Clinical trials: Surgery, Thoracic
Postoperative Pain
Comparison of Paravertebral Versus Epidural Block for Post-thoracotomy Pain Control
This is a randomized, assessor-blinded, non-inferiority clinical trial comparing continuous thoracic paravertebral block (BPV) versus continuous thoracic epidural block (BPD) for postoperative pain control in adult patients…
- Trial name
- NCT07763249
- Testing
- Continuous Thoracic Paravertebral Block, Continuous Thoracic Epidural Block
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Non Small Cell Lung Cancer, Lung Cancer
Phase II Lung Metcore - Preoperative Metformin for Lung Cancer
This is a phase II single centre open label single arm pre-operative window of metformin treatment in stage I-IIIa Non small cell lung cancer.
- Trial name
- Metcore (NCT03086733)
- Testing
- Metformin
- Where
- 2 sites in Canada
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Operative, Non Cardiac, Thoracic Disease
Comparison of Intra and Extraluminal Bronchial Blocker in Adults
The objective of this study is to evaluate the time and ease of placement of an extra-luminal Arndt bronchial blocker versus placing it intra-luminally.
- Trial name
- NCT02646813
- Testing
- Intraluminal Placement, Extraluminal Placement
- Volunteers
- 42 people
- Sponsor
- Wake Forest University Health Sciences
Pain, Postoperative, Pain, Chest
Ideal Initial Bolus and Infusion Rate for Erector Spinae Plane Block Catheters
This study would like to identify the best starting dose and infusion rate for nerve blocks and nerve catheters related to the erector spinae plane block that can improve functional status and pain control on cardiac surgery…
- Trial name
- NCT03961048
- Testing
- Ropivacaine 0.2%-Sodium Chloride 0.9% Injectable Solution bilaterally, Ropivacaine 0.2%-Sodium Chloride 0.9% Injectable Solution unilaterally
- Where
- United States
- Sponsor
- Virginia Commonwealth University
Video-assisted Thoracic Surgery, Pulmonary Nodules
Pulmonary Nodule Localization Prospective Validation
Localization is the key for successful excision of small target nodules under thoracoscopy, but the procedure also brings risks to patients. However, the criteria is still unclear.
- Trial name
- NCT04690790
- Testing
- Thoracoscopy
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- E-DA Hospital
Lung Neoplasms, Mixed Reality
Apple Vision Pro-Assisted Vascular Identification in Lung Surgery
This study is testing whether a new mixed-reality head-mounted display (Apple Vision Pro) can help surgeons see blood vessels more clearly during lung surgery.
- Trial name
- AVP-Lung (NCT07573748)
- Testing
- Apple Vision Pro
- Volunteers
- 20 people
- Sponsor
- The Second People's Hospital of Huai'an
Atrial Fibrillation, Pericardial Effusion
Active Clearance of Chest Tubes After Cardiac Surgery: A Prospective Randomized Controlled Study
The purpose of this study is to assess the effectiveness of the PleuraFlow® Active Tube Clearance (ATC) technology in reducing the rate of postoperative atrial fibrillation (POAF) among post cardiac surgery patients and to…
- Conditions
- Atrial Fibrillation, Pericardial Effusion, Pleural Effusion, Hemothorax
- Trial name
- NCT02808897
- Testing
- Standard drainage, Active Tube Clearance drainage
- Where
- 2 sites in Canada
- Volunteers
- 520 people, healthy volunteers welcome
- Sponsor
- Montreal Heart Institute
Chest Wall Disorder
Comparison of Analgesic Requirements in Patients Receiving Nuss Operation Using 2 Different Anesthetic Adjuvants
Nowadays, general anaesthesia is carried under "balanced anesthesia technique" in which many anesthetic adjuvants are used simultaneously, including opioid analgesics in order to reduce the amount of inhalation agents.
