Clinical trials: Surgery of Breast Cancer
Breast Cancer
Toxicity Outcomes of Simultaneous Integrated Boost in Adjuvant Breast Radiotherapy Acronym
This prospective study systematically evaluates toxicity outcomes in breast cancer patients treated with adjuvant radiotherapy using the simultaneous integrated boost (SIB) technique after breast-conserving surgery.
- Trial name
- SIB (NCT07407192)
- Testing
- Adjuvant Breast Radiotherapy With Simultaneous Integrated Boost (SIB)
- Where
- Slovenia
- Volunteers
- 93 people
- Sponsor
- Institute of Oncology Ljubljana
Breast Cancer
Trial of AVB-620 in Women With Primary, Non-Recurrent Breast Cancer Undergoing Surgery
This is a Phase 1, open-label, dose escalation study in women with primary, non-recurrent breast cancer undergoing surgery. AVB-620 will be administered prior to surgery.
- Trial name
- NCT02391194
- Testing
- AVB-620
- Where
- 3 sites in United States
- Volunteers
- 27 people
- Sponsor
- Avelas Biosciences, Inc.
Breast Cancer, Mastectomy; Lymphedema
Examining the Cosmetic Results, Quality of Life and Patient Satisfaction Achieved With Skin Reducing Nipple Sparing Mastectomy and Implant Based Breast Reconstruction, and Comparing it to Classic Skin- Sparing Mastectomy and Implant- Based Breast Reconstructive Surgeries
This is a response-adaptive (RAR) prospective randomized study with a long-term follow-up and the aim of this clinical study is to measure with qualitative and quantitative indicators the changes in cosmetic results, quality of…
- Conditions
- Breast Cancer, Mastectomy; Lymphedema, Quality of Life, Patient Satisfaction
- Trial name
- NCT04345081
- Testing
- Skin Reducing Nipple Sparing Mastectomy and Implant Based Breast Reconstruction, Skin- Sparing Mastectomy and Implant- Based Breast Reconstructive Surgery
- Where
- Hungary
- Volunteers
- 110 people
- Sponsor
- National Institute of Oncology, Hungary
Breast Cancer Female
Validation of Prone Crawl Radiotherapy for Whole-breast Irradiation After Breast Conserving Surgery
The aim of this study is to validate the obtained results of setup precision, comfort and setup time. The possibility of using breath hold for heart sparing in combination with prone crawl position will be tested.
- Trial name
- NCT05179161
- Testing
- Prone crawl positioning
- Volunteers
- 40 people
- Sponsor
- University Hospital, Ghent
Breast Cancer
Intraoperative Margin Assessment in Breast Cancer With HSI-Raman
Breast-conserving surgery (lumpectomy) aims to remove cancer while preserving healthy tissue, but up to 20% of patients require a second operation because cancer cells remain at the edge (margin) of the removed tissue.
- Trial name
- Spectra-BREAST (NCT07111728)
- Testing
- Spectra-BREAST system in Invasive Breast Cancer, Spectra-BREAST system in DCIS Breast Cancer
- Where
- Italy
- Volunteers
- 104 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Breast Cancer, Postoperative Sore Throat, Cough, Hoarseness
Hyaluronic Acid for Prevention of Post-Intubation Sore Throat and Hoarseness
The goal of this clinical trial is to find out whether applying Endotra Gel, a hyaluronic acid-based gel, to the endotracheal tube can help reduce sore throat and hoarseness after surgery.
- Conditions
- Breast Cancer, Postoperative Sore Throat, Cough, Hoarseness, Endotracheal Intubation, General Anesthesia
- Trial name
- NCT07040631
- Testing
- Endotra Gel
- Where
- South Korea
- Volunteers
- 132 people
- Sponsor
- Pusan National University Yangsan Hospital
Invasive Breast Cancer, Ductal Carcinoma in Situ of the Breast
Axillary Reverse Mapping (ARM) Technique
The purpose of this pilot study is to compare a new surgical technique (axillary reverse mapping) to standard axillary surgery in patients diagnosed with invasive or in situ breast cancer.
