Clinical trials: Surgery of Breast Cancer
Breast Cancer
Radiation Therapy in Treating Older Women Who Are Undergoing Surgery for Stage I or Stage II Breast Cancer
RATIONALE: Radiation therapy uses high-energy x rays to kill tumor cells. Giving radiation therapy after surgery may kill any tumor cells that remain after surgery.
- Trial name
- GERICO03 (NCT00104702)
- Testing
- adjuvant therapy, conventional surgery, radiation therapy
- Where
- 10 sites in France
- Volunteers
- 46 people
- Sponsor
- UNICANCER
Anatomic Stage IV Breast Cancer American Joint Committee on Cancer (AJCC) v8, Metastatic Breast Carcinoma
Testing Whether Treating Breast Cancer Metastases With Surgery or High-Dose Radiation Improves Survival
This randomized phase II/III trial studies how well standard of care therapy with stereotactic radiosurgery and/or surgery works and compares it to standard of care therapy alone in treating patients with breast cancer that has…
- Conditions
- Anatomic Stage IV Breast Cancer American Joint Committee on Cancer (AJCC) v8, Metastatic Breast Carcinoma, Metastatic Malignant Neoplasm in the Bone, Metastatic Malignant Neoplasm in the Liver
- Trial name
- NCT02364557
- Testing
- Stereotactic Body Radiotherapy, Surgery
- Where
- 162 sites in United States, Canada and 2 more
- Volunteers
- 129 people
- Sponsor
- NRG Oncology
Stage 0 Breast Cancer AJCC v6 and v7, Stage I Breast Cancer AJCC v7
Alternative Dosing of Exemestane Before Surgery in Treating Postmenopausal Patients With Stage 0-II Estrogen Positive Breast Cancer
This phase IIb trial studies how well alternative dosing of exemestane before surgery works in treating in postmenopausal patients with stage 0-II estrogen positive breast cancer.
- Conditions
- Stage 0 Breast Cancer AJCC v6 and v7, Stage I Breast Cancer AJCC v7, Stage IA Breast Cancer AJCC v7, Stage IB Breast Cancer AJCC v7
- Trial name
- NCT02598557
- Testing
- Exemestane, Laboratory Biomarker Analysis, Pharmacological Study
- Where
- 5 sites in United States, Italy
- Volunteers
- 180 people
- Sponsor
- National Cancer Institute (NCI)
Breast Cancer
Triptorelin in Preventing Early Menopause in Premenopausal Women Who Are Receiving Chemotherapy for Stage I, Stage II, or Stage III Breast Cancer That Has Been Removed By Surgery
RATIONALE: Chemotherapy may cause early menopause in premenopausal women. Triptorelin may prevent this from happening. PURPOSE: This randomized phase III trial is studying triptorelin to see how well it works in preventing early…
- Trial name
- NCT00311636
- Testing
- cyclophosphamide, docetaxel, doxorubicin hydrochloride
- Where
- 18 sites in Italy
- Volunteers
- 280 people
- Sponsor
- Gruppo Italiano Mammella (GIM)
Breast Cancer
Cosmetic and Functional Outcomes After Breast Conserving Surgery
The initial aesthetic and functional conditions are recorded with the help of the Breast Cancer Treatment Outcome Scale (BCTOS),an international validated questionnaire, and the Breast Cancer Conservative Treatment - cosmetic…
- Trial name
- NCT01496001
- Testing
- Lumpectomy, axillary block dissection, breast conserving surgery, Radiotherapy
- Where
- Hungary
- Volunteers
- 300 people
- Sponsor
- National Institute of Oncology, Hungary
Breast Cancer Surgery
Localization of Breast Cancer with the Sirius Pintuition Magnetic Seed
A prospective pilot study in the Czech Republic examining the use of magnetic seed Sirius Pintuition for the localization of non-palpable malignant breast tumors and pathological lymph nodes.
