Clinical trials: Surgery (Cardiac)
Coronary Artery Bypass
Neurocognitive Outcome After Coronary Artery Bypass Surgery Using Minimal Versus Conventional Extracorporeal Circulation
The aim of this study is to assess the effect of minimal (MECC) versus conventional (CECC) extracorporeal circulation on neurocognitive function after elective coronary bypass grafting (CABG) as well as whether this can be…
- Trial name
- NCT01213511
- Testing
- Coronary artery bypass grafting with the use of minimal extracorporeal circulation, Coronary artery bypass grafting under conventional extracorporeal circulation
- Where
- Greece
- Volunteers
- 64 people
- Sponsor
- AHEPA University Hospital
Coronary Artery Disease, Ischemic Heart Disease
Coronary Revascularization Outcomes Within Necessary Sex and Gender Aspects
The aim of this observational single-centre study is the optimization of coronary artery bypass grafting (CABG) tactics considering gender and sex approach on the basis of complex comparative evaluation of surgical…
- Conditions
- Coronary Artery Disease, Ischemic Heart Disease, Coronary Artery Bypass Grafting
- Trial name
- CROWN-SAGA (NCT06749171)
- Testing
- coronary artery bypass grafting
- Where
- Russia
- Volunteers
- 400 people
- Sponsor
- Federal State Budgetary Institution "Federal Center for Cardiovascular Surgery named after S.G. Sukh
Atrial Fibrillation, Cardiac Surgery
Assessing the Burden of Perioperative Atrial Fibrillation in Patients Undergoing Cardiac Surgery
Background and Significance: In the United States approximately 220,000 patients undergo cardiac surgery per annum. Among potential complications, the incidence of atrial fibrillation (AF) is estimated at 30 - 60 %, and therefore…
- Trial name
- NCT04880265
- Testing
- Vivalink wearable life sensors
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Brigham and Women's Hospital
Congenital Heart Disease, Cardiopulmonary Bypass
Influence of Lung Volume Optimization Maneuver on Cardiac Output and Lung Compliance in Ventilated Children With Congenital Heart Disease Undergoing Surgical Repair
The aim of this randomized interventional multi-center clinical trial is to determine whether a standardized lung volume optimization maneuver (LVOM), including PEEP titration, improves outcomes in children undergoing…
- Conditions
- Congenital Heart Disease, Cardiopulmonary Bypass, Mechanical Ventilation, Peep Titration in Lung Protective Ventilation
- Trial name
- ILOCO-CHD (NCT07486167)
- Testing
- End-expiratory lung volume optimization maneuver with PEEP titration, Standard Care (in control arm)
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Charite University, Berlin, Germany
Cardiovascular Disease, Vitamin D Deficiency
Acute Effect of Systemic Stress on Measured Blood Concentrations of 25 (OH) Vitamin D
Each patient who is admitted for preoperative preparation for elective open heart surgery at Intermountain Medical Center will be invited to participate in this study.
- Trial name
- ASSESS-D (NCT02460211)
- Testing
- Vitamin D3
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Intermountain Health Care, Inc.
Pain Measurement, Chronic Pain
Evaluation of Chronic Postsurgical Pain Risk in Patients Undergoing CIED Implantation Using an AID Support System
Chronic postsurgical pain (CPSP) remains a significant clinical and public health challenge despite major advances in surgical and anesthetic techniques.
- Conditions
- Pain Measurement, Chronic Pain, Cardiac Implantable Electrical Devices, Neuropathic Pain
- Trial name
- PAIN-AID (NCT07322900)
- Volunteers
- 180 people
- Sponsor
- Istanbul University - Cerrahpasa
Adrenal Insufficiency Neonatal
Impact of Pre-operative Steroids on Adrenal Insufficiency
Little is known regarding the incidence and clinical impact of AI in neonates during the acute postoperative period following separation from CPB.
- Trial name
- NCT02956707
- Testing
- No pre-operative steroids
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Alabama at Birmingham
Multiple Organ Dysfunction
Modulation of Microbiota Metabolism in Cardiac Surgery Patients
An imbalance in the microbiota (most often intestinal) largely determines the onset of a disease state, and often a critical state.
- Trial name
- MMMMODCS (NCT04921436)
- Testing
- cardiac surgery
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- Petrovsky National Research Centre of Surgery
Heart Defects, Congenital, Hypoplastic Left Heart Syndrome
Impact of Early Intervention on Maternal Stress in Mothers of Fetuses Diagnosed With Single Ventricle Physiology
This study evaluates maternal psychological distress and the impact of early palliative care team consultation on maternal anxiety and depression symptoms, coping, and quality of life/family functioning in the care of neonates…
- Conditions
- Heart Defects, Congenital, Hypoplastic Left Heart Syndrome, Single Ventricle Defect, Stress, Psychological
- Trial name
- NCT02462434
- Testing
- Early palliative care team consultation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Michigan
Coronary Artery Disease, Electro-Acupuncture
Electroacupuncture for Heart Protection: Clinical Application in Patients Undergoing Cardiac Bypass Surgery
Coronary artery disease (CAD) is the leading cause of death and disability in Singapore and worldwide. Many patients with multi-vessel CAD require surgical revascularisation by coronary artery bypass graft (CABG) surgery, and are…
- Trial name
- EA-CABG (NCT05514067)
- Testing
- Electro-Acupuncture
- Where
- Singapore
- Volunteers
- 10 people
- Sponsor
- National Heart Centre Singapore
Quality of Life
Quality of Life 12 Months After Cardiac Surgery
Cardiac surgical patients entering the hospital for operation were voluntarily recruited to participate a 12 month follow- up of health related quality of life (QOL)
- Trial name
- NCT05220111
- Testing
- Cardiac surgical operation (valve, aorta, coronary arteries)
- Volunteers
- 1,594 people
- Sponsor
- Tampere University Hospital
Cardiac Arrest, Perioperative Complication
The Factors Associated 30-day Mortality After Perioperative Cardiac Arrest in Adults Undergoing Non-cardiac Surgery.
