Clinical trials: Surgery, Thoracic
Postoperative Pain
Effects of Continuous Infusion of Intravenous Nefopam on Postoperative Pain and Opioid Consumption After VATS
This prospective, randomized, double-blinded study is designed to evaluate the postoperative analgesic effect of the continuous infusion of intravenous nefopam in patients undergoing video-assisted thoracic surgery (VATS).
- Trial name
- NCT04450355
- Testing
- Nefopam 80mg/day, Normal saline
- Where
- South Korea
- Volunteers
- 90 people
- Sponsor
- Seoul National University Hospital
Postoperative Pain Management in Video-Assisted Thoracoscopic Surgery
Intrathecal Morphine for Recovery and Outcomes After VATS
This study will compare two different methods of pain management in patients undergoing video-assisted thoracoscopic surgery (VATS).
- Trial name
- IMPROVE-VATS (NCT07231926)
- Testing
- Intrathecal Morphine, Serratus Anterior Plane Block (SAPB) group, Dexmedetomidine
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Ataturk University
Lung Cancer
Sensory Mapping and Thermal Thresholds After Thoracic Surgery
The study will investigate topography of sensory changes late after lung cancer surgery
- Trial name
- NCT01274858
- Where
- 2 sites in Denmark
- Volunteers
- 12 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Carcinoma, Lung Cancer
Monitoring of Circulating Tumor DNA and Its Aberrant Methylation in the Surveillance of Surgical Lung Cancer Patients (MEDAL, MEthylation Based Dynamic Analysis for Lung Cancer).
Conduct a prospective study to confirm the value of circulating tumor DNA and its aberrant methylation in longitudinal monitoring of surgical lung cancer patients.
- Conditions
- Carcinoma, Lung Cancer, NSCLC, Lung Neoplasm
- Trial name
- MEDAL (NCT03634826)
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking University People's Hospital
Thoracic Surgery
Analysis of Breath Sound During Thoracic Surgery
In modern thoracic surgery, double-lumen endobronchial tube (DLET) is the first choice for intubation. One lung ventilation can be perfectly performed by DLET, with the benefit of maintaining adequate gas exchange and…
- Trial name
- NCT05250635
- Testing
- electronic stethoscope
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Post Operative Pain, Acute
A Comparative Study Between Ultrasound Guided Thoracic Paravertebral Block VS Serrartus Anterior Muscle Block in VATS as Regard Their Effectiveness in Post-operative Analgesia
A comparative study between ultrasound guided thoracic paravertebral block VS ultrasound guided serrartus anterior muscle block in video-assisted thoracoscopic surgeries as regard their effectiveness in post-operative analgesia
- Trial name
- NCT05971368
- Testing
- thoracic paravertebal block, serratus anterior muscle block
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Thoracic Cancer
OFA in Thoracic Surgery
to investigate the efficacy and safety of opioid-free anesthesia for non-small-cell lung cancer resection and its underlying clinical value
- Trial name
- NCT05063396
- Testing
- opioid free anesthesia, Opioid-sparing anesthesia
- Where
- 2 sites in China
- Volunteers
- 60 people
- Sponsor
- Shanghai Zhongshan Hospital
Pain
Intravenous Lidocaine Infusion During Video-assisted Thoracic Procedures for Improved Pain Control
The purpose of this study is to determine whether intravenous lidocaine infusion during a video-assisted chest surgery is effective in reducing the pain involved after the surgery.
- Trial name
- NCT01277835
- Testing
- Lidocaine Infusion
- Where
- Canada
- Volunteers
- 48 people
- Sponsor
- University of Saskatchewan
Lung Cancer
Characterisation of Gut Microbiota, Bispectral Index Data and Plasma Kynurenine in Patients Undergoing Video-assisted Thoracic Surgery
The study is a case-controlled observational trial. Sixty patients will be divided into 2 groups (good or poor sleepers) depending on their first postoperative night Bispectral index data.
- Trial name
- NCT03985735
- Testing
- General anesthesia
- Where
- China
- Volunteers
- 20 people
- Sponsor
- China Medical University, China
Post Operative Pain
Post-Operative Kinesio Taping Impact on Pain in Thoracotomy vs Thoracoscopy
The project is of a comparative nature. It seeks to study pain reduction following two forms of chest surgery and compare results between both procedures. It will use kinesio taping as the studied pain reducer.
- Trial name
- NCT05200689
- Testing
- Kinesiotaping (KT)
- Where
- 5 sites in Egypt, Italy and 2 more
- Volunteers
- 310 people
- Sponsor
- Al-Quds University
One-Lung Ventilation, Obesity
Individualized vs Low PEEP in One Lung Ventilation
The aim of the prospective crossover study is to investigate the effect of individualized positive end-expiratory pressure (PEEP) on measures of tissue oxygenation, compared with low PEEP.
- Conditions
- One-Lung Ventilation, Obesity, Lung Diseases
- Trial name
- NCT03569774
- Testing
- One-lung ventilation with individualized PEEP, One-lung ventilation with low PEEP
- Where
- United States
- Sponsor
- Dionne Peacher
Lung Cancer
Combination Chemotherapy Followed by Radiation Therapy Before Surgery in Treating Patients With Stage IIIB NSCLC
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high energy x-rays to damage tumor cells.