- Trial name
- ARM (NCT03109522)
- Testing
- axillary reverse mapping (ARM), Standard axillary surgery (SLNB or ALND)
- Where
- 2 sites in Canada
- Volunteers
- 130 people
- Sponsor
- McMaster University
Breast Cancer
Cosmetic and Functional Outcomes After Breast Conserving Surgery
The initial aesthetic and functional conditions are recorded with the help of the Breast Cancer Treatment Outcome Scale (BCTOS),an international validated questionnaire, and the Breast Cancer Conservative Treatment - cosmetic…
- Trial name
- NCT01496001
- Testing
- Lumpectomy, axillary block dissection, breast conserving surgery, Radiotherapy
- Where
- Hungary
- Volunteers
- 300 people
- Sponsor
- National Institute of Oncology, Hungary
Breast Cancer
Combination Chemotherapy Before Surgery in Treating Women With Breast Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells and shrink tumors so they can be removed during…
- Trial name
- NCT00008034
- Testing
- capecitabine, cyclophosphamide, epirubicin hydrochloride
- Where
- Switzerland
- Volunteers
- 15 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Early-Stage Breast Carcinoma
Surgical Trial to Evaluate the Impact of a Lymphoscintigraphy Prior to Sentinel Node Biopsy in Early Breast Cancer
Sentinel node biopsy is a well established tool for axillary staging in early breast cancer. So far the impact of a preoperative lymph node scintigraphy is unclear.
- Trial name
- NCT02481128
- Testing
- without preoperative access to lymphoscintigraphy findings
- Where
- 23 sites in Germany, Switzerland
- Volunteers
- 1,198 people
- Sponsor
- Kliniken Essen-Mitte
Survival Outcomes
Effectiveness of Surgery for Improving Survival in Oligometastatic Breast Cancer Patients
Breast cancer is the most common malignancy in women, with stage IV disease at diagnosis in 5-10% of cases. Oligometastatic breast cancer (OMBC), defined as limited metastases (≤3-5 in ≤1-2 organs), may have better outcomes.
- Trial name
- SASI-MBC (NCT07586319)
- Testing
- surgery in accordance with current clinical guidelines, modified radical mastectomy or breast conservation surgery
- Where
- Pakistan
- Volunteers
- 110 people
- Sponsor
- Sharif Medical Research Center
Breast Cancer Survivors
The Effect of Myofascial Chain Release Techniques on Shoulder Joint Range of Motion in Breast Cancer Survivors
In breast cancer patients, limitation of shoulder joint movement occurs following mastectomy surgery. Studies have reported that damage to the fascia on the pectoralis major muscle during mastectomy surgery contributes to the…
- Trial name
- NCT05386628
- Testing
- conventional physiotherapy, Manual lymphatic drainage, Myofascial relasing
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Istanbul Medeniyet University
Breast Ductal Carcinoma In Situ
A Vaccine (H2NVAC) Before Surgery for the Treatment of HER2-Expressing Ductal Carcinoma In Situ
This phase Ib trial studies the side effects and best dose of a vaccine called H2NVAC before surgery in treating patients with HER2 expressing ductal carcinoma in situ.
- Trial name
- NCT04144023
- Testing
- Granulocyte-Macrophage Colony-Stimulating Factor, Multi-epitope HER2 Peptide Vaccine H2NVAC, Therapeutic Conventional Surgery
- Where
- 2 sites in United States
- Volunteers
- 43 people
- Sponsor
- Mayo Clinic
Breast Cancer
Analysis of Surgery in Patients Presenting With Stage IV Breast Cancer
The purpose of this study is to study patients presenting with stage IV breast cancer. Stage IV means that the breast cancer has spread to another part of the body outside the breast.
