Clinical trials: Surgery for Colorectal Cancer.
Colon Cancer
Response to Immunotherapy in MMR-deficient Localized Colon Cancer
The aim of this study is to evaluate the safety and efficacy of neoadjuvant treatment with pembrolizumab before colonic resection in patients with early-stage (I-III) deficient mismatch repair (dMMR) colon cancer (CC).
- Trial name
- RESET-C (NCT05662527)
- Testing
- Pembrolizumab
- Where
- Denmark
- Volunteers
- 85 people
- Sponsor
- Camilla Qvortrup
Colon Cancer, Colon Neoplasm
Geriatric Assessment and Intervention in Older Patients Undergoing Surgery for Colorectal Cancer
The GEPOC study investigates the effect of comprehensive geriatric assessment and intervention for frail older patients (65 years or older) undergoing elective surgery for colorectal cancer.
- Conditions
- Colon Cancer, Colon Neoplasm, Frail Elderly Syndrome, Colorectal Cancer
- Trial name
- GEPOC (NCT03719573)
- Testing
- Geriatric intervention
- Where
- Denmark
- Volunteers
- 67 people
- Sponsor
- Herlev and Gentofte Hospital
Rectal Cancer
Randomized Controlled Trial of the SurgDiff Model for Predicting Surgical Difficulty to Help Choose Approach in Mid-Low Rectal Cancer
This study aims to investigate the feasibility of utilizing the SurgDiff surgical difficulty prediction model to assist surgeons in formulating precise surgical plans.
- Trial name
- NCT07761169
- Testing
- AI-assisted decision-making
- Volunteers
- 68 people
- Sponsor
- Peking Union Medical College Hospital
Colorectal Cancer, Surgery
Incremental Cost-Utility Study on Prehabilitation Among Older Patients With Colorectal Cancer Undergoing Surgery
A prospective multicenter observational cost-utility study following older or high-risk patients with colorectal cancer with and without prehabilitation before surgery.
- Trial name
- PreColo CU (NCT04097795)
- Testing
- Prehabilitation
- Where
- 5 sites in Netherlands
- Volunteers
- 72 people
- Sponsor
- Radboud University Medical Center
Colorectal Neoplasms, Neoplasm Metastasis
New Adjuvant Chemotherapy of Asymptomatic Resectable Primary Lesion With Unresectable Liver-limited Metastases
To evaluate the survival benefit of pre-operation chemotherapy of primary tumor tesection (PTR) compared upfront PTR for colorectal cancer (CRC) patients with an asymptomatic resectable primary tumor and synchronous unresectable…
- Conditions
- Colorectal Neoplasms, Neoplasm Metastasis, Liver Neoplasms, Chemotherapy; Maternal, Affecting Fetus
- Trial name
- NCT01307878
- Testing
- chemotherapy ± targeted therapy
- Where
- China
- Volunteers
- 320 people
- Sponsor
- Fudan University
Anastomosis, Leaking
Anastomotic Leak in Covid-19
evaluate the incidence of anastomotic leak after colorectal surgery
- Trial name
- NCT06663033
- Testing
- colorectal surgery
- Where
- Egypt
- Volunteers
- 390 people
- Sponsor
- Zagazig University
Rectal Cancer
Effectiveness and Safety Study on Different Timing of Preventive Ileostomy Closure After Surgery for Rectal Cancer
The purpose of this study is to evaluate the appropriate timing to do preventive ileostomy closure after total mesorectal excision of rectal cancer.
- Trial name
- NCT02665026
- Testing
- stoma closure at different times
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Huashan Hospital
Colonic Neoplasms
Laparoscopic Surgery for T4 Tumor of the Colon Cancer
The purpose of this study is to compare the short- and long-term survival of laparoscopic surgery and conventional open surgery for T4 colon cancer.
- Trial name
- NCT02852915
- Testing
- Laparoscopic surgery
- Volunteers
- 1,960 people
- Sponsor
- LI XIN-XIANG
Colorectal Cancer, Anesthesia
Effects of Dexmedetomidine/Lidocaine/Intrathecal Morphine on Cancer Metastasis Biomarker After Colorectal Surgery
This is a prospective randomized controlled trial. Investigators aimed to compare the effect of three different anesthetic adjuvants (continuous infusion of lidocaine or dexmedetomidine, intrathecal morphine injection) on the…
- Conditions
- Colorectal Cancer, Anesthesia, Cancer Metastatic, Inflammation
- Trial name
- NCT05742438
- Testing
- Lidocaine IV, Dexmedetomidine IV, intrathecal morphine
- Where
- South Korea
- Volunteers
- 114 people
- Sponsor
- Samsung Medical Center
Colon Cancer
Complete Mesocolic Excision With Central Vessel Ligation Compared With Conventional Surgery for Colon Cancer
The aim of this study is to compare between complete mesocolic excision with central vascular ligation and conventional surgery of colon cancer regarding number of harvested lymph nodes, surgical outcome and complications.
- Trial name
- NCT02526836
- Testing
- Conventional Surgery, Complete mesocolic excision with central vascular ligation
- Where
- 2 sites in Egypt, Italy
- Volunteers
- 40 people
- Sponsor
- Mansoura University
Rectum Cancer, Faecal Incontinence
Exploring the Effect of Colonic J-pouch in Anorectal Preservation Surgery for Ultra-low Rectal Cancer.
The occurrence of colorectal cancer has increased from the third most common cancer in 2018 to the second most common cancer in 2023.
