Clinical trials: Surgery of Breast Cancer
Lymphedema, Edema
Prospective Evaluation of a Surgical Solution for Breast Cancer-Associated Lymphedema
To investigate whether addition of the Biobridge scaffold to the standard surgery for vascularized lymph node transfer will improve the outcome of surgical treatment in lymphedema of the upper arm.
- Trial name
- Biobridge (NCT02734979)
- Testing
- Biobridge and lymph node transfer
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Stanford University
Estrogen Receptor-negative Breast Cancer, Estrogen Receptor-positive Breast Cancer
Combination Chemotherapy and Filgrastim Before Surgery in Treating Patients With HER2-Positive Breast Cancer That Can Be Removed By Surgery
This phase II trial studies how well giving combination chemotherapy and filgrastim together before surgery works in treating patients with human epidermal growth receptor 2 (HER2)-positive breast cancer that can be removed by…
- Conditions
- Estrogen Receptor-negative Breast Cancer, Estrogen Receptor-positive Breast Cancer, HER2-positive Breast Cancer, Progesterone Receptor-negative Breast Cancer
- Trial name
- NCT00194779
- Testing
- doxorubicin hydrochloride, cyclophosphamide, paclitaxel
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Washington
DCIS, Breast Cancer
Radiotherapy Omission in Low Risk Ductal in Situ Carcinoma Breast
Following breast-conserving surgery (BCS) for localized ductal carcinoma in situ (DCIS) of the breast, whole-breast irradiation (WBRT) is a standard of care, reducing the absolute rate of in-breast recurrences (IBR) by more than…
- Conditions
- DCIS, Breast Cancer, Low Risk DCIS, Breast Conserving Surgery
- Trial name
- ROMANCE (NCT03878342)
- Testing
- Radiotherapy, No Radiotherapy
- Where
- 37 sites in France
- Volunteers
- 295 people
- Sponsor
- UNICANCER
Breast Cancer
Ablative SBRT in Elderly BC Patients
Stereotactic body radiotherapy (SBRT) is a modern radiotherapy technique, through which extremely high doses of irradiation are delivered in a very precise manner, within a few fractions.
- Trial name
- EASE (NCT06523894)
- Testing
- SBRT
- Where
- Switzerland
- Volunteers
- 36 people
- Sponsor
- University Hospital, Geneva
Breast Cancer, Breast Neoplasm
CRYoablation for Small Tumors As Local Treatment - SIX Trial
To demonstrate the non-inferiority of cryoablation compared to breast surgery for the local treatment of early-stage breast cancer and to conduct a cost-minimization analysis comparing direct costs between treatments.
- Trial name
- CRYSTAL - SIX (NCT06839001)
- Testing
- cryoablation, Breast Surgery (Lumpectomy or Mastectomy)
- Where
- 2 sites in Brazil
- Volunteers
- 750 people
- Sponsor
- Hospital do Coracao
Breast Cancer
Safety of Breast-Conserving Surgery for Multifocal or Multicentric Breast Cancer
The objective of this observational study is to evaluate the oncological safety of breast-conserving surgery combined with standard postoperative radiotherapy in adult female patients diagnosed with multifocal or multicentric…
- Trial name
- NCT07677956
- Testing
- Breast-conserving surgery, postoperative radiotherapy and individualized adjuvant systemic therapy
- Volunteers
- 100 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Thyroid Neoplasms
Comparative Study in Oral, Breast Approach and Open Thyroidectomy
Purpose: Total endoscopic thyroidectomy including oral approach and breast approach has excellent cosmetic and several functional results.
- Trial name
- NCT03479801
- Testing
- Thyroid Surgical Methods
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Breast Cancer
Randomized Study of Combination Chemotherapy With or Without Focused Microwave Thermotherapy Before Surgery in Treating Women With Large Breast Cancer Tumors
The purpose of this randomized Phase III study is to determine whether preoperative focused microwave heat treatment and chemotherapy combined are more effective than preoperative chemotherapy alone in the treatment of large…
- Trial name
- Medifocus301 (NCT01204801)
- Testing
- Focused Microwave Thermotherapy, Chemotherapy (control)
- Where
- 2 sites in United States, Canada
- Volunteers
- 238 people
- Sponsor
- Medifocus, Inc.
Triple Negative Breast Cancer
Clinical Trial of Neoadjuvant Chemotherapy With Atezolizumab or Placebo in Patients With Triple-Negative Breast Cancer Followed After Surgery by Atezolizumab or Placebo
The main purpose of this study is to learn if the usual chemotherapy given before surgery (neoadjuvant therapy) for breast cancer plus the experimental drug, atezolizumab, is better than the usual chemotherapy plus a placebo.
