Clinical trials: Supportive Therapy
Diabetes Insipidus
Shared Health Appointments and Reciprocal Enhanced Support
The purpose of this study is to evaluate the effectiveness of a peer-to-peer program (P2P) in addition to Shared Medical Appointments (SMAs) compared to SMAs alone for the treatment of diabetes in five VA health systems, and to…
- Trial name
- SHARES (NCT02132676)
- Where
- 5 sites in United States
- Volunteers
- 1,536 people
- Sponsor
- VA Office of Research and Development
Prostate Cancer Metastatic Disease, Chemotherapy Induced Peripheral Neuropathy (CIPN)
o Tadalafil for Prevention of Docetaxel-Induced Peripheral Neuropathy in Prostate Cancer
Docetaxel is a standard chemotherapy for metastatic prostate cancer but is associated with dose-limiting peripheral neuropathy. Currently, no pharmacologic agents are established for prevention.
- Conditions
- Prostate Cancer Metastatic Disease, Chemotherapy Induced Peripheral Neuropathy (CIPN), Neurotoxicity
- Trial name
- NCT07333976
- Testing
- Tadalafil 5 mg
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Nutrition Aspect of Cancer, Stem Cell Transplant Complications
Study on Intelligent Nutrition Support Therapy for Hematopoietic Stem Cell Transplantation Recipients
The use of high-dose radiotherapy, chemotherapy and preventive antibiotics in the preconditioning regimen before allogeneic hematopoietic stem cell transplantation can easily lead to damage to the gastrointestinal mucosa…
- Trial name
- NCT05590091
- Testing
- Parenteral nutrition;Enteral nutrition
- Volunteers
- 106 people
- Sponsor
- Hebei Yanda Ludaopei Hospital
Spinal Cord Injury/Damage
Body Weight Supported Treadmill Training as Physical Therapy Treatment to Spinal Cord Injury Patients
The purpose of this current prospective study is to assess the effects of body weight support treadmill training (BWSTT) in individuals with spinal cord injury (SCI).
- Trial name
- NCT02031835
- Testing
- BWSTT (3 days a week for maximum of 20 minutes session)
- Where
- Greece
- Volunteers
- 26 people
- Sponsor
- University of Ioannina
Pelvic Organ Prolapse (POP)
Operations and Pelvic Muscle Training in the Management of Apical Support Loss: The OPTIMAL Trial
Pelvic organ prolapse is common among women with a prevalence that has been estimated to be as high as 30%. Pelvic organ prolapse often involves a combination of support defects involving the anterior, posterior and/or apical…
- Trial name
- OPTIMAL (NCT00597935)
- Testing
- SSLF, ULS, PMT
- Where
- 9 sites in United States
- Volunteers
- 374 people
- Sponsor
- NICHD Pelvic Floor Disorders Network
Oral Mucositis, Hematopoietic Stem Cell Transplantation (HSCT)
Effect of a Standardized Oral Care Program on Oral Mucositis in Children Undergoing Hematopoietic Stem Cell Transplantation: A Randomized Controlled Trial(SOC-HSCT)
Oral mucositis is one of the most common and debilitating complications in pediatric patients undergoing hematopoietic stem cell transplantation (HSCT).
- Trial name
- SOC-HSCT (NCT07809451)
- Testing
- Standardized Oral Care Intervention, Routine Oral Care
- Where
- China
- Volunteers
- 126 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Cancer Patients
A Patient Consensus for the Research in Supportive Care in French Cancer Care Centers: the CyPRES Project
In oncology a number of supportive care therapies are proposed to patients. This study will identify the different therapies and prioritize these therapies from the patients' perspectives.
- Trial name
- CyPRES (NCT03320161)
- Where
- 58 sites in France, Martinique
- Volunteers
- 604 people
- Sponsor
- UNICANCER
Rectal Cancer, Self Efficacy
An Informational and Supportive Care Intervention for Patients With Locally Advanced Rectal Cancer
The aim of this study is to evaluate the feasibility and acceptability of conducting a randomized trial of a brief psychoeducational intervention versus enhanced usual care for patients with locally advanced rectal cancer who are…
- Trial name
- PATHWAYS (NCT05914766)
- Testing
- PATHWAYS, Enhanced usual care
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Massachusetts General Hospital
Epilepsy
Supporting Treatment Adherence Regimens in Pediatric Epilepsy: The STAR Trial
Fifty-eight percent of children with new-onset epilepsy do not take their antiepileptic drugs (AEDs) as prescribed (i.e., non-adherence).
- Trial name
- NCT01851057
- Testing
- STAR, Education Only
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Opioid Use Disorder
Feasibility Study of Novel Prescription Digital Therapeutic Supporting Unobserved Buprenorphine Initiation & Adherence
The purpose of this study is to assess feasibility of an at-home digital therapy designed to support buprenorphine initiation and adherence.
- Trial name
- NCT05412966
- Testing
- PEAR-002B, reSET-O
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Pear Therapeutics, Inc.
