Clinical trials: Surgery, Cardiovascular
Coarctation of Aorta
Clinical Assessment of Perfusion Techniques During Repair of Coarctation With Aortic Arch Hypoplasia in Infants
The purpose of this study is to evaluate safety and efficacy of three main perfusion methods in surgical repair of coarctation of aorta with aortic arch hypoplasia in infants.
- Trial name
- NCT02835703
- Testing
- Surgical repair of coarctation of aorta
- Where
- Russia
- Volunteers
- 45 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Hemorrhoids, Anal Fissure
Topical vs Oral Metronidazole After Benign Anorectal Surgery
While some investigators found oral metronidazole to be effective in reducing pain after hemorrhoidectomy, other researchers did not find a significant analgesic effect of systemic metronidazole.
- Conditions
- Hemorrhoids, Anal Fissure, Anal Fistula
- Trial name
- NCT05038605
- Testing
- Topical metronidazole, oral metronidazole
- Where
- Egypt
- Volunteers
- 108 people
- Sponsor
- Mansoura University
Bundle-Branch Block
The CRT-KIR Study (Cardiac Resynchronization Therapy [CRT] in the Early Phase After Heart Surgery)
In patients with broad QRS complexes on electrocardiogram (ECG), the delayed electrical activation of the left heart chamber will cause abnormal contraction.This has been shown to be possible to treat by a special pacemaker…
- Trial name
- NCT00192946
- Testing
- Temporary cardiac resynchronization therapy
- Volunteers
- 60 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Carotid Artery Disease
Proximal Protection With The Mo.Ma Device During Carotid Stenting
The objective of the ARMOUR study is to evaluate the safety and effectiveness of the Mo.Ma proximal flow blockage cerebral protection device for patients at high surgical risk for carotid endarterectomy who undergo carotid artery…
- Trial name
- ARMOUR (NCT00744523)
- Testing
- Mo.Ma cerebral protection device
- Where
- 2 sites in United States
- Volunteers
- 262 people
- Sponsor
- Medtronic Endovascular
Cardiovascular Surgery
International Nutrition Survey 2018
Malnutrition is common among critically ill patients, and has negative effects on clinical outcomes. Artificial nutrition therapy in the form of enteral or parenteral nutrition is therefore considered an integral part of standard…
- Trial name
- INS2018 (NCT03442946)
- Where
- 5 sites in United States, Canada and 3 more
- Volunteers
- 280 people
- Sponsor
- RWTH Aachen University
Cancer (Colon Cancer, Breast Cancer, Lymphoma, Chronic Lymphoma Leukemia, Multiple Myeloma)
Use of Preoperative Postbiotic Supplementation in Colorectal Cancer Surgery
The treatment of colorectal cancer, in the absence of metastases, is primarily based on surgical removal. Colorectal surgery, which involves resecting part of the intestine and restoring intestinal continuity, carries a risk of…
- Trial name
- POSBIO-CRC (NCT07268846)
- Testing
- Postbiotic
- Where
- Brazil
- Volunteers
- 164 people
- Sponsor
- AC Camargo Cancer Center
Shock, Surgical, Shock
Angiotensin II in the Perioperative Management of Hypotension in Kidney Transplant Recipients
The current standard of catecholamine vasopressor management of perioperative hypotension in kidney transplant patients carries significant risks and falls short in many ways.
- Conditions
- Shock, Surgical, Shock, Hypotension and Shock, Kidney Transplant; Complications
- Trial name
- NCT04529005
- Testing
- Angiotensin II
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Illinois Chicago
Cardiac Disease
Incidence and Risk Factors for Persistent Post-sternotomy Pain After Cardiac Surgery in Local Chinese Population: a Prospective Cohort Study
CPSP is common after cardiac surgery. The reported incidence was 28% to 56% up to 2 years postoperatively. Despite a large number of cross-sectional and retrospective studies, prospective cohort studies examining the incidence of…
- Trial name
- NCT04644666
- Where
- Hong Kong
- Volunteers
- 220 people
- Sponsor
- Chinese University of Hong Kong
Coronary Disease, Coronary Stenosis
A Comparison of Fractional Flow Reserve-Guided Percutaneous Coronary Intervention and Coronary Artery Bypass Graft Surgery in Patients With Multivessel Coronary Artery Disease
The purpose of this study is to determine whether Fractional flow reserve (FFR, (coronary pressure wire-based index for assessing the ischemic potential of a coronary lesion)-guided percutaneous coronary intervention (PCI) in…
- Trial name
- FAME 3 (NCT02100722)
- Testing
- FFR guided PCI, CABG, Resolute Integrity Stent
- Where
- 46 sites in United States, Australia and 14 more
- Volunteers
- 1,500 people
- Sponsor
- Stanford University
Cardiopathy, Coronary Artery Disease
Efficacy and Safety of Dexmedetomidine in the Analgesic Prophylaxis , in Patients Undergoing Cardiovascular Surgery
Acute pain is one of the complications after cardiothoracic surgeries . It can delay patients´recovery and may increase patients´morbity and mortality.
