Clinical trials: Supportive Therapy
Liver Diseases, Liver Cirrhosis
Palliative Care for Non-Malignant Diseases (COMPASS Trial)
The purpose of this study is to evaluate, through a randomized controlled trial, the impact of integrated comprehensive palliative care services on time to first hospital readmission and other hospital utilization outcomes…
- Conditions
- Liver Diseases, Liver Cirrhosis, NASH (Non-Alcoholic Steatohepatitis)
- Trial name
- COMPASS (NCT03022630)
- Testing
- Comprehensive Palliative Care services, Usual hepatic care
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Vanderbilt University Medical Center
Cancer, Childhood Cancer
Decision Aid for Education and Support About Cancer Treatment
The goals of this clinical trial are to evaluate DECIDES, a web-based decision support application that provides education about cancer and cancer treatment and provides support to encourage adolescent and young adult (AYA)…
- Trial name
- DECIDES B+ (NCT06191679)
- Testing
- Decision Aid for Education and Support about Cancer Treatment (DECIDES Intervention)
- Where
- United States
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
HIV/AIDS
CASA: Care and Support Access in HIV Disease
This is an investigator-initiated study to measure the impact of an educational intervention on the basic palliative approach for a multidisciplinary staff team at an outpatient HIV clinic.
- Trial name
- CASA (NCT02136680)
- Testing
- CASA Education
- Where
- United States
- Volunteers
- 197 people
- Sponsor
- University of Maryland
Psychotic Disorders
Mobile After-Care Intervention to Support Post-Hospital Transition (MACS)
This study examines the feasibility and acceptability of a mobile device-delivered app, called Mobile After-Care Support (MACS), to improve patients' coping and treatment adherence following a hospitalization related to their…
- Trial name
- MACS (NCT03769493)
- Testing
- Mobile After-Care Support (MACS) app
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Butler Hospital
COVID-19
Acalabrutinib Study With Best Supportive Care in Participants Hospitalized With COVID-19
Study D822FC00005 will investigate the Phamacokinetics, Safety and tolerability of Acalabrutinib suspension when delivered via a nasogastric tube and co-administered with a Proton Pump Inhibitor, in the treatment of COVID-19.
- Trial name
- NCT04497948
- Testing
- Acalabrutinib
- Where
- 4 sites in Brazil
- Volunteers
- 9 people
- Sponsor
- Acerta Pharma BV
Colorectal Carcinoma
BBI608 and Best Supportive Care vs Placebo and Best Supportive Care in Pretreated Advanced Colorectal Carcinoma
The purpose of this study is to find out whether it is better to receive a new drug, BBI608, or better to receive no further treatment for colon or rectal cancer.
- Trial name
- NCT01830621
- Testing
- BBI608, Best Supportive Care
- Where
- 63 sites in Australia, Canada and 1 more
- Volunteers
- 282 people
- Sponsor
- NCIC Clinical Trials Group
Frailty
Piloting Prehabilitation Before Abdominal Surgery
Frail Veterans are at increased risk for poor surgical outcomes, and as the Veteran population grows older and more frail, there is a critical need to identify effective strategies for reducing surgical risks for these patients.
- Trial name
- NCT03040336
- Testing
- Prehabilitation
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- VA Office of Research and Development
Devic's Disease
Hematopoietic Stem Cell Transplant in Devic's Disease
This study is designed to examine whether treating Devic's disease patients with high dose cyclophosphamide together with rabbit antithymocyte globulin (rATG)/rituximab (drugs which reduce the function of the immune system)…
- Trial name
- NCT00787722
- Testing
- Hematopoietic Stem Cell Transplantation, Cyclophosphamide, G-CSF
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Northwestern University
Fatigue
A Proof-of-Concept Trial on the Effect of Ketamine on Fatigue
Background: Many people experience fatigue as a side effect of their illnesses and treatments. There are no medicines to treat fatigue, but a drug called ketamine has reduced fatigue in depressed people.
- Trial name
- NCT04141696
- Testing
- Ketamine, Midazolam
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National Institute of Nursing Research (NINR)
Leukemia, Myeloid, Acute
Efficacy of Oral Azacitidine Plus Best Supportive Care as Maintenance Therapy in Subjects With Acute Myeloid Leukemia (AML) in Complete Remission
This study enrolled 472 participants, aged 55 or older, with a diagnosis of de novo acute myeloid leukemia (AML) or AML secondary to prior myelodysplastic disease or chronic myelomonocytic leukemia (CMML), and who have achieved…
- Trial name
- QUAZAR AML-001 (NCT01757535)
- Testing
- Oral Azacitidine
- Where
- 223 sites in United States, Australia and 21 more
- Volunteers
- 472 people
- Sponsor
- Celgene
Thrombotic Microangiopathy
Study of Ravulizumab in Pediatric Participants With HSCT-TMA
This study will evaluate the safety, efficacy, pharmacokinetics, and pharmacodynamics of ravulizumab administered by intravenous infusion to pediatric participants, from 1 month to < 18 years of age, with HSCT-TMA.
