Clinical trials: Surgery, Colorectal
Peritoneal Metastases from Colorectal Cancer
Systemic Antitumor Treatment with or Without Pressurized Intraperitoneal Aerosol Chemotherapy for Colon Peritoneal Metastases (PIPOX02)
The goal of this clinical trial is to learn if Pressurized intraperitoneal aerosol chemotherapy (PIPAC) significantly improve the progression-free survival (PFS) in patients with advanced peritoneal metastasis from colorectal…
- Trial name
- PIPOX02 (NCT06681038)
- Testing
- Standard Medical Therapy, PIPAC
- Where
- 15 sites in France
- Volunteers
- 114 people
- Sponsor
- Institut Cancerologie de l'Ouest
Colorectal Cancer
Effect of Implementation of Enhanced Recovery After Surgery on 3-year Survival After Colorectal Surgery for Cancer
Several recent studies have shown that the Enhanced Recovery After Surgery (ERAS) protocol reduces morbidity and mortality and shortens the length of stay compared to conventional recovery strategy (pre-ERAS).
- Trial name
- RACCOR (NCT05002855)
- Testing
- Enhanced Recovery After Surgery (ERAS)
- Where
- France
- Volunteers
- 1,001 people
- Sponsor
- University Hospital, Grenoble
Postoperative Hyperalgesia
Epidural Clonidine for Postoperative Hyperalgesia
We propose performing a study in which we compare the effects of bupivacaine and fentanyl with a different drug combination - bupivacaine and clonidine. The principal research questions of the study are: 1.
- Trial name
- NCT00417443
- Testing
- Clonidine
- Where
- United Kingdom
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Colorectal Cancer, Insulin Resistance
Prehabilitation Versus Enhanced Recovery Program for Elective Colorectal Cancer Surgery.
Elective surgery is the most effective treatment option for colorectal cancer, however it has been recognized to be associated with high morbidity and mortality risks.
- Trial name
- PrehabVsERAS (NCT03758209)
- Testing
- Prehabilitation + ERAS, ERAS
- Where
- Hungary
- Volunteers
- 184 people
- Sponsor
- St. Borbala Hospital
Colon Cancer, Colon Neoplasm
Long-term Results in Intracorporeal Versus Extracorporeal Anastomosis in Laparoscopic Right Colectomy
Advantages of laparoscopic right colectomy with intracorporeal anastomosis (IA) compared to extracorporeal anastomosis (EA) are widely studied.
- Conditions
- Colon Cancer, Colon Neoplasm, Malignant Neoplasm, Colon Neoplasia
- Trial name
- NCT05446558
- Testing
- Intracorporeal anastomosis, Extracorporeal anastomosis
- Where
- Spain
- Volunteers
- 140 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Liver Neoplasms, Sarcopenia
Impact of Sarcopenia on Postoperative Outcomes of Patients Undergoing Liver Resection
The investigators will investigate the impact of different biometric parameters (Body mass index, sarcopenia, lean muscle mass, hand-grip strength, gait speed, fat composition) on the postoperative outcomes of patients undergoing…
- Conditions
- Liver Neoplasms, Sarcopenia, Postoperative Complications
- Trial name
- NCT03630978
- Testing
- Liver resection
- Where
- Italy
- Volunteers
- 251 people, healthy volunteers welcome
- Sponsor
- San Camillo Hospital, Rome
Rectus Sheath Block, Transversus Abdominis Plane Block
Transversus Abdominis Plane and Rectus Sheath Block for Robotic Colectomy
This study aimed to evaluate the impact of ultrasound-guided bilateral transversus abdominis plane block combined with rectus sheath block on postoperative pain and recovery after robotic colectomy under an enhanced recovery…
- Conditions
- Rectus Sheath Block, Transversus Abdominis Plane Block, Enhanced Recovery After Surgery, Robotic Surgery
- Trial name
- NCT07624916
- Testing
- Ropivacaine, Saline
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Colorectal Surgery
Comparing Liposomal Bupivacaine Versus Standard Bupivacaine in Colorectal Surgery
The purpose of this study is to compare the difference between two different pain control methods in patients who will be having a colorectal surgery
- Trial name
- NCT03702621
- Testing
- liposomal Bupivacaine, Bupivacaine Hydrochloride
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Indiana University
Cancer of Colon, Surgery
Effect of Music Prehabilitation on Preoperative Anxiety Before Surgery
The goal of this multicenter randomized controlled trial is to investigate the effect of music prehabilitation on preoperative anxiety in patients undergoing elective oncological colorectal resection.
- Conditions
- Cancer of Colon, Surgery, Anxiety
- Trial name
- MU-PRIOR (NCT05982184)
- Testing
- Music
- Where
- 5 sites in Netherlands
- Volunteers
- 116 people
- Sponsor
- Erasmus Medical Center
Colon Cancer, Natural Orifice Transluminal Endoscopic Surgery
Feasibility and Safety of Hybrid Transvaginal Natural Orifice Transluminal Endoscopic Surgery for Colon Cancer
This study aims to evaluate the safety and efficacy of radical colectomy with hybrid transvaginal natural orifice transluminal endoscopic surgery (hvNOTES).
- Trial name
- NCT04048421
- Testing
- hvNOTES radical colectomy
- Where
- 6 sites in China
- Volunteers
- 55 people
- Sponsor
- Renmin Hospital of Wuhan University
Colorectal Cancer
Vaccine Therapy in Treating Patients With Stage II or Stage III Colon Cancer That Has Been Removed During Surgery
RATIONALE: Vaccines made from a patient's white blood cells and tumor cells may make the body build an immune response to kill tumor cells.
