Clinical trials: Surgery for Colorectal Cancer.
Rectal Cancer
Randomized Prospective Trial for Laparoscopic vs Open Resection for Rectal Cancer
The investigators designed the randomized prospective trial of comparing open and laparoscopic resection in locally advanced rectal cancer after preoperative chemoradiation in order to determine the oncologic and functional…
- Trial name
- CTS-179 (NCT00470951)
- Testing
- open rectal resection, laparoscopic rectal resection
- Where
- South Korea
- Volunteers
- 340 people
- Sponsor
- National Cancer Center, Korea
Colorectal Cancer, Anastomotic Leak
Quantitative ICG Fluorescence Angiography in Colorectal Surgery
Fluorescence angiography with indocyanine green (ICG-FA) has gained increased popularity in colorectal surgery to check perfusion to the newly-formed anastomotic area and decrease the rate of postoperative anastomotic leakage.
- Trial name
- QUANTICO (NCT05153954)
- Testing
- Quantitative Indocyanine Green Fluorescence Angiography
- Where
- 2 sites in Denmark
- Volunteers
- 114 people
- Sponsor
- Zealand University Hospital
Colorectal Cancer
Capecitabine, Oxaliplatin, and Radiation Therapy in Treating Patients Who Are Undergoing Surgery for Stage I Rectal Cancer
RATIONALE: Drugs used in chemotherapy, such as capecitabine and oxaliplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00114231
- Testing
- capecitabine, oxaliplatin, neoadjuvant therapy
- Where
- 67 sites in United States
- Volunteers
- 90 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Prevention of Venous Thromboembolism
Rivaroxaban or Placebo for Extended Antithrombotic Prophylaxis After Laparoscopic Surgery for Colorectal Cancer.
Rivaroxaban or placebo for extended antithrombotic prophylaxis after laparoscopic surgery for colorectal cancer: a randomized, double blind, placebo-controlled study.
- Trial name
- PRO-LAPSII (NCT03055026)
- Testing
- Rivaroxaban
- Where
- 17 sites in Italy
- Volunteers
- 582 people
- Sponsor
- Fadoi Foundation, Italy
Rectal Cancer
Robotic Versus Laparoscopic Surgery for Middle and Low Rectal Cancer: a Target Trial Emulation
This study aims to compare the effectiveness of robotic surgery versus laparoscopic surgery in treating low rectal cancer. While robotic surgery has gained popularity, there is limited long-term evidence regarding its outcomes.
- Trial name
- NCT06814093
- Testing
- Robotic surgery, Laparoscopic surgery
- Where
- China
- Volunteers
- 2,702 people
- Sponsor
- Xu jianmin
Peritoneal Metastases from Colorectal Cancer
Systemic Antitumor Treatment with or Without Pressurized Intraperitoneal Aerosol Chemotherapy for Colon Peritoneal Metastases (PIPOX02)
The goal of this clinical trial is to learn if Pressurized intraperitoneal aerosol chemotherapy (PIPAC) significantly improve the progression-free survival (PFS) in patients with advanced peritoneal metastasis from colorectal…
- Trial name
- PIPOX02 (NCT06681038)
- Testing
- Standard Medical Therapy, PIPAC
- Where
- 15 sites in France
- Volunteers
- 114 people
- Sponsor
- Institut Cancerologie de l'Ouest
Rectum Cancer, Recurrent, Brachytherapy, Radioisotope
The Physical Dosimetry Study and Preliminary Clinical Results of 3D-printing Non Co-planar Template Assisted With CT-guidance for Iodine-125 Seed Brachytherapy in Pelvic Recurrent Rectum Carcinoma After Surgery and External Beam Radiotherapy
This study observes the efficacy and side effects of 3D-printing non co-planar template(3D-PNCT) assisted with CT-guidance for radioactive Iodine-125 seed(RIS) brachytherapy in pelvic recurrent rectum carcinoma retrospectively…
- Trial name
- NCT03890926
- Testing
- radioactive Iodine-125 seed implantation under the guidance of 3D template
- Volunteers
- 66 people
- Sponsor
- Peking University Third Hospital
Colorectal Cancer, Intestinal Obstruction
Randomized Trial of Colonic Stents as a Bridge to Surgery
The objective of this randomized controlled trial was to evaluate the role colonic self-expanding metal stent (SEMS) placement as a bridge to surgery in patients with acute malignant left-sided colonic obstruction.
- Trial name
- NCT00758186
- Testing
- Emergency endoscopic colonic stenting, Emergency surgery
- Where
- Singapore
- Volunteers
- 40 people
- Sponsor
- Singapore General Hospital
Colorectal Cancer, Gastric Cancer
Performing Laparoscopic Surgery for Colorectal and Gastric Cancer Outside the Primary Registered Medical Institution
This study investigates the safety and feasibility of performing laparoscopic surgery for colorectal and gastric cancer inside versus outside the primary registered medical institution under multi-sites practice (MSP) policy.
- Trial name
- NCT04834661
- Testing
- surgery inside the primary institution, surgery outside the primary institution
- Where
- China
- Volunteers
- 1,130 people
- Sponsor
- Shanghai Minimally Invasive Surgery Center
Colorectal Cancer, Ovarian Carcinoma
Intraperitoneal LSTA1 in CRS-HIPEC
This Study is designed to test an investigational product (IP) called LSTA1 (Study drug). LSTA1 is a drug designed to improve the delivery of anti-cancer treatments, such as chemotherapy.