- Trial name
- NCT03281954
- Testing
- Atezolizumab
- Where
- 217 sites in United States, Canada
- Volunteers
- 1,550 people
- Sponsor
- NSABP Foundation Inc
Breast Cancer, Depression
The Effect of Melatonin on Depression, Anxiety, Cognitive Function and Sleep Disturbances in Breast Cancer Patients
The purpose of this study is to investigate the effect of 6 mg melatonin daily for 1 week preoperatively to 12 weeks postoperatively on depressive symptoms, anxiety, cognitive function and sleep disturbances in breast cancer…
- Trial name
- MELODY (NCT01355523)
- Testing
- Melatonin (N-acetyl-5-methoxytryptamine)
- Where
- Denmark
- Volunteers
- 54 people
- Sponsor
- Melissa Voigt Hansen
Breast Cancer, Breast Reconstruction
NIR Device for Assessment of Skin Flap Perfusion in Breast Surgery: A Pilot Interventional Study
The goal of this single-center, nonrandomized, interventional non-profit pilot study is to evaluate the feasibility and clinical utility of a non-invasive near-infrared spectroscopy (NIRS) imaging device for assessing skin-flap…
- Conditions
- Breast Cancer, Breast Reconstruction, Mastectomy
- Trial name
- ADisIRast (NCT07680296)
- Testing
- Snapshot NIR V3.0
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- National Research Council, Institute of Clinical Physiology, Italy
Post-Operative Nausea and Vomiting, Breast Cancer
Intraoperative Acupoint Stimulation to Prevent Post-Operative Nausea and Vomiting (PONV)
The goal of this clinical research study is to learn if light electrical stimulation to the wrist area during surgery is feasible in women having breast surgery.
- Trial name
- NCT02473042
- Testing
- Electrical Stimulation, Zofran, Dexamethasone
- Where
- United States
- Volunteers
- 188 people
- Sponsor
- M.D. Anderson Cancer Center
Axillary Web Syndrome
Extracorporeal Shock Wave and a Tailored Exercise Program on Axillary Web Syndrome
A total of 93 suitable patients will be randomly allocated into three groups: Group A will receive both low-energy extracorporeal shock wave therapy and a tailored exercise program, Group B will receive only low-energy…
- Trial name
- NCT05920369
- Testing
- low-energy extracorporeal shockwave and a tailored exercise program, low-energy extracorporeal shockwave, tailored exercise program
- Where
- 2 sites in Egypt
- Volunteers
- 93 people
- Sponsor
- Cairo University
Prostate Cancers, Breast Cancer
To Assess the Correlation of High-resolution Specimen PET-CT Imaging, Using the XEOS AURA 10 PET-CT, With the Histopathology Results and Long-term Outcome of Patients Undergoing Resective Cancer Surgery.
This registry study aims to evaluate the effectiveness and clinical impact of specimen PET-CT imaging by analyzing the correlation between specimen PET-CT images, intraoperative interpretations, and histopathological findings.
- Conditions
- Prostate Cancers, Breast Cancer, Head and Neck Cancer, Cancer
- Trial name
- PETRiS (NCT06970275)
- Where
- 5 sites in Belgium, Germany and 2 more
- Volunteers
- 850 people
- Sponsor
- XEOS Medical
Breast Cancer, Breast Surgery
Breathing Interventions for Postoperative Breast Surgery Patients
This randomized controlled trial aims to evaluate the effects of pranayama and pursed-lip breathing exercises on postoperative pain, anxiety, and vital signs in patients undergoing breast surgery.
- Conditions
- Breast Cancer, Breast Surgery, Postoperative Pain, Anxiety
- Trial name
- BREATH-RCT (NCT07449273)
- Testing
- Pranayama Breathing Exercise, Pursed-Lip Breathing Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 126 people
- Sponsor
- Ondokuz Mayıs University
Postoperative Pain
Modified Pectoral Nerves Block Versus Serratus Plane Block in Major Breast Cancer Surgery
The purpose of this study is to compare the analgesic profile of modified pectoral nerves block and serratus plane block in patients undergoing mastectomy.
- Trial name
- NCT02946294
- Testing
- Bupivacaine 0.25% with epinephrine
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Cairo University
Female Patients Under the Age of 65 Who Will Undergo Breast Cancer Surgery
The Effect of Premedication on Postoperative Pain and Anxiety in Breast Cancer Surgery
In this study, it was investigated whether the premedication drug administered before the surgery had an effect on postoperative pain and anxiety scores in female patients under the age of 65 who will undergo breast cancer…
- Trial name
- NCT05647642
- Testing
- Precedex and dormicum
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Programmed Cell Death 1
Effect of Anesthesia on Expression of Programmed Death-1 and Programmed Death-1 Ligand in Breast Cancer
Surgery is first-line treatment for solid tumors. However, surgical trauma-induced physiologic stress has been demonstrated to facilitate metastasis and recurrence in different types of cancer.
- Trial name
- NCT04657237
- Testing
- Thoracic Paravertebral block
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Assiut University
Breast Cancer
Comparing Decision on Aesthetics After Breast Cancer Locoregional Treatment.
Breast cancer is the most commonly diagnosed cancer, with an estimated 2.3 million new cases per year globally. Approximately 90% of these patients will undergo breast surgery with/without radiation (locoregional treatment).
- Trial name
- CINDERELLA (NCT05196269)
- Testing
- Artificial Intelligence and Digital Health Arm
- Where
- 6 sites in Germany, Israel and 3 more
- Volunteers
- 1,030 people
- Sponsor
- Fundacao Champalimaud
Breast Cancer, Surgery
Medico-economic Study of Three Strategies of Sentinel Lymph Node Analysis in Operable Breast Cancer
Breast carcinoma requires frequently an adjuvant therapy after surgical excision: in this way, one of the major criteria indicating the need of adjuvant chemotherapy is the diagnosis of a metastatic lymph-node invasion, mainly in…
- Trial name
- SAGE (NCT02056886)
- Testing
- SLN detection +/- complementary axillary lymphadenectomy
- Where
- 17 sites in France
- Volunteers
- 858 people
- Sponsor
- Institut Cancerologie de l'Ouest
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.