- Conditions
- Cardiopathy, Coronary Artery Disease, Valve Heart Disease, Pain
- Trial name
- NCT05079672
- Testing
- Dexmedetomidine, 0,9% Saline
- Where
- 2 sites in Brazil
- Volunteers
- 102 people
- Sponsor
- University of Sao Paulo
Monitored Anesthesia Care
Magnesium Sulphate Versus Fentanyl Sedation During Burr-hole Surgery
MgSO4 was found to reduce the perioperative anesthetic and analgesic requirements when used as an adjuvant to general anesthesia. Fentanyl is a potent opioid and used as adjuvant to other sedatives in awake craniotomy procedure.
- Trial name
- NCT03854812
- Testing
- Magnesium Sulphate, Fentanyl, Propofol
- Where
- Egypt
- Volunteers
- 32 people
- Sponsor
- Kasr El Aini Hospital
Postoperative Complications
Wireless Assessment of Respiratory and Circulatory Distress
A high percentage of patients undergoing major abdominal surgery will develop a postoperative complication. Our hypothesis is that by observing postoperative patients with continuous wireless monitoring, it is possible to detect…
- Trial name
- WARD (NCT03491137)
- Where
- 2 sites in Denmark
- Volunteers
- 505 people
- Sponsor
- Bispebjerg Hospital
Coronary Artery Disease
IRB-HSR# 14296 The Use of the Intrathoracic Pressure Regulator (ITPR) to Improve Systemic Blood Pressure in Patient Undergoing CABG Surgery
Briefly, after the induction of anesthesia and the placement of TEE, hemodynamic variables (pulmonary and systemic blood pressure, central and pulmonary venous pressure, cardiac output, calculated SVR, etc.) will be collected.
- Trial name
- NCT01205594
- Testing
- ITPR
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Virginia
Time Needed to Achieve a Successful Cannulation of the Femoral Artery in Pediatric Cardiac Surgery
Ultrasound-Guided vs Landmark Technique for Femoral Arterial Cannulation in Pediatric Cardiac Surgery
The use of ultrasound guidance by senior residents learning the technique of femoral artery catheterization is superior to the landmark technique.
- Trial name
- NCT02183857
- Testing
- Ultrasound, Landmark
- Where
- Lebanon
- Volunteers
- 106 people
- Sponsor
- American University of Beirut Medical Center
Diabetes Mellitus, Cardiovascular Diseases
Improving Neurologic Outcomes in People With Diabetes Who Are Undergoing Heart Surgery
Preliminary studies have shown that people with diabetes who undergo heart surgery may have a higher risk of developing cognitive functioning problems, including memory problems, than people without diabetes who undergo heart…
- Trial name
- NCT00836329
- Testing
- Intensive Glucose Management, Traditional Glucose Management:
- Where
- United States
- Volunteers
- 133 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Symptomatic Haemorrhoidal Disease Requiring Surgical Management
Randomized Controlled Trial Comparing Transanal Doppler-guided Arterial Ligation With Mucopexy and Stapled Haemorrhoidopexy
This multicentre RCT aims to compare two surgical treatments of haemorrhoidal disease: doppler-guided arterial ligation with mucopexy (DGALM) and stapled haemorrhoidopexy according to Longo (SH).
- Trial name
- LIGALONGO (NCT01240772)
- Testing
- doppler-guided arterial ligation with mucopexy, stapled haemorrhoidopexy according to Longo
- Where
- 22 sites in France
- Volunteers
- 407 people
- Sponsor
- Nantes University Hospital
Tumor, Brain, Arteriovenous Malformations
Functional Navigation in Surgery of Cerebral Tumors and Vascular Malformations
The purpose of the study is to assess accuracy, advantages of functional neuronavigation and calculate safe distance from motor areas to brain tumors and vascular malformations in image-guided surgery.
- Conditions
- Tumor, Brain, Arteriovenous Malformations, Cavernoma
- Trial name
- FUN (NCT05484219)
- Testing
- Functional navigation
- Where
- Russia
- Volunteers
- 50 people
- Sponsor
- Sklifosovsky Institute of Emergency Care
Arteritis, Takayasu
The Long-term Success of Cardiovascular Surgery in Takayasu Arteritis
Takayasu Arteritis (TA) affects medium and large caliber arteries causing stenosis, occlusion or aneurysms. It has great predilection for the aortic arch, subclavian and extracranial arteries.
- Trial name
- NCT03654222
- Where
- Mexico
- Volunteers
- 66 people
- Sponsor
- Instituto Nacional de Cardiologia Ignacio Chavez
Atrial Fibrillation, AFib
Stroke Feasibility Study
This is a feasibility study to assess the safety and efficacy of the AtriCure AtriClip when placed via Minimally Invasive Surgical Deployment to the Left Atrial Appendage.
- Trial name
- NCT01997905
- Testing
- AtriClip LAA Exclusion Device
- Where
- 7 sites in United States
- Volunteers
- 13 people
- Sponsor
- AtriCure, Inc.
Hemorrhoids
Effect of Red and Blue Light Irradiation on Wound Healing After Hemorrhoid Surgery
The subjects of this study were patients who took mixed haemorrhoidectomy during the period of December 2024 - December 2025 . The haemorrhoidectomy patients were randomly divided into routine group, red light group and red and…
- Trial name
- NCT07121686
- Testing
- Red light exposure, Red-blue light exposure
- Where
- China
- Volunteers
- 315 people
- Sponsor
- The Affiliated Hospital of Putian University
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