Clinical trials: Surgery for Colorectal Cancer.
Tumor Cells and Tumor Markers in Peritoneal Cavity
Intra-peritoneal Environmental Changes Following Surgery
The investigators hypothesize that the presence of tumor cells and tumor markers in peritoneal cavity are indicative for peritoneal spread during surgery, and may serve as early markers for systemic and/or intra-peritoneal…
- Trial name
- CRC (NCT02102074)
- Where
- 2 sites in Israel
- Volunteers
- 70 people
- Sponsor
- Meir Medical Center
Colorectal Cancer, Diverticular Disease
Precision Pain Management for Major Abdominal Surgery in Colorectal Surgery
The primary objectives of this study are to evaluate the potential for preoperative pharmacogenomics (PGx) testing to positively influence postoperative opioid use through visual analog scale (VAS) guided administration of…
- Conditions
- Colorectal Cancer, Diverticular Disease, Crohn Disease, Ulcerative Colitis
- Trial name
- PPaM (NCT03455751)
- Testing
- PGx-guided post-operative pain management
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- The Cleveland Clinic
Rectal Cancer
Comparison of Sphincter Preservation Surgery and Abdominoperineal Resection (APR): Prospective Clinical Trial
Sphincter preservation surgery in low rectal cancer has been increased due to better understanding of tumor biology and advances in surgical technology.
- Trial name
- ASPIRE (NCT01461525)
- Testing
- Abdominoperineal resection, Sphincter preservation surgery
- Where
- 6 sites in South Korea
- Volunteers
- 342 people
- Sponsor
- Seoul National University Hospital
Liver Cancer, Pancreas Cancer
PRIORITY-CONNECT 2 Pilot Trial
The provision of preoperative interventions (prehabilitation: including exercise, nutrition, and psychological treatment) have been reported to reduce postoperative complications by as much as 50% and reduce hospital stay by up…
- Conditions
- Liver Cancer, Pancreas Cancer, Oesophageal Cancer, Gastric Cancer
- Trial name
- NCT06212700
- Testing
- Preoperative Exercise, Postoperative Exercise, Preoperative Nutrition
- Where
- 2 sites in Australia
- Volunteers
- 20 people
- Sponsor
- Surgical Outcomes Research Centre (SOuRCe)
Colorectal Cancer
Natural Orifice Specimen Extraction Surgery for Colorectal Cancer
The goal of this type of study: a prospective, randomized controlled clinical trial is to assess the safety and feasibility of NOSE surgery to compare the NOSE and conventional laparoscopy groups in Colorectal cancer patients.
- Trial name
- NOSE (NCT05740267)
- Testing
- Natural Orifice Specimen Extraction
- Volunteers
- 318 people
- Sponsor
- Chang Gung Memorial Hospital
Colorectal Cancer, Liver Metastases
Prognostic Factors and Oncological Outcomes in Laparoscopic Liver Resection for CRLM
Laparoscopic liver resection (LLR) has gained acceptance as an effective treatment for colorectal liver metastases (CRLM) in selected patients, providing similar oncologic outcomes compared to open liver resection (OLR).