- Conditions
- Colorectal Cancer, Ovarian Carcinoma, Appendix Cancer, Peritoneal Metastases
- Trial name
- NCT06216561
- Testing
- CRS-HIPEC + LSTA1, CRS-HIPEC alone
- Where
- United States
- Sponsor
- University of California, San Diego
Colorectal Cancer
Prospective Randomised Trial of Exercise and / or Antioxidants in COlorectal Cancer Patients Undergoing Surgery.
Colorectal cancer is the fourth most common cancer in the UK. Surgical resection is the mainstay of curative therapy. With the screening program enabling early detection, surgery plays an important role in treatment strategies.
- Trial name
- PEACOCS (NCT02264496)
- Testing
- Exercise
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Rectum Cancer
Machine Learning-based Surgical Guidance System for Robot-assisted Rectal Surgery
The aim of the study is to evaluate the technical feasibility and applicability of a surgical assistance system based on image recognition algorithms in a first-in-human pilot study.
- Trial name
- CoBot2 (NCT05652361)
- Testing
- Additional visualisation of surgical assistance during surgery
- Where
- Germany
- Volunteers
- 12 people
- Sponsor
- Technische Universität Dresden
Colonic Neoplasms
COlon Cancer Laparoscopic or Open Resection
COLOR trial is a randomized, international, multi center study comparing the outcomes of laparoscopic and conventional resection of colon carcinoma with curative intent.
- Trial name
- NCT00387842
- Testing
- Laparoscopic surgery, Conventional surgery
- Volunteers
- 1,200 people
- Sponsor
- Erasmus Medical Center
Colorectal Cancer, Surgery
Impact of a Multidisciplinary Approach in the Perioperative Geriatrics Unit on Functional Status of Patients Aged 70 and Over Operated on for Colorectal Cancer
Health establishments encourage the development of specific care pathways for the elderly by supporting Geriatric Peri-Operative Units (GPOU).
- Trial name
- DIGER (NCT05993923)
- Testing
- GPOU
- Where
- 4 sites in France
- Volunteers
- 90 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Colorectal Cancer, Comprehensive Transitional Care Program
A Pilot Randomized Trial of a Comprehensive Transitional Care Program for Colorectal Cancer Patients
The primary hypothesis is that a comprehensive transitional care program based on the premise of a patient-centered medical home versus routine care reduces emergency room visits and hospital readmissions without increasing costs…
- Trial name
- NCT02202096
- Testing
- Patient education: One-on-one visit, Discharge planning: Assessment of barriers to discharge, Medication reconciliation: Patient medication review
- Where
- United States
- Sponsor
- The University of Texas Health Science Center, Houston
Colorectal Cancer
Adjuvant Chemotherapy Combined With Huaier Granule for Treating High-risk Stage II, Stage III Colorectal Cancer
A randomized, paralleled control clinical study investigating Huaier Granule for prevention of recurrence and metastasis of colorectal cancer after radical surgery, to evaluate the efficacy and safety.
- Trial name
- NCT02785146
- Testing
- Huaier Granule, Oxaliplatin, Calcium folinate
- Where
- China
- Volunteers
- 230 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Rectal Cancer, Erectile Dysfunction
Stem Cell Therapy Combined With NeuroRegen Scaffold™ in Patients With Erectile Dysfunction After Rectal Cancer Surgery
Erectile dysfunction (ED) is one of the commonest complications in men after rectal cancer treatment. The purpose of this study is to assess the safety and efficacy of autologous bone marrow mononuclear cells (BMMCs) or…
- Trial name
- NCT02648386
- Testing
- Laparoscopic surgery, NeuroRegen scaffold transplantation, NeuroRegen scaffold/BMMCs transplantation
- Where
- China
- Volunteers
- 34 people
- Sponsor
- Chinese Academy of Sciences
Colorectal Cancer
Natural Orifice Specimen Extraction Surgery for Colorectal Cancer
The goal of this type of study: a prospective, randomized controlled clinical trial is to assess the safety and feasibility of NOSE surgery to compare the NOSE and conventional laparoscopy groups in Colorectal cancer patients.
- Trial name
- NOSE (NCT05740267)
- Testing
- Natural Orifice Specimen Extraction
- Volunteers
- 318 people
- Sponsor
- Chang Gung Memorial Hospital
Colonic Neoplasms, Laparoscopy
ERAS in Laparoscopic Surgery for Colorectal Cancer: Risk Factors for Delayed Recovery
Although there is evidence for reducing complication rate and improving recovery after the implementation of Enhanced Recovery After Surgery (ERAS) protocols into colorectal surgery, most published papers include patients…
- Conditions
- Colonic Neoplasms, Laparoscopy, Perioperative Care
- Trial name
- NCT02527967
- Where
- Poland
- Volunteers
- 143 people
- Sponsor
- Jagiellonian University
Colon Cancer, Natural Orifice Transluminal Endoscopic Surgery
Feasibility and Safety of Hybrid Transvaginal Natural Orifice Transluminal Endoscopic Surgery for Colon Cancer
This study aims to evaluate the safety and efficacy of radical colectomy with hybrid transvaginal natural orifice transluminal endoscopic surgery (hvNOTES).
- Trial name
- NCT04048421
- Testing
- hvNOTES radical colectomy
- Where
- 6 sites in China
- Volunteers
- 55 people
- Sponsor
- Renmin Hospital of Wuhan University