Clinical trials: Surgery of Breast Cancer
Breast Cancer Female
Selective Omission of Axillary Surgery in Triple-negative and HER2-positive Breast Cancer After NACT
Neoadjuvant chemotherapy (NACT) is standard treatment for many triple-negative (TNBC) and HER2-positive breast cancer. Study showed about half of the biopsy-proven axillary disease will be eradicated by NACT and converted to ypN0…
- Trial name
- NCT05314114
- Testing
- No axillary surgery
- Where
- China
- Volunteers
- 136 people
- Sponsor
- Peking University
Breast Cancer
Prediction in Silico of Pathological Response in a Prospective Cohort Study of Early Breast Cancer Patients
Breast cancer (BC) is the most common cancer in women in France with nearly 58,500 new cases and 12,150 deaths estimated in 2018 . Two major achievements have been made in the last five years for breast cancer patients.
- Trial name
- NEOEPICURE (NCT05981326)
- Testing
- Biopsy, Blood samples, Questionnaires
- Where
- 2 sites in France
- Volunteers
- 300 people
- Sponsor
- Institut Cancerologie de l'Ouest
Breast Cancer
A Study of Women With an Early Diagnosis of Breast Cancer, Taking Celecoxib Between the Biopsy and Lumpectomy/Mastectomy
To assess the effects of short term administration of celecoxib 400 mg bid between biopsy and reexcision.
- Trial name
- NCT00328432
- Testing
- celecoxib 400 mg bid
- Where
- 7 sites in United States
- Volunteers
- 100 people
- Sponsor
- University of Kansas
Breast Cancer
Efficacy of Thoracic Paravertebral Block in the Reduction of Acute Post-surgical Pain in Patients With Breast Cancer
Surgical treatment of breast cancer is frequently associated with postoperative pain in the surgical area. Persistent pain after breast cancer management has considerable negative effects on the quality of life of survivors.
- Trial name
- NCT02609321
- Testing
- Thoracic Paravertebral Block, Surgical Wound Infiltration
- Where
- Colombia
- Volunteers
- 60 people
- Sponsor
- Instituto de Cancerología S.A.
Primary Operable Breast Cancer
Perioperative Administration of COX 2 Inhibitors and Beta Blockers to Women Undergoing Breast Cancer Surgery
Surgery for breast cancer has a major role in enhancing long term survival and cure, but several physiological aspects associated with surgery are implicated as enhancing tumor spread and formation of distant metastases.
- Trial name
- NCT00502684
- Testing
- Propranolol, etodolac
- Where
- 3 sites in Israel
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Kaplan Medical Center
Invasive Breast Cancer
Comparison of CNB and Surgical Specimens for ER, PgR, HER2 Status and Ki67 Index in Invasive Breast Cancer.
This is a prospective, single-center, non-randomized, non-controlled study. The estrogen receptor (ER), progesterone receptor (PgR), HER2 status and Ki67 index of CNB specimen are critical biomarkers for making neoadjuvant…
- Trial name
- NCT02773784
- Testing
- immunohistochemistry and/or FISH
- Where
- China
- Volunteers
- 314 people
- Sponsor
- Peking University
Breast Neoplasms
Evaluation of Chemotherapy Prior to Surgery With or Without Zometa for Women With Locally Advanced Breast Cancer
This study is designed to evaluate the impact of Zometa on clearance of bone marrow micrometastases; the protective effect on chemotherapy-induced loss of bone mineral density; and quality of life in women undergoing treatment…
- Trial name
- NCT00242203
- Testing
- Zometa, Epirubicin, Docetaxel
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Washington University School of Medicine
Lymphedema, Edema
Prospective Evaluation of a Surgical Solution for Breast Cancer-Associated Lymphedema
To investigate whether addition of the Biobridge scaffold to the standard surgery for vascularized lymph node transfer will improve the outcome of surgical treatment in lymphedema of the upper arm.
- Trial name
- Biobridge (NCT02734979)
- Testing
- Biobridge and lymph node transfer
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Stanford University
Breast Neoplasms, Pain, Postoperative
Comparison of Erector Spina Plane Block and Thoracic Epidural Block
The aim of this randomised controlled and double-blind study, is to compare the effects of erector spinae plane (ESP) and thoracic epidural (TEA) blocks on peri-operative hemodynamics and analgesia in patients undergoing…
- Trial name
- NCT04702061
- Testing
- Erector spina plane block before general anaesthesia, Thoracic epidural block before general anaesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Inonu University
Breast Cancer, Axillary Lymph Nodes Dissection
Audit of Targeted Sentinel Node Biopsy (TSNB) in Patients With Limited Nodal Disease Undergoing Primary Surgery
Axillary ultrasound scan (AUS) is routinely employed in the UK for preoperative axillary staging and can diagnose approximately 50 - 80% of node positive patients when combined with percutaneous needle biopsy techniques (either…
- Conditions
- Breast Cancer, Axillary Lymph Nodes Dissection, Axillary Metastases, Sentinel Lymph Node Biopsy (SLNB)
- Trial name
- NodeSMART (NCT07085442)
- Testing
- Targeted Sentinel Node Biopsy (TSNB)
- Where
- 14 sites in United Kingdom
- Volunteers
- 400 people
- Sponsor
- University Hospitals of Derby and Burton NHS Foundation Trust
Breast Cancer, Breast Surgery
Hemodynamic Effects of Intradermal Methylene Blue During Breast Surgery Under General Anesthesia
This prospective observational study aims to evaluate the effects of intradermal methylene blue injection on intraoperative hemodynamic stability in patients undergoing breast surgery under general anesthesia.