- Trial name
- NCT06799858
- Testing
- Breast cancer localisation with magnetic seed Sirius Pintuition
- Where
- Czechia
- Volunteers
- 40 people
- Sponsor
- Jan Žatecký
Pain, Postoperative, Disability Physical
Effects of Interpectoral-Pectoserratus Plane Block After Breast Cancer Surgery
The aim of this study: It was aimed to observe the effects of intraoperative and preoperative PECS II block on postoperative pain, amount of analgesic use and shoulder joint range of motion in patients who underwent breast cancer…
- Conditions
- Pain, Postoperative, Disability Physical, Quality of Life
- Trial name
- NCT05568589
- Testing
- Preoperative Interpectoral - Pectoserratus Plane Block, Intraoperative Interpectoral - Pectoserratus Plane Block, Non Block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Izmir Bakircay University
Breast Cancer
Preoperative Breast Magnetic Resonance Imaging for Patients Undergoing Mammoplasty
all female with operable breast cancer seeking health care at general surgery department Assiut university hospitals,and decision of therapeutic mammoplasty was taken depending on clinical examination, findings on mammography and…
- Trial name
- NCT03173469
- Testing
- magnetic resonance imaging of breast
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Assiut University
Carcinoma Breast
Ten Years Results of a Score System to Address Adjuvant Therapies After Breast Conserving Surgery for Ductal Carcinoma in Situ of the Breast
By this non-randomized prospective study, it's evaluated the outcome of patients underwent BCS for DCIS at whom an established score system to address adjuvant therapies have been prospectively applied, according to the wideness…
- Trial name
- DCIS (NCT03002766)
- Testing
- Breast conservative surgery
- Where
- Italy
- Volunteers
- 224 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8
Concurrent WOKVAC Vaccination, Chemotherapy, and HER2-Targeted Monoclonal Antibody Therapy Before Surgery for the Treatment of Patients With Breast Cancer
This phase II trial studies the immunologic response and side effects of using the WOKVAC vaccine in combination with chemotherapy and HER2-targeted monoclonal antibody therapy before surgery in treating patients with breast…
- Conditions
- Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8
- Trial name
- NCT04329065
- Testing
- pUMVC3-IGFBP2-HER2-IGF1R Plasmid DNA Vaccine, Paclitaxel, Trastuzumab
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Washington
Metastatic Breast Cancer
Systemic Therapy With or Without Upfront Surgery in Metastatic Breast Cancer
SUBMIT is a clinical trial that intends to answer the question whether up front breast surgery in patients with primary distant metastatic breast cancer will result in an improvement of the 2-year survival compared to the…
- Trial name
- SUBMIT (NCT01392586)
- Testing
- upfront breast surgery, systemic therapy
- Where
- 26 sites in Netherlands
- Volunteers
- 10 people
- Sponsor
- Jeroen Bosch Ziekenhuis
Cancer Breast, Hypovitaminosis D
Influence of Preoperative Vitamin D Level on Postoperative Pain in Breast Cancer Surgery Patients
Vitamin D deficiency is a general problem that vigorously affects human health . Breast cancer is the most frequently diagnosed life-threatening cancer in women and the leading cause of cancer death among women.Vitamin D…
- Trial name
- NCT06551688
- Testing
- Serum 25(OH)D level
- Where
- Egypt
- Volunteers
- 184 people
- Sponsor
- Fayoum University
Breast Cancer
Capecitabine and Paclitaxel (Albumin-Stabilized Nanoparticle Formulation) in Treating Women Undergoing Surgery for Stage II or Stage III Breast Cancer
RATIONALE: Drugs used in chemotherapy, such as capecitabine and paclitaxel (albumin-stablized nanoparticle formulation, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them…
- Trial name
- NCT00397761
- Testing
- capecitabine, paclitaxel albumin-stabilized nanoparticle formulation, neoadjuvant therapy
- Where
- United States
- Sponsor
- Medstar Health Research Institute
Lymphedema, Lymphedema Arm
Lymphovenous Anastomosis for Breast Cancer Lymphedema
This multi-center cohort study focuses on evaluating the efficacy of lymphovenous anastomosis (LVA) for treating pitting lymphedema in female breast cancer survivors.
