Clinical trials: Suppression of Ovulation
Suppression of Ovulation
Minimal Effective Dose of Nomegestrol Acetate Inhibiting the Ovulation in Women Receiving Estradiol
The aim of the present study was to evaluate the ability of several doses of NOMAC in combination with E2 to inhibit ovulation and to assess changes in the gonadotropin and ovarian hormone profiles, in comparison to a control…
- Trial name
- NCT01361958
- Testing
- NOMAC
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Theramex
Ovulation
A Phase 2, Dose-finding, Cross-over Study to Evaluate the Effect of a NES/E2 Transdermal Gel Delivery on Ovulation Suppression in Normal Ovulating Women
This is a Phase 2, dose-finding, cross-over study for the purposes of evaluating the effect of a NES/E2 transdermal gel delivery on ovulation suppression in normal ovulating women.
- Trial name
- NCT00796133
- Testing
- NES/E2 gel
- Where
- 3 sites in United States, Chile and 1 more
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Population Council
Contraception
Lower Dose Depo Provera® Contraceptive Injection
This is a randomized, partially-blinded, multi-center, parallel-group study to evaluate and compare the PD and PK of MPA after a single SC injection of either 45 mg/0.3 mL, 75 mg/0.5 mL or 105 mg/0.7 mL of Depo-Provera CI, and…
- Trial name
- NCT02732418
- Testing
- Depo-Provera CI, Depo-subQ 104
- Where
- 3 sites in Brazil, Chile and 1 more
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- FHI 360
Pregnancy, Contraception
Study to Evaluate Suppression of Ovulation and Pharmacokinetics of Medroxyprogesterone Acetate Following Administration of TV-46046 in Women With Ovulatory Cycle
The purpose of this pharmacodynamic and pharmacokinetic study is to identify a dose of TV-46046 (within the range 80 to 300 mg) that is both safe and consistent with contraceptive effect when injected every 6 months.
- Trial name
- NCT02817464
- Testing
- TV-46046 - 400 mg/mL, TV-46046 - 200 mg/mL
- Where
- 2 sites in United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Suppression of Ovulation
Dose Finding Study of Contraceptive Vaginal Ring With Different Estradiol Levels in Combination With Nestorone
This clinical trial investigates a new vaginal delivery system made of silicone rubber, containing Nestorone®, a 19-nor progesterone derivative and a low dose of serum estradiol (E2).
- Trial name
- NCT02626208
- Testing
- Nestorone®/Estradiol Contraceptive Vaginal Ring
- Where
- 7 sites in United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Premier Research
Ovulation Suppression
Evaluation of Pharmacodynamic Effects on Ovulation and Cycle Control
Evaluate the adequacy of ovulation suppression, cycle control, and safety of three transdermal contraceptive delivery systems (TCDSs).
- Trial name
- NCT01250210
- Testing
- levonorgestrel and ethinyl estradiol
- Where
- 11 sites in United States
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Agile Therapeutics
Contraception
Pharmacodynamics and Pharmacokinetics Study of Existing DMPA Contraceptive Methods
This is a randomized, multi-center, parallel-group Phase I study to evaluate the pharmacodynamics (PD) of Medroxyprogesterone Acetate (MPA) after a single subcutaneous (SC) injection of 150 mg/mL or 300 mg/2 mL Depo-Provera CI in…
- Trial name
- NCT02456584
- Testing
- DMPA 150, DMPA 300, DMPA 104
- Where
- 2 sites in United States, Dominican Republic
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- FHI 360
Infertility
Induction of Ovulation by Clomiphene Citrate Following Laparoscopic Surgery for Endometriosis Stage 1 and Stage 2 With and Without Suppression by Dienogest
This study aims at investigating the fertility outcome of endometriosis suppression with dienogest 2mg / day for 3 month followed by induction of ovulation for 3 month in endometriosis patients stage I and II.
- Trial name
- NCT02575248
- Testing
- Dienogest 2mg, Clomiphene citrate 5 mg
- Where
- Egypt
- Volunteers
- 310 people
- Sponsor
- Ain Shams University
Menopausal and Other Perimenopausal Disorders
Mirena and Estrogen for Control of Perimenopause Symptoms and Ovulation Suppression
Hormonal treatment of perimenopausal women has frequently utilized oral contraceptive pills (OCPs). Because of their ability to suppress ovulation and establish cycle control, OCPs have become a popular option, and one that is…
- Trial name
- NCT01613131
- Testing
- Mirena, Estradiol
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- University of Colorado, Denver
Functional Hypothalamic Amenorrhea, FHA
A Study to Investigate Mibavademab in Adult Women With Functional Hypothalamic Amenorrhea
This study is researching an experimental drug called mibavademab (also called "study drug"). The study is focused on participants with a condition called Functional Hypothalamic Amenorrhea (FHA).
- Trial name
- KYRIAD (NCT07235917)
- Testing
- Mibavademab
- Where
- 11 sites in United States
- Volunteers
- 34 people
- Sponsor
- Regeneron Pharmaceuticals
Suppression of Ovulation
A Dose-finding Study to Evaluate the Effect of a Contraceptive Vaginal Ring, Releasing Nestorone® and Estradiol, on Cycle Control, Ovulation Inhibition, and Pharmacokinetics in Normal Cycling Women
This clinical trial is an experimental research study using a potential new form of birth control. Clinical trials include people who volunteer to take part in a study.
- Trial name
- NCT01586000
- Testing
- 10 µg/day E2 with NES 200® µg/day, 20 µg/day E2 with NES 200® µg/day, 40 µg/day E2 with NES 200® µg/day
- Where
- 8 sites in United States
- Volunteers
- 197 people, healthy volunteers welcome
- Sponsor
- Kimberly Myer