Clinical trials: Surgery of Breast Cancer
Breast Cancer, Cardiac Toxicity
Doxorubicin and Cyclophosphamide Followed By Trastuzumab, Paclitaxel, and Lapatinib in Treating Patients With Early-Stage HER2-Positive Breast Cancer That Has Been Removed By Surgery
RATIONALE: Drugs used in chemotherapy, such as doxorubicin, cyclophosphamide, and paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00436566
- Testing
- trastuzumab, cyclophosphamide, doxorubicin hydrochloride
- Where
- United States
- Volunteers
- 122 people
- Sponsor
- Mayo Clinic
Breast Cancer
Docetaxel and Carboplatin With or Without Trastuzumab Before Surgery in Treating Women With Locally Advanced Breast Cancer
RATIONALE: Drugs used in chemotherapy, such as docetaxel and carboplatin, use different ways to stop tumor cells from dividing so they stop growing or die.
- Trial name
- NCT00068341
- Testing
- trastuzumab, carboplatin, docetaxel
- Where
- 4 sites in United States
- Volunteers
- 74 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Breast Cancer, Skin Cancer
Follow-up of Elderly Patients in Ambulatory Surgery
The number of surgical procedures performed in ambulatory hospitalization for cancers of the skin or breast is increasing for medical and economic reasons.
- Conditions
- Breast Cancer, Skin Cancer, Surgery, Ambulatory
- Trial name
- PAPA (NCT03604666)
- Testing
- Health care process with Nurse Navigator
- Where
- France
- Volunteers
- 320 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Anatomic Stage IV Breast Cancer AJCC v8, Astrocytoma
Ketoconazole Before Surgery in Treating Patients With Recurrent Glioma or Breast Cancer Brain Metastases
This trial studies the side effects and how well ketoconazole works before surgery in treating patients with glioma that has come back or breast cancer that has spread to the brain.
- Conditions
- Anatomic Stage IV Breast Cancer AJCC v8, Astrocytoma, Breast Carcinoma Metastatic in the Brain, Glioma
- Trial name
- NCT03796273
- Testing
- Best Practice, Ketoconazole
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Wake Forest University Health Sciences
Breast Cancer Female
Validation of Prone Crawl Radiotherapy for Whole-breast Irradiation After Breast Conserving Surgery
The aim of this study is to validate the obtained results of setup precision, comfort and setup time. The possibility of using breath hold for heart sparing in combination with prone crawl position will be tested.
- Trial name
- NCT05179161
- Testing
- Prone crawl positioning
- Volunteers
- 40 people
- Sponsor
- University Hospital, Ghent
Breast Cancer, Mastectomy, Modified Radical
Comparison of Operation Time, Drain Duration, and Seroma Formation After Modified Radical Mastectomy Using Ultrasonic Dissector Versus Electrocautery in Women With Breast Cancer
The goal of this clinical trial was to compare two surgical techniques-ultrasonic dissector and electrocautery-for performing axillary dissection in women undergoing modified radical mastectomy (MRM) for breast cancer.
- Conditions
- Breast Cancer, Mastectomy, Modified Radical, Mastectomy Plus Axillary Lymph Node Dissection, Seroma Following Procedure
- Trial name
- NCT07050329
- Testing
- Electrocautery, Ultrasonic dissector
- Where
- Pakistan
- Volunteers
- 138 people
- Sponsor
- Quaid-e-Azam Medical College
Newly Diagnosed Breast Cancer, Surgery Programmed
Factors Correlated With Fatigue in Breast Cancer
The aim of this study is to identify the determinants of cancer-related fatigue, and the long-term effect of the different adjuvants treatments will be explored.
- Trial name
- FATSEIN (NCT01064427)
- Where
- 3 sites in France
- Volunteers
- 557 people
- Sponsor
- Central Hospital, Nancy, France
HER2-positive Breast Cancer, Stage I Breast Cancer
Omission of Surgery in Clinically Low-risk HER2positive Breast Cancer With High HER2 Addiction and a Complete Response Following Standard Anti-HER2-based Neoadjuvant Therapy
This is a prospective, single arm, open-label, unicenter, exploratory study in women with primary operable HER2-positive, HER2-enriched/ERBB2-high breast cancer according to PAM50 intrinsic subtype and a ERBB2 pre-defined cutoff…
- Trial name
- ELPIS (NCT04578106)
- Testing
- Trastuzumab and pertuzumab Subcutaneous Fixed-Dose Combination
- Where
- Spain
- Volunteers
- 5 people
- Sponsor
- Fundacio Clinic Barcelona
Pain
Breast Cancer Rehabilitation With Acupuncture and Physical Therapy Protocol
The pain is very common complaint, and the neck is one of the most affected spots, mainly due to muscle contracture of the cervical and scapular region, triggered by emotional stress associated with muscle retraction involved…
- Trial name
- NCT02798263
- Testing
- Kinesiotherapy, Acupuncture, Stiper
- Where
- Brazil
- Volunteers
- 79 people
- Sponsor
- Federal University of São Paulo
Breast Neoplasms
Safety and Effectiveness Study of Single-Port Surgical System in Breast Tumor Surgery
This is a prospective, multicenter clinical study designed to evaluate the safety and effectiveness of remote surgery using the single-port thoracoabdominal endoscopic surgical system in breast tumor surgery.
