Clinical trials: Surgery for Colorectal Cancer.
Urinary Catheters, Rectal Cancer
Tamsulosin for Early Catheter Removal After Rectal Cancer Surgery
This study aims to systematically evaluate the safety and efficacy of different early urinary catheter removal strategies following radical resection of mid-low rectal cancer.
- Conditions
- Urinary Catheters, Rectal Cancer, Urinary Retention
- Trial name
- NCT07346586
- Testing
- Tamsulosin group, 24-Hour Removal Group, 48-Hour Removal Group
- Where
- 2 sites in China
- Volunteers
- 1,545 people
- Sponsor
- The First Hospital of Jilin University
Rectal Cancer
Robotic-assisted Versus Conventional Laparoscopic Approach for Rectal Cancer Surgery
This is a prospective randomized controlled study that was conducted on patients of both sexes and definite age group at National Cancer Institute-Egypt and with adenocarcinoma of the rectum located within 15 cm from the anal…
- Trial name
- NCT03589131
- Testing
- Total Operative time, Margin assessment, Conversion rate to open surgery
- Volunteers
- 57 people
- Sponsor
- National Cancer Institute, Egypt
Department of Anorectal Surgery, Changhai Hospital Affiliated to Naval Medical University
A Randomized, Controlled, Multicenter, Noninferiority Clinical Study of Perioperative and Oncological Safety in Patients With Rectal Cancer
Laparoscopic natural orifice specimen extraction surgery (NOSES) for low rectal cancer has a good minimally invasive effect. However, the NOSES prognosis studies are all small sample retrospective studies.
- Trial name
- NCT05503381
- Testing
- Laparoscopic radical resection of low rectal cancer with transanal specimens
- Volunteers
- 500 people
- Sponsor
- Changhai Hospital
Rectal Cancer, Colon Cancer
Trial on Mechanical Bowel Preparation in Laparoscopic Colorectal Surgery
This is a Randomized trial on Mechanical Bowel Preparation in Laparoscopic Colorectal Surgery. In this trial patients with left sided colon and rectal tumors were randomized to receive mechanical bowel preparation or no…
- Trial name
- MBP (NCT01797770)
- Testing
- polyethylene glycol, No Preparation
- Where
- India
- Volunteers
- 90 people
- Sponsor
- PVS Memorial Hospital
Colo-rectal Cancer
Total Neoadjuvant Treatment Without Surgery For Locally Advanced Rectal Cancer
NO-CUT is a one-stage phase II trial seeking to establish whether an oxaliplatin-based chemotherapy preceding standard neo-adjuvant fluoropyrimidines-based chemo radiotherapy, can safely spare demolitive surgical intervention in…
- Trial name
- NO-CUT (NCT03565029)
- Testing
- XELOX, Radiotherapy
- Where
- Italy
- Volunteers
- 180 people
- Sponsor
- Niguarda Hospital
Colorectal Cancer
Intra-operative Chemotherapy With 5-FU for Colorectal Cancer Patients Receiving Curative Resection: Efficacy and Safety
The purpose of this study is to investigate efficacy and safety of intra-operative chemotherapy with 5-FU for colorectal cancer patients receiving curative resection.
- Trial name
- IOCCRC (NCT01465451)
- Testing
- curative resection for colorectal cancer, intra-operative 5-FU chemotherapy
- Where
- China
- Volunteers
- 695 people
- Sponsor
- Sun Yat-sen University
Colonic Neoplasms
Laparoscopic Surgery VS Laparoscopic Surgery + Neoadjuvant Chemotherapy for T4 Tumor of the Colon Cancer
Primary Outcome Measures: Disease free survival Secondary Outcome Measures: Overall survival Adverse events (Mortality, morbidity) The proportion of completion of Laparoscopic Surgery Estimated Enrollment: Oct, 2016 Study Start…
- Trial name
- NCT02777437
- Testing
- XELOX or FOLFOX chemotherapy
- Volunteers
- 1,960 people
- Sponsor
- Fudan University
Colorectal Cancer
Rectal Reconstruction in Treating Patients Who Are Undergoing Surgery for Rectal Cancer
RATIONALE: Rectal reconstruction after surgery to treat rectal cancer may help patients keep some of their bowel function. It is not yet known which method of rectal reconstruction is most effective after surgery.
- Trial name
- NCT00238381
- Testing
- 5 cm colon-J-pouch, side-to-end anastomosis, straight coloanal anastomosis
- Where
- 18 sites in Germany, Switzerland
- Volunteers
- 336 people
- Sponsor
- Swiss Cancer Institute
Colorectal Disorders, Colorectal Neoplasms
Value of Butyrylcholinesterase as a Marker of Surgical Site Infection Following Surgery for Colorectal Diseases
Butyrylcholinesterase (BChE) is an α-glycoprotein synthesized in the liver. BchE's serum level decreases in many clinical conditions such as acute and chronic liver damage, inflammation, injury and infections, and malnutrition.
- Trial name
- NCT04748744
- Testing
- Butyrylcholinesterase
- Where
- Greece
- Volunteers
- 400 people
- Sponsor
- University Hospital of Patras
Cancer Colon
The Efficacy Of Complete Mesocolic Excision With Central Vessel Ligation Technique On Lymph Nodes And Safety Margins Compared With Conventional Surgery For Colon Cancer Treatment
Cancer Colon is one of the major public health problems worldwide. Complete eradication of the tumor with no recurrence or residual masses is a challenge which faces all the surgeons and medical staff all over the world.