- Conditions
- Rectum Cancer, Faecal Incontinence, Faecal Incontinence with Faecal Urgency, Low Anterior Resection Syndrome
- Trial name
- NCT06601985
- Testing
- J-pouch anastomosis, direct anastomosis
- Where
- China
- Volunteers
- 154 people
- Sponsor
- Shanghai 10th People's Hospital
Breast Neoplasms, Colonic Neoplasms
Cancer and Anesthesia: Survival After Radical Surgery - a Comparison Between Propofol or Sevoflurane Anesthesia
The purpose of this study is to determine whether anesthesia maintained with propofol results in better one- and five-year-survival than anesthesia maintained with sevoflurane.
- Conditions
- Breast Neoplasms, Colonic Neoplasms, Rectal Neoplasms
- Trial name
- CAN (NCT01975064)
- Testing
- Propofol, Sevoflurane
- Where
- 15 sites in China, Poland and 1 more
- Volunteers
- 5,774 people
- Sponsor
- Uppsala University
Peritoneal Metastases From Colorectal Cancer
Patient-tailored Hyperthermic Intraperitoneal Chemotherapy (HIPEC) for Colorectal Peritoneal Metastases (OrganoHIPEC)
The objective of this clinical trial is to demonstrate that cytoreductive surgery and patient-tailored hyperthermic intra-peritoneal chemotherapy (HIPEC) will increase efficacy in controlling peritoneal disease.
- Trial name
- OrganoHIPEC (NCT06057298)
- Testing
- Patient-tailored hyperthermic intraperitoneal chemotherapy (HIPEC)
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Colorectal Neoplasm, Circadian Rhythm Sleep Disorder
Sleep and Survival in Colorectal Cancer
Objective The objective of the current trial is to investigate the effect of perioperative sleep and circadian rhythm on the natural course of survival among patient diagnosed with colorectal cancer.
- Conditions
- Colorectal Neoplasm, Circadian Rhythm Sleep Disorder, Depression, Quality of Life
- Trial name
- NCT03254836
- Testing
- Standard of care
- Where
- Denmark
- Volunteers
- 45 people
- Sponsor
- Zealand University Hospital
Rectum Cancer, Recurrent, Brachytherapy, Radioisotope
The Physical Dosimetry Study and Preliminary Clinical Results of 3D-printing Non Co-planar Template Assisted With CT-guidance for Iodine-125 Seed Brachytherapy in Pelvic Recurrent Rectum Carcinoma After Surgery and External Beam Radiotherapy
This study observes the efficacy and side effects of 3D-printing non co-planar template(3D-PNCT) assisted with CT-guidance for radioactive Iodine-125 seed(RIS) brachytherapy in pelvic recurrent rectum carcinoma retrospectively…
- Trial name
- NCT03890926
- Testing
- radioactive Iodine-125 seed implantation under the guidance of 3D template
- Volunteers
- 66 people
- Sponsor
- Peking University Third Hospital
Lower Abdominal Surgery, Pelvic Surgery
Objective to Evaluate the Safety and Effectiveness of LED Light Source System for Endoscopy in Ureteral Radiography
This clinical trial is a prospective, multi-center, single-blind, parallel, randomized controlled superiority clinical trial. The trial will be carried out in 5 centers, involving 120 subjects as estimated who will be divided…
- Trial name
- IRIS (NCT04561414)
- Testing
- LED light source system for endoscope, Ureteral stent (Cook Ireland Ltd.)
- Where
- 4 sites in China
- Sponsor
- Stryker Orthopaedics
Colorectal Cancer, Colonic Neoplasms
Single-incision Versus Conventional Laparoscopic Surgery for Colorectal Cancer
This study is designed to evaluate the short-term and long-term results after single incision laparoscopic surgery for colorectal cancer（SILSC） compared with conventional laparoscopic surgery for colorectal cancer（CLSC）.
- Conditions
- Colorectal Cancer, Colonic Neoplasms, Rectal Neoplasms, Colon Disease
- Trial name
- mSILSC (NCT03633539)
- Testing
- Single-incision Laparoscopic Surgery, Conventional Laparoscopic Surgery
- Where
- China
- Sponsor
- Ruijin Hospital
Colorectal Cancer
Use a Wearable Devices to Observe Complications of Mobilization for Colorectal Cancer After Surgery
This study aims to help patients recover faster after colorectal cancer surgery by using wearable devices to monitor early movement.
- Trial name
- NCT07289685
- Where
- Taiwan
- Volunteers
- 192 people
- Sponsor
- Chang Gung Memorial Hospital
Colorectal Cancer, Colon Cancer
Oncologic Outcomes of Single-incision Versus Conventional Laparoscopic Surgery for Colorectal Cancer
This study is designed to investigate long-term oncologic outcomes of single-incision laparoscopic surgery (SILS) compared to conventional laparoscopic surgery (CLS) for colorectal cancer.
- Conditions
- Colorectal Cancer, Colon Cancer, Rectal Cancer
- Trial name
- CSILS (NCT04527861)
- Testing
- Single-incision Laparoscopic Surgery, Conventional Laparoscopic Surgery
- Where
- 11 sites in China
- Volunteers
- 710 people
- Sponsor
- Ruijin Hospital
Gastrointestinal Cancers, Gastrointestinal Cancers - Stomach
Safety and Efficacy of NOM and OPFS Versus RO for dMMR/MSI-H or POLE-Mutated Gastrointestinal Cancers
Purpose: The purpose of this study is to evaluate the safety and efficacy of Non-Operative Management (NOM) and Organ Preservation First Strategy (OPFS) compared with Radical Operation (RO) in patients with deficient mismatch…
- Conditions
- Gastrointestinal Cancers, Gastrointestinal Cancers - Stomach, Gastrointestinal Cancers - Colorectal, Gastrointestinal Cancers - Anus
- Trial name
- NOR-MP (NCT07642323)
- Testing
- NOM/OPFS
- Volunteers
- 22 people
- Sponsor
- Peking University Cancer Hospital & Institute