- Trial name
- NCT07879963
- Testing
- Robotic-assisted breast tumor surgery, Single-port surgical system operation
- Volunteers
- 25 people
- Sponsor
- haiyanli
Persistent Postoperative Pain
Swiss Multi-centre, Randomized, Placebo Controlled Trial of Pregabalin for Prevention of Persistent Pain in High Risk Patients Undergoing Breast Cancer Surgery
This study will test the benefits and risks of using pregabalin perioperatively to prevent persistent postoperative pain in patients at high risk (>30%) of developing such pain after breast cancer surgery.
- Trial name
- PREVENT (NCT03216187)
- Testing
- Pregabalin
- Where
- 6 sites in Switzerland
- Volunteers
- 126 people
- Sponsor
- Benno Rehberg-Klug
Sensation Disorder
A Comparative Study of Nipple Sensation Preservation After Nipple-Sparing Mastectomy With Conventional, Endoscopic, Robotic Techniques
The goal of this comparative study is to learn how different surgical methods affect nipple and skin sensation after nipple-sparing mastectomy (NSM).
- Trial name
- NIPSENSE (NCT07062458)
- Testing
- Nipple Sensation Assessment
- Where
- Italy
- Volunteers
- 90 people
- Sponsor
- Candiolo Cancer Institute - IRCCS
Breast Neoplasms, Surgery Scheduled
Proof of Concept of the Aiinane Preoperative Risk Assessment Tool.
BACKGROUND: Each year, over 13,000 patients in Catalonia and more than 4 million worldwide experience last-minute surgery cancellations (LMC) due to preoperative inefficiencies.
- Conditions
- Breast Neoplasms, Surgery Scheduled, Surgery Related Complications Rate, Preanesthetic Medication
- Trial name
- aiinane-24-1 (NCT07021235)
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Ancor Serrano
Breast Cancer
Luteal vs Follicular Surgical Oophorectomy and Tamoxifen in Premenopausal Women With Metastatic Hormone Receptor Positive Breast Cancer
This study will determine if hormone receptor positive premenopausal metastatic breast cancer patients who undergo removal of the ovaries in mid-luteal versus mid-follicular phase have a longer survival.
- Trial name
- NCT00293540
- Testing
- oophorectomy, Tamoxifen
- Where
- 21 sites in United States, Bangladesh and 8 more
- Volunteers
- 249 people
- Sponsor
- International Breast Cancer Research Foundation
Breast Cancer, Surgery--Complications
Surgical and Patient Reported Outcomes of Robotic Nipple-Sparing Mastectomy
Nipple-sparing mastectomy (NSM) with immediate reconstruction is one of the standard of care surgical treatments of breast cancer (BC) and is used for risk reduction in patients with a high risk for BC.
- Conditions
- Breast Cancer, Surgery--Complications, Genetic Predisposition to Disease, Surgery
- Trial name
- RNSM (NCT04151368)
- Testing
- Robotic Nipple-Sparing Mastectomy (RNSM)
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University Health Network, Toronto
Breast Cancer
Survival of BCS vs Mx in Asymptomatic Screen-detected NPBC
We performed this study on a consecutive cohort of women with asymptomatic screen-detected NPBC. The clinicopathological characteristics, 10-year relapse-free survival (RFS) and overall survival (OS) were compared between BCS and…
- Trial name
- NCT06103032
- Testing
- Breast Conserving Surgery, Mastectomy
- Where
- China
- Volunteers
- 1,020 people
- Sponsor
- Peking Union Medical College Hospital
Breast Cancer, Surgery
Targeted Resection of Axillary Metastatic Lymph Nodes After Breast Cancer Neoadjuvant Chemotherapy
This study evaluates the efficacy and feasibility of Carbon Nanoparticle Suspension Injection (CNSI) for Targeted Axillary Dissection (TAD) in breast cancer patients undergoing neoadjuvant chemotherapy (NAC), compared to…
- Conditions
- Breast Cancer, Surgery, Lymph Node Metastases
- Trial name
- NCT04744506
- Testing
- Tissue Marker Clip, Carbon Nanoparticle Suspension Injection
- Where
- China
- Volunteers
- 126 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Breast Cancer (Early Breast Cancer), Sentinel Lymph Node Biopsy
NAUTILUS-04: No Axillary Surgical Treatment in Low-Risk Clinically Node-Negative Breast Cancer Without Whole-Breast Radiotherapy
The safety of omitting sentinel lymph node biopsy (SLNB) has been established only in patients undergoing breast-conserving surgery with whole-breast radiotherapy, as demonstrated in the prior randomized trials.
- Trial name
- NAUTILUS-04 (NCT07841704)
- Testing
- Omission of axillary surgery, Sentinel lymph node biopsy
- Where
- South Korea
- Volunteers
- 1,520 people
- Sponsor
- Wonshik Han
Breast Cancer
Evaluation of Breast Cancer Recurrence Rates Following Surgery in Women With Ductal Carcinoma In Situ
RATIONALE: The evaluation of breast cancer recurrence rates may improve the ability to plan cancer treatment for patients with breast cancer.
- Trial name
- NCT00002934
- Testing
- long-term screening
- Where
- 30 sites in United States, South Africa
- Volunteers
- 711 people
- Sponsor
- Eastern Cooperative Oncology Group
Breast Cancer, Surgery
Analgesic Effect of Resistance Training for Breast Cancer Survivors
Persistent pain after treatment for breast cancer is a major clinical problem, affecting 25-60 % of the patients and is a source of considerable physical disability and psychological distress.
- Conditions
- Breast Cancer, Surgery, Chemotherapy Effect, Radiotherapy Side Effect
- Trial name
- (ANTRAC) (NCT04509284)
- Testing
- Training, Control
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Aalborg University
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