- Trial name
- NCT00030810
- Testing
- Hyperfractionated, Taxotere/Cisplatin, conventional surgery
- Where
- Switzerland
- Volunteers
- 46 people
- Sponsor
- Swiss Cancer Institute
Non-small Cell Lung Cancer
CyberKnife Radiosurgical Treatment of Inoperable Early Stage Non-Small Cell Lung Cancer
The purpose of this study is to assess the short and long-term outcomes after CyberKnife stereotactic radiosurgery for early stage non-small cell lung cancer (NSCLC) in patients who are medically inoperable.
- Trial name
- NCT00643318
- Testing
- CyberKnife Stereotactic Radiosurgery
- Where
- 23 sites in United States, China
- Volunteers
- 40 people
- Sponsor
- Accuray Incorporated
Recurrent Non-small Cell Lung Cancer, Stage IIA Non-small Cell Lung Cancer
Hypofractionated Boost Before Chemoradiation for Patients With Stage II-III Non-small Cell Lung Cancer Unsuitable for Surgery
This phase II trial studies how well giving a hypofractionated boost to the primary tumor before standard chemotherapy and radiation therapy works in treating patients with stage II or III non-small cell lung cancer that cannot…
- Conditions
- Recurrent Non-small Cell Lung Cancer, Stage IIA Non-small Cell Lung Cancer, Stage IIB Non-small Cell Lung Cancer, Stage IIIA Non-small Cell Lung Cancer
- Trial name
- NCT02262325
- Testing
- hypofractionated radiation therapy, cisplatin, etoposide
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Aortic Surgery
Changes in Elastic Properties of Descending Thoracic Aorta After Ascending Aorta Replacement
The aim of our study was to evaluate the impact of aortic root replacement by a graft on the elastic properties of the descending thoracic aorta using cardiac Magnetic Resonance Imaging (MRI) and automatic post-processing.
- Trial name
- NCT03817008
- Testing
- Ascending aorta replacement with graft
- Volunteers
- 19 people
- Sponsor
- Centre Hospitalier La Chartreuse
Pulmonary Surgery
Erector Spinae Block, Epidural Analgesia and Intrathecal Analgesia in Thoracic Surgery
Pulmonary thoracic surgery is often responsible for severe postoperative pain, which is associated with an increase in postoperative morbidity and mortality.
- Trial name
- SPIRIT (NCT04147754)
- Testing
- Epidural anesthesia, Intrathecal morphine, Erector spinae block
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Angers
Valvular Heart Disease, Aortic Arch Aneurysm
The Effects of Intermittent Hypoxic-hyperoxic Preconditioning for Patients Undergoing Cardiopulmonary Bypass.
The aim of the study is to evaluate the effects of intermittent hypoxic-hyperoxic training (IHHT) to protect myocardium against perioperative myocardial injury during cardiac surgery using cardiopulmonary bypass.
- Conditions
- Valvular Heart Disease, Aortic Arch Aneurysm, Surgery
- Trial name
- NCT04833283
- Testing
- ReOxy Cardio device, intermittent hypoxic-hyperoxic training ( IHHT), ReOxy Cardio device
- Where
- Russia
- Volunteers
- 115 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Lung Neoplasms
Pre-operative Localization of Ground Glass Solitary Pulmonary Nodules
Objectives: The main drawback of the hook-wire technique for locating ground glass nodules before video assisted thoracoscopic surgery (VATS) resection is the risk of the hook dislodging during single lung ventilation as the lung…
- Trial name
- SLIDINGWIRE (NCT06195657)
- Where
- France
- Volunteers
- 54 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Pain, Hemodynamic Changes
Effect of Stress Ball During Chest Tube Removal After Open Heart Surgery
15 minutes before the procedure, nurses (FEÖ and NT) will explain and demonstrate how to use the stress ball. The stress ball will be applied for approximately five minutes, including the chest tube removal procedure.
- Conditions
- Pain, Hemodynamic Changes, Anxiety
- Trial name
- Stress ball (NCT07251270)
- Testing
- Stress ball
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Mersin University
Adenocarcinoma of the Lung, Adenosquamous Cell Lung Cancer
Image-Guided Hypofractionated Radiation Therapy With Stereotactic Body Radiation Therapy Boost and Combination Chemotherapy in Treating Patients With Stage II-III Non-Small Cell Lung Cancer That Cannot Be Removed By Surgery
This clinical trial studies image-guided hypofractionated radiation therapy (RT) when given together with hypofractionated RT boost and combination chemotherapy in treating patients with stage II-III non-small cell lung cancer…
- Conditions
- Adenocarcinoma of the Lung, Adenosquamous Cell Lung Cancer, Large Cell Lung Cancer, Recurrent Non-small Cell Lung Cancer
- Trial name
- NCT01345851
- Testing
- hypofractionated radiation therapy, laboratory biomarker analysis, image-guided radiation therapy
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Jonsson Comprehensive Cancer Center