Clinical trials: Surgery, Cardiovascular
Acute Myocardial Infarction, Disorder; Heart, Functional, Postoperative, Cardiac Surgery
High-sensitivity Troponin T in Acute Myocardial Infarction After Cardiac Valvular Surgery
A measurable degree of heart muscle tissue injury is expected in patients undergoing heart valvular surgery. The level of this injury can be measured by cardiac biomarkers in blood samples.
- Conditions
- Acute Myocardial Infarction, Disorder; Heart, Functional, Postoperative, Cardiac Surgery, Myocardial Infarction, Heart Valve Diseases
- Trial name
- NCT02518282
- Testing
- Serum levels of high-sensitivity troponin T, Twelve-lead ECGs, Transthoracic echocardiography (TTE)
- Where
- Spain
- Volunteers
- 800 people
- Sponsor
- University of Valladolid
MI Related Malignant Ventricular Arrhythmia
Effect of Radiofrequency Ablation in Patients With Ventricular Arrhythmia Undergoing CABG
Patients with myocardial infarction related potential malignant ventricular arrhythmia have high risk of sudden death. The aim of this clinical trial is evaluating therapeutic efficacy of unipolar or bipolar radiofrequency…
- Trial name
- RACAVA (NCT02991170)
- Testing
- unipolar or bipolar radiofrequency ablation+CABG, CABG
- Where
- 3 sites in China
- Volunteers
- 180 people
- Sponsor
- Beijing Anzhen Hospital
Atrial Fibrillation, Venous Thromboembolism
Perioperative Anticoagulant Use for Surgery Evaluation Emergency Registry
Among patients who are receiving long-term anticoagulant therapy, whether with a direct oral anticoagulant (DOAC) or vitamin K antagonist (VKA), approximately 3-5% who require treatment interruption for a surgery will do so in an…
- Conditions
- Atrial Fibrillation, Venous Thromboembolism, Arterial Vascular Disease
- Trial name
- PAUSE-ER (NCT04195113)
- Where
- 3 sites in Canada
- Volunteers
- 242 people
- Sponsor
- McMaster University
Aneurysm, Dissecting, Acute Kidney Injury
Prediction of Acute Kidney Injury After Operation of Acute Type A Aortic Dissection Based on Multimodal Model
Acute kidney injury is one of the most common postoperative complications of acute type A aortic dissection, which is closely related to early postoperative death.
- Trial name
- NCT05017896
- Testing
- Normal CT Renal Perfusion imaging indexes, Low CT Renal Perfusion imaging indexes
- Volunteers
- 242 people
- Sponsor
- Qilu Hospital of Shandong University
Coagulopathy, Congenital Heart Disease
FFP Usage in Pediatric CV Surgery
When small children undergo heart surgery with the heart-lung machine, in the past, blood products to help the blood clot such as Fresh Frozen Plasma (FFP) was routinely used in children under 10kg.
- Trial name
- NCT05819788
- Where
- Canada
- Volunteers
- 431 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Heart Failure, Coronary Artery Disease
The Usefulness of Growth Differentiation Factor 15 (GDF-15) for Risk Stratification in Cardiac Surgery
Growth determination factor 15 (GDF-15) and high sensitive troponin-t (hsTnT) are emerging humoral markers for risk stratification in clinically stable heart failure patients and in patients with stable coronary artery disease.
- Trial name
- NCT01166360
- Where
- Germany
- Volunteers
- 2,000 people
- Sponsor
- University of Luebeck
Aortic Aneurysm, Thoracic, Endothelial Dysfunction
Vasculopathic Injury and Plasma as Endothelial Rescue - OCTAplas Trial (EudraCT no. 2014-000452-28)
Effects of OctaplasLG® on endothelial integrity in patients undergoing emergency surgery for thoracic aortic dissections - a randomized, controlled, single-blinded investigator-initiated pilot trial
- Trial name
- VIPER-OCTA (NCT02253082)
- Testing
- OctaplasLG®, Fresh frozen plasma
- Where
- Denmark
- Volunteers
- 44 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Cardiogenic Shock
Awake Axillary Impella 5.5 Placement - A Feasibility Trial
The Abiomed Impella 5.5 is a surgically placed temporary mechanical support device used in patients in cardiogenic shock. The investigators propose using regional anesthesia (3 separate peripheral nerve blocks) to facilitate…
- Trial name
- NCT05782491
- Testing
- Interscalene Block, PECS II Block, Superficial Cervical Plexus Block
- Where
- 2 sites in United States
- Sponsor
- University of Pennsylvania
Atrial Fibrillation (AF), Cerebral Vascular Accident (CVA)
Pilot Study to Determine the Optimal Protocol for Preoperative Transcutaneous Vagal Neurostimulation
Post-operative atrial fibrillation (POAF) is a frequent complication of surgical aortic valve replacement, affecting 38 to 63% of patients, and increasing risks of stroke, heart failure, and long-term mortality.