Failure, Prosthesis, Dental Prosthesis, Implant-Supported
Clinical Performance of All-on-4 PEEK and Conventional Prostheses
The all-on-4 treatment approach for completely edentulous mandible is a proven concept. However, there are still issues regarding the use of metal substructure to support the prostheses such as allergy, metallic taste, and…
- Conditions
- Failure, Prosthesis, Dental Prosthesis, Implant-Supported, Survival, Prosthesis, Complete Edentulism
- Trial name
- NCT06388395
- Testing
- Accuracy of full-arch surgical guides, Survival and complications of the prostheses, Survival and complications of the implants
- Where
- United Arab Emirates
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Sharjah
High-Grade Lymphomas
HDS Plus PBPC Transplant Vs 4 More Courses of FrontLine Therapy in Pts With Aggressive NHL in PR After Induction Therapy
The study is planned to compare the outcome of aggressive NHL patients in partial remission after four courses of front-line therapy, randomly assigned to receive either additional four courses of the same regimen or a modified…
- Trial name
- NCT00866203
- Testing
- HDS vs ProMECE/CytaBOM
- Where
- Italy
- Volunteers
- 441 people
- Sponsor
- Gruppo Italiano Studio Linfomi
Ovarian Cancer, Peritoneal Cancer
Trial of Best Supportive Care and Either Cisplatin or Paclitaxel to Treat Patients With Primary Ovarian Cancer, Primary Peritoneal Cancer or Fallopian Tube Cancer and Inoperable Malignant Bowel Obstruction
The best way to treat MBO in patients with ovarian cancer has not been studied enough by trials that assess how more than one treatment arm (surgical, chemotherapeutic, supportive care approaches) affects clinical outcomes like…
- Conditions
- Ovarian Cancer, Peritoneal Cancer, Fallopian Tube Cancer, Bowel Obstruction
- Trial name
- NCT01083537
- Testing
- Cisplatin, Paclitaxel
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- University Health Network, Toronto
Chlorhexidine, Gingivitis
Clinical and Microbiological Comparison of 0.12% CHX and 0.05% CHX+0.05%CPC Mouthwashes in TPS Patients
The present study compares the effectiveness of two mouthwash formulations (0.12% CHX and 0.05% CHX+0.05%CPC) in reducing gingival inflammation and microbial colonization in individuals with gingivitis and in preventing…
- Conditions
- Chlorhexidine, Gingivitis, Periodontitis, Cetylpyridinium Chloride
- Trial name
- NCT06411522
- Testing
- Mouthwash containing 0.12% CHX (Chlorhexidine), Mouthwash containing 0.05% CHX (Chlorhexidine) and 0.05% CPC (Cetylpyridinium Chloride)
- Where
- Italy
- Volunteers
- 72 people
- Sponsor
- University of Siena
Acute Upper Respiratory Infection, Signs and Symptoms
Comparison of Supportive Therapies for Symptom Relief From Pediatric Upper Respiratory Infections (URIs)
This is a nonblinded randomized controlled trial which is a survey-based comparison between supportive treatments for symptom relief from pediatric upper respiratory infection (URI).
- Trial name
- NCT01814293
- Testing
- Handheld humidifier
- Where
- United States
- Sponsor
- University of California, San Francisco
Dental Caries
Oral-Spray Bacillus Spore Probiotic in Preventing and Supporting Treatment of Dental Caries in Children
Despite advances in oral health care, cavities remain highly prevalent worldwide, especially among children. Conventional treatment methods focus on removing damaged tooth tissue but fail to completely eliminate or control…
- Trial name
- NCT07241052
- Testing
- oral-spray 0.9% NaCl physiological saline solution, Smile Care
- Where
- Vietnam
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Anabio R&D
Postpartum Depression, Postpartum Anxiety
The SUPPORT Study: Effectiveness and Usability of a Web-Enabled Resource for Postpartum Mental Health
The SUPPORT Study aims to evaluate the effectiveness and usability of postpartumcare.ca, a web-enabled resource for postpartum depression (PPD) and postpartum anxiety (PPA), created based on the input of birthing parents in…
- Conditions
- Postpartum Depression, Postpartum Anxiety, Postnatal Depression, Perinatal Disorder
- Trial name
- SUPPORT (NCT05382884)
- Testing
- Postpartumcare.ca (Web-Enabled Intervention)
- Where
- Canada
- Volunteers
- 103 people
- Sponsor
- University of British Columbia
Convulsion, Non-Epileptic
Retraining and Control Therapy (ReACT) R33 Phase
The purpose of this study is to assess sense of control and catastrophic symptom expectations as targets for Retraining and Control Therapy (ReACT- an intervention focused on changing behaviors and thoughts) for treatment of…
- Trial name
- ReACT (NCT06007053)
- Testing
- ReACT, Supportive Therapy
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Oral Mucositis, Total Body Irradiation
Chlorophyllin for Reducing Oral Mucositis in Total Body Irradiation Prior to Transplant
The goal of this phase II, single-arm interventional clinical trial is to evaluate whether oral sodium copper chlorophyllin (CHL) can reduce the frequency and severity of oral mucositis in patients aged 12-65 years undergoing…
- Conditions
- Oral Mucositis, Total Body Irradiation, Hematological Malignancies, Hematopoietic Stem Cell Transplantation (HSCT)
- Trial name
- ChROMME-TBI (NCT07709195)
- Testing
- Sodium Copper Chlorophyllin
- Where
- India
- Volunteers
- 17 people
- Sponsor
- Tata Memorial Centre
Insomnia
SleepFix for Youth: Digital Behavioural Therapy for Insomnia With E-Psychologist Support
This pilot randomised, open-label, parallel-group controlled trial will evaluate the feasibility, acceptability and effects of a psychologist-supported digital behavioural therapy for insomnia (dBTi) compared to a wait-listed…
- Trial name
- iSLEEPY (NCT07405775)
- Testing
- SleepFix + e-psychologist support calls, Sleep Health Education (Active control)
- Where
- Australia
- Volunteers
- 40 people
- Sponsor
- Woolcock Institute of Medical Research
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