Clinical trials: Surgery of Breast Cancer
Breast Cancer
Preoperative Magnetic Resonance Imaging to Obtain Adequate Resection Margins in Breast Conserving Surgery, (PRIMAR) Trial
The goal of this randomised study is to investigate if a supplementary preoperative breast Magnetic Resonance Imaging (MRI) improves the assessment of breast cancer and can help surgical planning such that sufficient resection…
- Trial name
- PRIMAR (NCT05825768)
- Testing
- Breast MRI, standard breast imaging
- Where
- 2 sites in Denmark
- Volunteers
- 227 people
- Sponsor
- Aarhus University Hospital
Breast Cancer
Chemotherapy Plus Surgery in Treating Women With Breast Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining surgery with chemotherapy may kill more tumor cells.
- Trial name
- NCT00003013
- Testing
- CMF regimen, cyclophosphamide, doxorubicin hydrochloride
- Where
- 28 sites in Austria, Czechia and 9 more
- Volunteers
- 450 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Breast Cancer, Anesthesia
Opioid-free Anaesthesia in Breast Cancer Surgery
Background: Various analgesic modalities are adopted for perioperative analgesia in breast cancer surgeries. Opioid-free and opioid-sparing techniques are gaining popularity due to the lack of opioid-dependent undesirable…
- Conditions
- Breast Cancer, Anesthesia, Pain, Postoperative, Pain, Chronic
- Trial name
- NCT06404983
- Testing
- Opioid Free Anaesthesia (OFA), Conventional General Anaesthesia (CGA)
- Where
- Greece
- Volunteers
- 200 people
- Sponsor
- University of Ioannina
Breast Cancer
Impact of Regional Anesthesia on Chronic Post-operative Pain
Approximately 55,000 cases of breast cancer are diagnosed in Italy every year and the first-line therapy for carcinoma in situ, stage I, II and IIIA is surgical removal of the tumour.
- Trial name
- IRACPoP (NCT05876390)
- Testing
- Breast surgery, analgesia
- Where
- Italy
- Volunteers
- 1,500 people
- Sponsor
- Niguarda Hospital
Breast Cancer, Colorectal Cancer
Prospective Collection of Surplus Surgical Tumor Tissues and Pre-surgical Blood Samples
The study is intended to collect specimens to support the application of genome analysis technologies, including large-scale genome sequencing.
- Conditions
- Breast Cancer, Colorectal Cancer, Lung Cancer, Prostate Cancer
- Trial name
- GBCPRT0008 (NCT01792882)
- Where
- United States
- Sponsor
- Global BioClinical
Breast Cancer
DHEA in Treating Women Undergoing Surgery for Stage I, Stage II, or Stage III Breast Cancer
RATIONALE: Dehydroepiandrosterone (DHEA) may slow the growth of tumor cells and be an effective treatment for women with breast cancer.
- Trial name
- NCT00972023
- Testing
- DHEA, Surgical resection
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Barbara Ann Karmanos Cancer Institute
Breast Cancer Patient
Evaluation in the Treatment of Neuropathic Pain Post Breast Surgery
Breast cancer is the most common cancer in women in Europe. Therefore, breast cancer has become a chronic disease and patients need to learn to live with it as well as with the adverse effects related to the disease itself or to…
- Trial name
- CAPTRANE (NCT03794388)
- Testing
- Capsaicin, Pregabalin
- Where
- 11 sites in France
- Volunteers
- 140 people
- Sponsor
- Institut Cancerologie de l'Ouest
Breast Cancer
Surgery to Remove the Sentinel Lymph Node and Axillary Lymph Nodes After Chemotherapy in Treating Women With Stage II, Stage IIIA, or Stage IIIB Breast Cancer
RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00881361
- Testing
- systemic chemotherapy, axillary lymph node dissection, neoadjuvant therapy
- Where
- 324 sites in United States
- Volunteers
- 756 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Breast Cancer, Invasive Breast Cancer
Sentinel Node Biopsy Following NeoAdjuvant Chemotherapy in Biopsy Proven Node Positive Breast Cancer
Title of Study: Sentinel node biopsy following neoadjuvant chemotherapy in biopsy proven node positive breast cancer. Objectives of the study: Primary objective 1.
