rarely available in community primary care settings.
- Trial name
- NCT06494384
- Testing
- Problem Solving Treatment as usual (PST as usual), Problem Solving Treatment Aid (PST-Aid)
- Where
- United States
- Volunteers
- 410 people
- Sponsor
- University of Washington
Colorectal Cancer (CRC)
Normobaric Oxygen Therapy in Colorectal Cancer Patients
Colorectal cancer (CRC) patients undergoing chemotherapy often experience anemia, oxidative stress, and immune suppression, significantly impacting their quality of life and treatment outcomes.
- Trial name
- NBO-ONCO (NCT06946004)
- Testing
- Normobaric oxygen therapy
- Where
- Poland
- Volunteers
- 254 people
- Sponsor
- 4th Military Clinical Hospital with Polyclinic, Poland
HIV/AIDS, Adherence
Real-Time Antiretroviral Therapy Adherence Intervention in Uganda
Development of Real-Time Antiretroviral Therapy Adherence Intervention in Uganda (The Wisepill Study).
- Trial name
- NCT01957865
- Testing
- Fixed SMS, real-time monitoring, Triggered SMS, real-time monitoring
- Where
- Uganda
- Volunteers
- 63 people
- Sponsor
- Massachusetts General Hospital
Cardiogenic Shock, Acute Decompensated Heart Failure
SURPASS Impella 5.5 Study
A multi-center, prospective \& retrospective, observational single-arm study of the clinical outcomes up to one year collected from electronic health records of patients which have undergone standard of care implantation of…
- Trial name
- NCT05100836
- Testing
- Impella 5.5
- Where
- 15 sites in United States
- Volunteers
- 1,017 people
- Sponsor
- Abiomed Inc.
JIA, Support Program
JASP-1 for Children Recently Diagnosed and Their Parents
To implement and evaluate a patient-and family-centered Juvenile Arthritis Support Program during one year (JASP-1) for children recently diagnosed with JIA and their parents and after 12 months compare satistaction with care and…
- Conditions
- JIA, Support Program, Patient Satisfaction, Patient Outcome Assessment
- Trial name
- JASP-1 (NCT06284616)
- Testing
- JASP-1
- Where
- Sweden
- Volunteers
- 82 people
- Sponsor
- Region Stockholm
Gastrointestinal Disease, Signs and Symptoms, Digestive
Nexium Dyspepsia/AST
The aim is to evaluate if the resolution of upper abdominal symptoms (pain or burning) during an acid suppressive test trial of esomprazole given daily for 7 days predicts symptoms resolution at the end of a subsequent treatment…
- Conditions
- Gastrointestinal Disease, Signs and Symptoms, Digestive, Dyspepsia
- Trial name
- NCT00251992
- Testing
- Esomeprazole
- Where
- 183 sites in Austria, Belgium and 11 more
- Volunteers
- 1,200 people
- Sponsor
- AstraZeneca
HIV Infection
Effects of Facility-based Mother Support Groups on Prevention of mother-to Child Transmission Outcomes in Zimbabwe
The investigators hypothesize that a strategy of establishing facility-based mother support groups (MSGs) for HIV-positive mothers will result in increased retention rates of HIV-exposed infants in clinic-based PMTCT follow-up…
- Trial name
- EPAZ (NCT02216734)
- Testing
- Mother support groups for HIV+ mothers
- Where
- 2 sites in Zimbabwe
- Volunteers
- 300 people
- Sponsor
- Family AIDS Caring Trust
Heart Failure, Cardiogenic Shock
INitiation and Titration of Guideline Directed Medical TheRApy in HearT Failure Cardiogenic Shock With ImpElla 5.5 for Cardiac Recovery
The study will evaluate the impact of a combined device-drug strategy with Impella 5.5 with best practices and optimized GDMT on heart recovery outcomes in patients with decompensated heart failure and cardiogenic shock.
- Conditions
- Heart Failure, Cardiogenic Shock, Reduced Ejection Fraction Heart Failure
- Trial name
- INTeGRATE (NCT06965504)
- Testing
- Impella 5.5 SmartAssist
- Where
- 17 sites in United States
- Volunteers
- 250 people
- Sponsor
- Abiomed Inc.