- Conditions
- Colorectal Cancer, Liver Metastases, Surgery
- Trial name
- NCT05036265
- Volunteers
- 200 people
- Sponsor
- General Hospital Groeninge
Colorectal Neoplasms, Neoplasm Metastasis
Resection Versus Microwave Ablation for Resectable Colorectal Cancer Liver Metastases
This single-center, prospective, randomized clinical trial is designed to compare the clinical characteristics and outcomes of hepatic resection and microwave ablation (MWA) to determine the optimal operative intervention for the…
- Conditions
- Colorectal Neoplasms, Neoplasm Metastasis, Hepatic Neoplasms
- Trial name
- NCT02866344
- Testing
- Microwave ablation, Hepatic resection
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Wake Forest University Health Sciences
Colon Neoplasms, Right Colon Tumors
Multicenter Prospective Study Protocol for Validating Surgical Quality Standards in D3 Lymphadenectomy for Oncological Right Hemicolectomy
Introduction: D3 lymphadenectomy (D3L) for right hemicolectomy, proposed by Eastern guidelines, aims to improve oncological outcomes by extending resection to include lymphatic drainage zones beyond those addressed by complete…
- Conditions
- Colon Neoplasms, Right Colon Tumors, Lymphadenectomy
- Trial name
- D3L (NCT07847216)
- Testing
- Right Colectomy & D3 Lymphadenectomy
- Volunteers
- 120 people
- Sponsor
- Fundació d'investigació Sanitària de les Illes Balears
Colorectal Cancer, Neoadjuvant Chemotherapy
Camrelizumab Combined With Neoadjuvant Chemotherapy After Stent Placement for Left-Sided Obstructive Colonic Cancer
Patients with obstruction are associated with worse oncologic outcomes compared with those having nonobstructive tumors. Conventionally, patients with malignant large bowel obstruction receive emergency surgery, with morbidity…
- Conditions
- Colorectal Cancer, Neoadjuvant Chemotherapy, Stent, Obstruction
- Trial name
- NACSOC-02 (NCT05202314)
- Testing
- Immunotherapy (Camrelizumab)
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Beijing Chao Yang Hospital
Rectal Cancer, Gender
Gender Differences in Robotic Surgery for Rectal Cancer: a Retrospective Study
Objective: To investigate gender-based differences in outcomes following robotic surgery for rectal cancer. Methods: A retrospective study was conducted on 155 patients (82 males, 73 females) who underwent robotic surgery for…
- Conditions
- Rectal Cancer, Gender, Complication,Postoperative, Surgery-Complications
- Trial name
- NCT06391060
- Testing
- Impact of Gender on Davinci rectal surgery
- Where
- China
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Daorong Wang
Cancer, Sigmoid, Cancer, Rectum
Effect of Endovascular Inferior Mesenteric Artery Embolization on Colonic Perfusion Prior to Rectal Surgery for Rectal Tumor or Sigmoid Colon Surgery
The investigators hypothesize that a primary embolization, 3-4 weeks before surgery, would allow development of vascular collaterality, in particular for the marginal artery which will ensure a better colonic perfusion.
- Trial name
- AMIREMBOL (NCT03628248)
- Testing
- embolization of the inferior mesenteric artery, Inferior mesenteric artery ligation
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Hereditary Breast and Ovarian Cancer Syndrome, Colorectal Neoplasms, Hereditary Nonpolyposis
Risk-Reducing Surgeries for Hereditary Ovarian Cancer
Based on studies of "Inherited Susceptible Genes Among Epithelial Ovarian Cancer" (NCT03015376, clinicaltrials.gov) and "Cohort Study of Universal Screening for Lynch Syndrome in Chinese Patients of Endometrial Cancer"…
- Conditions
- Hereditary Breast and Ovarian Cancer Syndrome, Colorectal Neoplasms, Hereditary Nonpolyposis, Ovariectomy, Hysterectomy
- Trial name
- NCT03294343
- Testing
- salpingo-oophorectomy only by laparoscopy, salpingo-oophorectomy with hysterectomy by laparoscopy, Follow-up
- Where
- China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Lei Li
Colorectal Cancer (Diagnosis), Laparoscopic Surgery
Superior HypogastrIc plExus bLock During Laparoscopic Colorectal Cancer Surgery
This trial seeks to assess the efficacy of a superior hypogastric plexus block for early quality of recovery after laparoscopic colorectal cancer surgery.
- Conditions
- Colorectal Cancer (Diagnosis), Laparoscopic Surgery, Superior Hypogastric Plexus Block
- Trial name
- SHIELDS (NCT07579780)
- Testing
- Superior hypogastric plexus block
- Where
- China
- Volunteers
- 170 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Colorectal Cancer
Lymphatic Mapping for Sentinel Node Identification and Analysis
The main objective of this study is to determine whether the first (sentinel) lymph nodes in the drainage pathway of colonic tumour can be detected at the time of surgery using a new technique.
