Clinical trials: Surgery of Breast Cancer
Paravertebral Catheter Insertion, Mastectomy
Prevention of Post-Mastectomy Breast Pain Using Ambulatory Continuous Paravertebral Blocks
Research study to determine if putting local anesthetic-or numbing medication-through a tiny tube placed next to the nerves that go to a breast prior to and following a mastectomy will decrease subsequent pain.
- Conditions
- Paravertebral Catheter Insertion, Mastectomy, Breast Cancer
- Trial name
- NCT01231204
- Testing
- Ropivicaine 0.4% Continuous Infusion
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of California, San Diego
Breast Cancer
Clinical and Biologic Effects of Metformin in Early Stage Breast Cancer
The study will be testing metformin in patients with breast cancer who are about to undergo surgery. Patients will take metformin 3 times daily for about 2-3 weeks prior to their surgery date.
- Trial name
- NCT00897884
- Testing
- Metformin
- Where
- 2 sites in Canada
- Volunteers
- 39 people
- Sponsor
- Mount Sinai Hospital, Canada
Breast Cancer
Investigation of Novel Surgical Imaging for Tumor Excision
This is a multi-center, two-arm randomized, blinded pivotal study to demonstrate the safety and efficacy of the LUM Imaging System (LUM015 imaging agent in conjunction with the LUM Imaging Device and decision software), in…
- Trial name
- INSITE (NCT03686215)
- Testing
- Study Device Arm
- Where
- 14 sites in United States
- Volunteers
- 406 people
- Sponsor
- Lumicell, Inc.
Fibroadenoma, Breast Fibroadenoma
Management of Breast Fibroadenoma: Comparing Observation, Microwave Ablation, and Surgical Excision
The purpose of this study is to evaluate and compare three different management strategies for benign breast fibroadenoma: conservative management with clinical and radiological follow-up (observation), ultrasound-guided…
- Conditions
- Fibroadenoma, Breast Fibroadenoma, Benign Breast Disease
- Trial name
- NCT07890766
- Testing
- Ultrasound-guided percutaneous microwave ablation, Conventional open surgical excision
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Sohag University
Breast Adenocarcinoma, Hormone Receptor Positive
Hormone Therapy With or Without Combination Chemotherapy in Treating Women Who Have Undergone Surgery for Node-Negative Breast Cancer (The TAILORx Trial)
This randomized phase III trial studies the best individual therapy for women who have node-negative, estrogen-receptor positive breast cancer by using a special test (Oncotype DX), and whether hormone therapy alone or hormone…
- Conditions
- Breast Adenocarcinoma, Hormone Receptor Positive, Stage IA Breast Cancer AJCC v7, Stage IB Breast Cancer AJCC v7
- Trial name
- TAILORx (NCT00310180)
- Testing
- Anastrozole, Exemestane, Laboratory Biomarker Analysis
- Where
- 1,222 sites in United States, Australia and 6 more
- Volunteers
- 10,273 people
- Sponsor
- National Cancer Institute (NCI)
Postoperative Pain
Dexmedetomidine in Erector Spinae Block in Postoperative Analgesia
60 female patients scheduled for breast cancer surgeries, allocated in 3 groups for erector spinae block with bupivacaine and erector spinae block with dexmedetomidine added to bupivacaine and control group.
- Trial name
- NCT04920669
- Testing
- erector spinae block with bupivacaine, erector spinae block with bupivacaine + dexmedetomidine
- Where
- Egypt
- Volunteers
- 58 people
- Sponsor
- Mohamed Elsayed Hassan
Ductal Breast Carcinoma in Situ, Estrogen Receptor-positive Breast Cancer
4-Hydroxytamoxifen or Tamoxifen Citrate in Treating Women With Newly Diagnosed Ductal Breast Carcinoma in Situ
This randomized phase II trial is studying 4-hydroxytamoxifen to see how well it works compared with tamoxifen citrate in treating women with newly diagnosed ductal breast carcinoma in situ.
- Trial name
- NCT00952731
- Testing
- afimoxifene, tamoxifen citrate
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Northwestern University
Breast Cancer Stage I
Non Surgical Treatment (Microwave Ablation) of Breast Cancer
In the Netherlands approximately one out of seven women will develop breast cancer during her life. Most of these breast cancers are early stage, 40% of the women have stage 1.
- Trial name
- MASTER (NCT05887154)
- Testing
- Microwave ablation
- Volunteers
- 15 people
- Sponsor
- University Medical Center Groningen
Axillary Web Syndrome
Effectiveness of Cohesive Bandage on Axillary Web Syndrome After
Objective: To determine the effectiveness of cohesive bandage on the axillary web syndrome in improving pain, reducing swelling and increasing mobility and functionality of the shoulder.
- Trial name
- CBaws (NCT04338334)
- Testing
- Manual drainage & arm therapeutic exercise, Cohesive bandaging & arm therapeutic exercise
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- University of Alcala
Breast Cancer
Effect of Surgery and Radiation Therapy on Tc-99M Sestamibi Uptake Patterns in Molecular Breast Imaging
The investigators hope to prove that radiation and surgical scarring does not result in changes that affect the MBI pattern 6-12 months after completion of treatment.