- Conditions
- Atrial Fibrillation (AF), Cerebral Vascular Accident (CVA), Heart Failure, Myocardial Infarction (MI)
- Trial name
- VAGASTIMA-PILT (NCT07891390)
- Testing
- tVNS session on the left earlobe
- Where
- 3 sites in France
- Volunteers
- 64 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Heart Failure with Preserved Ejection Fraction, Atrial Fibrillation
Bariatric Surgery Evaluation and Assessment of Treatment Efficacy - Intervention Trial
The goal of this clinical trial is to evaluate if a bariatric surgery strategy will improve clinical endpoints, cardiac parameters and functional status in patients with obesity (with BMI 32-40 kg/m2) and symptomatic HF with…
- Trial name
- BEAT-IT (NCT06065124)
- Testing
- Bariatric surgery strategy
- Where
- 2 sites in Netherlands
- Volunteers
- 108 people
- Sponsor
- University Medical Center Groningen
Major Surgery, Coronary Artery Disease
Vitamins in Nitrous Oxide Study
In this study, we want to find out if laughing gas (nitrous oxide) leads to a higher rate of cardiac complications after surgery in patients with a specific genetic profile (mutations in the MTHFR gene) and if this risk can be…
- Trial name
- VINO (NCT00655980)
- Testing
- Vitamin B12 and folic acid, standard of care
- Where
- United States
- Volunteers
- 687 people
- Sponsor
- Washington University School of Medicine
Tricuspid Valve Disease
Characteristics and Prognosis of Moderate or Severe Tricuspid Regurgitation
The tricuspid valve : its evaluation is relatively difficult in echocardiography and the management of tricuspid valve diseases remains poorly codified.
- Trial name
- EPIT (NCT03546231)
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Eye Abnormalities, Arrythmia
Relation Between Oculocardiac Reflex and Laryngospasm
The aim of this study is to evaluate whether there is a significant relation between various arrhythmias during the surgeon's stretching the eye muscles and laryngospasm and emergence agitation in strabismus surgeries
- Trial name
- NCT05339880
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- TC Erciyes University
Congenital Heart Disease (CHD)
Mesenchymal Stromal Cells for Infants With Congenital Heart Disease (MedCaP)
The proposed study will be a prospective, open-label, single-center, safety and feasibility phase 1 trial of allogeneic bone marrow-derived mesenchymal stromal cell (BM-MSC) delivery though cardiopulmonary bypass (CPB) using a…
- Trial name
- MedCaP (NCT04236479)
- Testing
- BM-MSC
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Catherine Bollard
Noncardiac Surgery, Postoperative Myocardial Infarction
The Prognostic Capabilities Of A Preoperative Six-Minute Walk Test To Independently Inform Cardiovascular Risk After Major Noncardiac Surgery
This prospective cohort study aims to determine whether the addition of the 6MWT to the RCRI score improves the risk prediction of postoperative cardiovascular outcomes after noncardiac surgery.
- Conditions
- Noncardiac Surgery, Postoperative Myocardial Infarction, Postoperative Death, Risk Assessment
- Trial name
- NCT02860754
- Testing
- Six-minute walk test to perform before surgery
- Where
- Canada
- Volunteers
- 1,000 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Obesity, Diabetes
Role of Adiposomes in Endothelial Dysfunction
The development of type II diabetes (T2D) is strongly associated with obesity and both are well-established risk factors for cardiovascular disease.
- Conditions
- Obesity, Diabetes, Cardiovascular Diseases
- Trial name
- NCT05199454
- Testing
- Exercise training
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Illinois Chicago
Venous Thromboembolism, Varicose Veins
Caprini Score in Venous Surgery: a Prospective Cohort Study
The aim of the study is to make a validation of Caprini score in patients undergoing varicose veins surgery, especially endovascular procedures (endovascular laser treatment - EVLT, radiofrequency ablation - RFA…
- Trial name
- CAPSIVS (NCT03041805)
- Testing
- EVLT, RFA, USFS
- Where
- Russia
- Volunteers
- 3,000 people
- Sponsor
- Pirogov Russian National Research Medical University
Myocardial Infarction, Coronary Revascularization
Transfusion Trigger After Operations in High Cardiac Risk Patients
The goal of the proposed study is to determine whether a liberal transfusion strategy (transfusion trigger at Hb < 10 gm/dl) in Veterans at high cardiac risk who undergo major open vascular and general surgery operations is…
- Conditions
- Myocardial Infarction, Coronary Revascularization, Acute Renal Failure
- Trial name
- TOP (NCT03229941)
- Testing
- Blood Transfusion
- Where
- 16 sites in United States
- Volunteers
- 1,424 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Cardiovascular Disease, Aortic Dissection
Additive Anti-inflammatory Action for Critically Ill Patients With Cardiovascular Surgery (Xuebijing) IV
XueBiJing, a Chinese herbal derived therapeutic, has been approved to treat severe infections (sepsis) in critically ill patients (China Food and Drug Administration; Beijing, China, Number Z20040033).
- Conditions
- Cardiovascular Disease, Aortic Dissection, Coronary Artery Disease, Valve Heart Disease
- Trial name
- NCT04993794
- Testing
- XueBiJing Injection, Normal saline
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Nanjing Medical University
Insufficiency;Cardiac
Effect of Parenteral Glutamine on Myocardial Injury and Inflammation Biomarkers
The effect of parenteral glutamine on the biomarkers of myocardial injury and inflammation in patients undergoing cardiac surgery with and without cardiopulmonary bypass (DCP) will be analyzed.
- Trial name
- NCT06065566
- Testing
- L-alanyl-L-glutamine dipeptide
- Where
- Mexico
- Volunteers
- 56 people
- Sponsor
- Instituto Mexicano del Seguro Social
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