Clinical trials: Surgery, Cardiac
Postoperative Pain, Pulmonary Function Tests
The Effect of Superficial Parasternal Intercostal Plane Block on Pulmonary Function Tests After Cardiac Surgery
In adult patients undergoing cardiac surgery, does adding an sPIP block to standard care compared to standard care alone result in a smaller decrease in PFTs?
- Trial name
- PIPACS (NCT05999721)
- Testing
- superficial parasternal intercostal plane block, Standard care
- Where
- 2 sites in Israel
- Volunteers
- 100 people
- Sponsor
- Shai Fein
Aortic Valve Disease, Myocardial Ischemia
Remote Ischemic Preconditioning in Patients Undergoing Isolated Aortic Valve Replacement Surgery
The goal is to investigate the efficacy, safety and possible neuro- and cardioprotective effects of remote ischemic preconditioning (RIPC) in adult cardiac patients undergoing isolated aortic valve replacement surgery with a…
- Trial name
- NCT02694016
- Testing
- Remote ischemic preconditioning
- Where
- Finland
- Volunteers
- 4 people
- Sponsor
- Oulu University Hospital
Surgical Wound Infection, Coronary Artery Bypass
Ultrasound to Prevent Leg Wound Complications in Heart Bypass.
The long saphenous vein is traditionally harvested for use as a conduit in coronary artery bypass grafting surgery. Currently, the long saphenous vein is not imaged prior to surgery.
- Trial name
- NCT02307084
- Testing
- Ultrasound imaging of the long saphenous vein
- Where
- United Kingdom
- Volunteers
- 55 people
- Sponsor
- University Hospitals Bristol and Weston NHS Foundation Trust
Myocardial Reperfusion Injury, Hypoxia
Effects of Hypoxic-hyperoxic Preconditioning in Cardio-surgical Patients
Coronary artery bypass grafting (CABG) with cardiopulmonary bypass is a common surgical therapy for patients suffering from coronary artery diseases.
- Conditions
- Myocardial Reperfusion Injury, Hypoxia, Hyperoxia, Coronary Artery Disease
- Trial name
- NCT05354648
- Testing
- Hypoxic-hyperoxic preconditioning
- Volunteers
- 120 people
- Sponsor
- Alexander Averyanov
Postoperative Pain
Efficacy of Erector Spinae Plane Block Analgesia After Off Pump Cardiac Surgery
In this study the investigators will investigate the efficacy of ESPB as a part of Enhanced recovery after surgery on postoperative analgesia and recovery criteria after off pump cardiac surgery.
- Trial name
- ESPB (NCT05769309)
- Testing
- Erector spinae block, Fentanyl
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Menoufia University
Cardiac Surgery, Training
Impact of Left-Handed Tailored Endoscopic Mitral Simulation Training on Skill Acquisition for Left-handed Surgeons
Study Characteristics and Structure are as follows: All Left-handed cardiac surgeons and residents attending the 2024 EACTS annual meeting (october 2024) are invited to any of the 3-day 8-endoscopic sessions as part of this study…
- Conditions
- Cardiac Surgery, Training, Suture, Left-handed
- Trial name
- NCT07533214
- Testing
- Endoscopic annular suture placement guided by left handed instructor
- Where
- Portugal
- Volunteers
- 30 people
- Sponsor
- Academisch Ziekenhuis Maastricht
Mitral Regurgitation, Computed Tomography
Atrial Fibrillation Risk After Miniinvasive Mitral Valve Repair
This retrospective cohort study investigates how CT-derived tissue quality parameters, serving as markers of metabolic status, predict post-operative atrial fibrillation risk in patients undergoing minimally invasive mitral valve…
- Conditions
- Mitral Regurgitation, Computed Tomography, Atrial Fibrillation
- Trial name
- NCT06707506
- Volunteers
- 114 people
- Sponsor
- Nemocnice AGEL Trinec-Podlesi a.s.
Pain
Pain Control After Cardiac Surgery Using Intravenous Acetaminophen
Evaluate the efficacy of IV acetaminophen; compared to a placebo, in reducing opioid consumption and/or pain intensity scores after cardiac surgery.
- Trial name
- NCT01822821
- Testing
- IV Acetaminophen
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- The Cleveland Clinic
Patients Undergoing Valvular Heart Surgery
Association Between Post-operative Anemia and Mortality After Valvular Heart Surgery
The investigators aimed to evaluate whether postoperative anemia can predict 1-year mortality after valvular heart surgery independent of preoperative anemia.
- Trial name
- NCT06647758
- Where
- South Korea
- Volunteers
- 3,000 people
- Sponsor
- Yonsei University
Analgesia
Dexmedetomidine Ropivacaine Versus Plain Ropivacaine in Bilateral Pectoralis Nerve (PECS) Block
In 2012 Blanco et al. [1] described the ultrasound technique for Pectoral nerve (PECS) block as a new, less invasive regional analgesic technique for breast surgeries.