- Trial name
- NCT00016133
- Testing
- BCG vaccine, autologous tumor cell vaccine, fluorouracil
- Where
- 2 sites in United States
- Sponsor
- Intracel
Acute Diverticulitis, Stoma Colostomy
Surgical Italian Guide for the Management of Complicated Acute Diverticulitis Emergency Setting (SIGMA-D). A Prospective Observational Multicenter Study on Behalf of the Italian Society of Colorectal Surgery (SICCR).
This study will include data collected from surgical units performing emergency surgery in Italy during 2024, with a one-year follow-up period for each patient.
- Conditions
- Acute Diverticulitis, Stoma Colostomy, Stoma Ileostomy
- Trial name
- SIGMA-D (NCT06344078)
- Testing
- sigmoid resection and anastomosis / stoma
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- Societa Italiana di Chirurgia ColoRettale
Fasting, Immune Suppression
Effects of Fasting Strategies on Postoperative Recovery and Long-term Prognosis in Patients With Colorectal Cancer
In 2018, colorectal cancer is the third most common malignant tumor in terms of morbidity and second mortality in the world. Surgical resection is still the main treatment for colorectal cancer.With the introduction of the ERAS…
- Conditions
- Fasting, Immune Suppression, Complication of Surgical Procedure, Colorectal Cancer
- Trial name
- NCT04345978
- Testing
- Fasting hours
- Where
- 7 sites in China
- Volunteers
- 2,400 people
- Sponsor
- Fudan University
Peripheral Perfusion, Bowel Ischemia
Peripheral and Mesenteric Perfusion in Elective Surgical Patients
An important goal of haemodynamic monitoring and resuscitation is early detection of insufficient tissue perfusion and oxygenation.
- Conditions
- Peripheral Perfusion, Bowel Ischemia, Colorectal Surgery, Haemodynamic Instability
- Trial name
- NCT03395483
- Testing
- Haemodynamic monitoring
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Hvidovre University Hospital
Colorectal Surgery
Web-based Visit for Colorectal Surgery
The purpose of this study to evaluate how well an online format would work for the first post-operative visit after a patient undergoes colon and rectal surgery. This online format is integrated into Epic MyChart.
- Trial name
- Web-visit (NCT05084131)
- Testing
- Use of an online questionnaire as follow-up after abdominal colorectal surgery
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of Massachusetts, Worcester
Rectal Cancer
Fluorescence Molecular Endoscopy and Molecular Fluorescence-guided Surgery in Locally Advanced Rectal Cancer
Treatment of patients with locally advanced rectal cancer (LARC) is multidisciplinary and consists of neoadjuvant chemoradiotherapy (nCRT) followed by surgical removal of the rectal tumor and potentially tumor positive lymph…
- Trial name
- TRACT-II (NCT04638036)
- Testing
- Cetuximab-IRDye800, Fluorescent molecular endoscopy and surgery
- Where
- Netherlands
- Volunteers
- 11 people
- Sponsor
- University Medical Center Groningen
Rectal Cancer
Robotic Versus Laparoscopic Surgery for Middle and Low Rectal Cancer: a Target Trial Emulation
This study aims to compare the effectiveness of robotic surgery versus laparoscopic surgery in treating low rectal cancer. While robotic surgery has gained popularity, there is limited long-term evidence regarding its outcomes.
- Trial name
- NCT06814093
- Testing
- Robotic surgery, Laparoscopic surgery
- Where
- China
- Volunteers
- 2,702 people
- Sponsor
- Xu jianmin
Early Rectal Cancer, Large Rectal Adenomas
Endoscopic Submucosal Dissection Versus Transanal Endoscopic Microsurgery For Early Rectal Neoplasms And Large Rectal Adenomas: Сomparison Of Treatment Efficacy And Safety.
Transanal endoscopic microsurgery is the main treatment option for rectal tumors such as large adenoma, early cancer because of lower complications and mortality rates and shorter hospital stays rather than conventional surgery.
- Trial name
- NCT03718351
- Testing
- transanal endoscopic microsurgery, endoscopic submucosal dissection
- Where
- Russia
- Volunteers
- 236 people
- Sponsor
- State Scientific Centre of Coloproctology, Russian Federation
Colon Cancer, Rectal Cancer
Comparison of Two Bundles of Care to Reduce Surgical Site Infection in Colorectal Surgery (CCR-VINCat 2)
There is controversy about the maximum number of elements to be included in a surgical site infection (SSI) prevention bundle and the possibility of its implementation at a multi-center level.
- Conditions
- Colon Cancer, Rectal Cancer, Surgical Site Infection
- Trial name
- CCR-VINCat2 (NCT06244836)
- Testing
- Implementation of a bundle of care
- Where
- Spain
- Volunteers
- 32,205 people
- Sponsor
- Hospital de Granollers
Colorectal Neoplasms, Incisional Hernia
AP-NOSES: A Prospective Multicentre Registry of Natural Orifice Specimen Extraction in Minimally Invasive Colorectal Surgery
Natural orifice specimen extraction (NOSE) is a minimally invasive colorectal surgical technique in which the surgical specimen is removed through a natural orifice, including transanal or transvaginal routes, thereby avoiding an…
- Trial name
- AP-NOSES (NCT07615036)
- Testing
- Natural Orifice Specimen Extraction, Transabdominal Specimen Extraction
- Where
- Singapore
- Volunteers
- 800 people
- Sponsor
- Singapore General Hospital