- Trial name
- SN-FNAC (NCT00909441)
- Testing
- Sentinel Lymph Node Biopsy
- Where
- Canada
- Volunteers
- 153 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Breast Cancer
My Surgical Success: A Randomized Controlled Pilot Study of a Pre-surgical Psychological Intervention
The primary purpose of this study is to determine the feasibility and preliminary efficacy of a remote, Internet-based, pre-surgical psychoeducational intervention delivered to patients scheduled for breast cancer surgery…
- Trial name
- NCT03076190
- Testing
- Psychoeducational My Surgical Success Video
- Volunteers
- 131 people
- Sponsor
- Stanford University
Breast Cancer
Assessment of Health Related Quality of Life in Women Who Underwent Breast Reconstruction After Radical Surgery
Nowadays, breast reconstruction is an integral care after mastectomy in breast cancer patient. With the personalized care, choice a breast reconstructive is an important step involving decisions and mutual accord between patients…
- Trial name
- RMQOL (NCT04938505)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Centre Georges Francois Leclerc
Breast Cancer
Clinical Efficacy and Safety Assessment of Breast-Conserving Surgery for Central Breast Cancer: A Prospective Randomized Controlled Trial
This study enrolled 158 patients with primary central early-stage breast cancer and randomly assigned them to two groups. The control group underwent total mastectomy (with optional prosthetic implantation or autologous tissue…
- Trial name
- NCT06938360
- Testing
- breast-conserving surgery combined with radiotherapy
- Where
- China
- Volunteers
- 158 people
- Sponsor
- Xijing Hospital
Breast Cancer, Breast Surgery
Measuring Patient Satisfaction and Quality of Life Following Body Image Altering Surgery
The goal of this study is to develop a questionnaire to measure patient satisfaction with their breast surgery. This questionnaire will help surgeons better understand how patients feel about their surgical results.
- Conditions
- Breast Cancer, Breast Surgery, Breast Reconstruction, Breast Reduction
- Trial name
- NCT00605670
- Testing
- questionnaires
- Where
- 5 sites in United States, Canada
- Volunteers
- 722 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Vitamin C, Post-mastectomy Pain Syndrome
Vitamin C on Acute and Chronic Post Mastectomy Pain
This prospective randomized double-blinded controlled study will be conducted to evaluate the effect of perioperative vitamin C on acute and chronic post mastectomy pain after breast cancer surgery
- Trial name
- NCT05770596
- Testing
- vitamin C group
- Where
- Egypt
- Volunteers
- 204 people
- Sponsor
- Tanta University
Postoperative Pain, Breast Cancer
The Effect of Double Injection Erector Spinae Plane Block on Postoperative Pain Following Breast Surgery
Postoperative analgesia in breast surgery is a difficult and overworked issue due to extensive surgery and complex innervation of the breast.
- Trial name
- NCT03415646
- Testing
- Erector Spinae Plane Block, Intravenous Morphine patient controlled analgesia device
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Kocaeli University
Breast Cancer
Randomized Study of Hypofractionated and Conventional Fractionation Radiotherapy After Breast Conservative Surgery
Early-stage breast cancer patients treated with breast conservative surgery are enrolled in this study if they meet defined criteria.
- Trial name
- NCT01413269
- Testing
- radiotherapy
- Where
- 4 sites in China
- Volunteers
- 720 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Invasive Ductal Carcinoma, Ductal Carcinoma in Situ
Safety and Efficacy Study of the Xoft® Axxent® eBx® IORT System®
The purpose of this trial is to assess the safety and efficacy of the Xoft Axxent eBx System when used for single-fraction IORT in early stage breast cancer.
- Trial name
- NCT01644669
- Testing
- Intra-operative Radiation Therapy - IORT
- Where
- 24 sites in United States, Australia and 1 more
- Volunteers
- 1,200 people
- Sponsor
- Xoft, Inc.
Female Breast Carcinoma, Female Ductal Carcinoma In Situ
A Pre-Surgical PK Study of IM and Intraductally Delivered Fulvestrant
This is an open-label, non-randomized pharmacokinetic study of fulvestrant in women scheduled for mastectomy or lumpectomy. Eligible subjects will be identified with breast cancer or DCIS.
- Trial name
- 007 (NCT02540330)
- Testing
- Fulvestrant
- Where
- 3 sites in United States
- Volunteers
- 3 people
- Sponsor
- Atossa Therapeutics, Inc.
Breast Cancer
Acupuncture in the Management of Post Operative Symptoms in Breast Cancer Patients
This study is for the woman who will have axillary (armpit) surgery as part of their breast cancer treatment. The purpose of this project is to evaluate if acupuncture is helpful to control pain and improve range of motion (arm…
- Trial name
- NCT00419822
- Testing
- Acupuncture
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Legacy Health System
Early Breast Cancer
A Pharmacodynamics Pre-surgical Study of LEE011 in Early Breast Cancer Patients (MONALEESA-1)
This is a multi-center, open-label Phase II randomized pre-surgical pharmacodynamics study.
- Trial name
- MONALEESA-1 (NCT01919229)
- Testing
- LEE011 (ribociclib), letrozole
- Where
- 7 sites in United States, Singapore and 1 more
- Volunteers
- 14 people
- Sponsor
- Novartis Pharmaceuticals
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