Clinical trials: Surgery, Cardiovascular
Cardiovascular Disease, Coronary Artery Bypass
Safety and Efficacy Study of AVI-5126 When Used on Vein Grafts Before Use in Heart by-Pass Graft Surgery (CABG)
For some people who have heart by-pass surgery, the vein that is used to by-pass a blockage will, after some time, become narrowed and possibly blocked.
- Trial name
- NCT00451256
- Testing
- AVI-5126
- Where
- Ukraine
- Volunteers
- 600 people
- Sponsor
- Sarepta Therapeutics, Inc.
MI Related Malignant Ventricular Arrhythmia
Effect of Radiofrequency Ablation in Patients With Ventricular Arrhythmia Undergoing CABG
Patients with myocardial infarction related potential malignant ventricular arrhythmia have high risk of sudden death. The aim of this clinical trial is evaluating therapeutic efficacy of unipolar or bipolar radiofrequency…
- Trial name
- RACAVA (NCT02991170)
- Testing
- unipolar or bipolar radiofrequency ablation+CABG, CABG
- Where
- 3 sites in China
- Volunteers
- 180 people
- Sponsor
- Beijing Anzhen Hospital
Ischemic Stroke, Brain Tumor
Confounding Factors in the Detection of Intracranial Hemorrhage With the Infrascanner
The investigators prospectively want to use the Infrascanner in patients with ischemic stroke, patients with brain surgery, patients with brain tumors, patients with intracranial hemorrhage and patients with a normal CT scan of…
- Conditions
- Ischemic Stroke, Brain Tumor, Brain Surgery, Intracranial Hemorrhage
- Trial name
- NCT02809651
- Testing
- Infrascanner
- Where
- Belgium
- Volunteers
- 89 people
- Sponsor
- Ziekenhuis Oost-Limburg
Bicuspid Aortic Valve Disease
TAVR vs SAVR in Severe Bicuspid Aortic Stenosis
The study is a multicenter, randomized superiority trial of standard of care therapies for severe aortic stenosis (AS) in patients with a bicuspid aortic valve (BAV).
- Trial name
- BELIEVERS (NCT07413965)
- Testing
- Transcatheter Aortic Valve Replacement, the open chest surgery to replace the aortic valve
- Where
- United States
- Volunteers
- 1,200 people
- Sponsor
- Cedars-Sinai Medical Center
Carotid Artery Stenosis
Gao's Triple Eversion Carotid Endarterectomy
Carotid endarterectomy (CEA), an important surgical approach for managing carotid plaque, has evolved over more than 70 years but still cannot be applied to all tandem carotid lesions (TCLs) because of the wide range of these…
- Trial name
- NCT06722222
- Testing
- Gao's triple eversion carotid endarterectomy
- Where
- China
- Volunteers
- 11 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Hypotension
Control Mean Arterial Pressure in the Intensive Care Unit
The goal of this randomized controlled trial is to compare two different strategies of postoperative mean arterial pressure (MAP) management (manual versus automated) in patients who underwent a major surgery and admitted in the…
- Trial name
- COMAP-ICU (NCT04639037)
- Testing
- Automated adjustment of vasopressor, Manual adjustment of vasopressor
- Where
- 2 sites in France
- Volunteers
- 53 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Critical Limb Ischemia, Malnutrition
Nutrition in Patient With Critical Limb Ischemia
A prospective pilot study examining nutritional supplements among vascular surgery patients with Critical Limb Ischemia (CLI). CLI patients have a high rate of malnutrition and has the potential to benefit greatly from…
- Conditions
- Critical Limb Ischemia, Malnutrition, Nutritional Supplements
- Trial name
- NutriVasc (NCT03529019)
- Testing
- Ensure Surgery Immunonutrition Shake, Ensure Enlive Advanced Nutrition Shake
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Boston Medical Center
Surgery, Brain Tumor
Neurosurgical Transitional Care Programme
Readmissions increasingly serve as a metric of hospital performance, inviting quality improvement initiatives in both medicine and surgery.
- Conditions
- Surgery, Brain Tumor, Brain Tumor, Recurrent, Brain Pathology
- Trial name
- TCP (NCT03593330)
- Testing
- Transitional Care Programme
- Where
- United Kingdom
- Volunteers
- 242 people
- Sponsor
- Barts & The London NHS Trust
Cardiovascular Surgery, Postoperative Recovery
Virtual Reality Supported Mindfulness Meditation After Cardiovascular Surgery
The early postoperative period following cardiovascular surgery is often associated with increased anxiety, stress, and physiological instability.
- Conditions
- Cardiovascular Surgery, Postoperative Recovery, Anxiety, Stress
- Trial name
- VR-MIND-CVS (NCT07523594)
- Testing
- Virtual Reality-Supported Mindfulness Meditation
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Kutahya Health Sciences University
Venous Thrombosis
Evaluation of PD 0348292 for Preventing Blood Clots in the Lungs or Deep Leg Veins of Patients After Knee Surgery
To study the safety and effectiveness of several doses of PD 0348292 compared to enoxaparin in preventing blood clots in the lungs or deep leg veins of patients after knee surgery
- Trial name
- NCT00306254
- Testing
- PD 0348292, Enoxaparin
- Where
- 134 sites in United States, Australia and 14 more
- Volunteers
- 1,225 people
- Sponsor
- Pfizer
Congenital Cardiovascular Defects, Low Cardiac Output Syndrome
Levosimendan in Congenital Cardiac Surgery
Many pediatric patients undergoing cardiac surgery under cardiopulmonary bypass for repair of complex congenital malformations, require inotropic support for low cardiac output syndrome.