- Trial name
- NCT04557735
- Testing
- Ravulizumab, Best Supportive Care
- Where
- 26 sites in United States, Israel and 5 more
- Volunteers
- 41 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
Heart Failure
PEGASUS CRT Study: Atrial Support Study in Cardiac Resynchronization Therapy
This study will look at different pacing modes (how a device is programmed to pace one's heart), and how these modes may assist in one's daily activities and how one is feeling.
- Trial name
- PEGASUS CRT (NCT00146848)
- Testing
- Atrial support pacing through cardiac resynchronization therapy. Device: RENEWAL family of CRT-D devices
- Where
- United States
- Volunteers
- 1,742 people
- Sponsor
- Boston Scientific Corporation
Major Depressive Disorder
Deplin® P.L.U.S. Program (Progress Through Learning Understanding & Support)
This study will be an observational study in which patients who have been prescribed Deplin® are invited to participate in surveys regarding their experiences with Deplin®.
- Trial name
- NCT01369030
- Testing
- Deplin®
- Where
- 2 sites in United States
- Volunteers
- 554 people, healthy volunteers welcome
- Sponsor
- Pamlab, Inc.
HIV
A Technology-Delivered Peer-to-Peer Support ART Adherence Intervention for Substance-using HIV+ Adults
The "Thrive With Me" (TWM) trial is testing the efficacy of a mobile enhanced website aimed at improving Antiretroviral Therapy (ART) adherence for HIV-positive men who have sex with men (MSM).
- Trial name
- TWM (NCT02704208)
- Testing
- Thrive With Me Control, Thrive With Me Intervention
- Where
- United States
- Volunteers
- 410 people
- Sponsor
- University of Minnesota
Healthy
A Study to Compare Two Different Formulations of Lasmiditan in Healthy Participants
The main purpose of this study is to compare the amount of lasmiditan that gets into the blood stream and how long it takes the body to get rid of it, when given as a oral-disintegrating (OD) tablet compared to immediate-release…
- Trial name
- NCT04881747
- Testing
- Lasmiditan
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Tuberculosis, Treatment Adherence
TB Treatment Support Tool Interactive Mobile App and Direct Adherence Monitoring on TB Treatment Outcomes
The overall goal of this study is to conduct a Randomized Clinical Trial (RCT) to evaluate a tuberculosis treatment support tool (TB-TST), a cellular phone app developed using user-centered design principles and a paper-based…
- Trial name
- TB-TST (NCT04221789)
- Testing
- TB treatment assistant
- Where
- Argentina
- Volunteers
- 555 people
- Sponsor
- Institute for Clinical Effectiveness and Health Policy
Spinal Cord Injuries
Acute Intermittent Hypoxia and Body Weight Supported Treadmill Training for Incomplete Spinal Cord Injury Patients
Spinal cord injury (SCI) interrupts descending synaptic pathways from brainstem premotor neurons to spinal motor neurons, thereby paralyzing muscles below the neurological level.
- Trial name
- NCT02441179
- Testing
- Acute Intermittent Hypoxia, Body weight-assisted treadmill training
- Where
- 2 sites in Chile
- Volunteers
- 35 people
- Sponsor
- Sociedad Pro Ayuda del Niño Lisiado
Sleep Apnea, Obstructive
Group-based Peer Support Versus Individual Education for Patients Undergoing CPAP Treatment
The investigators will compare two alternatives designed to maximize adherence to continuous positive airway pressure (CPAP) therapy for obstructive sleep apnea (OSA) - peer-support administered in groups, versus individual…
- Trial name
- NCT02538419
- Testing
- CPAP + Peer Support, CPAP + Individual Education
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Brigham and Women's Hospital
PreDiabetes
Using Peer Support to Aid in Prevention and Treatment in Prediabetes
An estimated 86 million adults in the United States have prediabetes, and low-income Latino and African American adults have disproportionately high rates compared to non-Hispanic adults.
- Trial name
- UPSTART (NCT03689530)
- Testing
- Peer Support, Enhanced Usual Care
- Where
- 2 sites in United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Stroke
Locomotor Experience Applied Post Stroke Trial
The purpose of this study is to compare two different treatments to improve walking after stroke (or post-stroke).
- Trial name
- LEAPS (NCT00243919)
- Testing
- Early locomotor training program, Late locomotor training program, Home Exercise Program
- Where
- 8 sites in United States
- Volunteers
- 408 people
- Sponsor
- Duke University