Caregiver, Malignant Neoplasm
Comic Art Creation as Supportive Care in Cancer Patients and Caregivers
This pilot clinical trial studies how well comic art creation works as supportive care in cancer patients and caregivers. Participating in a comic art creation workshop may help patients and their family members or friends share…
- Trial name
- NCT03067766
- Testing
- Art Therapy, Interview, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Urinary Tract Stone
Effectiveness of WhatsApp Education and Support Messages for Urolithiasis Prevention
Kidney and ureteral stones are a common problem in primary care practice with increasing prevalence over the last few decades. Prevention of recurrent stones (which are usually composed primarily of calcium oxalate) is aimed at…
- Trial name
- StoneApp (NCT05627622)
- Testing
- WhatsApp health education message
- Where
- Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Rabin Medical Center
COVID-19 Severe Pneumonia, Acute Lung Injury
Efficacy and Safety Study of IV Ravulizumab in Patients With COVID-19 Severe Pneumonia
This study evaluated the efficacy, safety, pharmacokinetics, and pharmacodynamics of ravulizumab administered in adult participants with coronavirus disease 2019 (COVID-19) severe pneumonia, acute lung injury, or acute…
- Conditions
- COVID-19 Severe Pneumonia, Acute Lung Injury, Acute Respiratory Distress Syndrome, Pneumonia, Viral
- Trial name
- NCT04369469
- Testing
- Ravulizumab, BSC
- Where
- 39 sites in United States, France and 3 more
- Volunteers
- 202 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
Decision Support Systems, Clinical
Clinical Decision Support System for Remote Monitoring of Cardiovascular Disease Patients
Cardiovascular diseases (CVD) are the leading cause of death worldwide, taking an estimated 17.9 million lives each year. The reduction of CVD-related mortality and morbidity is a key global health priority.
- Trial name
- mHEART4U (NCT05196802)
- Testing
- mHeart.4u
- Volunteers
- 212 people
- Sponsor
- Escola Superior de Enfermagem de Coimbra
Pneumonia, Viral, Corona Virus Infection
Convalescent Antibodies Infusion in COVID 19 Patients
The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which originated in Wuhan, China, has become a major concern all over the world.
- Trial name
- NCT04418531
- Testing
- Anti-coronavirus antibodies (immunoglobulins) obtained with DFPP form convalescent patients
- Sponsor
- Piero Luigi Ruggenenti
Refractory Multiple Myeloma, Smoldering Multiple Myeloma
Melphalan and Radiation Therapy Followed By Lenalidomide in Treating Patients Who Are Undergoing Autologous Stem Cell Transplant for Stage I, Stage II, or Stage III Multiple Myeloma
RATIONALE: Melphalan, a chemotherapeutic agent, has been found to be an effective treatment choice for destroying myeloma cells, especially when given at high (bone marrow ablative) doses.
- Conditions
- Refractory Multiple Myeloma, Smoldering Multiple Myeloma, Stage I Multiple Myeloma, Stage II Multiple Myeloma
- Trial name
- NCT00112827
- Testing
- total marrow irradiation, melphalan, peripheral blood stem cell transplantation
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- City of Hope Medical Center
Physician-patient Relationship, Fibromyalgia
Brain Mechanisms of Psychosocial Aspects of Acupuncture Therapy
The overall aim of the present proposal is to investigate how patients' and clinicians' (Licensed acupuncturists, LAc) neural and autonomic processes during treatment interaction correlate to patient outcomes.
- Conditions
- Physician-patient Relationship, Fibromyalgia, Acupuncture Therapy
- Trial name
- NCT02908022
- Testing
- Electroacupuncture Analgesia, Hokanson Rapid Cuff Inflator
- Where
- 2 sites in United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Oral Mucositis in Head and Neck Cancer
Propolis for Radiotherapy-Induced Oral Mucositis in Head and Neck Cancer
This clinical trial evaluated whether a 15% propolis solution could delay or prevent severe oral mucositis in patients with head and neck cancer receiving radiotherapy or concurrent chemoradiotherapy.
- Trial name
- NCT07597525
- Testing
- 15% Propolis solution, Standard oral care
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Ankara Oncology Research and Training Hospital
Gastric Cancer (GC), Colorectal Cancer
Agreement Between Large Language Model-Generated Treatment Recommendations With Guideline-Based and Tumor Board Decisions in Gastrointestinal Cancer
The goal of this observational study is to learn whether a computer program can suggest cancer treatments that match expert recommendations for people with gastrointestinal cancer (cancer of the pancreas, stomach, or colon and…
- Conditions
- Gastric Cancer (GC), Colorectal Cancer, Pancreatic Cancer
- Trial name
- KITuKo (NCT07592338)
- Testing
- Treatment recommendation according to official German cancer guideline, Treatment recommendation of a LLM, Treatment recommendation of a multidisciplinary tumor board
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Medizinische Hochschule Brandenburg Theodor Fontane
Colorectal Cancers
Open-Label Phase IIb Efficacy Trial of Cancer Macrobeads Compared to Best Supportive Care in Colorectal Cancer Patients
This is a clinical research study of an investigational (FDA IND-BB 10091) treatment for patients with advanced colorectal cancer that no longer responds to standard therapies.
- Trial name
- NCT02046174
- Testing
- RENCA macrobeads
- Where
- 4 sites in United States
- Volunteers
- 70 people
- Sponsor
- The Rogosin Institute
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