- Trial name
- NCT06636578
- Testing
- dexmedetomidine, ropivacaine, fentanyl
- Where
- 2 sites in Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Fayoum University
Congenital Heart Disease, Congenital Heart Defect
Characterization of the Cardiac Reinnervation of Patients With Transposition of the Great Arteries Long After Repair With the Arterial Switch Operation. Correlation With Electrocardiographic and Exercise Test Parameters
Cardiac denervation is inherent to the arterial switch (ASO) technique for the repair of transposition of the great arteries (TGA) and the long term reinnervation process has not been studied.
- Conditions
- Congenital Heart Disease, Congenital Heart Defect, Transposition of the Great Arteries
- Trial name
- NCT03469843
- Testing
- Non intervention
- Where
- Spain
- Volunteers
- 25 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Cardiomyopathy, Obstructive Hypertrophic Cardiomyopathy
Patients' Long-Term Survival of Obstructive Hypertrophic Cardiomyopathy (HCM)
Background: HCM is a genetic heart disease. It can cause fatigue, chest pain, or even death. For more than 50 years, a surgery called septal myectomy has been used to help people with this disease. Dr. Andrew G.
- Trial name
- NCT04603521
- Where
- United States
- Volunteers
- 325 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Coronary Artery Disease Amenable to Bypass Graft Surgery
Graft Patency in Beating Heart Vs. Conventional CABG Using Cardiac CT
The purpose of this study is to compare graft patency rates following coronary artery bypass graft surgery performed by beating heart vs. conventional techniques using cardiac CT scanning to evaluate the bypass grafts.
- Trial name
- NCT00259493
- Testing
- Off-Pump Coronary Artery Bypass Graft Surgery
- Where
- Canada
- Volunteers
- 350 people
- Sponsor
- Trillium Health Centre
Heart Diseases
POC - Transfusion Algorithm Cardiac Study
This multi-centre study will provide sound, generalizable data on the effectiveness of a POC-based algorithm to determine to what extent this guideline can reduce blood product transfusions.
- Trial name
- TACS (NCT02200419)
- Testing
- POC-based transfusion algorithm
- Where
- 12 sites in Canada
- Volunteers
- 7,402 people
- Sponsor
- University Health Network, Toronto
Coronary Artery Bypass, Anesthesia, Conduction
Effect of Transversus Thoracic Muscle Plane Block (TTMP) on Analgesia
In this prospective and controlled study, the investigators investigated the effect of transversus thoracic muscle plane block (TTMP) on analgesia in patients who undergo coronary artery bypass graft (CABG) surgery with median…
- Conditions
- Coronary Artery Bypass, Anesthesia, Conduction, Nerve Block, Pain, Postoperative
- Trial name
- NCT06601530
- Testing
- Transversus Thoracic Muscle Plane Block, Tramadol
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people
- Sponsor
- Istanbul University - Cerrahpasa
Open-Heart Surgery
Development of Delirium in Patients Undergoing Open-Heart Surgery
Malnutrition is a prevalent issue among patients undergoing cardiac surgery. This can lead to delirium risk factors, including postoperative functional and cognitive impairment.
- Trial name
- NCT06195592
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Kubra Gunes
Hypotension, Hip Fractures
Heart and Renal Failure in Hip Fracture Surgery
Patients with acute hip fractures are old and vulnerable. With a majoriry classified as being ASA 3 or more. Frequently they receive spinal anesthesia perioperatively inducing hypotension.
- Conditions
- Hypotension, Hip Fractures, Renal Insufficiency, Heart Injuries
- Trial name
- NCT03532919
- Testing
- Serum Tropinin
- Where
- Sweden
- Volunteers
- 105 people
- Sponsor
- Sahlgrenska University Hospital
Congenital Heart Disease
Fibrinogen Concentrate vs Cryoprecipitate
One of the most common hemostatic derangements in pediatric open- heart surgery is an acute acquired hypofibrinogenemia. This compromises fibrin clot generation and platelet aggregation, resulting in increased bleeding and…
- Trial name
- NCT03014700
- Testing
- Fibrinogen Concentrate, Cryoprecipitate
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Stanford University
Adult Patients Undergoing Open Heart Surgery
Prospective Validation of the Model Predicting Postoperative Delirium Occurrence With Machine Learning-based Analysis of Intraoperative Biological Signals During Anesthesia in Cardiac Surgery
Postoperative delirium (POD) not only increases the length of hospitalization and intensive care unit stay and medical costs, but is also closely associated with negative prognosis, including postoperative mortality, increased…
- Trial name
- NCT05320965
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Yonsei University
Mitral Valve Insufficiency
Multicenter International Trial Ring AnnulopLasty
This clinical study is a multicenter, prospective non-randomized observational study without concurrent or matched controls in which 150 patients receiving an SJM® Rigid Saddle Ring will be included.
- Trial name
- MITRAL (NCT00727012)
- Testing
- mitral valve repair (SJM® Rigid Saddle Ring)
- Where
- Germany
- Volunteers
- 180 people
- Sponsor
- Abbott Medical Devices