Clinical trials: Supratentorial Brain Tumor
Brain and Central Nervous System Tumors, Cognitive/Functional Effects
Quality of Life in Patients Who Have Undergone Previous Treatment for Primitive Neuroectodermal Tumors
RATIONALE: Questionnaires that measure quality of life may improve the ability to plan treatment for patients with primitive neuroectodermal tumors.
- Conditions
- Brain and Central Nervous System Tumors, Cognitive/Functional Effects, Long-term Effects Secondary to Cancer Therapy in Children, Psychosocial Effects of Cancer and Its Treatment
- Trial name
- NCT00278239
- Testing
- cognitive assessment, psychosocial assessment and care, quality-of-life assessment
- Where
- 21 sites in Ireland, United Kingdom
- Sponsor
- Children's Cancer and Leukaemia Group
Childhood Atypical Teratoid/Rhabdoid Tumor, Childhood Central Nervous System Germ Cell Tumor
Lenalidomide in Treating Young Patients With Recurrent, Progressive, or Refractory CNS Tumors
This phase I trial is studying the side effects and best dose of lenalidomide in treating young patients with recurrent, progressive, or refractory CNS tumors.
- Conditions
- Childhood Atypical Teratoid/Rhabdoid Tumor, Childhood Central Nervous System Germ Cell Tumor, Childhood Choroid Plexus Tumor, Childhood Craniopharyngioma
- Trial name
- NCT00100880
- Testing
- lenalidomide, perfusion-weighted magnetic resonance imaging, diffusion-weighted magnetic resonance imaging
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- National Cancer Institute (NCI)
Brain and Central Nervous System Tumors
Lonafarnib and Temozolomide in Treating Patients With Recurrent Primary Supratentorial Gliomas
RATIONALE: Lonafarnib may stop the growth of tumor cells by blocking the enzymes necessary for their growth. Drugs used in chemotherapy, such as temozolomide, work in different ways to stop tumor cells from dividing so they stop…
- Trial name
- NCT00083096
- Testing
- lonafarnib, temozolomide
- Where
- 3 sites in France, Switzerland
- Volunteers
- 30 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Brain and Central Nervous System Tumors
Radiation Therapy and Combination Chemotherapy in Treating Young Patients With Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Ependymoma
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00303810
- Testing
- carboplatin, cisplatin, cyclophosphamide
- Where
- Germany
- Volunteers
- 567 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Pituitary Neoplasms
Clinical Evaluation of [68Ga]Ga-NOTA-RF PET Imaging Targeting RFVT3 in Patients With Pituitary Tumors
This study aims to evaluate the clinical application value of [68Ga]Ga-NOTA-RF, a novel PET molecular probe targeting riboflavin transporter 3 (RFVT3), in patients with pituitary adenomas.
- Trial name
- NCT07254104
- Testing
- [68Ga]Ga-NOTA-RF
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Pituitary Neoplasm
Effects of Hormone Stimulation on Brain Scans for Cushing s Disease
Background: Cushing s disease can be caused by a tumor of the pituitary gland, a small gland about the size of a pea located at the base of the brain.
- Trial name
- NCT01459237
- Testing
- Acthrel
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Adult Anaplastic Astrocytoma, Adult Anaplastic Ependymoma
Yoga Therapy in Treating Patients With Malignant Brain Tumors
This clinical trial studies yoga therapy in treating patients with malignant brain tumors. Yoga therapy may improve the quality of life of patients with brain tumors
- Conditions
- Adult Anaplastic Astrocytoma, Adult Anaplastic Ependymoma, Adult Anaplastic Meningioma, Adult Anaplastic Oligodendroglioma
- Trial name
- NCT01234805
- Testing
- yoga therapy, questionnaire administration, quality-of-life assessment
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Wake Forest University Health Sciences
Supratentorial Brain Tumor
Effects of Two Different Goals of Fluid Management in Patients Undergoing Supratentorial Tumour Resection
Neurosurgical operations are characterised by major fluid shift, frequent use of diuretics, and prolonged operative time. The role of fluid therapy in these patients is very critical; hypovolemia might decrease cerebral…
- Trial name
- NCT05561894
- Testing
- pulse pressure variation index guided fluid therapy
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Assiut University
Brain and Central Nervous System Tumors, Cognitive/Functional Effects
Observing Young Patients With Ependymoma Undergoing Standard Combination Chemotherapy
RATIONALE: Gathering information about how young patients with ependymoma respond to standard combination chemotherapy and learning about the long-term effects of this treatment may help doctors plan better treatment.
- Conditions
- Brain and Central Nervous System Tumors, Cognitive/Functional Effects, Long-term Effects Secondary to Cancer Therapy in Children, Ototoxicity
- Trial name
- NCT00683319
- Testing
- carboplatin, cisplatin, cyclophosphamide
- Where
- 10 sites in United Kingdom
- Volunteers
- 50 people
- Sponsor
- Children's Cancer and Leukaemia Group
Pituitary Tumor
A Pilot Study of Rosiglitazone in the Treatment of GH Secreting Pituitary Adenomas
Growth hormone secreting pituitary adenomas(GHomas) produce excessive GH, stimulating excessive insulin like growth factor 1(IGF-1) synthesis in the liver, thus causing multiple systemic complications.