- Conditions
- Breast Cancer, Breast Surgery, Sentinel Lymph Node Biopsy, Methylene Blue
- Trial name
- NCT07040540
- Testing
- Methylene Blue, Standard Surgical Care Without Dye
- Where
- Turkey (Türkiye)
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8
Hypofractionated Radiotherapy Before or After Breast Surgery for Treatment of Patients With Non-Metastatic Breast Cancer
This phase II trial studies how well hypofractionated radiotherapy before (preoperative) or after (postoperative) breast surgery works in treating patients with different types of non-metastatic (has not spread from original…
- Conditions
- Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8, Breast Carcinoma
- Trial name
- NCT06635980
- Testing
- Biopsy of Breast, Biospecimen Collection, Breast Surgery
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Mayo Clinic
Breast Cancer Female
Safety, Feasibility, and Outcomes of Early Rehabilitation After Breast Cancer Surgery
Breast cancer is one of the most common tumours in women. Advances in diagnosis and treatment have increased survival, but many women experience functional sequelae after breast and/or axillary surgery, including pain, reduced…
- Trial name
- EMOVE-BCS (NCT07651696)
- Testing
- Early Postoperative Rehabilitation Protocol
- Volunteers
- 110 people
- Sponsor
- Marta Aguilar-Rodriguez
Anatomic Stage 0 Breast Cancer AJCC v8, Anatomic Stage I Breast Cancer AJCC v8
Ipilimumab, Nivolumab, and Talimogene Laherparepvec Before Surgery in Treating Participants With Localized, Triple-Negative or Estrogen Receptor Positive, HER2 Negative Breast Cancer-deleted
This phase I trial studies talimogene laherparepvec given together with ipilimumab and nivolumab before surgery in patients with triple-negative or estrogen receptor positive, HER2 negative localized breast cancer.
- Conditions
- Anatomic Stage 0 Breast Cancer AJCC v8, Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8, Anatomic Stage IB Breast Cancer AJCC v8
- Trial name
- NCT04185311
- Testing
- Ipilimumab, Nivolumab, Talimogene Laherparepvec
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Breast Cancer
The Impact of Surgeon-Interpreted Intraoperative Margin Assessment During Breast Conserving Surgery on Postoperative Treatment
To learn if Pegulicianine Fluorescence-Guided Surgery (pFGS), which is part of the Lumicell Direct Visualization System, and Digital Breast Tomosynthesis (DBT) can improve the identification of tumor margins during a partial…
- Trial name
- NCT07140965
- Testing
- Pegulicianine Fluorescence-Guided Surgery, Digital Breast Tomosynthesis, Breast Conserving Therapy
- Where
- United States
- Volunteers
- 175 people
- Sponsor
- M.D. Anderson Cancer Center
Breast Disease, Phyllodes Breast Tumor
Cryotherapy in Breast B3 Lesions
To determine the feasibility of cryotherapy for B3 fibroepithelial lesions
- Trial name
- NCT04571307
- Testing
- cryotherapy
- Where
- Singapore
- Volunteers
- 12 people
- Sponsor
- KK Women's and Children's Hospital
Breast Cancer, Drug/Agent Toxicity by Tissue/Organ
Combination Chemotherapy After Surgery With or Without Chinese Herbal Therapy to Treat Symptoms in Women With Breast Cancer
RATIONALE: Herbs used in traditional Chinese medicine may decrease the side effects of chemotherapy. PURPOSE: Randomized phase I/II trial to study the effectiveness of herbs used in traditional Chinese medicine in decreasing the…
- Trial name
- NCT00028964
- Testing
- Chinese herbs, cyclophosphamide, doxorubicin hydrochloride
- Where
- United States
- Sponsor
- University of California, San Francisco
Breast Fibroadenoma
Treatment of Breast Fibroadenoma With High Intensity Focused Ultrasound (HIFU)
This is a multi-center, crossover study with cluster randomization and a planned accrual of 300 patients with diagnosed breast fibroadenoma (One fibroadenoma treated per patient).
- Trial name
- NCT03742401
- Testing
- Surgery, HIFU (Echopulse)
- Where
- 12 sites in France
- Volunteers
- 2 people
- Sponsor
- Theraclion
Axillary Web Syndrome
Effectiveness of Cohesive Bandage on Axillary Web Syndrome After
Objective: To determine the effectiveness of cohesive bandage on the axillary web syndrome in improving pain, reducing swelling and increasing mobility and functionality of the shoulder.
- Trial name
- CBaws (NCT04338334)
- Testing
- Manual drainage & arm therapeutic exercise, Cohesive bandaging & arm therapeutic exercise
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- University of Alcala
Breast Cancer
Establishment and Clinical Application of Precise SLNB System in Breast Cancer: a Randomized, Multicenter, Controlled Study
The investigatorsconduct the precise sentinel lymph node biopsy using preoperative computed tomographic lymphography in breast cancer.
- Trial name
- NCT03857932
- Testing
- Participants receive SLNB as well as non SLNs resection
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Shandong University
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