- Trial name
- NCT00941759
- Where
- 20 sites in United States
- Volunteers
- 100 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Body Weight, Breast Neoplasms
Ventilation Efficacy of Size 3 or Size 4 I-gel in Female Patient Weighing 50 to 60 Kilograms
Currently, the main method for selecting an i-gel® size is based on the body weight recommendation (30-60 kg for size 3 and 50-90 kg for size 4) according to the manufacturer's recommendation.
- Conditions
- Body Weight, Breast Neoplasms, Laryngeal Masks
- Trial name
- NCT03528590
- Testing
- size 3 i-gel supraglottic airway device, size 4 i-gel supraglottic airway device
- Where
- Taiwan
- Volunteers
- 98 people
- Sponsor
- National Taiwan University Hospital
Postoperative Analgesia, Hand Strength
Long-term Outcomes of Breast Cancer Patients After Wound Infiltration Analgesia
In the study that was conducted from 05.01.2009 - 31.12.2012. 120 patients were examined. By drawing random numbers, the patients were randomized into 3 groups for postoperative analgesia: 1. Diclofenac 2 mg/kg/day - control, 2.
- Conditions
- Postoperative Analgesia, Hand Strength, Health Related Quality of Life, Chronic Shoulder Pain
- Trial name
- NCT05829707
- Testing
- Diclofenac Sodium, Levobupivacaine bolus analgesia, Levobupivacaine PCA group
- Volunteers
- 120 people
- Sponsor
- Osijek University Hospital
Ductal Breast Carcinoma in Situ
Surgical Excision vs Neoadjuvant Radiotherapy+Delayed Surgical Excision of Ductal Carcinoma
The purpose of this pilot study is to compare by pathological findings surgical excision versus neoadjuvant radiotherapy followed by delayed surgical excision of ductal carcinoma in situ (DCIS)
- Trial name
- NORDIS (NCT03909282)
- Testing
- Lumpectomy, Partial breast irradiation prior to surgery
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Stanford University
Adenocarcinoma of the Gastroesophageal Junction, HER2-positive Breast Cancer
Akt Inhibitor MK2206, Lapatinib Ditosylate, and Trastuzumab in Treating Patients With Locally Advanced or Metastatic HER2-Positive Breast , Gastric, or Gastroesophageal Cancer That Cannot Be Removed By Surgery
This phase I trial studies the side effects and best dose of Akt inhibitor MK2206 and lapatinib ditosylate when given together with trastuzumab in treating patients with locally advanced or metastatic human epidermal growth…
- Conditions
- Adenocarcinoma of the Gastroesophageal Junction, HER2-positive Breast Cancer, Male Breast Cancer, Recurrent Breast Cancer
- Trial name
- NCT01705340
- Testing
- Akt inhibitor MK2206, trastuzumab, lapatinib ditosylate
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National Cancer Institute (NCI)
Breast Tissue Accessory, Breast Cancer
Motiva Flora Tissue Expander PMCF
The Motiva Flora® Tissue Expander clinical study (hereafter Motiva Flora® TE study) is a 6-month, open-label, prospective, multicentre post-marketing follow-up study designed to confirm the Safety and Effectiveness/Performance of…
- Trial name
- NCT05447988
- Testing
- Breast Tissue Expander
- Where
- 5 sites in Chile, Costa Rica and 2 more
- Volunteers
- 136 people
- Sponsor
- Establishment Labs
Breast Cancer
PEAK PlasmaBlade™ 4.0 Versus Traditional Electrosurgery in Lumpectomy
The purpose of this clinical study is to quantify the difference in thermal injury depth at the surgical margin in breast lumpectomy specimens excised with the PlasmaBlade; to subjectively assess histopathologic sample quality…
- Trial name
- PRECISE (NCT00960154)
- Testing
- PEAK PlasmaBlade, Traditional Electrosurgery with scalpel
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Medtronic Surgical Technologies
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