Perioperative cardiac arrest (PCA) in patients undergoing noncardiac surgery is a rare but potentially catastrophic event associated with high mortality.
- Trial name
- NCT06712134
- Volunteers
- 105 people
- Sponsor
- Siriraj Hospital
Coagulopathy
Trial of RiaSTAP Versus Cryoprecipitate to Lower Operative Transfusions
The study aligns with the strategic plan of New York-Presbyterian Hospital (NYPH) to reduce allogeneic blood product use and decrease unnecessary laboratory costs.
- Trial name
- TOP-CLOT (NCT02540434)
- Testing
- ROTEM, Cryoprecipitate, RiaSTAP
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Weill Medical College of Cornell University
Aortic Diseases, Aortic Dissection
Proximal Aortopathy in Scotland - Epidemiology and Surgical Outcomes
The aorta is the principal arterial vessel arising from the left heart that transfers blood to the body. Certain genetic and familial disease processes are known to weaken the aortic wall resulting in dilation and potential…
- Conditions
- Aortic Diseases, Aortic Dissection, Aortic Aneurysm, Thoracic, Aortic Ectasia
- Trial name
- NCT05389865
- Testing
- Surgery on the proximal aorta (aortic root +/- ascending aorta), Patients diagnosed with thoracic aortopathy but not operated upon
- Where
- United Kingdom
- Volunteers
- 1,662 people
- Sponsor
- Golden Jubilee National Hospital
Heart Valve Diseases, Pulmonary Complication
Perioperative Rehabilitation of Cardiac Valvular Surgery
Approximately 70,000 cardiac valve surgeries are performed in China every year. Although guidelines or consensus recommendations recommend perioperative rehabilitation after valve surgery, clinical studies are still lacking…
- Trial name
- PORT (NCT03709511)
- Testing
- Cardiac rehabilitation
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Guangdong Provincial People's Hospital
Excessive Amount of Blood / Fluid Transfusion
Blood Transfusions in Coronary Artery Bypass Surgery
The hemolytic product free-hemoglobin (fHb) reduces nitric oxide (NO) bioavailability. The present study aims to establish whether transfusions of stored allogenic blood or intraoperative autologous salvaged blood result in…
- Trial name
- NCT02953951
- Testing
- blood transfusion
- Where
- Italy
- Volunteers
- 95 people
- Sponsor
- Universita di Verona
Coronary Artery Disease (CAD), Left Ventricular (LV) Systolic Dysfunction
Ketamine-lidocaine Versus Ketamine-fentanyl for Induction of Anesthesia in Patients With Left Ventricular Systolic Dysfunction Undergoing Elective Coronary Artery Bypass
This study compares ketamine/fentanyl versus ketamine/lidocaine in term of their impact on cerebral perfusion during CABG. No prior data address these effects, and the goal is to identify the induction regimen that better…
- Conditions
- Coronary Artery Disease (CAD), Left Ventricular (LV) Systolic Dysfunction, Induction Anesthesia, Coronary Bypass Graft Surgery
- Trial name
- NCT07248202
- Testing
- Fentanyl (IV), lidocaine
- Where
- Egypt
- Volunteers
- 48 people
- Sponsor
- Cairo University
Heart Failure, Systolic, Robotic Surgery
Cardiac Performance During Steep Trendelenburg Position in Patients Undergoing Robotic Surgery Surgery.
The field of robotic-assisted laparoscopic surgery increases all the time. Older and more fragile patients which are not suitable for major open surgery could be scheduled for robotic- assisted surgery.
- Trial name
- NCT06336746
- Testing
- Esophageal Doppler
- Where
- Sweden
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Karlstad Central Hospital
Patients With History of Ischemic Heart Disease With LV Dysfunction Undergoing Noncardiac Surgery
ACTIONS - Aortic Counterpulsation to Improve Outcomes in Noncardiac Surgery
The use of the IABP, in addition to standard care, in high-risk cardiac patients undergoing major noncardiac surgery is feasible and may result in improved perioperative outcomes at 30 days compared with standard care alone…
- Trial name
- ACTIONS (NCT01253356)
- Testing
- IABP
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Datascope Corp.
Cardiac Surgery Associated - Acute Kidney Injury, CKD (Chronic Kidney Disease) Stage 5D
Incidence and Prognostic of Cardiac Surgery-Associated Acute Kidney Injury: A Spanish Multicenter Study (SCARS-AKI)
To predict the renal damage caused by cardiac surgery in patients to try to mitigate it as soon as possible
- Conditions
- Cardiac Surgery Associated - Acute Kidney Injury, CKD (Chronic Kidney Disease) Stage 5D, Acute Kidney Injury, Acute Kidney Disease
- Trial name
- SCARS-AKI (NCT07370831)
- Testing
- CARDIAC SURGERY
- Where
- Spain
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Universidad de Oviedo