- Trial name
- NCT03309319
- Testing
- Rosiglitazone
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Zhaoyun Zhang
Supratentorial Tumor
Desflurane and Brain Relaxation in Craniotomy
Optional brain relaxation improves the surgeon's operating conditions and is likely to minimize the degree of retraction injury ,with the potential for providing patients with a better outcome.
- Trial name
- NCT04691128
- Testing
- Desflurane, Propofol
- Where
- China
- Volunteers
- 111 people
- Sponsor
- Beijing Tiantan Hospital
Acromegaly
Dose Escalation of Octreotide-LAR as First-Line Therapy in Resistant Acromegaly
Epidemiological data indicate that patients with active acromegaly have reduced life expectancy because of cardiovascular (60%) and respiratory diseases (25%) mainly (1-10).
- Trial name
- HDacro (NCT00461149)
- Testing
- Octreotide-LAR
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Federico II University
Glioblastoma, Astrocytoma
Stem Cell Transplant for High Risk Central Nervous System (CNS) Tumors
The primary goal of this study is to determine if a stem cell transplant in patients with newly diagnosed high risk CNS tumors (glioblastoma multiforme [GBM], high grade astrocytoma, pineoblastoma, rhabdoid tumor, supratentorial…
- Conditions
- Glioblastoma, Astrocytoma, Pineoblastoma, Rhabdoid Tumor
- Trial name
- NCT00179803
- Testing
- Stem Cell Transplant
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Supratentorial Neoplasms
Remifentanil Infusion Alone During the Closure Period for Early Emergence Following Craniotomy
Total intravenous anaesthesia using propofol and remifentanil are routinely used drugs for this purpose. The hemodynamic stability and at the same time early emergency are the main goals following neurosurgery.
- Trial name
- NCT02593942
- Testing
- Remifentanil, Propofol
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Yeditepe University Hospital
Brain Neoplasm, Glioblastoma
Evaluation of Factors in Human Brain Tumors
Presently, patients with primary malignant brain tumors have a life expectancy of 15 weeks following surgery unless they receive additional types of therapy (chemotherapy, radiotherapy, and/or immunotherapy).
- Conditions
- Brain Neoplasm, Glioblastoma, Glioma, Pituitary Neoplasm
- Trial name
- NCT00001171
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Brain and Central Nervous System Tumors, Intraocular Melanoma
Monoclonal Antibody Therapy in Treating Patients With Leptomeningeal Cancer
RATIONALE: Monoclonal antibodies can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells.
- Conditions
- Brain and Central Nervous System Tumors, Intraocular Melanoma, Lung Cancer, Melanoma (Skin)
- Trial name
- NCT00003022
- Testing
- iodine I 131 monoclonal antibody 3F8
- Where
- United States
- Sponsor
- Memorial Sloan Kettering Cancer Center
Resectable, Non-functioning Pituitary Adenoma
Exploratory Study of Farletuzumab to Treat Resectable, Non-functioning Pituitary Adenomas
The purpose of this study is to evaluate whether therapy with farletuzumab is effective and safe in the treatment of resectable, non-functioning pituitary adenomas.
- Trial name
- NCT01203618
- Testing
- Farletuzumab
- Where
- United States
- Sponsor
- Morphotek
Glioblastoma, CNS Disease
Dasatinib Plus Radiation Therapy/Temozolomide in Newly-Diagnosed Glioblastoma
Phase I: Primary Objectives: -To define the maximum tolerated dose (MTD) of dasatinib (Sprycel) with radiotherapy (RT) and 6 weeks of concomitant temozolomide (TMZ) administered at 75 mg/m^2/day in patients with newly-diagnosed…
- Conditions
- Glioblastoma, CNS Disease, Brain Diseases
- Trial name
- NCT00895960
- Testing
- Dasatinib, RT (Radiotherapy), TMZ (Temozolomide)
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- M.D. Anderson Cancer Center
Pituitary Adenoma
Multicentric Prospective Validation of the Zurich Pituitary Score
Predictive analytics for GTR, EOR and RV are useful in surgical decision-making, particularly whenever there is no unequivocal indication for surgery. Several factors have been shown to have a role in predicting GTR.
- Trial name
- NCT04076046
- Where
- 10 sites in United States, Austria and 4 more
- Volunteers
- 408 people
- Sponsor
- University of Zurich
Hypopituitarism, Pituitary Tumors
Effect of 5 Years of GH Replacement on Atherosclerosis
Adult patients with hypopituitarism under adequate conventional hormone replacement therapy have reduced life expectancy due to excess vascular events (1-4).
- Conditions
- Hypopituitarism, Pituitary Tumors, Growth Hormone Deficiency
- Trial name
- 5yrGH (NCT00462475)
- Testing
- Recombinant Growth Hormone, Genotropin (Pfizer)
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Federico II University