- Conditions
- Lymphedema, Lymphedema Arm, Breast Cancer Lymphedema, Lymphedema, Secondary
- Trial name
- NCT06302361
- Testing
- Lymphovenous anastomosis (LVA)
- Where
- Denmark
- Volunteers
- 47 people
- Sponsor
- Odense University Hospital
Breast Cancer, Breast Adenocarcinoma
Definitive Radiation Therapy for Inoperable Breast Cancer
The purpose of this study is to find out if adding radiation therapy to routine medications for breast cancer helps in reducing and preventing the cancer from getting worse.
- Trial name
- DEFINE (NCT07122713)
- Testing
- Whole breast radiation with simultaneous integrated boost (WB-SIB) to primary breast tumor, Whole breast radiation with simultaneous integrated boost (WB-SIB) to primary breast tumor and ipsilateral axillary lymph nodes
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Alexander Stessin
Breast Cancer
Intraoperative Margin Assessment in Breast Cancer With HSI-Raman
Breast-conserving surgery (lumpectomy) aims to remove cancer while preserving healthy tissue, but up to 20% of patients require a second operation because cancer cells remain at the edge (margin) of the removed tissue.
- Trial name
- Spectra-BREAST (NCT07111728)
- Testing
- Spectra-BREAST system in Invasive Breast Cancer, Spectra-BREAST system in DCIS Breast Cancer
- Where
- Italy
- Volunteers
- 104 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Tumors, Breast
Exploratory Study of Safety and ex Vivo Fluorescence of BLZ-100 in Adult Subjects With Solid Tumors Undergoing Surgery
Surgery is the primary treatment modality for many types of cancer and the extent of surgical resection is directly related to patient survival.
- Trial name
- NCT02496065
- Testing
- BLZ-100
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Blaze Bioscience Inc.
Pain, Pain Management
Evaluating The Efficacy Of Pecs II Blockade Compared To Local Anesthetic Infiltration In Controlling Postoperative Pain In Patients Undergoing Oncologic Breast Surgery Under Opioid Free/Sparing Anesthesia.
Breast cancer is the malignant neoplasm with the highest incidence in women in Brazil, with the exception of non-melanoma skin tumors.
- Conditions
- Pain, Pain Management, Anesthesia
- Trial name
- pain (NCT06889870)
- Testing
- Pectoral Nerve Block, Local Anesthesia
- Where
- Brazil
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Faculdade de Ciências Médicas de Minas Gerais
Astrocytoma, Brain Cancer
Dose Escalation Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of QBS10072S
This is a multi-center, open-label, dose escalation study to determine the safety, tolerability, pharmacokinetics, pharmacodynamics, and maximum tolerated dose (MTD) of QBS10072S in patients with advanced or metastatic cancers…
- Conditions
- Astrocytoma, Brain Cancer, Brain Metastases, Bladder Cancer
- Trial name
- NCT04430842
- Testing
- QBS10072S
- Where
- 2 sites in Australia
- Volunteers
- 15 people
- Sponsor
- Quadriga Biosciences, Inc.
Invasive Breast Cancer, Mastectomy, Segmental
Digital Breast Tomosynthesis (DBT) to Improve Assessment of Resection Margins in Invasive Breast Cancer
The challenge of breast conserving surgery (BCS) is to obtain free resection margins, by removing the invasive tumor and the precursor cells: DCIS (Ductal Carcinoma in Situ).
- Conditions
- Invasive Breast Cancer, Mastectomy, Segmental, Margins of Excision
- Trial name
- DBT (NCT04478669)
- Where
- Denmark
- Volunteers
- 250 people
- Sponsor
- Aarhus University Hospital
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