- Trial name
- ARNRD (NCT04073758)
- Testing
- Dexmedetomidine
- Where
- South Korea
- Volunteers
- 62 people
- Sponsor
- Jung Min Koo
Pain Management, Parasternal Block
Influence of Superficial Parasternal Intercostal Plane Block on Internal Thoracic Artery Caliber to Facilitate Surgical Harvesting in CABG
Influence of Superficial Parasternal Intercostal Plane Block (SPIPB) on Internal Thoracic Artery (ITA) Caliber and Surgical Harvesting Efficiency in Coronary Artery Bypass Grafting (CABG)
- Conditions
- Pain Management, Parasternal Block, CABG Graft Integrity
- Trial name
- IMA CABG PIPB (NCT07663435)
- Testing
- Bupivacaine
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
Thoracic Surgery, Postoperative Pulmonary Complications (PPCs)
Perioperative Inhaled Therapy in Carcinological Thoracic Surgery in Patients at High Risk of Postoperative Pulmonary Complications
The objective of the study is to evaluate, in a clinical trial, the efficacy of peri operative administration of long-acting inhaled ß-2 mimetics on the occurrence of postoperative pulmonary complications
- Trial name
- TICTAC (NCT06865040)
- Testing
- Formoterol Fumarate 12 mcg (Foradil Aerolizer), Usual treatment
- Where
- France
- Volunteers
- 266 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Pain, Postoperative
Erector Spinae Plane Block vs Erector Spinae Plane Block With Serratus Anterior Plane Block in Thoracic Surgery
This pilot study will prospectively compare continuous Erector Spinae Plane block (ESP) versus combination of continuous Erector Spinae Plane block and single shot Serratus Anterior Plane block for post-operative pain management…
- Trial name
- NCT04349774
- Testing
- Control Group - ESP block with SAP block, Treatment Group - ESP block with SAP normal saline
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Anna Uskova
Lung Cancer
Multimodal Prehabilitation to Enhance Functional Recovery After Lung Surgery
The investigators propose a randomized controlled study in patients undergoing lung resection for cancer to compare the impact of multimodal intervention composed of exercise, nutritional supplement and psychological well-being…
- Trial name
- NCT02938104
- Testing
- Whey Protein Isolate Powder, Physical Exercise Program, Relaxation Techniques
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Franco Carli
Diaphragmatic Plication, Diaphragmatic Paralysis
Short- and Long-term Effects of Robot-assisted Plication in Diaphragmatic Paralysis
Diaphragmatic paralysis may lead to severe symptoms such as breathlessness and reduced physical capacity. Diaphragmatic plication using Robotic-Assisted Thoracic Surgery (RATS) is a minimally invasive surgical technique developed…
- Conditions
- Diaphragmatic Plication, Diaphragmatic Paralysis, Diaphragmatic Eventration
- Trial name
- RAPIDLY (NCT06919185)
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Uppsala County Council, Sweden
Cerebral Small Vessel Diseases, Long Term Adverse Effects
Functional Prognosis of Post-operative Patients With Cerebral Small Vascular Disease(CSVD)
The investigators perform a retro-prospective exploratory cohort study among patients 65 to 85 years old with pre-operative head MRI result after thoracic surgery in Renji Hospital Affiliated to Shanghai Jiaotong University from…
- Trial name
- NCT05359588
- Where
- China
- Volunteers
- 212 people
- Sponsor
- RenJi Hospital
Surgery, Anesthesiology
Reducing Low-Value Preoperative Investigations in Patients Undergoing Low Risk Surgery
The purpose of this study is to evaluate if a multi-component behavioral intervention given to anesthesiologists and surgeons is associated with decreasing low value preoperative testing orders in patients undergoing low risk…
- Trial name
- Pre-Op (NCT05526495)
- Testing
- Reducing preoperative low-value test ordering
- Where
- 4 sites in Canada
- Volunteers
- 22 people
- Sponsor
- Ottawa Hospital Research Institute
Lung Cancer
Postoperative Pain After Single Port, Two Ports and Three Ports VATS Lobectomy
This single-center, prospective, randomized controlled trial was designed to assess and compare the postoperative pain after VATS lobectomy performed though one, two and three incisions.
- Trial name
- NCT03228056
- Testing
- pain intensity measured in VAS scale
- Where
- 2 sites in Poland
- Volunteers
- 90 people
- Sponsor
- Pulmonary Hospital Zakopane
Pain, Chest
Bilateral Pecto Intercostal Fascial Plane Block After Open Heart Surgeries
The objective is to test the effect of pecto intercostal fascial plane block (PIFB) as regard its impact on pain after sternotomy involved open heart surgery.
- Trial name
- PIFB (NCT04134637)
- Testing
- ultrasound, Bupivacaine Hydrochloride 5 MG/ML
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Fayoum University Hospital
Lung Cancer, Esophageal Cancer
Pilot Study of Allogeneic Tumor Cell Vaccine With Metronomic Oral Cyclophosphamide and Celecoxib in Patients Undergoing Resection of Lung and Esophageal Cancers, Thymic Neoplasms, and Malignant Pleural Mesotheliomas
Background: Certain types of lung, esophageal, or thymic cancers and mesotheliomas have specific antigens (protein molecules) on their surfaces.
- Conditions
- Lung Cancer, Esophageal Cancer, Malignant Pleural Mesothelioma, Sarcoma
- Trial name
- NCT01143545
- Testing
- Allogeneic Tumor Cell Vaccine (K562), Celecoxib, cyclophosphamide
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National Cancer Institute (NCI)
Thoracic Surgery, Pneumonectomy
Personalized Postoperative Pain Management Following Thoracic Surgery in Adults
The proposed research is an important extension of an ongoing perioperative personalized analgesia and intravenous opioid pharmacogenetic research.
- Conditions
- Thoracic Surgery, Pneumonectomy, Lobectomy, Segmentectomy
- Trial name
- NCT05525923
- Where
- 4 sites in United States
- Volunteers
- 200 people
- Sponsor
- OpalGenix, Inc
Lung Neoplasms, Erlotinib
Efficacy of Erlotinib in Neoadjuvant Setting in Patients With Stage IIIA, N2-positive Non-Small Cell Lung Cancer
This study propose neoadjuvant chemotherapeutic role by erlotinib.
- Conditions
- Lung Neoplasms, Erlotinib, Neoadjuvant Therapy
- Trial name
- NCT01130753
- Testing
- Erlotinib
- Where
- South Korea
- Volunteers
- 43 people
- Sponsor
- Samsung Medical Center
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