- Trial name
- NCT04079946
- Testing
- Total Mesocolic Excision with Central Vessel Ligation, conventional surgery of cancer colon
- Volunteers
- 40 people
- Sponsor
- Assiut University
Lung Neoplasms, Breast Neoplasms
PERCIST Criteria for Response Evaluation With Solid Tumors
Chemo-radiotherapy and targeted therapy are widely used as non-surgical treatments for solid tumors. Early assessment of treatment response is considered efficient and helpful to clinical management and personalized…
- Conditions
- Lung Neoplasms, Breast Neoplasms, Colonic Neoplasms, Lymphoma
- Trial name
- NCT02765620
- Testing
- drug&radiation
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Rectal Cancer
Robotic Versus Laparoscopic Approach for Rectal Cancer Surgery
Colorectal cancer is a common malignancy in Viet Nam. Laparoscopic surgery becomes a standard treatment in many centers. Today, robotic surgery is a new option for treating colorectal cancer with some advantages such as magnified…
- Trial name
- NCT03931980
- Testing
- Robotic-assisted rectal cancer resection and Laparoscopic rectal cancer resection
- Where
- Vietnam
- Volunteers
- 100 people
- Sponsor
- Binh Dan Hospital
Colorectal Neoplasm, Effects of Radiation Therapy
Randomized Trial of Primary Surgery Followed Selective Radiochemotherapy for Rectal Cancer With MRI Negative CRM
The purpose of this study is to determine whether primary radiotherapy can be omitted for the locally advanced rectal cancer with Magnetic Resonance Imaging (MRI) negative circumferential margin.
- Conditions
- Colorectal Neoplasm, Effects of Radiation Therapy, Effects of Chemotherapy, Surgery
- Trial name
- PSSR (NCT02121405)
- Testing
- Rectectomy, Radiotherapy, Capecitabine
- Where
- 7 sites in China
- Volunteers
- 350 people
- Sponsor
- Zhejiang University
Large Bowel Cancer
Effects of Different Strategy of Fluids Administration on Acid/Base Disorders and Inflammatory Mediators
Aim of the study is to ascertain whether a different strategy of fluids administration can be responsible of differences in terms of acid/base disorders (Stewart approach), pro-inflammatory and inflammatory mediators.
- Trial name
- NCT01320891
- Testing
- balanced solutions, not balanced
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Università degli Studi di Ferrara
Rectal Cancer
Timing to Minimally Invasive Surgery After Neoadjuvant Chemoradiotherapy for Rectal Cancer
The trial is a multicenter, prospective, randomized controlled, unblinded, parallel-group trial comparing standard and delayed surgery after neoadjuvant chemoradiotherapy for the curative treatment of rectal cancer.
- Trial name
- TiMiSNAR (NCT03465982)
- Testing
- Surgery after 8 weeks from chemoradiation treatment, Surgery after 12 weeks from chemoradiation treatment
- Where
- 14 sites in Italy
- Volunteers
- 340 people
- Sponsor
- Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria
Localized Colon Carcinoma, Stage IIB Colon Cancer AJCC v8
Immunotherapy (Toripalimab) for Reducing Recurrence Risk After Surgery for Mismatch Repair Deficient Stage IIB, IIC, or III Colon Cancer
This phase II trial tests how well immunotherapy (toripalimab) works for reducing the risk of cancer recurrence after surgery in patients with mismatch repair deficient stage IIB, IIC, or III colon cancer.
- Conditions
- Localized Colon Carcinoma, Stage IIB Colon Cancer AJCC v8, Stage IIC Colon Cancer AJCC v8, Stage III Colon Cancer AJCC v8
- Trial name
- NCT07140679
- Testing
- Biopsy Procedure, Biospecimen Collection, Colonoscopy
- Where
- 5 sites in United States
- Volunteers
- 40 people
- Sponsor
- Emory University
Colon Cancer
Performance of the Water-Enema Computed Tomography (WE-CT)
The WE-CT is an innovative and easy practice imaging technique of colon tumors; it is based on the colon distension by a high volume of warm water and a multidetector CT acquisition after IV (intravenous) contrast, allowing image…
- Trial name
- NCT00188110
- Testing
- Water-Enema Computed Tomography
- Where
- 5 sites in France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Angers
Stage III Colon Cancer
Cytokine-induced Killer Cell Immunotherapy for Surgical Resected Stage III Colorectal Cancer Patients After Chemotherapy
We hypothesize through this randomized, prospective, single center adjuvant study, that cytokine-induced killer cell in patients with stage III colon cancer can improve survival in this patient population over control.
- Trial name
- NCT02280278
- Testing
- Radical surgery, Adjuvant chemotherapy, Cytokine-induced killer cell immunotherapy
- Where
- China
- Volunteers
- 550 people
- Sponsor
- Sun Yat-sen University
Colon Cancer, Inflammatory Bowel Diseases
Spinal Analgesia for Colonic Resection Using an Enhanced Recovery After Surgery (ERAS) Program
This is a blinded randomized controlled trial in patients undergoing laparoscopic colon surgery. The aim of this study is to assess whether spinal analgesia with a mixture of bupivacaine and morphine provides better pain relief…
- Conditions
- Colon Cancer, Inflammatory Bowel Diseases, Diverticulitis
- Trial name
- NCT01477190
- Testing
- Spinal analgesia, Patient Control Analgesia (PCA) Morphine
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Anastomotic Leakage, Colorectal Cancer
Predictive Factors for Anastomotic Leakage After Colorectal Surgery
Rationale: Colorectal cancer is the fourth most common cause of cancer death worldwide, estimated to be responsible for almost 610,000 deaths in 2008.
- Conditions
- Anastomotic Leakage, Colorectal Cancer, Anastomotic Leak, Colorectal Neoplasms
- Trial name
- REVEAL (NCT02347735)
- Testing
- No interventions, only data collection
- Where
- 4 sites in Netherlands
- Volunteers
- 774 people
- Sponsor
- Maastricht University Medical Center