- Trial name
- NCT01662752
- Testing
- Indocyanine green
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Imperial College London
Sigmoid Neoplasms
Five Year Oncological Outcome After CME for Sigmoid Colon Cancer
Study based in existing databases investigating the causal oncological treatment effects of complete mesocolic excision on UICC stage I-III sigmoid colon cancer
- Trial name
- NCT03774134
- Testing
- Complete mesocolic excision, Conventional colon resection
- Volunteers
- 920 people
- Sponsor
- Nordsjaellands Hospital
Rectal Cancer
Short-course Preoperative Chemoradiotherapy Followed by Delayed Operation for Locally Advanced Rectal Cancer
Concurrent chemoradiotherapy (CRT) Radiotherapy 25 ㏉/5 fractions (start concomitantly at D1) ↓ ↓ ↓ ↓ ↓ Radical surgery 6 weeks after completion of chemoradiotherapy ↑ ↑ ↑ ↑ ↑ D1 - - - - - D5 5-Fluorouracil 400㎎/㎡/day + LV…
- Trial name
- NCT01129700
- Testing
- Radiation: short-course preoperative chemoradiotherapy
- Where
- South Korea
- Volunteers
- 73 people
- Sponsor
- National Cancer Center, Korea
Colon Cancer
Laparoscopic Right Hemicolectomy With Transrectal Specimen Extraction for Colon Cancer
The purpose of this study is to investigate the preliminary surgical outcomes of laparoscopic right hemicolectomy with transrectal specimen extraction.
- Trial name
- NCT06362902
- Testing
- Laparoscopic right hemicolectomy with transrectal specimen extraction
- Where
- China
- Volunteers
- 37 people
- Sponsor
- National Cancer Center, China
Rectal Cancer
Evaluation of the Safety and the Efficacy of Transanal TME in Difficult Cases
The purpose of this study is evaluation of the safety and the efficacy of transanal total mesorectal excision in difficult case. Difficult case is defined as below; If any one of the following (1 or 2 or 3) 1. BMI: 30 or more 2.
- Trial name
- NCT02421432
- Testing
- Transanal total mesorectal excision
- Where
- South Korea
- Volunteers
- 12 people
- Sponsor
- National Cancer Center, Korea
Recurrent Colon Cancer, Recurrent Rectal Cancer
2 Phase Comparison of Pre-operative CT and PET Images for Metastatic Colorectal Cancer
This pilot phase II studies how well computed tomography (CT) and positron emission tomography (PET) imaging works in detecting disease in patients undergoing surgery for metastatic colorectal cancer.
- Conditions
- Recurrent Colon Cancer, Recurrent Rectal Cancer, Stage IV A Bladder Cancer, Stage IV A Rectal Cancer
- Trial name
- NCT01821105
- Testing
- PET Scan, CT Scan, fludeoxyglucose F 18
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Malignant Abdominal Neoplasm, Malignant Pelvic Neoplasm
Heated Intra-peritoneal Chemotherapy With Doxorubicin and Cisplatin for Abdominal for Pelvic Tumors in Pediatric Patients
This early phase I trial studies how well heated intra-peritoneal chemotherapy with doxorubicin and cisplatin work for the treatment of abdominal or pelvic tumors that can be removed by surgery (resectable), does not respond to…
- Conditions
- Malignant Abdominal Neoplasm, Malignant Pelvic Neoplasm, Recurrent Colon Carcinoma, Recurrent Desmoplastic Small Round Cell Tumor
- Trial name
- TOASTIT (NCT04213794)
- Testing
- Cisplatin, Cytoreductive Surgery, Doxorubicin
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Mayo Clinic