- Trial name
- NCT01027767
- Testing
- Molecular Breast Imaging
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Mayo Clinic
Taxane-induced Peripheral Neuropathy
Evaluation of the Efficacy of Compression With Tight Surgical Gloves in Patients With Taxane-based Therapy
In this study, the effect of compression therapy of the hands with tight surgical gloves to reduce peripheral neuropathy in adult patients during the application of taxanes will be evaluated.
- Trial name
- ComPrendo (NCT06464536)
- Testing
- Compression
- Where
- Switzerland
- Volunteers
- 114 people
- Sponsor
- St.Gallen University of Applied Sciences
Breast Cancer, Perforator Flap
Deep Inferior Epigastric Artery Flap for Breast Reconstruction
Background: There is no consensus on the duration of prophylactic antibiotics for autologous breast reconstruction after mastectomy.
- Conditions
- Breast Cancer, Perforator Flap, Anti-Infectives Adverse Reaction, Infections
- Trial name
- NCT05088239
- Testing
- prophylactic antibiotics duration
- Volunteers
- 108 people
- Sponsor
- Chiayi Christian Hospital
Breast Cancer
Radiation Therapy in Treating Women Who Have Undergone Surgery for Early-Stage Invasive Breast Cancer
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Radiation to the tumor site and surrounding area may kill more tumor cells.
- Trial name
- NCT00005957
- Testing
- Standard Breast Irradiation, Breast Radiation plus Regional Radiation
- Where
- 26 sites in Canada
- Volunteers
- 1,832 people
- Sponsor
- NCIC Clinical Trials Group
Breast Cancer
A Study to Evaluate the Use of Supine MRI Images in Breast Conserving Surgery
This is a 2 Phase study. In the first phase of the study, patients with palpable invasive breast cancer underwent pre-operative supine MRI and optical scanning in the surgical position.
- Trial name
- NCT01929395
- Testing
- Supine MRI
- Where
- United States
- Volunteers
- 159 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Breast Disease, Phyllodes Breast Tumor
Cryotherapy in Breast B3 Lesions
To determine the feasibility of cryotherapy for B3 fibroepithelial lesions
- Trial name
- NCT04571307
- Testing
- cryotherapy
- Where
- Singapore
- Volunteers
- 12 people
- Sponsor
- KK Women's and Children's Hospital
Breast Cancer, Surgery
Real Time Tissue Characterisation Using Mass Spectrometry REI-EXCISE iKnife Study
REI-EXCISE is a multicentre, prospective, non-randomised feasibility study, aimed to evaluate the diagnostic accuracy of rapid ionisation mass spectroscopy using an iKnife device.
- Trial name
- REI-EXCISE (NCT03432429)
- Testing
- REIMS iKnife
- Where
- 3 sites in United Kingdom
- Volunteers
- 158 people
- Sponsor
- Imperial College London
Breast Cancer, Cognitive/Functional Effects
Fatigue Caused by Chemotherapy in Women Who Have Undergone Surgery for Breast Cancer and in Healthy Volunteers
RATIONALE: Gathering information over time from women undergoing chemotherapy for breast cancer may help doctors learn more about mental and physical fatigue caused by treatment.
- Conditions
- Breast Cancer, Cognitive/Functional Effects, Fatigue, Long-term Effects Secondary to Cancer Therapy in Adults
- Trial name
- NCT00909662
- Testing
- assessment of therapy complications, cognitive assessment, fatigue assessment and management
- Where
- 2 sites in United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Case Comprehensive Cancer Center
Breast Cancer
Anti-tumour Effects & Tolerability of Faslodex Alone or in Combination With Arimidex in Post Menopausal Women Prior to Surgery for Primary Breast Cancer
To compare the anti-tumour effects as measured by changes in various biomarkers, of a combination of Faslodex and Arimidex with Faslodex alone and Arimidex alone in postmenopausal women patients with primary breast cancer who are…
- Trial name
- NCT00259090
- Testing
- Fulvestrant, Anastrazole
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- AstraZeneca
Breast Cancer Surgery, Quality of Life
Quality of Life After Breast Cancer Surgery
The goal of this observational study is to prospectively collect data on quality of life after oncoplastic breast surgery. Participants will be followed-up and answer quality of life questionnaire for a duration of 5 years after…
- Trial name
- SOCOM-QoL (NCT06761196)
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 1,500 people
- Sponsor
- Centre Hospitalier de Colmar
Breast Cancer Early Stage Breast Cancer (Stage 1-3), SBRT
A Phase I Dose-escalation Trial of Definitive Single Dose Stereotactic Body Radiotherapy in Low-risk Breast Cancer Patients: DESERT I Trial
Radiotherapy (RT) is a fundamental pillar in the fight against cancer. In the case of breast cancer, RT has traditionally been applied as an adjuvant treatment following surgery.
- Trial name
- DESERT-I (NCT06671691)
- Testing
- SBRT level I, SBRT level II, SBRT level III
- Where
- Spain
- Volunteers
- 15 people
- Sponsor
- Universitat de les Illes Balears
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.