- Trial name
- NCT00695929
- Testing
- Levosimendan, Milrinone
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Coagulopathy in Patients Having Thoraco-Abdominal Aneurysm Repair
Fibrinogen as an Alternative to FFP in Aortic Surgery.
Thoracoabdominal aneurysm (TAAA) repair is a major elective vascular operation associated with a large blood loss and potentially life-threatening clotting abnormalities.
- Trial name
- NCT00994045
- Testing
- Fibrinogen concentrate, Fresh Frozen Plasma
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Edinburgh
Coronary Artery Bypass, Graft Failure
Graft Failure and Consequences of Coronary Artery Bypass Graft Surgery
Coronary artery bypass graft (CABG) surgery is the commonest type of heart operation performed. During this, arteries or veins (termed 'grafts') are used to supply blood around blockages within the blood vessels that supply the…
- Conditions
- Coronary Artery Bypass, Graft Failure, Coronary Artery Bypass Graft, Coronary Artery Bypass Graft Surgery (CABG)
- Trial name
- NCT06800430
- Testing
- Hybrid [18F]-GP1, [68Ga]-DOTATATE, [68Ga]-FAPI total-body positron emission tomography and coronary computed tomography coronary angiography
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- University of Edinburgh
Coronary Stenosis, Coronary Artery Disease
Long-term Follow-up of a Randomized Comparison of Percutaneous Coronary Intervention Versus Coronary Artery Bypass Surgery
This is a long-term follow-up of a completed clinical trial which compared percutaneous coronary intervention (PCI) using sirolimus-eluting stents and coronary artery bypass grafting (CABG) in patients with unprotected left main…
- Trial name
- NCT05963620
- Testing
- percutaneous coronary intervention vs bypass graft surgery
- Where
- 4 sites in Germany
- Volunteers
- 201 people
- Sponsor
- Heart Center Leipzig - University Hospital
Atrial Fibrillation
Implanted Loop Recorder Post Atrial Fibrillation Ablation
This is a pilot study to determine if implanted loop recorders can more effectively monitor atrial fibrillation recurrence after atrial fibrillation ablation.
- Trial name
- NCT00915720
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Thoracic & Cardiovascular Healthcare Foundation
Hypotension, Anesthesia
Avoiding Postinduction Hypotension: the Clinical ZERO-HYPOTENSION Proof-of-concept Study
In this clinical proof-of-concept study, the aim is to investigate the efficacy of a hypotension avoidance strategy to prevent post-induction hypotension.
- Conditions
- Hypotension, Anesthesia, Hypotension on Induction
- Trial name
- NCT05842759
- Testing
- Monitoring, Norepinephrine preparation, Propofol administration
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Pulmonary Hypertension, Cancer
Natrecor in Pulmonary Hypertension
The goal of this clinical research study is to learn if the drug nesiritide (Natrecor) is effective in lowering the pressure in your lungs.
- Conditions
- Pulmonary Hypertension, Cancer, Lung Disease, Cardiothoracic Surgery
- Trial name
- NCT00075179
- Testing
- Nesiritide (Natrecor), Right Heart Catheterization
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- M.D. Anderson Cancer Center
Morbid Obesity, Diabetes
Bariatric Surgery and Fatty Liver Disease
The study is based on data from morbidly obese patients who fulfilled the criteria for bariatric surgery during 2016-2018 at the Department of Surgery, University Hospital Ostrava, Czech Republic.
- Conditions
- Morbid Obesity, Diabetes, Hypertension
- Trial name
- NCT04569396
- Testing
- Biochemistry analysis, NAFLD fibrosis score, BMI measurement
- Where
- Czechia
- Volunteers
- 72 people
- Sponsor
- University Hospital Ostrava
Sudden Cardiac Death, Ventricular Fibrillation
LifeVest Post-CABG Registry
This is a multi-center prospective registry of patients with an ejection fraction (EF) ≤ 35% following coronary artery bypass graft (CABG) surgery in order to test the hypothesis that wearable defibrillators (WD) will decrease…
- Conditions
- Sudden Cardiac Death, Ventricular Fibrillation, Ventricular Tachycardia, Ventricular Dysfunction
- Trial name
- NCT01448005
- Testing
- wearable defibrillator (LifeVest)
- Where
- 5 sites in United States
- Volunteers
- 69 people
- Sponsor
- Zoll Medical Corporation
Hypovolemia, Surgery
Focused Assessed Echocardiography to Predict Fluid Responsiveness
The aims of the study are: 1. To evaluate the feasibility of echocardiography monitoring in postoperative unit; 2. To assess diagnostic value of different focussed echocardiography parameters to define fluid responsiveness for…
- Conditions
- Hypovolemia, Surgery, Hypotension
- Trial name
- fluidres (NCT03044405)
- Testing
- Fluid challenge, Focused transthoracic echocardiography
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Lithuanian University of Health Sciences
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