Clinical trials: Surgery, Cardiovascular
Old Myocardial Infarction, Chronic Myocardial Ischemia
Cell Therapy in Patients With Chronic Ischemic Heart Disease Undergoing Cardiac Surgery
This prospective, randomized, placebo-controlled study was designed to assess the safety, feasibility and efficacy of intramyocardial injection of autologous bone marrow mononuclear cells in patients with severe, chronic ischemic…
- Conditions
- Old Myocardial Infarction, Chronic Myocardial Ischemia, Left Ventricular Dysfunction
- Trial name
- NCT01267331
- Testing
- bone marrow mononuclear cells injection
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Chinese PLA General Hospital
Cardiovascular Surgical Procedures
The Effect of Eye Mask and Earplugs on Sleep Quality and Delirium in Coronary Artery Bypass Graft Patients: A Randomized Controlled Study
Coronary artery bypass grafting is the most commonly performed surgical procedure among cardiovascular diseases. Nursing care for patients undergoing cardiac surgery involves a process that includes preoperative preparation and…
- Trial name
- NCT06752980
- Testing
- Eye mask, Earplugs, Eye Mask and Earplugs
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people
- Sponsor
- Necmettin Erbakan University
Cardiovascular Disease
Special Drug Use Investigation for ARIXTRA (Fondaparinux) Abdominal General Surgery
The purpose of this study is to collect and assess information on safety and efficacy of fondaparinux in patients undergoing general surgery of the lower limb at high risk of developing venous thromboembolism.
- Trial name
- NCT01390896
- Testing
- Fondaparinux Sodium
- Volunteers
- 329 people
- Sponsor
- GlaxoSmithKline
Hemorrhage, Cerebrovascular Accident
Antiplatelet Therapy Continuation in Spine Surgery - Its Effect on Postoperative Morbidity and Mortality
The objective of this study is to evaluate the safety of antiplatelet (APA)therapy continuation in patients undergoing lumbar spine surgery (laminectomy, discectomy and foraminotomy), and to gather evidence-based data regarding…
- Conditions
- Hemorrhage, Cerebrovascular Accident, Myocardial Infarction, Pulmonary Embolism
- Trial name
- NCT01006083
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Analgesia, Surgery
Serratus Anterior Plane Block Versus Standard of Care After Totally Endoscopic Aortic Valve Replacement
The aim of this study is to assess and compare the efficacy of a serratus anterior plane (SAP) block and our current pain protocol (Patient Controlled Intravenous Analgesia with opioids) in the prevention and treatment of acute…
- Conditions
- Analgesia, Surgery, Cardiac Disease
- Trial name
- NCT04699422
- Testing
- Serratus anterior plane block, PCIA with Piritramide
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- Jessa Hospital
Abdominal Aortic Aneurysm, Carotid Atherosclerosis
Preconditioning Shields Against Vascular Events in Surgery
Major vascular surgery involves operations to repair swollen blood vessels, clear debris from blocked arteries or bypass blocked blood vessels.
- Conditions
- Abdominal Aortic Aneurysm, Carotid Atherosclerosis, Critical Lower Limb Ischaemia
- Trial name
- SAVES-F (NCT02097186)
- Testing
- Remote ischaemic preconditioning
- Where
- 6 sites in Ireland
- Volunteers
- 400 people
- Sponsor
- Mid Western Regional Hospital, Ireland
Coronary Artery Disease, Coronary Artery Bypass Grafting
Effects of PEEP on Parameters of Tissue Perfusion in Patients Post Cardiac Surgery
Pulmonary dysfunction is a condition inherent in cardiac surgery because of various interventions, such as general anesthesia, a median sternotomy, cardiopulmonary bypass and establishment of internal thoracic artery dissection.
- Conditions
- Coronary Artery Disease, Coronary Artery Bypass Grafting, Acute Lung Injury
- Trial name
- NCT03753022
- Testing
- Group G5, Group G10, Group G15
- Volunteers
- 125 people
- Sponsor
- Federal University of São Paulo
Cardiac Disease
Non-invasive Forehead Skin Temperature in Cardiac Surgery
This study is to see if the zero-heat-flux (ZHF) thermometry monitoring in cardiac surgery with moderate hypothermic cardiopulmonary bypass differs from Temp-NP, which reflects central body temperature 30 minutes after the end of…
- Trial name
- NCT04160845
- Testing
- cardiac surgery
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Konkuk University Medical Center
Sleep Deprivation, Delirium
Sleep/Wake Protocol Implementation to Improve Sleep Quality in the ICU
The purpose of this study is to analyze a multi-component sleep/wake protocol for optimization of environmental factors (noise, light, nursing activities) as well as non-environmental factors (pain, mechanical support devices…
- Trial name
- NCT03313115
- Testing
- Sleep/Wake Protocol
- Where
- United States
- Volunteers
- 685 people
- Sponsor
- University of Utah
Myocardial Ischemia
Optimization of Cardioprotection in Diabetic Patients Undergoing Cardiac Surgery
This study evaluates the myocardial protection against perioperative ischemia comparing two standard anesthetic regimes in diabetic patients undergoing elective cardiac surgery.
- Trial name
- OPT (NCT02407626)
- Testing
- Propofol, Sevoflurane
- Where
- Switzerland
- Volunteers
- 2 people
- Sponsor
- Triemli Hospital
Hemorrhoids, Fissure in Ano
Pre-Emptive Analgesia in Ano-Rectal Surgery
The perianal region is the region around the anus. Administering a pain medication before a surgery starts is called preemptive analgesia.
- Conditions
- Hemorrhoids, Fissure in Ano, Rectal Fistula, Anal Condyloma
- Trial name
- PEAARS (NCT02402543)
- Testing
- Gabapentin, Ketamine, Acetaminophen
- Where
- 2 sites in United States
- Volunteers
- 90 people
- Sponsor
- University of Vermont
Pacing Therapy, Postoperative Care
Postoperative Pacing for Cardiac Efficiency
The goal of this study is to determine whether temporarily increasing a child's heart rate after heart surgery can improve blood flow and oxygen supply to the body's tissues.
- Conditions
- Pacing Therapy, Postoperative Care, Pediatric Congenital Heart Surgery, Cardiac Pacing
- Trial name
- POSTPACE (NCT07852390)
- Testing
- Temporary Atrial Pacing
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Robert G. Webster, MD, MPH
Chronic Periodontitis, Cardiovascular Diseases
NSPT On Vitronectin And Fetuin-A Levels In Patients With Periodontitis And Coronary Artery Disease
Periodontitis is a chronic inflammatory disease mainly caused by the oral microbial biofilm. It involves the periodontal supporting tissues mainly features gum inflammation, alveolar bone resorption, periodontal pocket formation…
- Conditions
- Chronic Periodontitis, Cardiovascular Diseases, Periodontal Inflammation
- Trial name
- NCT05663476
- Testing
- Non Surgical Periodontal Therapy
- Where
- India
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Meenakshi Ammal Dental College and Hospital
Myocardial Injury, Myocardial Infarction
Implementation of a Clinical Screening and Response System for Cardiac Complications After Noncardiac Surgery
The investigators aim to show the feasibility and medicoeconomic impact of implementing a clinical screening and response system for the early detection of perioperative cardiac complications in high-risk patients.
- Conditions
- Myocardial Injury, Myocardial Infarction, Perioperative Complication
- Trial name
- ImplementPMI (NCT05859620)
- Testing
- Patient assessment and follow-up
- Where
- 5 sites in Austria, Switzerland
- Volunteers
- 900 people
- Sponsor
- University Hospital, Basel, Switzerland
Transposition of the Great Arteries, Artery Switch Operation
Cardiovascular MRI and Cardiopulmonary Exercise Capacity After Neonatal ASO) in Young Adults
Magnetic Resonance Imaging of the heart at rest and stress conditions relative to the cardiopulmonary exercise capacity in young adults after neonatal surgery for transposition of the great arteries.
- Trial name
- ASO (NCT02415491)
- Testing
- Correlation Heart Magnetic Resonance Imaging at rest and stress with Cardiopulmonary stress test
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- RWTH Aachen University
Coronary Artery Disease
A Study of Anginera In Patients Undergoing Coronary Artery Bypass Graft (CABG) Surgery
This is a first in man, Phase I safety study of Anginera in adults with Left Ventricular Dysfunction (LVD) and Reversible Myocardial Ischemia undergoing a CABG procedure.
- Trial name
- NCT00364390
- Testing
- Anginera, a human tissue replacement therapy
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Theregen, Inc.
Hypertension, Pulmonary
Riociguat in Patients With Chronic Thromboembolic Pulmonary Hypertension (CTEPH)
The aim of the study is to assess safety, tolerability and clinical effects of different doses of riociguat in patients with inoperable Chronic Thromboembolic Pulmonary Hypertension (CTEPH) and who are not satisfactorily treated…
- Trial name
- EAS (NCT01784562)
- Testing
- Adempas (Riociguat, BAY63-2521)
- Where
- 102 sites in United States, Austria and 18 more
- Sponsor
- Bayer
Aortic Stenosis
The Effects of High Spinal Anesthesia on Heart Function, Stress Response and Pain Control in Aortic Valve Surgery
This study is looking at the effects of high spinal anesthesia (also known as total spinal anesthesia) combined with general anesthesia versus general anesthesia alone on the following: Stress response: Patients undergoing aortic…
- Trial name
- NCT00348920
- Testing
- High Spinal and General Anesthesia
- Where
- Canada
- Volunteers
- 14 people
- Sponsor
- University of Manitoba
Ischemia Reperfusion Injury
The Effect of Remote Ischemic Preconditioning in Patients Undergoing Major Liver Surgery
The project has been designed to determine whether a brief period of leg ischemia will reduce the I/R injury sustained by the liver during liver surgery and liver transplantation.
- Trial name
- NCT00796588
- Testing
- remote preconditioning
- Where
- United Kingdom
- Volunteers
- 48 people
- Sponsor
- Royal Free Hampstead NHS Trust
Venous Thromboembolism, Pulmonary Embolism
Intervention to Improve Utilization of Extended Venous Thromboembolism Prophylaxis After Cancer Surgery
While blood clots after major cancer surgery are common and harmful to patients, the medications to decrease blood clot risk are seldom used after patients leave the hospital despite the recommendation of multiple professional…
- Conditions
- Venous Thromboembolism, Pulmonary Embolism, Deep Vein Thrombosis, Cancer
- Trial name
- NCT06451003
- Testing
- Exposure to clinical decision support system and education
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Medical University of South Carolina
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